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Volumn 6, Issue 1, 1997, Pages 1-18

The molecular genetics of pancreatic cancer

Author keywords

Cancer; Genetics; Pancreas

Indexed keywords

ACINAR CELL CARCINOMA; ASPIRATION BIOPSY; CANCER ADJUVANT THERAPY; CANCER MORTALITY; CANCER STAGING; CANCER SURVIVAL; CYTOGENETICS; DISEASE PREDISPOSITION; EARLY DIAGNOSIS; FAMILIAL CANCER; GENE MUTATION; HUMAN; MOLECULAR GENETICS; ONCOGENE; ONCOGENE K RAS; PANCREAS CANCER; PLOIDY; PRIORITY JOURNAL; REVIEW; TUMOR SUPPRESSOR GENE; UNITED STATES;

EID: 0030813228     PISSN: 09607404     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-7404(97)00001-7     Document Type: Review
Times cited : (39)

References (143)
  • 2
    • 0029991497 scopus 로고    scopus 로고
    • Long term survival following curative resection for pancreatic ductal adenocarcinoma: Clinico-pathological analysis of 5-year survivors
    • Conlon K. C., Klimstra D. S. and Brennan M. F. Long term survival following curative resection for pancreatic ductal adenocarcinoma: Clinico-pathological analysis of 5-year survivors. Annals of Surgery 1996, 223, 273-279.
    • (1996) Annals of Surgery , vol.223 , pp. 273-279
    • Conlon, K.C.1    Klimstra, D.S.2    Brennan, M.F.3
  • 3
    • 0028985078 scopus 로고
    • Treatment and survival in 13560 patients with pancreatic cancer, and incidence of the disease in the West Midlands: An epidemiological study
    • Bramhall S. R., Allum S. R., Jones A. G., Allwood A., Cummins C. and Neoptolemus J. P. Treatment and survival in 13560 patients with pancreatic cancer, and incidence of the disease in the West Midlands: An epidemiological study. British Journal of Surgery 1995, 82, 111-115.
    • (1995) British Journal of Surgery , vol.82 , pp. 111-115
    • Bramhall, S.R.1    Allum, S.R.2    Jones, A.G.3    Allwood, A.4    Cummins, C.5    Neoptolemus, J.P.6
  • 4
    • 0028091420 scopus 로고
    • Results of resection for cancer of the exocrine pancreas: A study from the French Association of Surgery
    • Baumel H., Huguier M., Manderscheid J. C., Fabre J. M., Houry S. and Fagot H. Results of resection for cancer of the exocrine pancreas: A study from the French Association of Surgery. British Journal of Surgery 1994, 81, 102-1017.
    • (1994) British Journal of Surgery , vol.81 , pp. 102-1017
    • Baumel, H.1    Huguier, M.2    Manderscheid, J.C.3    Fabre, J.M.4    Houry, S.5    Fagot, H.6
  • 5
    • 0028888708 scopus 로고
    • Long-term survival after resection for ductal adenocarcinoma of the pancreas: Is it really improving?
    • Nitecki S. S., Sarr M. G., Colby T. V. and van Heerden J. A. Long-term survival after resection for ductal adenocarcinoma of the pancreas: Is it really improving? Annals of Surgery 1995, 221, 59-66.
    • (1995) Annals of Surgery , vol.221 , pp. 59-66
    • Nitecki, S.S.1    Sarr, M.G.2    Colby, T.V.3    Van Heerden, J.A.4
  • 6
    • 0028328255 scopus 로고
    • Genetics and pancreatic cancer
    • Lynch H. T. Genetics and pancreatic cancer. Archives of Surgery 1994, 129, 266-268.
    • (1994) Archives of Surgery , vol.129 , pp. 266-268
    • Lynch, H.T.1
  • 8
    • 0023233894 scopus 로고
    • Familial pancreatic adenocarcinoma in three generations: A case report and review of the literature
    • Ehrenthal D., Haeger L., Griffin T. and Compton C. Familial pancreatic adenocarcinoma in three generations: a case report and review of the literature. Cancer 1987, 59, 1661-1664.
    • (1987) Cancer , vol.59 , pp. 1661-1664
    • Ehrenthal, D.1    Haeger, L.2    Griffin, T.3    Compton, C.4
  • 9
    • 76949133404 scopus 로고
    • Pedigree of a family with hereditary chronic relapsing pancreatitis
    • Comfort M. W. and Steinberg A. G. Pedigree of a family with hereditary chronic relapsing pancreatitis. Gastroenterology 1952, 21, 54-63.
    • (1952) Gastroenterology , vol.21 , pp. 54-63
    • Comfort, M.W.1    Steinberg, A.G.2
  • 10
    • 0015519769 scopus 로고
    • Case 25-1972, case records of the Massachusetts general hospital
    • Castleman B. Case 25-1972, case records of the Massachusetts General Hospital. New England Journal of Medicine 1972, 286, 1353-1359.
    • (1972) New England Journal of Medicine , vol.286 , pp. 1353-1359
    • Castleman, B.1
  • 11
    • 0000923352 scopus 로고
    • Hereditary pancreatitis. Description of a fifth kindred and summary of clinical features
    • Gross J. B., Gambill E. E. and Ulrich J. A. Hereditary pancreatitis. Description of a fifth kindred and summary of clinical features. American Journal of Medicine 1962, 33, 358.
    • (1962) American Journal of Medicine , vol.33 , pp. 358
    • Gross, J.B.1    Gambill, E.E.2    Ulrich, J.A.3
  • 13
  • 14
    • 0022342912 scopus 로고
    • The multiple endocrine neoplasia syndromes
    • Brunt L. M. and Wells S. A. The multiple endocrine neoplasia syndromes. Investigative Radiology 1985, 20, 916-927.
    • (1985) Investigative Radiology , vol.20 , pp. 916-927
    • Brunt, L.M.1    Wells, S.A.2
  • 15
  • 16
    • 0023828816 scopus 로고
    • Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma
    • Larsson K., Skogseid B., Oberg K., Nakamura Y. and Nordenskjold M. Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature 1988, 332, 85-87.
    • (1988) Nature , vol.332 , pp. 85-87
    • Larsson, K.1    Skogseid, B.2    Oberg, K.3    Nakamura, Y.4    Nordenskjold, M.5
  • 17
    • 0018665933 scopus 로고
    • The radiographic manifestations of von Hippel-Lindau disease
    • Fill W. L., Lamiell J. M. and Polk N. O. The radiographic manifestations of von Hippel-Lindau disease. Radiology 1979, 133, 289-295.
    • (1979) Radiology , vol.133 , pp. 289-295
    • Fill, W.L.1    Lamiell, J.M.2    Polk, N.O.3
  • 18
    • 0028326867 scopus 로고
    • Pancreatic lesions in von Hippel-Lindau disease: Prevalence, clinical significance, and CT findings
    • Hough D. M., Stephens D. H. and Johnson C. D. Pancreatic lesions in von Hippel-Lindau disease: prevalence, clinical significance, and CT findings. American Journal of Roentgenology 1994, 162, 1091-1094.
