A new enhancer of position-effect variegation in Drosophila melanogaster encodes a putative RNA helicase that binds chromosomes and is regulated by the cell cycle

Genetics

Volumn 146, Issue 3, 1997, Pages 951-963

  Eberl, Daniel F ^a   Lorenz, Lori J ^a   Melnick, Michael B ^a,d   Sood, Vanita ^b,e   Lasko, Paul ^b   Perrimon, Norbert ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MCGILL UNIVERSITY   (Canada)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d NEW ENGLAND BIOLABS   (United States)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

RNA HELICASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE; CHROMATIN STRUCTURE; CHROMOSOME CONDENSATION; CHROMOSOME STRUCTURE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; ENHANCER REGION; EYE COLOR; FEMALE; GENE DELETION; GENE LOCUS; GENE MUTATION; MALE; MITOSIS; NONHUMAN; POSITION EFFECT; PRIORITY JOURNAL; SALIVARY GLAND; SUPPRESSOR GENE;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL CYCLE; CELL NUCLEUS; CHROMOSOMES; CLONING, MOLECULAR; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENHANCER ELEMENTS (GENETICS); FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, INSECT; MALE; MITOSIS; MOLECULAR SEQUENCE DATA; OOGENESIS; RNA HELICASES; RNA NUCLEOTIDYLTRANSFERASES; SEQUENCE HOMOLOGY, AMINO ACID;

ANIMALIA; DROSOPHILA MELANOGASTER; MAMMALIA; MELANOGASTER;

