Expression of P-Glycoprotein 170 in nasal mucosa may be increased with topical steroids

American Journal of Rhinology

Volumn 11, Issue 4, 1997, Pages 317-321

  Henriksson, Gert ^a   Norlander, Tomas ^a   Zheng, Xi ^b   Stierna, Pontus ^a   Westrin, Karl Magnus ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BUDESONIDE; GLUCOCORTICOID; GLYCOPROTEIN P; STEROID; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; HUMAN; HUMAN TISSUE; INTRANASAL DRUG ADMINISTRATION; NOSE MUCOSA; NOSE POLYP; PROTEIN EXPRESSION; TOPICAL DRUG ADMINISTRATION;

EID: 0030823456     PISSN: 10506586     EISSN: None     Source Type: Journal    
DOI: 10.2500/105065897781446603     Document Type: Article

References (15)

1. Endicott JA, Ling V. The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu Rev Biochem 58:137-171, 1989.
2. Pinedo HM, Giaccone G. P-glycoprotein - a marker of cancer-cell behavior. N Engl J Med 333:1417-1419, 1995.
3. Ueda K, Okamura N, Hirai M, et al. Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J Biol Chem 267:24248-24252, 1992.
4. Bourgeois S, Groul DJ, Newby RF, Rajah FM. Expression of an mdr gene is associated with a new form of resistance to dexamethasone-induced apoptosis. Mol Endocrinol 7:840-851, 1993.
5. Zhao JY, Ikeguchi M, Eckersberg T, Tien Kuo M. Modulation of multidrug resistance gene expression by dexamethasone in cultured hepatoma cells. Endocrinology 133:521-528, 1993.
6. Thomas GA, Barrand MA, Steward S, et al. Expression of the multidrug resistance-associated protein (MRP) gene in human lung tumours and normal tissue as determined by in situ hybridization. Eur J Cancer 30A:1705-1709, 1994.
7. Flens MJ, Zaman GJR, van der Valk P, et al. Tissue distribution of the multidrug resistance protein. Am J Pathol 148:1237-1247, 1996.
8. Stride BD, Valdimarsson G, Gerlach JH, et al. Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, an ATP-binding cassette transporter. Mol Pharmacol 49:962-971, 1996.
9. Zheng X, Hu L, Ghen F, Christensson B. Expression of Ki67 antigen, epidermal growth factor receptor and Epstein-Barr virus-encoded latent membrane protein (LMP 1) in nasopharyngeal carcinoma. Eur J Cancer Oral Oncol 30B:290-295, 1994.
10. Werner S, Thorén M, Gustafsson JÅ, Brönnegård M. Glucocorticoid receptor abnormalities in fibroblasts from patients with idiopathic resistance to dexamethasone diagnosed when evaluated for adrenocortical disorders. J Clin Endocrinol Metab 75: 1005-1009, 1992.
11. Adcock IM, Lane SJ, Brown CR, et al. Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma. J Exp Med 182:1951-1958, 1995.
12. Brönnegård M, Stierna P, Marcus C. Glucocorticoid resistant syndromes -molecular basis and clinical presentations. J Neuroendocrinol 8:405-415, 1996.
13. Knutsson PU, Brönnegård M, Marcus C, Stierna P. Regulation of glucocorticoid receptor mRNA in nasal mucosa by local administration of fluticasone and budesonide. J Allergy Clin Immunol 97:655-661, 1996.
14. Lechapt E, Commo F, Lacave R, et al. Expression of the multidrug resistance (MDR 1) gene in adult human airways. Abstract. Eur Resp J 7, suppl 18:183, 1994.
15. Groul DJ, Zee MC, Trotter J, Bourgeois S. Reversal of multidrug resistance by RU 486. Cancer Res 54:3088-3091, 1994.