    • (1994) American Journal of Roentgenology , vol.162 , pp. 1091-1094
    • Hough, D.M.1    Stephens, D.H.2    Johnson, C.D.3
  • 19
    • 0027240519 scopus 로고
    • Identification of the von Hippel-Lindau disease tumor suppressor gene
    • Latif F., Tory K., Gnarra J., et al. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 1993, 260, 1317-1320.
    • (1993) Science , vol.260 , pp. 1317-1320
    • Latif, F.1    Tory, K.2    Gnarra, J.3
  • 20
    • 0017238344 scopus 로고
    • Malignant neoplasms in the families of patients with ataxia telengectasia
    • Swift M., Sholman L., Pery M. and Chase C. Malignant neoplasms in the families of patients with ataxia telengectasia. Cancer Research 1976, 36, 209-215.
    • (1976) Cancer Research , vol.36 , pp. 209-215
    • Swift, M.1    Sholman, L.2    Pery, M.3    Chase, C.4
  • 22
    • 0025963801 scopus 로고
    • Pancreatic cancer and the familial atypical multiple mole melanoma (FAMMM) syndrome
    • Lynch H. T. and Fusaro R. M. Pancreatic cancer and the familial atypical multiple mole melanoma (FAMMM) syndrome. Pancreas 1991, 6, 127-131.
    • (1991) Pancreas , vol.6 , pp. 127-131
    • Lynch, H.T.1    Fusaro, R.M.2
  • 23
    • 0026547212 scopus 로고
    • The association between cholangiocarcinoma and hereditary nonpolyposis colorectal carcinoma
    • Mecklin J.-P., Jarvinen H. J. and Virolainen M. The association between cholangiocarcinoma and hereditary nonpolyposis colorectal carcinoma. Cancer 1992, 69, 1112-1114.
    • (1992) Cancer , vol.69 , pp. 1112-1114
    • Mecklin, J.-P.1    Jarvinen, H.J.2    Virolainen, M.3
  • 25
    • 0026579633 scopus 로고
    • Nonrandom chromosomal rearrangements in pancreatic carcinomas
    • Johansson B., Bardi G., Heim S., et al. Nonrandom chromosomal rearrangements in pancreatic carcinomas. Cancer 1992, 69, 1674-1681.
    • (1992) Cancer , vol.69 , pp. 1674-1681
    • Johansson, B.1    Bardi, G.2    Heim, S.3
  • 26
    • 0027190815 scopus 로고
    • Karyotypic abnormalities in tumors of the pancreas
    • Bardi G., Johansson B., Pandis N., et al. Karyotypic abnormalities in tumors of the pancreas. British Journal of Cancer 1993, 67, 1106-1112.
    • (1993) British Journal of Cancer , vol.67 , pp. 1106-1112
    • Bardi, G.1    Johansson, B.2    Pandis, N.3
  • 28
    • 0023230620 scopus 로고
    • Retrospective analysis of the prognostic significance of DNA content and proliferative activity in large bowel carcinoma
    • Schutte B., Reynders M. M. J., Wiggers T., et al. Retrospective analysis of the prognostic significance of DNA content and proliferative activity in large bowel carcinoma. Cancer Research 1987, 47, 5494-5496.
    • (1987) Cancer Research , vol.47 , pp. 5494-5496
    • Schutte, B.1    Reynders, M.M.J.2    Wiggers, T.3
  • 30
    • 0025103344 scopus 로고
    • Retrospective analysis of the prognostic significance of DNA ploidy patterns and S-phase fraction in gastric carcinoma
    • Yonemura Y., Ooyama S., Sugiyama K., et al. Retrospective analysis of the prognostic significance of DNA ploidy patterns and S-phase fraction in gastric carcinoma. Cancer Research 1990, 50, 509-514.
    • (1990) Cancer Research , vol.50 , pp. 509-514
    • Yonemura, Y.1    Ooyama, S.2    Sugiyama, K.3
  • 31
    • 0023669516 scopus 로고
    • Ploidy as prognostic determinant in pancreatic cancer
    • Weger A. R., Graf A. H., Askensten U., et al. Ploidy as prognostic determinant in pancreatic cancer. Lancet 1987, ii, 1031.
    • (1987) Lancet , vol.2 , pp. 1031
    • Weger, A.R.1    Graf, A.H.2    Askensten, U.3
  • 32
    • 0028008609 scopus 로고
    • Factors influencing survival after resection of pancreatic cancer. A DNA analysis and a histomorphologic study
    • Bottger T. C., Storkel S., Wellek S., Stockle M. and Junginger T. Factors influencing survival after resection of pancreatic cancer. A DNA analysis and a histomorphologic study. Cancer 1994, 73, 63-73.
    • (1994) Cancer , vol.73 , pp. 63-73
    • Bottger, T.C.1    Storkel, S.2    Wellek, S.3    Stockle, M.4    Junginger, T.5
  • 33
    • 0029002348 scopus 로고
    • Pancreaticoduodenectomy for cancer of the head of the pancreas
    • Yeo C. J., Cameron J. L., Lillemoe K. D., et al. Pancreaticoduodenectomy for cancer of the head of the pancreas. Annals of Surgery 1995, 221, 721-733.
    • (1995) Annals of Surgery , vol.221 , pp. 721-733
    • Yeo, C.J.1    Cameron, J.L.2    Lillemoe, K.D.3
  • 34
    • 0027319762 scopus 로고
    • Prognostic significance of DNA ploidy in adenocarcinoma of the pancreas
    • Forschen R., Remy U., Bevers G., Schauseil S., Hengels K. J. and Borchard F. Prognostic significance of DNA ploidy in adenocarcinoma of the pancreas. Cancer 1993, 71, 3846-3850.
    • (1993) Cancer , vol.71 , pp. 3846-3850
    • Forschen, R.1    Remy, U.2    Bevers, G.3    Schauseil, S.4    Hengels, K.J.5    Borchard, F.6
  • 35
    • 0025340802 scopus 로고
    • Nuclear DNA distribution pattern of the parenchymal cells in adenocarcinomas of the pancreas and in chronic pancreatitis
    • Weger A.-R., Falkmer U. G., Schwab G., et al. Nuclear DNA distribution pattern of the parenchymal cells in adenocarcinomas of the pancreas and in chronic pancreatitis. Gastroenterology 1990, 99, 237-242.
    • (1990) Gastroenterology , vol.99 , pp. 237-242
    • Weger, A.-R.1    Falkmer, U.G.2    Schwab, G.3
  • 36
    • 0025265052 scopus 로고
    • Clinical significance of nuclear DNA content in pancreatic carcinoma
    • Alanen K. A., Joensuu H., Klemi P. J. and Nevalainen T. J. Clinical significance of nuclear DNA content in pancreatic carcinoma. Journal of Pathology 1990, 160, 313-320.