EID: 0030822804     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. ALTSCHUL., S. F., W. GISH, W. MILLER, E. W. MEYERS and D. J. LIPMAN, 1990 Basic local alignment search tool. J. Mol. Biol. 215: 403-410.
2. AMREIN, H., and R. AXEL., 1997 Genes expressed in neurons of adult male Drosophila. Neuron 88: 459-469.
3. ASHBURNKR, M., 1989 Quantitative measurement of red-eye pigments, p. 312 in Drsophila: A Laboratory Manual. Cold Spring Harbor Laboraton Press, Cold Spring Harbor, NY.
4. AXTON, J. M., V. DOMBRÁDI, P. T. W. COHEN and D. M. GLOVER, 1990 One of the protein phosphatase 1 isoenzymes in Drosophila is essential for mitosis. Cell 63: 33-46.
5. BAKSA, K., H. MORAWIETZ, V. DOMBRÁDI, M. AXTON, H. TAUBERT et al., 1993 Mutations in the protein phosphatase 1 gene at 87B can differentially affect suppression of position-effect variegation and mitosis in Drosophila melanogaster. Genetics 135: 117-125.
6. BASHAW, G. J., and B. S. BAKER, 1996 Dosage compensation and chromatin structure in Drosophila. Curr. Opin. Genet. Devel. 6: 496-501.
7. BORK, P., and E. V. KOONIN, 1993 An expanding family of helicases within the 'DEAD/H' superfamily. Nucleic Acids Res. 21: 751-752.
8. BROCKDORFF, N., A. ASHWORTH, G. F. KAY, V. M. MCCABE, D. P. NORRIS et al., 1992 The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus. Cell 71: 515-526.
9. BROWN, C. J., B. D. HENDRICH, J. L. RUPERT. R. G. LAFRENIERE, Y. XING et al., 1992 The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus. Cell 71: 527-542.
10. BROWN, N. H., and F. C. KAFATOS, 1988 Functional cDNA libraries from Drosophila embryos. J. Mol. Biol. 203: 423-487.
11. CHOU, T.-B., and N. PERRIMON, 1996 The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogetster. Genetics 144: 1673-1679.
12. CLEMSON, C. M., J. A. MCNEIL, H. F. WILLARD and J. B. LAWRENCE., 1996 XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure. J. Cell Biol. 132: 259-275.
13. DEL, SAL, G., G. MANFIOLETTI and C. SCHNEIDER, 1989 The CTAB-DNA precipitation method: a common miniscale preparation of template DNA from phagemids, phages or plasmids suitable for sequencing. Biotechniques 7: 514-519.
14. DORN, R., V. KRAUSS, G. REUTER and H. SAUMWEBER, 1993a The enhancer of position-effect variegation of Drosophila, E(var)393D, codes for a chromatin protein containing a conserved domain common to several transcriptional regulators. Proc. Natl. Acad. Sci. USA 90: 11376-11380.
15. DORN, R., H. MORAWIETZ, G. REUTER and H. SAUMWEBER, 1993b Identification of an essential Drosophila gene that is homologous to the translation initiation factor eIF-4A of yeast and mouse. Mol. Gen. Genet. 237: 233-240.
16. EISSENBERG, J. C., 1989 Position effect variegation in Drosophila: towards a genetics of chromatin assembly. BioEssays 11: 14-17.
17. EISSENBERG, J. C., T. C. JAMES, D. M. FOSTER-HARTNETT, T. HARTNETT, V. NGAN et al., 1990 Mutation in a heterochromatin-specifie chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 87: 9923-9927.
18. EISSENBERG, J. C., G. D. MORRIS, G. REUTER and T. HARTNETT, 1992 The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent, effects on positioneffect variegation. Genetics 131: 345-352.
19. FARKAS G., J. GAUSZ, M. GALLONI, G. REUTER, H. GYURKOVICS et al., 1994 The Trithorax-like gene encodes the Drosophila GAGA factor. Nature 371: 806-808.
20. FOE, V. E., 1989 Mitotic domains reveal early commitment of cells in Drosophila embryos. Development, 107: 1-22.
21. FOE, V. E., G. M. ODELL and B. A. EDGAR, 1993 Mitosis and morphogenesis in the Drosophila embryo: point and counterpoint, pp. 149-300 in The Development of Drosophila melanogaster, Vol. 1, edited by M. BATE and A. MARTINEZ ARIAS. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
22. GARZINO, V., A. PEREIRA, P. LAURENTI, Y. GRARA, R.W. LEVIS et al., 1992 Cell lineage-specific expression of modulo, a dose-dependent modifier of variegation in Drosophila. EMBO J. 11: 4471-4479.
23. GENETICS COMPUTER GROUP, 1991 Program Manual for the GCG Package, Version 7, April 1991. 575 Science Dr., Madison, WI 53711.
24. GERASIMOVA, T. I., D. A. GDULA, D. V. GERASIMOV, O. SIMONOVA and V. G. CORCES, 1995 A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation. Cell 82: 587-597.
25. 0 is translated from either of two developmentally regulated mRNA species apparently encoded by a single gene. J. Cell Biol, 106: 585-596.
26. GUKURAJAN, R., L. MATHEWS, F. J. LONGO and D. WEEKS, 1994 An3 mRNA encodes an RNA helicase that colocalizes with nucleoli in Xenopus oocytes in a stage-specific manner. Proc. Natl. Acad. Sci. USA 91: 2056-2060.
27. HENCHOZ., S., F. DE RUBERTIS, D. PAULI and P. SPIERER, 1996 The dose of a putative ubiquitin-specific protease affects positioneffect variegation in Drosophila melanogaster. Mol. Cell. Biol. 16: 5717-5725.
28. HENDERSON, D. S., S. S. BANGA, T. Z. GRIGLIATTI and J. B. BOYD, 1994 Mutagen sensitivity and suppression of position-effect variegation result from mutations in mus209, the Drosophila gene encoding PCNA. EMBO J. 13: 1450-1459.
29. HENIKOFF, S., 1981 Position-effect variegation and chromosome structure of a heat shock puff in Drosophila. Chromosoma 83: 381-393.
30. HENIKOFF, S., 1990 Position-effect variegation after 60 years. Trends Genet. 6: 422-426.
31. HIRLING, H., M. SCHEFFNER, T. RESTLE and H. STAHL, 1989 RNA helicase activity associated with the human p68 protein. Nature 339: 562-564.
32. HODGMAN, T. C., 1988 A new superfamily of replicative proteins. Nature 333: 22-23.
33. KASSIS, J. A., E. NOLL, E. P. VANSICKLE, W. F. ODENWALD and N. PERRIMON, 1992 Altering the insertional specificity of a Drosophila transposable element. Proc. Natl. Acad. Sci. USA 89: 1919-1923.
