Human thymine-DNA glycosylase maps at chromosome 12q22-q24.1: A region of high loss of heterozygosity in gastric cancer

Cancer Research

Volumn 57, Issue 14, 1997, Pages 3010-3015

  Schmutte, Christoph ^a   Baffa, Raffaele ^a   Veronese, Luisa M ^a   Murakumo, Yoshiki ^a   Fishel, Richard ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA GLYCOSYLTRANSFERASE; THYMINE;

ARTICLE; BASE MISPAIRING; CHROMOSOME 12Q; CLINICAL ARTICLE; DNA REPAIR; GENE LOCUS; GENE MAPPING; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STOMACH CANCER; STOMACH CARCINOGENESIS;

BASE SEQUENCE; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 12; DEOXYRIBONUCLEASE (PYRIMIDINE DIMER); DNA REPAIR; ENDODEOXYRIBONUCLEASES; HUMANS; MOLECULAR SEQUENCE DATA; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; STOMACH NEOPLASMS;

EID: 0030812371     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Hollstein, M., Sidransky, D., Vogelstein, B., and Harris, C. C. p53 mutations in human cancers. Science (Washington DC), 253: 49-53, 1991.
2. Greenblatt, M. S., Bennett, W. P., Hollstein, M., and Harris, C. C. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res., 54: 4855-4878, 1994.
3. Sved, J., and Bird, A. The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutation model. Proc. Natl. Acad. Sci. USA, 87: 4692-4696, 1990.
4. Schorderet, D. F., and Gartler, S. M. Analysis of CpG suppression in methylated and nonmethylated species. Proc. Natl. Acad. Sci. USA, 89: 957-961, 1992.
5. Spruck, C. H., Rideout, W. M., and Jones, P. A. DNA methylation and cancer. In: J. P. Jost and H. P. Saluz (eds.), DNA Methylation: Molecular Biology and Biological Significance, pp. 487-509. Basel: Birkhäuser Verlag, 1993.
6. Coulondre, C., Miller, J. H., Farabaugh, P. J., and Gilbert, W. Molecular basis of base substitution hotspots in Escherichia coli. Nature (Lond.), 274: 775-780, 1978.
7. Cooper, D. N., and Youssoufian, H. The CpG dinucleotide and human genetic disease. Hum. Genet., 78: 151-155, 1988.
8. Schmutte, C., Yang, A. S., Nguyen, T. T., Beart, R. W., and Jones, P. A. Mechanisms for the involvement of DNA methylation in colon carcinogenesis. Cancer Res., 56: 2375-2381, 1996.
9. Rideout, W. M. I., Coetzee, G. A., Olumi, A. F., and Jones, P. A. 5-methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes. Science (Washington DC), 249: 1288-1290, 1990.
10. Wang, R. Y., Kuo, K. C., Gehrke, C. W., Huang, L. H., and Ehrlich, M. Heat- and alkali-induced deamination of 5-methylcytosine and cytosine residues in DNA. Biochim. Biophys. Acta, 697: 371-377, 1982.
11. Shen, J. C., Rideout, W. M., and Jones, P. A. The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNA. Nucleic Acids Res., 22: 972-976, 1994.
12. Duncan, B. K., and Weiss, B. Specific mutator effects of ung (uracil-DNA glycosylase) mutations in Escherichia coli. J. Bacteriol., 151: 750-755, 1982.
13. Lieb, M., and Bhagwat, A. S. Very short patch mismatch repair activity associated with gene dcm is not conferred by a plasmid coding for EcoRII methylase. J. Bacteriol., 170: 4967-4968, 1988.
14. Hennecke, F., Kolmar, H., Brundl, K., and Fritz, H. J. The vsr gene product of E. coli K-12 is a strand- and sequence-specific DNA mismatch endonuclease. Nature (Lond.), 353: 776-778, 1991.