    • (1990) Journal of Pathology , vol.160 , pp. 313-320
    • Alanen, K.A.1    Joensuu, H.2    Klemi, P.J.3    Nevalainen, T.J.4
  • 37
    • 0026471016 scopus 로고
    • Prognostic markers of colorectal cancer: An evaluation of DNA content, epidermal growth factor receptor, and Ki-67
    • Hemming A. W., Davis N. L., Kluftinger A., et al. Prognostic markers of colorectal cancer: An evaluation of DNA content, epidermal growth factor receptor, and Ki-67. Journal of Surgical Oncology 1992, 51, 147-152.
    • (1992) Journal of Surgical Oncology , vol.51 , pp. 147-152
    • Hemming, A.W.1    Davis, N.L.2    Kluftinger, A.3
  • 38
    • 0026737586 scopus 로고
    • Flow cytometric analysis of nuclear DNA content of duct cell carcinoma of the pancreas
    • Yoshimura T., Manabe T., Imamura T., et al. Flow cytometric analysis of nuclear DNA content of duct cell carcinoma of the pancreas. Cancer 1992, 70, 1069-1074.
    • (1992) Cancer , vol.70 , pp. 1069-1074
    • Yoshimura, T.1    Manabe, T.2    Imamura, T.3
  • 40
    • 0025322438 scopus 로고
    • DNA ploidy and cell-cycle analysis in pancreatic and ampullary carcinoma: Flow cytometry study of formalin-fixed paraffin-embedded tissue
    • Baisch H., Kloppel G. and Reinke B. DNA ploidy and cell-cycle analysis in pancreatic and ampullary carcinoma: Flow cytometry study of formalin-fixed paraffin-embedded tissue. Virchows Archiv 1990, 417, 145-150.
    • (1990) Virchows Archiv , vol.417 , pp. 145-150
    • Baisch, H.1    Kloppel, G.2    Reinke, B.3
  • 41
  • 43
    • 0027480316 scopus 로고
    • A comparison of flow cytometric and absorption cytometric DNA values as prognostic indicators for pancreatic cancer
    • Bose K. K., Allison D. C., Hruban R. H., et al. A comparison of flow cytometric and absorption cytometric DNA values as prognostic indicators for pancreatic cancer. Cancer 1993, 71, 691-700.
    • (1993) Cancer , vol.71 , pp. 691-700
    • Bose, K.K.1    Allison, D.C.2    Hruban, R.H.3
  • 44
    • 0027360364 scopus 로고
    • Heterogeneity in the nuclear DNA content of cells in carcinomas of the biliary tract and pancreas
    • Suto T., Sasaki K., Sugai T., Kanno S. and Saito K. Heterogeneity in the nuclear DNA content of cells in carcinomas of the biliary tract and pancreas. Cancer 1993, 72, 2920-2928.
    • (1993) Cancer , vol.72 , pp. 2920-2928
    • Suto, T.1    Sasaki, K.2    Sugai, T.3    Kanno, S.4    Saito, K.5
  • 45
    • 0027136679 scopus 로고
    • K-ras gene mutation as a pathogenetic and diagnostic marker in human cancer
    • Fearon E. R. K-ras gene mutation as a pathogenetic and diagnostic marker in human cancer. Journal of the National Cancer Institute 1993, 85, 1978-1980.
    • (1993) Journal of the National Cancer Institute , vol.85 , pp. 1978-1980
    • Fearon, E.R.1
  • 47
    • 0023256456 scopus 로고
    • Prevalence of ras gene mutations in human colorectal cancers
    • Bos J. L., Fearon E. R., Hamilton S. R., et al. Prevalence of ras gene mutations in human colorectal cancers. Nature 1987, 327, 293-297.
    • (1987) Nature , vol.327 , pp. 293-297
    • Bos, J.L.1    Fearon, E.R.2    Hamilton, S.R.3
  • 49
    • 0025608147 scopus 로고
    • Pancreatic ductal adenocarcinomas induced in Syrian hamsters by N-nitrosobis-(2-oxopropyl)amine contain a c-Ki-ras oncogene with a point-mutated codon 12
    • Fujii H., Egami H., Chaney W., Pour P. and Pelling J. Pancreatic ductal adenocarcinomas induced in Syrian hamsters by N-nitrosobis-(2-oxopropyl)amine contain a c-Ki-ras oncogene with a point-mutated codon 12. Molecular Carcinogenesis 1990, 3, 296-301.
    • (1990) Molecular Carcinogenesis , vol.3 , pp. 296-301
    • Fujii, H.1    Egami, H.2    Chaney, W.3    Pour, P.4    Pelling, J.5
  • 50
    • 0026808451 scopus 로고
    • K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster
    • Cerny W. L., Mangold K. A. and Scarpelli D. G. K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster. Cancer Research 1992, 52, 4507-4513.
    • (1992) Cancer Research , vol.52 , pp. 4507-4513
    • Cerny, W.L.1    Mangold, K.A.2    Scarpelli, D.G.3
  • 51
    • 0023666146 scopus 로고
    • Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice
    • Quaife C. J., Pinkert C. A., Ornitz D. M., Palmiter R. D. and Brinster R. L. Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice. Cell 1987, 48, 1023-1034.
    • (1987) Cell , vol.48 , pp. 1023-1034
    • Quaife, C.J.1    Pinkert, C.A.2    Ornitz, D.M.3    Palmiter, R.D.4    Brinster, R.L.5
  • 52
    • 0023262990 scopus 로고
    • Detection of high incidence of K-ras oncogenes during human colorectal tumorigenesis
    • Forrester K., Almoguerra C., Han K., Grizzle W. E. and Perucho M. Detection of high incidence of K-ras oncogenes during human colorectal tumorigenesis. Nature 1987, 327, 298-303.
    • (1987) Nature , vol.327 , pp. 298-303
    • Forrester, K.1    Almoguerra, C.2    Han, K.3    Grizzle, W.E.4    Perucho, M.5
  • 53
    • 0028351157 scopus 로고
    • K-ras-2 topographic genotyping of pancreatic adenocarcinoma
    • Finkelstein S. D., Przygodzki R., Pricolo V. E., et al. K-ras-2 topographic genotyping of pancreatic adenocarcinoma. Archives of Surgery 1994, 129, 367-372.
    • (1994) Archives of Surgery , vol.129 , pp. 367-372
    • Finkelstein, S.D.1    Przygodzki, R.2    Pricolo, V.E.3
  • 54
    • 0025196234 scopus 로고
    • Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing
    • Tada M., Yokosuka O., Omata M., Ohto M. and Isono K. Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing. Cancer 1990, 66, 930-935.
    • (1990) Cancer , vol.66 , pp. 930-935
    • Tada, M.1    Yokosuka, O.2    Omata, M.3    Ohto, M.4    Isono, K.5
  • 55
    • 0024560104 scopus 로고
    • High frequency of ras oncogene activation in all stages of human thyroid tumorigenesis
    • Lemoine N. R., Mayall E. S., Wyllie F. S., et al. High frequency of ras oncogene activation in all stages of human thyroid tumorigenesis. Oncogene 1989, 4, 159-164.
