Agonistic and antagonistic variants of ciliary neurotrophic factor (CNTF) reveal functional differences between membrane-bound and soluble CNTF α-receptor

Journal of Biological Chemistry

Volumn 272, Issue 37, 1997, Pages 23069-23075

  Di Marco, Annalise ^a   Gloaguen, Isabelle ^a   Demartis, Anna ^a   Saggio, Isabella ^a,b   Graziani, Rita ^a   Paonessa, Giacomo ^a   Laufer, Ralph ^a  

^a IRBM   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; RECEPTOR SUBUNIT;

ARTICLE; BINDING AFFINITY; GENE EXPRESSION; HEPATOMA CELL; HUMAN; HUMAN CELL; LIGAND BINDING; MEMBRANE BINDING; NERVE CELL; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ANTIGENS, CD; BIOLOGICAL ASSAY; CILIARY NEUROTROPHIC FACTOR; CYTOKINE RECEPTOR GP130; DOSE-RESPONSE RELATIONSHIP, DRUG; GROWTH INHIBITORS; HUMANS; INTERLEUKIN-6; LEUKEMIA INHIBITORY FACTOR; LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT; LYMPHOKINES; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MODELS, CHEMICAL; MUTATION; NERVE TISSUE PROTEINS; PROTEIN BINDING; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, CILIARY NEUROTROPHIC FACTOR; RECEPTORS, CYTOKINE; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, OSM-LIF; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SOLUBILITY;

EID: 0030823457     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.37.23069     Document Type: Article

References (17)

1. Manthorpe, M., Louis, J. C., Hagg, T., and Varon, S. (1993) in Neurotrophic Factors (Loughlin, S. E., and Fallon, J. H., eds) pp. 443-473, Academic Press, San Diego
2. Ip, N. Y., and Yancopoulos, G. D. (1996) Annu. Rev. Neurosci. 19, 491-515
3. Hughes, S. M., Lillien, L. E., Raff, M. C., Rohrer, H., and Sendtner, M. (1988) Nature 335, 70-73
4. Louis, J.-C., Magal, E., Takayama, S., and Varon, S. (1993) Science 259, 689-692
5. Schooltink, H., Stoyan, T., Roeb, E., Heinrich, P. C., and Rose John, S. (1992) FEBS Lett. 314, 280-284
6. Helgren, M. E., Squinto, S. P., Davis, H. L., Parry, D. J., Boulton, T. G., Heck, C. S., Zhu, Y., Yancopoulos, G. D., Lindsay, R. M., and DiStefano, P. S. (1994) Cell 76, 493-504
7. Conover, J. C., Ip, N. Y., Poueymirou, W. T., Bates, B., Goldfarb, M. P., DeChiara, T. M., and Yancopoulos, G. D. (1993) Development 119, 559-565
8. Gimble, J. M., Wanker, F., Wang, C.-S., Bass, H., Wu, X., Kelly, K., Yancopoulos, G. D., and Hill, M. R. (1994) J. Cell. Biochem. 54, 122-133
9. Zhang, X.-G., Gu, J.-J., Lu, Z.-Y., Yasukawa, K., Yancopoulos, G. D., Turner, K., Shoyab, M., Taga, T., Kishimoto, T., Bataille, R., and Klein, B. (1994) J. Exp. Med. 177, 1337-1342
10. Kishimoto, T., Akira, S., Narazaki, M., and Taga, T. (1995) Blood 86, 1243-1254
11. Davis, S., Aldrich, T. H., Valenzuela, D. M., Wong, V., Furth, M. E., Squinto, S. P., and Yancopoulos, G. D. (1991) Science 253, 59-63
12. Ip, N. Y., McClain, J., Barrezueta, N. X., Aldrich, T. H., Pan, L., Li, Y., Wiegand, S. J., Friedman, B., Davis, S., and Yancopoulos, G. D. (1993) Neuron 10, 89-102
13. Davis, S., Aldrich, T. H., Ip, N. Y., Stahl, N., Scherer, S., Farruggella, T., DiStefano, P. S., Curtis, R., Panayotatos, N., Gascan, H., Chevalier, S., and Yancopoulos, G. D. (1993) Science 259, 1736-1739
14. Dittrich, F., Thoenen, H., and Sendtner, M. (1994) Ann. Neurol. 35, 151-163
15. Saggio, I., Gloaguen, I., Poiana, G., and Laufer, R. (1995) EMBO J. 14, 3045-3054
16. Di Marco, A., Gloaguen, I., Graziani, R., Paonessa, G., Saggio, I., Hudson, K. R., and Laufer, R. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 9247-9252
17. Hemsley, A., Arnheim, N., Toney, M. D., Cortopassi, G., and Galas, D. J. (1989) Nucleic Acids Res. 17, 6545-6551