15. Brown, T. C., and Jiricny, J. Different base/base mispairs are corrected with different efficiencies and specificities in monkey kidney cells. Cell, 54: 705-711, 1988.
16. Yang, A. S., Gonzalgo, M. L., Zingg, J-M., Millar, R. P., Buckley, J. D., and Jones, P. A. The rate of CpG mutations in Alu repetitive elements within the p53 tumor suppressor gene in the primate germ line. J. Mol. Biol., 258: 240-250, 1996.
17. Wiebauer, K., and Jiricny, J. In vitro correction of G.T mispairs to G.C pairs in nuclear extracts from human cells. Nature (Lond.), 339: 234-236, 1989.
18. Wiebauer, K., and Jiricny, J. Mismatch-specific thymine DNA glycosylase and DNA polymerase β mediate the correction of G.T mispairs in nuclear extracts from human cells. Proc. Natl. Acad. Sci. USA, 87: 5842-5845, 1990.
19. Neddermann, P., and Jiricny, J. Efficient removal of uracil from G.U mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells. Proc. Natl. Acad. Sci. USA, 91: 1642-1646, 1994.
20. Sibghat-Ullah, , and Day, R. S. D. DNA-substrate sequence specificity of human G:T mismatch repair activity. Nucleic Acids Res., 21: 1281-1287, 1993.
21. Griffin, S., and Karran, P. Incision at DNA G.T mispairs by extracts of mammalian cells occurs preferentially at cytosine methylation sites and is not targeted by a separate G.T binding reaction. Biochemistry, 32: 13032-13039, 1993.
22. Sibghat-Ullah, Gallinari, P., Xu, Y. Z., Goodman, M. F., Bloom, L. B., Jiricny, J., and Day, R. S. Base analog and neighboring base effects on substrate specificity of recombinant human G-T mismatch-specific thymine-DNA glycosylase. Biochemistry, 35: 12926-12932, 1996.
23. Glazer, P. M., Sarkar, S. N., Chisholm, G. E., and Summers, W. C. DNA mismatch repair detected in human cell extracts. Mol. Cell. Biol., 7: 218-224, 1987.
24. Holmes, J. J., Clark, S., and Modrich, P. Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines. Proc. Natl. Acad. Sci. USA, 87: 5837-5841, 1990.
25. Thomas, D. C., Roberts, J. D., and Kunkel, T. A. Heteroduplex repair in extracts of human HeLa cells. J. Biol. Chem., 266: 3744-3751, 1991.
26. Parsons, R., Li, G. M., Longley, M. J., Fang, W. H., Papadopoulos, N., Jen. J., de la Chapelle, A., Kinzler, K. W., Vogelstein, B., and Modrich, P. Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell, 75: 1227-1236, 1993.
27. Bhattacharyya, N. P., Skandalis, A., Ganesh, A., Groden, J., and Meuth, M. Mutator phenotypes in human colorectal carcinoma cell lines. Proc. Natl. Acad. Sci. USA, 91: 6319-6323, 1994.
28. Fishel, R., Lescoe, M. K., Rao, M. R. S., Copeland, N. G., Jenkins, N. A., Garber, J., Kane, M., and Kolodner, R. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell, 75: 1027-1038, 1993.
29. Leach, F. S., Nicolaides, N. C., Papadopoulos, N., Liu, B., Jen, J., Parsons, R., Peltomäki, P., Sistonen, P., Aaltonen, L. A., Trent, J. M., de la Chapelle, A., Kinzler, K. W., and Vogelstein, B. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell, 75: 1215-1225, 1993.
30. Bronner, C. E., Baker, S. M., Morrison, P. T., Warren, G., Smith, L. G., Lescoe, M. K., Kane, M., Earabino, C., Lipford, J., Lindblom, A., Tannergård, P., Bollag, R. J., Godwin, A. R., Ward, D. C., Nordenskjøld, M., Fishel, R., Kolodner, R., and Liskay, R. M. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary nonpolyposis colon cancer Nature (Lond.), 368: 258-261, 1994.