    • (1989) Oncogene , vol.4 , pp. 159-164
    • Lemoine, N.R.1    Mayall, E.S.2    Wyllie, F.S.3
  • 56
    • 0026483405 scopus 로고
    • Detection of K-ras mutations by denaturing gradient gel electrophoresis (DGGE): A study on pancreatic cancer
    • Pellegata N. S., Losekoot M., Fodde R., et al. Detection of K-ras mutations by denaturing gradient gel electrophoresis (DGGE): a study on pancreatic cancer. Anticancer Research 1992, 12, 1731-1735.
    • (1992) Anticancer Research , vol.12 , pp. 1731-1735
    • Pellegata, N.S.1    Losekoot, M.2    Fodde, R.3
  • 57
    • 0028211438 scopus 로고
    • Pancreatic cancer in Europe: Ki-ras gene mutation pattern shows geographical differences
    • Scarpa A., Capelli P., Villaneuva A., et al. Pancreatic cancer in Europe: Ki-ras gene mutation pattern shows geographical differences. International Journal of Cancer 1994, 57, 167-171.
    • (1994) International Journal of Cancer , vol.57 , pp. 167-171
    • Scarpa, A.1    Capelli, P.2    Villaneuva, A.3
  • 58
    • 0024292722 scopus 로고
    • Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
    • Almoguera C., Shibata D., Forrester K., Martin J., Arnheim N. and Perucho M. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988, 53, 549-554.
    • (1988) Cell , vol.53 , pp. 549-554
    • Almoguera, C.1    Shibata, D.2    Forrester, K.3    Martin, J.4    Arnheim, N.5    Perucho, M.6
  • 59
    • 0027443009 scopus 로고
    • Comparison of mutations of ras oncogene in human pancreatic exocrine and endocrine tumors
    • Yashiro T., Fulton N., Hara H., et al. Comparison of mutations of ras oncogene in human pancreatic exocrine and endocrine tumors. Surgery 1993, 114, 758-764.
    • (1993) Surgery , vol.114 , pp. 758-764
    • Yashiro, T.1    Fulton, N.2    Hara, H.3
  • 61
    • 0024333967 scopus 로고
    • High frequency of Ki-ras codon 12 mutations in pancreatic adenocarcinomas
    • Grunewald K., Lyons J., Frohlich A., et al. High frequency of Ki-ras codon 12 mutations in pancreatic adenocarcinomas. International Journal of Cancer 1989, 43, 1037-1041.
    • (1989) International Journal of Cancer , vol.43 , pp. 1037-1041
    • Grunewald, K.1    Lyons, J.2    Frohlich, A.3
  • 62
    • 0025306220 scopus 로고
    • Frequent glycine to aspartic acid mutations at codon 12 of c-Ki-ras gene in human pancreatic cancer in Japanese
    • Nagata Y., Abe M., Motoshima K., Nakayama E. and Shiku H. Frequent glycine to aspartic acid mutations at codon 12 of c-Ki-ras gene in human pancreatic cancer in Japanese. Japanese Journal of Cancer Research 1990, 81, 135-140.
    • (1990) Japanese Journal of Cancer Research , vol.81 , pp. 135-140
    • Nagata, Y.1    Abe, M.2    Motoshima, K.3    Nakayama, E.4    Shiku, H.5
  • 63
    • 0025720078 scopus 로고
    • Mutations in the Kirsten-ras oncogene are common but lack correlation with prognosis and tumor stage in human pancreatic carcinoma
    • Motojima K., Urano T., Nagata Y., Shiku H., Tsunoda T. and Kanematsu T. Mutations in the Kirsten-ras oncogene are common but lack correlation with prognosis and tumor stage in human pancreatic carcinoma. American Journal of Gastroenterology 1991, 86, 1784-1788.
    • (1991) American Journal of Gastroenterology , vol.86 , pp. 1784-1788
    • Motojima, K.1    Urano, T.2    Nagata, Y.3    Shiku, H.4    Tsunoda, T.5    Kanematsu, T.6
  • 64
    • 0026457022 scopus 로고
    • Ras mutations in endocrine tumors: Mutation detection by polymerase chain reaction-single strand conformational polymorphism
    • Yoshimoto K., Iwahana H., Fukuda A., et al. Ras mutations in endocrine tumors: mutation detection by polymerase chain reaction-single strand conformational polymorphism. Japanese Journal of Cancer Research 1992, 83, 1057-1062.
    • (1992) Japanese Journal of Cancer Research , vol.83 , pp. 1057-1062
    • Yoshimoto, K.1    Iwahana, H.2    Fukuda, A.3
  • 65
    • 0026338569 scopus 로고
    • Distinguishing pancreatic carcinoma from other periampullary carcinomas by analysis of mutations in the Kirsten-ras oncogene
    • Motojima K., Tsunoda T., Kanematsu T., Nagata Y., Urano T. and Shiku H. Distinguishing pancreatic carcinoma from other periampullary carcinomas by analysis of mutations in the Kirsten-ras oncogene. Annals of Surgery 1991, 214, 657-662.
    • (1991) Annals of Surgery , vol.214 , pp. 657-662
    • Motojima, K.1    Tsunoda, T.2    Kanematsu, T.3    Nagata, Y.4    Urano, T.5    Shiku, H.6
  • 66
    • 0027770570 scopus 로고
    • Neoplasia of the ampulla of Vater. Ki-ras and p53 mutations
    • Scarpa A., Capelli P., Zamboni G., et al. Neoplasia of the ampulla of Vater. Ki-ras and p53 mutations. American Journal of Pathology 1993, 142, 1163-1172.
    • (1993) American Journal of Pathology , vol.142 , pp. 1163-1172
    • Scarpa, A.1    Capelli, P.2    Zamboni, G.3
  • 67
    • 0028170509 scopus 로고
    • ras-family gene mutations in neoplasia of the ampulla of Vater
    • Scarpa A., Zamboni G., Achille A., et al. ras-family gene mutations in neoplasia of the ampulla of Vater. International Journal of Cancer 1994, 59, 39-42.
    • (1994) International Journal of Cancer , vol.59 , pp. 39-42
    • Scarpa, A.1    Zamboni, G.2    Achille, A.3
  • 69
    • 0025804315 scopus 로고
    • Detection of k-ras mutations in pancreatic and hepatic neoplasms by non-isotopic mismatched polymerase chain reaction
    • Stork P., Loda M., Bosari S., Wiley B., Poppenhusen K. and Wolfe H. Detection of K-ras mutations in pancreatic and hepatic neoplasms by non-isotopic mismatched polymerase chain reaction. Oncogene 1991, 6, 857-862.
    • (1991) Oncogene , vol.6 , pp. 857-862
    • Stork, P.1    Loda, M.2    Bosari, S.3    Wiley, B.4    Poppenhusen, K.5    Wolfe, H.6
  • 70
    • 0025169651 scopus 로고
    • Analysis of ras gene mutations in human hepatic malignant tumors by polymerase chain reaction and direct sequencing
    • Tada M., Omata M. and Ohto M. Analysis of ras gene mutations in human hepatic malignant tumors by polymerase chain reaction and direct sequencing. Cancer Research 1990, 50, 1121-1124.
