Phenotypic properties of herpes simplex virus 1 containing a derepressed open reading frame P gene

Journal of Virology

Volumn 70, Issue 3, 1996, Pages 1810-1817

  Lagunoff, Michael ^a   Randall, Glenn ^a   Roizman, Bernard ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS DNA;

ANIMAL CELL; ARTICLE; BINDING SITE; DNA SEQUENCE; GENE EXPRESSION; GENE LOCATION; HERPES SIMPLEX VIRUS 1; NONHUMAN; OPEN READING FRAME; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; TRIGEMINUS GANGLION; VIRUS DETECTION; VIRUS INHIBITION; VIRUS TRANSCRIPTION;

EID: 0030061035     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.3.1810-1817.1996     Document Type: Article

References (34)

1. Ackermann, M., J. Chou, M. Sarmiento, R. A. Lerner, and B. Roizman. 1986. identification by antibody to a synthetic peptide of a protein specified by a diploid gene located in the terminal repeats of the L component of herpes simplex virus genome. J. Virol. 58:843-850.
2. Block, T. M., S. Deshmane, J. Masonis, .I. Maggioncalda, T. Valyi-Nagi, and N. W. Fraser. 1993. An HSV LAT null mutant reactivates slowly from latent infection and makes small plaques on CV-1 monolayers Virology 192:618-630.
3. L region. J Virol. 67:632-642.
4. 134.5, a gene nonessential for growth in culture. Science 250:1262-1266.
5. 134.5 gene of herpes simplex virus J Virol. 68:8304-8311.
6. 134 5 gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells. Proc. Natl. Acad. Sci USA 89:3266-3270.
7. 134 5 gene function which blocks the host response to infection maps in the homologous domain of the genes expressed during growth arrest and DNA damage. Proc. Natl. Acad. Sci. USA 91:5247-5251.
8. Devi-Rao, G. B., S. A. Goodart, L. M. Hecht, R. Rochford, M. K. Rice, and E. K. Wagner. 1991 Relationship between polyadenylated and nonpolyadenylated herpes simplex virus type 1 latency-associated transcripts. J. Viorl. 65:2179-2190.
9. Dobson, A. T., F. Sederati, G. Devi-Rao, W. M. Flanagan, M. J. Farrell, J. G. Stehens, E. K. Wagner, and L. T. Feldman. 1989. Identification of the latency-associated transcript promoter by expression of rabbit beta-globin mRNA in mouse sensory nerve ganglia latently infected with a recombinant herpes simplex virus. J. Virol 63:3844-3851.
10. Ejercito, P. M., E. D. Kieff, and B. Roizman. 1967. Characterization of herpes simplex virus strains differing in their effects on social behaviour of infected cells. J. Gen. Virol. 2:357-364
11. Faber, S. W., and K. W. Wilcox. 1986. Association of the herpes simplex virus regulatory protein ICP4 with specific nucleotide sequences in DNA Nucleic Acids Res. 14:6067-6083.
12. Hill, J. M., F. Sedarati, R. T. Javier, E. K. Wagner, and J. G. Stevens. 1990. Herpes simplex virus latent phase transcription facilitates m vivo reactivation. Virology 174:117-125.
13. Ho, D. Y. 1992. Herpes simplex virus latency: molecular aspects. Prog. Med. Virol 39:76-115
14. Igarashi, K., R. Fawl, R. J. Roller, and B. Roizman. 1993. Construction and properties of a recombinant herpes simplex virus 1 lacking both S-component origins of DNA synthesis. J. Virol. 67:2123-2132.
15. Javier, R. T., J. G. Stevens, V. B. Diskette, and E. K. Wagner. 1988. A herpes simplex virus transcript abundant in latently infected neurons is dispensable for establishment of the latent state. Virology 166:254-257.
16. 134.5 gene and transcribed by an RNA ′' coterminal with the unspliced latency-associated transcript. J. Virol. 68:6021-6028.
