Budding yeast Rad50, Mre11, Xrs2, and Hdf1, but not Rad52, are involved in the formation of deletions on a dicentric plasmid

Molecular and General Genetics

Volumn 255, Issue 5, 1997, Pages 543-547

  Tsukamoto, Y ^a   Kato, J ^a   Ikeda, H ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

DNA end joining; Double strand break repair; hdf1; Illegitimate recombination; rad50

Indexed keywords

ARTICLE; CELL CYCLE; CELL TRANSFORMATION; DELETION MUTANT; DNA STRAND BREAKAGE; MITOSIS; NONHUMAN; PLASMID; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; YEAST;

BASE SEQUENCE; DNA REPAIR; DNA, FUNGAL; DNA-BINDING PROTEINS; ENDODEOXYRIBONUCLEASES; EXODEOXYRIBONUCLEASES; FUNGAL PROTEINS; GENE DELETION; GENES, FUNGAL; MOLECULAR SEQUENCE DATA; PLASMIDS; RAD52 DNA REPAIR AND RECOMBINATION PROTEIN; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CERVISIAE; SACCHAROMYCETALES;

EID: 0030812904     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380050527     Document Type: Article

References (32)

1. Allgood ND, Silhavy TJ (1988) Illegitimate recombination in bacteria. In: Kucherlapati R, Smith GR (eds) Genetic recombination. American Society for Microbiology, Washington, DC, pp 309-330
2. Cao L, Alani E, Kleckner N (1990) A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae. Cell 61:1089-1101
3. Chow TYK, Resnick MA (1987) Purification and characterization of an endo-exonuclease from Saccharomyces cerevisiae that is influenced by the RAD52 gene. J Biol Chem 262:17659-17667
4. Chow TYK, Resnick MA (1988) An endo-exonuclease activity of yeast that requires a functional RAD52 gene. Mol Gen Genet 211:41-48
5. Dolganov GM, Maser RS, Novikov A, Tosto L, Chong S, Bressan DA, Petrini JHJ (1996) Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair. Mol Cell Biol 16:4832-4841
6. Feldmann H, Winnacker EL (1993) A putative homologue of the human autoantigen Ku from Saccharomyces cerevisiae. J Biol Chem 268:12895-12900
7. Gietz D, Jean AS, Woods RA, Schiestl RH (1992) Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res 20:1425
8. Greenwell PW, Kronmal SL, Porter SE, Gassenhuber J, Obermaier B, Petes TD (1995) TELI, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell 82:823-829
9. Haber JE, Thorburn PC (1984) Healing of broken linear dicentric chromosomes in yeast. Genetics 106:207-226
10. Hill A, Bloom K (1989) Acquisition and processing of a conditional dicentric chromosome in Saccharomyces cerevisiae. Mol Cell Biol 9:1368-1370
11. Ikeda H (1994) DNA topoisomerase-mediated illegitimate recombination. Adv Pharmacol 29A:147-165
12. Ivanov EL, Korolev VG, Fahre F (1992) XRS2. a DNA repair gene of Saccharomyces cerevisiae. is needed for meiotic recombination. Genetics 132:651-664
13. Jager D, Philippsen P (1989) Stabilization of dicentric chromosomes in Saccharomyces cerevisiae by telomere addition to broken ends or by centromere deletion. EMBO J 8:247-254
14. Johzuka K, Ogawa H (1995) Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosis-specilic doublestrand break formation in Saccharomyces cerevisiae. Genetics 139:1521-1532
15. Koshland D, Rutledge L, Fitzgerald-Hayes M, Hartwell LH (1987) A genetic analysis of dicentric minichromosomes in Saccharomyce cerevisiae. Cell 48:801-812
16. Kramer KM, Brock JA, Bloom K, Moore JK, Haber JE (1994) Two different types of double-strand breaks in Saccharomyces cerevisiae are repaired by similar RAD52- independent. nonhomologous recombination events. Mol Cell Biol 14:1293-1301
17. Mann C, Davis RW (1983) Instability of dicentric plasmids in yeast. Proc Natl Acad Sci USA 80:228-232
18. McClintock B (1941) The stability of broken ends of chromosome in Zea mays. Genetics 26:234-282
19. Milne GT, Jin S, Shannon KB, Weaver DT (1996) Mutations in two Ku homologs dehne a DNA end-joining repair pathway in Saccharomyces cerevisiae. Mol Cell Biol 16:4189-4198
20. Moore JK, Haber JE (1996) Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of doublestrand breaks in Saccharomyces cerevisiae. Mol Cell Biol 16:2164-2173
21. Morrow DM, Tagle DA, Shiloh Y, Collins FS, Hieter P (1995) TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell 82:831-840
22. Nakayama N, Miyajima A, Arai K (1985) Nucleotide sequences of STE2 and STE3, cell type-specific sterile genes from Saccharomyces cerevisiae. EMBO J 4:2643-2648
23. Neff MW, Burke DJ (1992) A delay in the Saccharomyces cerevisiae cell cycle that is induced by a dicentric chromosome and dependent upon mitotic checkpoints. Mol Cell Biol 12:3857-3864
24. Petrini JHJ, Walsh ME, Mare CD, Korenberg JR, Chen XN, Weaver DT (1995) Isolation and characterization of the human MRE11 homologue. Genomics 29:80-86
25. Resnick MA, Sugino A, Nitiss J, Chow T (1984) DNA polymerases, deoxyribonucleases, and recombination during meiosis in Saccharomyces cerevisiae. Mol Cell Biol 4:2811-2817
26. Roth D, Wilson J (1988) Illegitimate recombination in mammalian cells. In: Kucherlapati R, Smith GR (eds) Genetic recombination. American Society for Microbiology, Washington, DC, pp 621-653
27. Rothstein RJ (1983) One-step gene disruption in yeast. Methods Enzymol 101:202-211
28. Schiestl RH, Zhu J, Petes TD (1994) Effect of mutations in genes affecting homologous recombination on restriction enzymemediated and illegitimate recombination in Saccharomyces cerevisiae. Mol Cell Biol 14:4493-4500
29. Sugawara N, Ivanov EL, Fishman-Lobell J, Ray BL, Wu X, Haber JE (1995) DNA structure-dependent requirements for yeast RAD genes in gene conversion. Nature 373:84-86
30. Tsukamoto Y, Kalo J, Ikeda H (1996a) Effects of mutations of RAD50, RAD51, RAD52, and related genes on illegitimate recombination in Saccharomyces cerevisiae. Genetics 142:383-391
31. Tsukamoto Y, Kalo J, Ikeda H (1996b) Hdf1, a yeast Ku-protein homologue, is involved in illegitimate recombination, but not in homologous recombination. Nucleic Acids Res 24:2067-2072
32. Weaver DT (1995) What to do at an end: DNA double-strand-break repair. Trends Genet 11:388-392