    • (1990) Cancer Research , vol.50 , pp. 1121-1124
    • Tada, M.1    Omata, M.2    Ohto, M.3
  • 71
    • 0025933890 scopus 로고
    • Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique
    • Levi S., Urbano-Ispizua A., Gill R., et al. Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique. Cancer Research 1991, 51, 3497-3502.
    • (1991) Cancer Research , vol.51 , pp. 3497-3502
    • Levi, S.1    Urbano-Ispizua, A.2    Gill, R.3
  • 72
    • 0020599046 scopus 로고
    • Exocrine pancreatic tumors and their histological classification
    • Morohoshi T., Held G. and Kloppel G. Exocrine pancreatic tumors and their histological classification. Histopathology 1983, 7, 645-661.
    • (1983) Histopathology , vol.7 , pp. 645-661
    • Morohoshi, T.1    Held, G.2    Kloppel, G.3
  • 74
    • 0027718103 scopus 로고
    • Pancreatic acinar cell carcinoma. An analysis of cell lineage markers, p53 expression, and Ki-ras expression
    • Hoorens A., Lemoine N. R., McLellan E., et al. Pancreatic acinar cell carcinoma. An analysis of cell lineage markers, p53 expression, and Ki-ras expression. American Journal of Pathology 1993, 143, 685-698.
    • (1993) American Journal of Pathology , vol.143 , pp. 685-698
    • Hoorens, A.1    Lemoine, N.R.2    McLellan, E.3
  • 75
    • 0025058916 scopus 로고
    • Detection of c-K-ras mutations in fine needle aspirates from human pancreatic adenocarcinomas
    • Shibata D., Almoguera C., Forrester K., et al. Detection of c-K-ras mutations in fine needle aspirates from human pancreatic adenocarcinomas. Cancer Research 1990, 50, 1279-1283.
    • (1990) Cancer Research , vol.50 , pp. 1279-1283
    • Shibata, D.1    Almoguera, C.2    Forrester, K.3
  • 76
    • 0027131520 scopus 로고
    • Detection of c-Ki-ras mutation by PCR/RFLP analysis and diagnosis of pancreatic adenocarcinomas
    • Urban T., Ricci S., Grange J. D., et al. Detection of c-Ki-ras mutation by PCR/RFLP analysis and diagnosis of pancreatic adenocarcinomas. Journal of the National Cancer Institute 1993, 85, 2008-2012.
    • (1993) Journal of the National Cancer Institute , vol.85 , pp. 2008-2012
    • Urban, T.1    Ricci, S.2    Grange, J.D.3
  • 77
    • 0028294001 scopus 로고
    • Detection of point mutations in the Ki-ras oncogene at codon 12 in pure pancreatic juice for the diagnosis of pancreatic carcinoma
    • Kondo H., Sugano K., Fukayama N., et al. Detection of point mutations in the Ki-ras oncogene at codon 12 in pure pancreatic juice for the diagnosis of pancreatic carcinoma. Cancer 1994, 73, 1589-1594.
    • (1994) Cancer , vol.73 , pp. 1589-1594
    • Kondo, H.1    Sugano, K.2    Fukayama, N.3
  • 78
    • 0028123230 scopus 로고
    • Diagnosis of pancreatic adenocarcinoma by polymerase chain reaction from pancreatic secretions
    • Trumper L. H., Burger B., von Bonin F., et al. Diagnosis of pancreatic adenocarcinoma by polymerase chain reaction from pancreatic secretions. British Journal of Cancer 1994, 70, 278-284.
    • (1994) British Journal of Cancer , vol.70 , pp. 278-284
    • Trumper, L.H.1    Burger, B.2    Von Bonin, F.3
  • 79
    • 0027261269 scopus 로고
    • Identification of K-ras oncogene mutations in the pure pancreatic juice of patients with ductal pancreatic cancers
    • Watanabe H., Sawabu N., Ohta H., et al. Identification of K-ras oncogene mutations in the pure pancreatic juice of patients with ductal pancreatic cancers. Japanese Journal of Cancer Research 1993, 84, 961-965.
    • (1993) Japanese Journal of Cancer Research , vol.84 , pp. 961-965
    • Watanabe, H.1    Sawabu, N.2    Ohta, H.3
  • 80
    • 0027232296 scopus 로고
    • Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma
    • Tada M., Omata M., Kawai S., et al. Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma. Cancer Research 1993, 53, 2472-2474.
    • (1993) Cancer Research , vol.53 , pp. 2472-2474
    • Tada, M.1    Omata, M.2    Kawai, S.3
  • 81
    • 0028342395 scopus 로고
    • Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia
    • Caldas C., Hahn S. A., Hruban R. H., Redston M. S., Yeo C. J. and Kern S. E. Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia. Cancer Research 1994, 54, 3568-3573.
    • (1994) Cancer Research , vol.54 , pp. 3568-3573
    • Caldas, C.1    Hahn, S.A.2    Hruban, R.H.3    Redston, M.S.4    Yeo, C.J.5    Kern, S.E.6
  • 82
    • 0022646788 scopus 로고
    • Localization of gene for human p53 tumour antigen to band 17p13
    • Isobe M., Emanuel B. S., Givol G., Oren M. and Croce C. M. Localization of gene for human p53 tumour antigen to band 17p13. Nature 1986, 320, 84-85.
    • (1986) Nature , vol.320 , pp. 84-85
    • Isobe, M.1    Emanuel, B.S.2    Givol, G.3    Oren, M.4    Croce, C.M.5
  • 83
    • 0027109075 scopus 로고
    • p53, guardian of the genome
    • Lane D. P. p53, guardian of the genome. Nature 1992, 358, 15-16.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 85
    • 0025040233 scopus 로고
    • Suppression of human colorectal carcinoma cell growth by wild-type p53
    • Baker S. J., Markowitz S., Fearon E. R., Willson J. K. V. and Vogelstein B. Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 1990, 149, 912-915.
    • (1990) Science , vol.149 , pp. 912-915
    • Baker, S.J.1    Markowitz, S.2    Fearon, E.R.3    Willson, J.K.V.4    Vogelstein, B.5
  • 86
    • 0025085667 scopus 로고
    • Different tumor-derived p53 mutants exhibit distinct biological activities
    • Halevy O., Michalovitz D. and Oren M. Different tumor-derived p53 mutants exhibit distinct biological activities. Science 1990, 250, 113-116.
    • (1990) Science , vol.250 , pp. 113-116
    • Halevy, O.1    Michalovitz, D.2    Oren, M.3
  • 87
    • 0026740449 scopus 로고
    • Amplification of a gene encoding a p53-associated protein in human sarcomas
    • Oliner J. D., Kinzler K. W., Meltzer P. S., George D. L. and Vogelstein B. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 1992, 358, 80-83.
    • (1992) Nature , vol.358 , pp. 80-83
    • Oliner, J.D.1    Kinzler, K.W.2    Meltzer, P.S.3    George, D.L.4    Vogelstein, B.5
  • 88
    • 0025633582 scopus 로고
    • Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
    • Malkin D., Li F. P., Strong L. C., et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 1990, 250, 1233-1238.