17. Lagunoff, M., and B. Roizman. 1995. The regulation of synthesis and properties of the protein product of open reading frame P of the herpes simplex virus 1 genome. J. Viral. 69:3615-3623.
18. Leib, D. A., C. L. Bogard, M. Kosz-Vnenchak, K. A. Hicks, D. M. Coen, D. M. Knipe, and P. A. Schaffer. 1989. A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency. J. Virol. 63:2893-2900.
19. Michael, N., and B. Roizman. 1993. Repression of the herpes simplex virus 1 α4 gene by its gene product occurs within the context of the viral genome and is associated with all three identified cognate sites. Proc. Natl. Acad. Sci. USA 90:2286-2290.
20. Mitchell, W. J., K. P. Lirette, and N. W. Fraser. 1990. Mapping of low abundance latency-associated RNA in the trigemmal ganglia of mice latently infected with herpes simplex virus type 1. J. Gen. Virol. 71:125-132.
21. Post, L. E., S. Mackem, and B. Roizman. 1981. Regulation of α genes of herpes simplex virus, expression of chimeric genes produced by fusion of thymidine kinase with α gene promoters. Cell 24:555-565.
22. Post, L. E., and B. Roizman. 1981. A generalized technique for deletion of specific genes m large genomes: a gene 22 of herpes simplex virus 1 is not essential for growth. Cell 25:227-232.
23. Reed, L. J., and H. Muench. 1938. A simple method of estimating fifty per cent endpoints. Am. J. Hyg. 27:493-197.
24. Roizman, B., and A. S. Sears. 1987. An inquiry into the mechanisms of herpes simplex virus latency. Annu. Rev. Microbiol. 41:543-571.
25. s11 negatively regulates the accumulation of a truncated viral mRNA. J. Virol. 65:5873-5879.
26. Sears, A. E., V. Hukkanen, M. A. Labow, A. J. Levine, and B. Roizman. 1991. Expression of the herpes simplex virus 1 of transinducing factor (VP16) does not induce reactivation of latent virus or prevent the establishment of latency in mice. J. Virol. 65:2929-2935.
27. Sedarati, F., K. M. Izumi, E. K. Wagner, and J. G. Stevens. 1989 Herpes Simplex virus type l latency-associated transcription plays no role m establishment or maintenance of a latent infection in murine sensory neurons. J. Virol. 63:4455-4458.
28. Spivack, J. G., and N. W. Fraser. 1987. Detection of herpes simplex virus type 1 transcripts during latent infection in mice. J. Virol 61:3841-3847.
29. Steiner, I., J. G. Spivack, R. P. Lirette, S. M. Brown, A. R. MacLean, J. H. Subak-Sharpe, and N. W. Fraser. 1989. Herpes simplex virus type 1 latency-associated transcripts are evidently not essential for latent infection. EMBO J. 8:505-511.
30. Stevens, J. G., E. K. Wagner, G. B. Devi-Rao, M. L. Cook, and L. T. Feldman. 1987. RNA complementary to a herpesvirus α gene mRNA is prominent in latently infected neurons. Science 235:1056-1059
31. Ward, P. L., and B. Roizman. 1994. Herpes simplex genes: the blueprint of a successful human pathogen. Trends Genet. 10:267-274.
32. 134.5 deletion mutants in rodent models. J. Clin. Invest. 91:2837-2843.
33. Yeh, L., and P. A. Schaffer. 1993. A novel class of transcripts expressed with late kinetics in the absence of ICP4 spans the junction between the long and short segments of the herpes simplex virus type 1 genome. J. Virol 67:7373-7382.
34. Zwaagstra, J. C., H. Ghiasi, S. M. Slanina, A. B. Nesburn, S. C. Wheatley, K. Lillycrop, J. Wood, D. S. Latchman, K. Patel, and S. L. Wechsler. 1990. Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript. J. Virol. 64:5019-5028.