34. KORNHER, J. S., and S. A. KAUFFMAN, 1986 Variegated expression of the Sgs-4 locus in Drosophila melanogaster. Chromosoma 94: 205-216.
35. KURODA, M. I., M. J. KERNAN, R. KREBER, B. GANETZKY and B. S. BAKER, 1991 The maleless protein associates with the X chromosome to regulate dosage compensation in Drosophila. Cell 66: 935-947.
36. LAIN, S., J. L. RIECHMANN, M. T. MARTIN and J. A. GARCIA, 1989 Homologous potyvirus and flavivirus proteins belonging to a super-family of helicase-like proteins. Gene 82: 357-362.
37. LAIN, L., J. L. RIECHMANN and J. A. GARCIA, 1990 RNA helicase: a novel activity associated with a protein encoded by a positive strand RNA virus. Nucleic Acids Res. 18: 7003-7006.
38. LEE, C.-G., and J. HURWITZ, 1993 Human RNA helicase A is homologous to the Maleless protein of Drosophila. J. Biol. Chem. 268: 16822-16830.
39. LIANG, L., W. DIEHL-JONES and P. LASKO, 1994 Localization of vasa protein to the Drosophila pole plasm is independent of its RNA-binding and helicase activities. Development 120: 1201-1211.
40. LINDER, P., P. F. LASKO, M. ASHBURNER, P. LEROY, P. J. NIELSEN et al., 1989 Birth of the D-E-A-D box. Nature 337: 121-122.
41. n · repeats and heat shock elements have distinct roles in chromatin structure and transcriptional activation of the Drosophila hsp26 gene. Mol. Cell. Biol. 13: 2802-2814.
42. MALDONADO-CODINA, G., S. LIAMAZARES and D. M. GLOVER, 1993 Heat shock results in cell cycle delay and synchronisation of mitotic domains in cellularised Drosophila. melanogaster embryos. J. Cell Sci. 105: 711-720.
43. MELLER, V. H., K. H. WU, G. ROMAN, M. I. KURODA and R. L. DAVIS, 1997 roX1 RNA paints the X chromosome of male Drosophila and is regulated by the dosage compensation system. Neuron 88: 445-457.
44. NAIR, S., R. DEY, J. P. SANFORD and D. DOYLE, 1992 Molecular cloning and analysis of an eIF-4A-related rat liver nuclear protein. J. Biol. Chem. 267: 12928-12935.
45. PATTON, J., X. V. GOMES and P. K. GEYER, 1992 Position-independent germline transformation in Drosophila using a cuticle pigmentation gene as a selectable marker. Nucleic Acids Res. 20: 5859-5860.
46. PAUSE, A., and N. SONENBERG, 1992 Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A. EMBO J. 11: 2643-2654.
47. PAUSE, A., N. METHOT and N. SONEXBERG, 1993 The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis. Mol. Cell. Biol. 13: 6789-6798.
48. PEELMAN, L. J., P. CHARDON, M. NUMES, C. RENARD, C. GEFFROTIN et al., 1995 The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family. Genomics 26: 210-218.
49. REUTER, G., M. GIARRE, J. FARAH, J. GAUSZ, A. SPIERER et al., 1990 Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein. Nature 344: 219-223.
50. REUTER, G., and P. SPIERER, 1992 Position effect variegation and chromatin proteins. BioEssays 14: 605-612.
51. ROBERTSON, H. M., C. R. PRESTON, R. W. PHILIPS, D. M. JOHNSONSCHLITZ, W. K. BENZ et al., 1988 A stable genomic source of P element transposase in Drosophila melanogaster Genetics 118: 461-470.
52. ROZEN, F., I. EDERY, K. MEEROVITCH, T. E. DEVER, W. C. MERRICK et al., 1990 Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F. Mol. Cell. Biol. 10: 1134-1144.
53. RUSHLOW, C. A., W. BENDER and A. CHOVNICK, 1984 Studies on the mechanism of hererochromatic position effect at the rosy locus of Drosophila melanogaster. Genetics 108: 603-615.
54. SCHMID, S. R., and P. LINDER, 1992 D-E-A-D protein family of putative RNA helicases. Mol. Microbiol. 6: 283-292.
55. SCHULTZ, J., 1936 Variegation in Drosophila and the inert chromosome regions. Proc. Natl. Acad. Sci. USA 22: 27-33.
56. SEUM, C., A. SPIERER, D. PAULI, J. SZIDONYA, G. REUTER et al., 1996 Position-effect variegation in Drosophila depends on the dose of the gene encoding the E2F transcriptional activator and cell cycle regulator. Development 122: 1949-1956.
57. SIGRIST, S., H. JACOBS, R. STRATMANN and C. F. LEHNER, 1995 Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A. B and B3. EMBO J. 14: 4827-4838.
58. SPRADLING, A. C., 1986 P element-mediated transformation, pp. 175-197 in Drosophila: A Practical Approach, edited by D. B. ROBERTS. IRL, Oxford.
59. SZIDONYA, J., and G. REUTER, 1988 Cytogenetic analysis of the echinoid (ed), dumpy (dp) and clot (cl) region in Drosophila melanogaster. Genet. Res. 51: 197-208.
60. TARTOF, K. D., C. BISHOP, M. JONES, C. A. HOBBS and J. LOCKE, 1989 Towards an understanding of position effect variegation. Dev. Genet. 10: 162-176.
61. THUMMEL, C. S., A. M. BOULET and H. D. LIPSHITZ, 1988 Vectors for Drosophila P-element-mediated transformation and tissue culture transfection. Gene 74: 445-456.
62. TSCHIERSCH, B., A. HOFMANN, V. KRAUSS, R. DORN, G. KORGE et al., 1994 The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes. EMBO J. 13: 3822-3831.
63. TSUKIYAMA, T., P. B. BECKER and C. Wu, 1994 ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor. Nature 367: 525-532.
64. WALKER,J. E., M. SARASTE, M. J. RUNSWICK and N. J. GAY, 1982 Distantly related sequences in the α- and β-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J. 1: 945-951.
65. WARBRICK, E., and D. GLOVER, 1994 A Drosophila gene encoding a DEAD box RNA helicase can suppress loss of weel/milk1 function in Schizosaccharomyces pombe. Mol. Gen. Genet. 245: 654-657.
66. WATERSTON, R., C. MARTIN, M. CRAXTON, C. HUYNH, A. COULSON et al., 1992 A survey of expressed genes in Caenorhabditis elegans. Nat. Genet. 1: 114-123.
67. ZHANG, H., Y. XIONG and D. BEACH, 1993 Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Mol. Biol. Cell 4: 897-906.