    • (1990) Science , vol.250 , pp. 1233-1238
    • Malkin, D.1    Li, F.P.2    Strong, L.C.3
  • 90
    • 0028308492 scopus 로고
    • p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions
    • Redston M. S., Caldas C., Seymour A. B., Hruban R. H., da Costa L. and Yeo C. J. p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions. Cancer Research 1994, 54, 3025-3033.
    • (1994) Cancer Research , vol.54 , pp. 3025-3033
    • Redston, M.S.1    Caldas, C.2    Seymour, A.B.3    Hruban, R.H.4    Da Costa, L.5    Yeo, C.J.6
  • 91
    • 0027743438 scopus 로고
    • Pancreatic adenocarcinomas frequently show p53 gene mutations
    • Scarpa A., Capelli P., Mukai K., et al. Pancreatic adenocarcinomas frequently show p53 gene mutations. American Journal of Pathology 1993, 142, 1534-1543.
    • (1993) American Journal of Pathology , vol.142 , pp. 1534-1543
    • Scarpa, A.1    Capelli, P.2    Mukai, K.3
  • 92
    • 0027216028 scopus 로고
    • p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis
    • Casey G., Yamanaka Y., Friess H., et al. p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis. Cancer Letters 1993, 69, 151-160.
    • (1993) Cancer Letters , vol.69 , pp. 151-160
    • Casey, G.1    Yamanaka, Y.2    Friess, H.3
  • 93
    • 0026334753 scopus 로고
    • Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer. British journal of
    • Barton C. M., Staddon S. L., Hughes C. M., et al. Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer. British Journal of Cancer 1991, 64, 1076-1082.
    • (1991) Cancer , vol.64 , pp. 1076-1082
    • Barton, C.M.1    Staddon, S.L.2    Hughes, C.M.3
  • 94
    • 0028567257 scopus 로고
    • Expression of p53 tumor suppressor gene, oncoprotein c-erb-2, cellular proliferation and differentiation in malignant versus benign pancreatic lesions
    • Jaskiewicz K., Krige J. E. J. and Thomson J. Expression of p53 tumor suppressor gene, oncoprotein c-erb-2, cellular proliferation and differentiation in malignant versus benign pancreatic lesions. Anticancer Research 1994, 14, 1919-1922.
    • (1994) Anticancer Research , vol.14 , pp. 1919-1922
    • Jaskiewicz, K.1    Krige, J.E.J.2    Thomson, J.3
  • 95
    • 0028268635 scopus 로고
    • K-ras and p53 gene mutations in pancreatic cancer: Ductal and nonductal tumors progress through different genetic lesions
    • Pellegata N. S., Sessa F., Renault B., et al. K-ras and p53 gene mutations in pancreatic cancer: Ductal and nonductal tumors progress through different genetic lesions. Cancer Research 1994, 54, 1556-1560.
    • (1994) Cancer Research , vol.54 , pp. 1556-1560
    • Pellegata, N.S.1    Sessa, F.2    Renault, B.3
  • 96
    • 0028922149 scopus 로고
    • Association of p53 gene mutations with short survival in pancreatic adenocarcinoma
    • Nakamori S., Yashima K., Murakami Y., et al. Association of p53 gene mutations with short survival in pancreatic adenocarcinoma. Japanese Journal of Cancer Research 1995, 86, 174-181.
    • (1995) Japanese Journal of Cancer Research , vol.86 , pp. 174-181
    • Nakamori, S.1    Yashima, K.2    Murakami, Y.3
  • 97
    • 0023572211 scopus 로고
    • The gene for familial polyposis coli maps to the long arm of chromosome 5
    • Leppert M., Dobbs M., Scambler P., et al. The gene for familial polyposis coli maps to the long arm of chromosome 5. Science 1987, 238, 1411-1413.
    • (1987) Science , vol.238 , pp. 1411-1413
    • Leppert, M.1    Dobbs, M.2    Scambler, P.3
  • 98
    • 0023223410 scopus 로고
    • Localization of the gene for familial adenomatous polyposis on chromosome 5
    • Bodmer W. F., Bailey C. J., Bodmer J., et al. Localization of the gene for familial adenomatous polyposis on chromosome 5. Nature 1987, 328, 614-616.
    • (1987) Nature , vol.328 , pp. 614-616
    • Bodmer, W.F.1    Bailey, C.J.2    Bodmer, J.3
  • 99
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon E. R. and Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990, 61, 759-767.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 100
    • 0025817880 scopus 로고
    • Identification of FAP locus genes from chromosome 5q21
    • Kinzler K. W., Nilbert M. C., Su L., et al. Identification of FAP locus genes from chromosome 5q21. Science 1991, 253, 661-665.
    • (1991) Science , vol.253 , pp. 661-665
    • Kinzler, K.W.1    Nilbert, M.C.2    Su, L.3
  • 101
    • 0025899162 scopus 로고
    • Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
    • Nishisho I., Nakamura Y., Myoshi Y., et al. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 1991, 253, 665-669.
    • (1991) Science , vol.253 , pp. 665-669
    • Nishisho, I.1    Nakamura, Y.2    Myoshi, Y.3
  • 102
    • 0025941471 scopus 로고
    • Identification of deletion mutations and three new genes at the familial polyposis locus
    • Joslyn G., Carlson M., Thliveris A., et al. Identification of deletion mutations and three new genes at the familial polyposis locus. Cell 1991, 66, 601-613.
    • (1991) Cell , vol.66 , pp. 601-613
    • Joslyn, G.1    Carlson, M.2    Thliveris, A.3
  • 103
    • 0025938038 scopus 로고
    • Identification and characterization of the familial adenomatous polyposis coli gene
    • Groden J., Thliveris A., Samowitz W., et al. Identification and characterization of the familial adenomatous polyposis coli gene. Cell 1991, 66, 589-600.
    • (1991) Cell , vol.66 , pp. 589-600
    • Groden, J.1    Thliveris, A.2    Samowitz, W.3
  • 104
    • 0025909734 scopus 로고
    • Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers
    • Kinzler K. W., Nilbert M. C., Su L., et al. Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science 1991, 251, 1368-1370.
    • (1991) Science , vol.251 , pp. 1368-1370
    • Kinzler, K.W.1    Nilbert, M.C.2    Su, L.3
  • 105
    • 0026470030 scopus 로고
    • Frequent somatic mutations of the APC gene in human pancreatic cancer
    • Horii A., Nakaturu S., Miyoshi Y., et al. Frequent somatic mutations of the APC gene in human pancreatic cancer. Cancer Research 1992, 52, 6696-6698.
    • (1992) Cancer Research , vol.52 , pp. 6696-6698
    • Horii, A.1    Nakaturu, S.2    Miyoshi, Y.3
  • 106
    • 0027438517 scopus 로고
    • Abnormalities affecting the APC and MCC tumour suppressor gene loci on chromosome 5q occur frequently in gastric cancer but not in pancreatic cancer
    • McKie A. B., Filipe M. I. and Lemoine N. R. Abnormalities affecting the APC and MCC tumour suppressor gene loci on chromosome 5q occur frequently in gastric cancer but not in pancreatic cancer. International Journal of Cancer 1993, 55, 598-603.
