The activity of dihydropyrimidine dehydrogenase in human blood cells

Journal of Inherited Metabolic Disease

Volumn 20, Issue 3, 1997, Pages 331-334

  Van Kuilenburg, A B P ^a,c   Blom, M J ^a   Van Lenthe, H ^a   Mul, E ^b   Van Gennip, A H ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b CENTRAL LABORATORY   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROPYRIMIDINE DEHYDROGENASE; DRUG METABOLIZING ENZYME; FLUOROURACIL;

BLOOD CELL; CONFERENCE PAPER; ENZYME ACTIVITY; ERYTHROCYTE; GRANULOCYTE; HUMAN; HUMAN CELL; LYMPHOCYTE; MONOCYTE; NORMAL HUMAN; THROMBOCYTE;

ADULT; BLOOD CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIHYDROURACIL DEHYDROGENASE (NADP); HUMANS; NADP; OXIDOREDUCTASES; PARTICLE SIZE; REFERENCE VALUES;

EID: 0030816022     PISSN: 01418955     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005305323052     Document Type: Conference Paper

References (8)

1. Bakkeren JAJM, De Abreu RA, Sengers RCA, Gabreëls FNM, Maas JM, Renier WO (1984) Elevated urine, blood and cerebrospinal fluid levels of uracil and thymine in a child with dihydropyrimidine dehydrogenase deficiency. Clin Chim Acta 140: 247-256.
2. De Boer M, Roos D (1986) Metabolic comparison between basophils and other leukocytes from human blood. J Immunol 136: 3447-3454.
3. Diasio RB, Harris BE (1989) Clinical pharmacology of 5-fluorouracil. Clin Pharmacokinet 16: 215-237.
4. Lu Z, Zhang R, Diasio RB (1993) Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy. Cancer Res 53: 5433-5438.
5. Naguib FNM, el Kouni MH, Cha S (1985) Enzymes of uracil catabolism in normal and neoplastic human tissues. Cancer Res 45: 5405-5412.
6. Pero RW, Johnson D, Olsson A (1984) Catabolism of exogenously supplied thymidine to thymine and dihydrothymine by platelets in human peripheral blood. Cancer Res 44: 4955-4961.
7. Van Gennip AH, Abeling NGGM, Stroomer AEM, Van Lenthe H, Bakker HD (1994) Clinical and biochemical findings in six patients with pyrimidine degradation defects. J Inher Metab Dis 17: 130-132.
8. Van Kuilenburg ABP, Van Lenthe H, Van Gennip AH (1996) Identification and tissue-specific expression of a NADH-dependent activity of dihydropyrimidine dehydrogenase. Anticancer Res 16: 389-394.