Synthesis of novel succinamide derivatives having the 5,11-dihydro-6h- pyrido[2,3-b][1,4]benzodiazepin-6-one skeleton as potent and selective M2 muscarinic receptor antagonists. I

Chemical and Pharmaceutical Bulletin

Volumn 45, Issue 6, 1997, Pages 996-1007

  Watanabe, Toshihiro ^a   Kinoyama, Isao ^a   Kakefuda, Akio ^a   Okazaki, Toshio ^a   Takizawa, Kenji ^a   Hirano, Seiko ^a   Shibata, Hiroshi ^a   Yanagisawa, Isao ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

AF DX 116; Bradycardia; Selective M2 muscarinic receptor antagonist; Succinamide

Indexed keywords

ATROPINE; BENZODIAZEPIN 2 ONE DERIVATIVE; DIAMINE DERIVATIVE; METHYLSCOPOLAMINE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR ANTAGONIST; MUSCARINIC M3 RECEPTOR; OTENZEPAD; OXOTREMORINE; PIRENZEPINE; QUINUCLIDINYL BENZILATE; RECEPTOR SUBTYPE; SUCCINIMIDE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRADYCARDIA; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; HEART RATE; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; RAT; RECEPTOR OCCUPANCY; SALIVATION; STRUCTURE ACTIVITY RELATION;

EID: 0030822913     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.45.996     Document Type: Article

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