    • (1993) International Journal of Cancer , vol.55 , pp. 598-603
    • McKie, A.B.1    Filipe, M.I.2    Lemoine, N.R.3
  • 107
    • 0028033602 scopus 로고
    • Mutations in the adenomatous polyposis coli gene in the mutation cluster region: Comparison of human pancreatic and colorectal cancers
    • Yashima K., Nakamori S., Murakami Y., et al. Mutations in the adenomatous polyposis coli gene in the mutation cluster region: Comparison of human pancreatic and colorectal cancers. International Journal of Cancer 1995, 59, 43-47.
    • (1995) International Journal of Cancer , vol.59 , pp. 43-47
    • Yashima, K.1    Nakamori, S.2    Murakami, Y.3
  • 108
    • 0025056930 scopus 로고
    • Identification of a chromosome 18q gene that is altered in colorectal cancers
    • Fearon E. R., Cho K. R., Nigro J. M., et al. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 1990, 247, 49-247.
    • (1990) Science , vol.247 , pp. 49-247
    • Fearon, E.R.1    Cho, K.R.2    Nigro, J.M.3
  • 109
    • 0026653164 scopus 로고
    • Frequent loss of expression of the potential tumor suppressor gene DCC in ductal pancreatic adenocarcinoma
    • Hohne M. W., Halatsch M. E. K. G. F. and Weinel R. J. Frequent loss of expression of the potential tumor suppressor gene DCC in ductal pancreatic adenocarcinoma. Cancer Research 1992, 52, 2616-2619.
    • (1992) Cancer Research , vol.52 , pp. 2616-2619
    • Hohne, M.W.1    Halatsch, M.E.K.G.F.2    Weinel, R.J.3
  • 110
    • 0028302545 scopus 로고
    • Frequent alterations of the tumor suppressor genes p53 and DCC in human pancreatic carcinoma
    • Simon B., Weinel R., Hohne M., et al. Frequent alterations of the tumor suppressor genes p53 and DCC in human pancreatic carcinoma. Gastroenterology 1994, 106, 1645-1651.
    • (1994) Gastroenterology , vol.106 , pp. 1645-1651
    • Simon, B.1    Weinel, R.2    Hohne, M.3
  • 111
    • 0029031872 scopus 로고
    • Abnormalities of the RB1 and DCC tumor suppressor genes: Uncommon in human pancreatic adenocarcinoma
    • Barton C. M., McKie A. B., Hogg A., et al. Abnormalities of the RB1 and DCC tumor suppressor genes: Uncommon in human pancreatic adenocarcinoma. Molecular Carcinogenesis 1995, 13, 61-69.
    • (1995) Molecular Carcinogenesis , vol.13 , pp. 61-69
    • Barton, C.M.1    McKie, A.B.2    Hogg, A.3
  • 112
    • 0022588291 scopus 로고
    • p185, a product of the neu proto-oncogene, is a receptor like protein associated with tyrosine kinase activity
    • Stern D. F., Hefferman P. A. and Weinberg R. A. p185, a product of the neu proto-oncogene, is a receptor like protein associated with tyrosine kinase activity. Molecular and Cellular Biology 1986, 6, 1729-1740.
    • (1986) Molecular and Cellular Biology , vol.6 , pp. 1729-1740
    • Stern, D.F.1    Hefferman, P.A.2    Weinberg, R.A.3
  • 113
    • 0022486379 scopus 로고
    • Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo
    • Yokata J., Yamamoto T., Toyoshima K., et al. Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo. Lancet 1986, i, 765-766.
    • (1986) Lancet , vol.1 , pp. 765-766
    • Yokata, J.1    Yamamoto, T.2    Toyoshima, K.3
  • 114
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slalom D. J., Clark G. M., Wong S. G., Levin W. J., Ullrich A. and McGuire W. L. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987, 235, 177-182.
    • (1987) Science , vol.235 , pp. 177-182
    • Slalom, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 115
    • 0023733226 scopus 로고
    • Different structural alterations up-regulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene
    • Segato O., King C. R., Pierce J. H., DiFiore P. P. and Aaronson S. A. Different structural alterations up-regulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene. Molecular and Cellular Biology 1988, 8, 5570-5574.
    • (1988) Molecular and Cellular Biology , vol.8 , pp. 5570-5574
    • Segato, O.1    King, C.R.2    Pierce, J.H.3    Difiore, P.P.4    Aaronson, S.A.5
  • 116
  • 118
  • 119
    • 0028121279 scopus 로고
    • A cell cycle regulator potentially involved in genesis of many tumor types
    • Kamb A., Gruis N. A., Weaver-Feldhaus J., et al. A cell cycle regulator potentially involved in genesis of many tumor types. Science 1994, 264, 436-440.
    • (1994) Science , vol.264 , pp. 436-440
    • Kamb, A.1    Gruis, N.A.2    Weaver-Feldhaus, J.3
  • 120
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano M., Hannon G. J. and Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993, 366, 704-707.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 121
    • 0029091503 scopus 로고
    • Frequency of homozygous deletion at p16/CDKN2 in primary human tumours
    • Cairns P., Polascik T. J., Eby Y., et al. Frequency of homozygous deletion at p16/CDKN2 in primary human tumours. Natural Genetics 1995, 11, 210-212.
    • (1995) Natural Genetics , vol.11 , pp. 210-212
    • Cairns, P.1    Polascik, T.J.2    Eby, Y.3
  • 122
    • 0028059330 scopus 로고
    • Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
    • Caldas C., Hahn S. A., da Costa L. T., et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Natural Genetics 1994, 8, 27-32.
    • (1994) Natural Genetics , vol.8 , pp. 27-32
    • Caldas, C.1    Hahn, S.A.2    Da Costa, L.T.3
  • 123
    • 0028798818 scopus 로고
    • MTS-1 (CDKN2) tumor suppressor gene deletions are a frequent event in esophagus squamous cancer and pancreatic adenocarcinoma cell lines
    • Liu Q., Yan Y. X., McClure M., Nakagawa H., Fujimura F. and Rustgi A. K. MTS-1 (CDKN2) tumor suppressor gene deletions are a frequent event in esophagus squamous cancer and pancreatic adenocarcinoma cell lines. Oncogene 1995, 10, 619-622.
    • (1995) Oncogene , vol.10 , pp. 619-622
    • Liu, Q.1    Yan, Y.X.2    McClure, M.3    Nakagawa, H.4    Fujimura, F.5    Rustgi, A.K.6
  • 125
    • 0029129816 scopus 로고
    • Increased risk of pancreatic cancer in melanoma-prone kindreds with p16INK4 mutations
    • Goldstein A. M., Fraser M. C., Struewing J. P., et al. Increased risk of pancreatic cancer in melanoma-prone kindreds with p16INK4 mutations. New England Journal of Medicine 1995, 333, 970-974.
