Mono and bis double ester prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 14, 1997, Pages 1811-1816

  Lin, Yang I ^a   Bitha, Panayota ^a   Li, Zhong ^a   Sakya, Subas M ^a   Strohmeyer, Timothy W ^a   Lang Jr , Stanley A ^a   Yang, Youjun ^a   Bhachech, Niraja ^a   Weiss, William J ^a   Petersen, Peter J ^a   Jacobus, Nilda V ^a   Bush, Karen ^a   Testa, Raymond T ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAPENEM DERIVATIVE; CILASTATIN PLUS IMIPENEM; IMIPENEM; PRODRUG;

ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; BIOAVAILABILITY; CONTROLLED STUDY; DRUG STABILITY; DRUG SYNTHESIS; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MORTALITY; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; REACTION ANALYSIS; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030816697     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00305-3     Document Type: Article

References (9)

1. (a) Lin, Y.-I; Bitha, P.; Sakya, S. M.; Strohmeyer, T. W.; Li, Z.; Lee, V. J.; Lang, S. A., Jr.; Yang, Y.; Bhachech, N.; Weiss, W. J.; Petersen, P. J.; Jacobus, N. V.; Bush, K.; Testa, R. T.; Tally, F. P. Bioorg. Med. Chem. Lett. 1997, 7, 1671.
2. (b) Lin, Y-I; Bitha, P.; Sakya, S. M.; Strohmeyer, T. W.; Feigelson, G. B.; Ziegler, C. B., Jr.; Lee, V. J.; Tally, F. P. 34th Interscience Conference on Antimicrobial Agents and Chemotherapy. Orlando 1994. Abstract F70.
3. Lin, Y.-I; Bitha, P.; Sakya, S. M.; Strohmeyer, T. W.; Yang, Y.; Weiss, W. J.; Jacobus, N. V.; Bush, K.; Testa, R. T.; Tally, F. P. 34th ICAAC. Orlando 1994. Abstract F72.
4. Weiss, W. J.; Yang, Y.; Petersen, P. J.; Shelofsky, A. G.; Bush, K.; Jacobus, N. V.; Bitha, P.; Lin, Y.-I; Testa, R. T.; Tally, F. P. 34th ICAAC Orlando 1994. Abstract F74.
5. (e) Bush, K.; Bhachech, N.; Yang, Y.; Weiss, W. J.; Lin, Y-I; Testa, R. T.; Tally, F. P. 34th ICAAC. Orlando 1994. Abstract F76.
6. (f) Weiss, W. J.; Petersen, P. J.; Jacobus, N. V.; Bitha, P.; Lin, Y.-I; Testa, R. T.; Tally, F. P. 34th ICAAC. Orlando 1994. Abstract F78.
7. Lin, Y.-I; Bitha, P.; Sakya, S. M.; Li, Z.; Strohmeyer, T. W.; Lang, S. A., Jr.; Yang, Y.; Bhachech, N.; Weiss, W. J.; Petersen, P. J.; Jacobus, N. V.; Bush, K.; Testa, R. T. Bioorg. Med Chem. Lett. 1997, 7, 1665.
8. A private communication with Dr. M. Hui and Dr. S. Ku.
9. Alexander, J.; Cargill, R.; Michelson, S. R.; Schwam, H. J. Med. Chem. 1988, 31, 318.