Indirect in vivo 5-HT(1A)-agonistic effects of the new antidepressant mirtazapine

Psychopharmacology

Volumn 133, Issue 3, 1997, Pages 275-282

  Berendsen, Hemmie H G ^a   Broekkamp, Chris L E ^a  

^a NV ORGANON   (Netherlands)

Author keywords

5 HT(1A) receptors; Antidepressants; Conditioned taste aversion; Lower lip retraction; Mirtazapine

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; 6 CHLORO 2 (1 PIPERAZINYL)PYRAZINE; FLUOXETINE; MIRTAZAPINE; PINDOLOL; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CONTROLLED STUDY; LOWER LIP; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; TASTE AVERSION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; AMPHETAMINES; ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BEHAVIOR, ANIMAL; CONDITIONING, OPERANT; FLUOXETINE; MALE; MIANSERIN; MICE; MICE, INBRED ICR; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN UPTAKE INHIBITORS; TASTE;

EID: 0030813541     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050402     Document Type: Article

References (28)

1. Andrews JS, Jansen JHM, Linders S, Princen A, Drinkenburg WHIM, Coenders CJH, Vossen JHM (1994) Effects of imipramine and mirtazapine on operant performance in rats. Drug Dev Res 32:58-66
2. Berendsen HHG (1995) Interactions between 5-hydroxytryptamine receptor subtypes: is a disturbed receptor balance contributing to the symptomatology of depression in humans? Pharmacol Ther 66:17-37
3. Berendsen HHG, Broekkamp CLE (1990) Behavioural evidence for functional interactions between 5-HT-receptor subtypes in rats and mice. Br J Pharmacol 101:667-673
4. Berendsen HHG, Broekkamp CLE (1994) Comparison of stimulus properties of fluoxetine and 5-HT receptor agonists in a conditioned taste aversion procedure. Eur J Pharmacol 253: 83-89
5. 1A receptors induces lower lip retraction in the rat. Pharmacol Biochem Behav 33:821-827
6. Berendsen HHG, Broekkamp CLE, Van Delft AML (1990a) Antagonism of 8-OH-DPAT-induced behaviour in rats. Eur J Pharmacol 187:97-103
7. 1C-receptors in drug-induced penile erections in rats. Psychopharmacology 101:57-61
8. Clement HH, Gemsa D, Weseman W (1992) The effect of adrenergic drugs on serotonin metabolism in the nucleus raphe dorsalis of the rat, studies by in vitro voltametry. Eur J Pharmacol 217:43-48
9. Davis R, Wilde MI (1996) Mirtazapine. A review of its pharmacology and therapeutic potential in the management of major depression. CNS Drugs 5:389-402
10. 1A agonist 8-OH-DPAT. Psychopharmacology 112: 121-128
11. De Beun R, Peeters BWMM, Broekkamp CLE (1993b) Stimulus characterization of estradiol applying a cross-familiarization taste aversion procedure in female mice. Physiol Behav 53:715-719
12. De Boer Th, Mauri G, Raiteri M, De Vos CJ, Wieringa J, Pinder RM (1988) Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers. Neuropharmacology 27:399-408
13. 2-antagonist Org 3770 enhances serotonin transmission in vivo. Eur J Pharmacol 253:R5-R6
14. ®) enhances noradrenergic and serotonergic transmission. Hum Psychopharmacol 10:S107-S118
15. De Boer Th, Nefkens F, Van Helvoirt A, Van Delft AML (1996) Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazapine, mianserin and idazoxan. J Pharmacol Exp Ther 277:852-860
16. 1A receptors in anxiety. In: Briley M, File SE (eds) New concepts in anxiety. MacMillan, London, pp 94-129
17. 2B-adrenoceptor subtype. Naunyn-Schmiedeberg's Arch Pharmacol 342:382-386
18. 2-adrenoceptor blockade in the central nervous system and the effects of the enantiomers of mianserin and its aza-analog Org 3770. Arch Int Pharmacodyn 29:185-201
19. Grant VL (1987) Do conditioned taste aversions result from activation of emetic mechanisms? Psychopharmacology 93: 405-415
20. Hjorth S, Carlsson A (1985) ( )Pindolol stereo-specifically inhibits rat brain serotonin (5-HT) synthesis. Neuropharmacology 24:1143-1146
21. 1 recognition sites. J Rec Res 8:59-81
22. Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PPA (1994) International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol Rev 46:157-203
23. Hunt T, Amit Z (1987) Conditioned taste aversion induced by self-administered drugs: paradox revisited . Neurosci Biobehav Rev 11:107-130
24. 3 receptors ion cultured mouse neuroblastoma cells. Neuropharmacology 33:501-510
25. Lehman EL (1974) Nonparametrics: statistical methods based on ranks. McGraw Hill, London
26. ® (Org 3770), an atypical antidepressant with "typical" efficacy. Abstract No. 109, 9th World Congress of Psychiatry, Rio de Janeiro
27. 2-adrenoceptor regulated serotonin release in the rat hippocampus. Neurosci Lett 192:161-164
28. O'Connor WT, Leonard BE (1986) Effect on chronic administration of the 6-aza analogue of mianserin (Org 3770) and its enantiomers on behaviour and changes in noradrenaline metabolism of olfactory-bulbectomised rats in the "open field" apparatus. Neuropharmacology 25:267-270