    • (1995) New England Journal of Medicine , vol.333 , pp. 970-974
    • Goldstein, A.M.1    Fraser, M.C.2    Struewing, J.P.3
  • 126
    • 0029102927 scopus 로고
    • A familial syndrome of pancreatic cancer and melanoma with a mutation in the CDKN2 tumor-suppressor gene
    • Whelan A. J., Bartsch D. and Goodfellow P. J. A familial syndrome of pancreatic cancer and melanoma with a mutation in the CDKN2 tumor-suppressor gene. New England Journal of Medicine 1995, 333, 975-977.
    • (1995) New England Journal of Medicine , vol.333 , pp. 975-977
    • Whelan, A.J.1    Bartsch, D.2    Goodfellow, P.J.3
  • 127
    • 0027314411 scopus 로고
    • Microsatellite instability in cancer of the proximal colon
    • Thibodeau S. N., Bren G. and Schaid D. Microsatellite instability in cancer of the proximal colon. Science 1993, 260, 816-819.
    • (1993) Science , vol.260 , pp. 816-819
    • Thibodeau, S.N.1    Bren, G.2    Schaid, D.3
  • 128
    • 0027158031 scopus 로고
    • Clues to the pathogenesis of familial colorectal cancer
    • Aaltonen L. A., Peltomaki P., Leach F. S., et al. Clues to the pathogenesis of familial colorectal cancer. Science 1993, 260, 812-816.
    • (1993) Science , vol.260 , pp. 812-816
    • Aaltonen, L.A.1    Peltomaki, P.2    Leach, F.S.3
  • 129
    • 0027742295 scopus 로고
    • The human mutator gene homolog MSH2 and its association with hereditary nonpolposis colon cancer
    • Fischel R., Lescoe M. K., Rao M. R. S., et al. The human mutator gene homolog MSH2 and its association with hereditary nonpolposis colon cancer. Cell 1993, 75, 1027-1038.
    • (1993) Cell , vol.75 , pp. 1027-1038
    • Fischel, R.1    Lescoe, M.K.2    Rao, M.R.S.3
  • 130
    • 0027145633 scopus 로고
    • Mutations of a muts homolog in hereditary nonpolyposis colorectal cancer
    • Leach F. S., Nicolaides N. C. and Papadopoulus N., et al. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 1993, 75, 1215-1225.
    • (1993) Cell , vol.75 , pp. 1215-1225
    • Leach, F.S.1    Nicolaides, N.C.2    Papadopoulus, N.3
  • 131
    • 0028350601 scopus 로고
    • Mutation of a mutL homolog in hereditary colon cancer
    • Papadopoulos N., Nicolaides N. C., Wei Y. F., et al. Mutation of a mutL homolog in hereditary colon cancer. Science 1994, 263, 1625-1629.
    • (1994) Science , vol.263 , pp. 1625-1629
    • Papadopoulos, N.1    Nicolaides, N.C.2    Wei, Y.F.3
  • 132
    • 0028221943 scopus 로고
    • Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer
    • Bronner C. E., Baker S. M., Morrison P. T., et al. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 1994, 368, 258-261.
    • (1994) Nature , vol.368 , pp. 258-261
    • Bronner, C.E.1    Baker, S.M.2    Morrison, P.T.3
  • 133
    • 0027933070 scopus 로고
    • Mutations of two PMS homologues in hereditary nonpolyposis colon cancer
    • Nicolaides N. C., Papadopoulos N., Liu B.. et al. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature 1994, 371, 75-80.
    • (1994) Nature , vol.371 , pp. 75-80
    • Nicolaides, N.C.1    Papadopoulos, N.2    Liu, B.3
  • 135
    • 0027363208 scopus 로고
    • Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer
    • Han H. J., Yanagisawa A., Kato Y., Park J. G. and Nakamura Y. Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer. Cancer Research 1993, 53, 5087-5089.
    • (1993) Cancer Research , vol.53 , pp. 5087-5089
    • Han, H.J.1    Yanagisawa, A.2    Kato, Y.3    Park, J.G.4    Nakamura, Y.5
  • 136
    • 0029023147 scopus 로고
    • Microsatellite instability and K-ras mutations associated with pancreatic adenocarcinoma and pancreatitis
    • Brentnall T. A., Chen R., Lee J. G., et al. Microsatellite instability and K-ras mutations associated with pancreatic adenocarcinoma and pancreatitis. Cancer Research 1995, 55, 4264-4267.
    • (1995) Cancer Research , vol.55 , pp. 4264-4267
    • Brentnall, T.A.1    Chen, R.2    Lee, J.G.3
  • 137
    • 0028225322 scopus 로고
    • Allelotype of pancreatic adenocarcinoma
    • Seymour A. B., Hruban R. H., Redston M., et al. Allelotype of pancreatic adenocarcinoma. Cancer Research 1994, 54, 2761-2764.
    • (1994) Cancer Research , vol.54 , pp. 2761-2764
    • Seymour, A.B.1    Hruban, R.H.2    Redston, M.3
  • 138
    • 0026663706 scopus 로고
    • Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes
    • Ruggeri B., Zhang S. Y., Caamano J., DiRado M., Flynn S. D. and Klein-Szanto A. J. P. Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes. Oncogene 1992, 7, 1503-1511.
    • (1992) Oncogene , vol.7 , pp. 1503-1511
    • Ruggeri, B.1    Zhang, S.Y.2    Caamano, J.3    DiRado, M.4    Flynn, S.D.5    Klein-Szanto, A.J.P.6
  • 140
    • 0026500701 scopus 로고
    • Ki-ras oncogene activation in preinvasive pancreatic cancer
    • Lemoine N. R., Jain S., Hughes C. M., et al. Ki-ras oncogene activation in preinvasive pancreatic cancer. Gastroenterology 1992, 102, 230-236.
    • (1992) Gastroenterology , vol.102 , pp. 230-236
    • Lemoine, N.R.1    Jain, S.2    Hughes, C.M.3
  • 141
    • 0027447152 scopus 로고
    • Detection of point mutations in the Kirsten-ras oncogene provides evidence for the multicentricity of pancreatic carcinoma
    • Motojima K., Urano T., Nagata Y., Shiku H., Tsurifune T. and Kanematsu T. Detection of point mutations in the Kirsten-ras oncogene provides evidence for the multicentricity of pancreatic carcinoma. Annals of Surgery 1993, 217, 138-143.
    • (1993) Annals of Surgery , vol.217 , pp. 138-143
    • Motojima, K.1    Urano, T.2    Nagata, Y.3    Shiku, H.4    Tsurifune, T.5    Kanematsu, T.6
  • 142
    • 0028269061 scopus 로고
    • Frequent K-ras mutations and absence of p53 mutations in mucin-producing tumors of the pancreas
    • Hoshi T., Imai M. and Ogawa K. Frequent K-ras mutations and absence of p53 mutations in mucin-producing tumors of the pancreas. Journal of Surgical Oncology 1994, 55, 84-91.
    • (1994) Journal of Surgical Oncology , vol.55 , pp. 84-91
    • Hoshi, T.1    Imai, M.2    Ogawa, K.3


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