31. Papadopoulos, N., Nicolaides, N. C., Wei, Y. F., Ruben, S. M., Carter, K. C., Rosen, C. A., Haseltine, W. A., Fleischmann, R. D., Fraser, C. M., Adams, M. D., Venter, J. C., Hamilton, S. R., Lynch, H. T., Peltomäki, P., Mecklin, J. P., de la Chapelle, A., Kinzler, K. W., and Vogelstein, B. Mutation of a mutL homolog in hereditary colon cancer. Science (Washington DC), 263: 1625-1629, 1994.
32. Nicolaides, N. C., Papadopoulos, N., Liu, B., Wei, Y. F., Carter, K. C., Ruben, S. M., Rosen, C. A., Haseltine, W. A., Fleischmann, R. D., Fraser, C. M., Adams, M. D., Venter, J. C., Hamilton, S. R., Petersen, G. M., de la Chapelle, A., Vogelstein, B., and Kinzler, K. W. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature (Lond.), 371: 75-80, 1994.
33. Apte, A. N., and Siebert, P. D. Anchor-ligated cDNA libraries: a technique for generating a cDNA library for the immediate cloning of the 5′ end of mRNAs. Biotechniques, 15: 890-893, 1993.
34. Hudson, T., Stein, L., Gerety, S., Ma, J., Castle, A., Silva, J., Slonim, D., Baptista, R., Kruglyak, L., Xu, S., Hu, X., Colbert, A., Rosenberg, C., Reeve-Daly, M., Rozen, S., Hui, L., Wu, X., Vestergaard, C., Wilson, K., Bae, J., Maitra, S., Ganiatsas, S., Evans, C., DeAngelis, M., Ingalls, K., Nahf, R., Horton, L., Oskin, M., Collymore, A., Ye, W., Kouyoumjian, V., Zernsteva, I., Tarn, J., Devine, R., Courtney, D., Renaud, M., Nguyen, H., O'Connor, T., Fizames, C., Faure, S., Gyapay, G., Dib, C., Morissette, J., Orlin, J., Birren, B., Goodman, N., Weissenbach, J., Hawkins, T., Foote, S., Page, D., and Lander, E. An STS-based map of the human genome. Science (Washington DC), 270: 1945-1954, 1995.
35. Veronese, M. L., Ohta, M., Finan, J., Nowell, P. C., and Croce, C. M. Detection of myc translocations in lymphoma cells by fluorescence in situ hybridization with yeast artificial chromosomes. Blood, 85: 2132-2138, 1995.
36. Sambrook, J., Fritsch, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual, 2nd edition. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1989.
37. Baffa, R., Negrini, M., Mandes, B., Rugge, M., Ranzani, G. N., Hirohashi, S., and Croce, C. M. Loss of heterozygosity for chromosome 11 in adenocarcinoma of the stomach. Cancer Res., 56: 268-272, 1996.
38. Neddermann, P., Gallinari, P., Lettieri, T., Schmid, D., Truong, O., Hsuan, J. J., Wiebauer, K., and Jiricny, J. Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase. J. Biol. Chem., 271: 12767-12774, 1996.
39. Gardiner-Garden, M., and Frommer, M. CpG islands in vertebrate genomes. J. Mol. Biol., 196: 261-282, 1987.
40. Haug, T., Skorpen, F., Lund, H., and Krokan, H. E. Structure of the gene for human uracil-DNA glycosylase and analysis of the promoter function. FEBS Lett., 353: 180-184, 1994.
41. Sano, T., Tsujino, T., Yoshida, K., Nakayama, H., Haruma, K., Ito, H., Nakamura, Y., Kajiyama, G., and Tahara, E. Frequent loss of heterozygosity on chromosomes 1q, 5q, and 17p in human gastric carcinomas. Cancer Res., 51: 2926-2931, 1991.
42. Ionov, Y., Peinado, M. A., Malkhosyan, S., Shibata, D., and Perucho, M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature (Lond.), 363: 558-561, 1993.
43. Thibodeau, S. N., Bren, G., and Schaid, D. Microsatellite instability in cancer of the proximal colon. Science (Washington DC), 260: 816-819, 1993.
44. Schmutte, C., Yang, A. S., Beart, R. W., and Jones, P. A. Base excision repair of U:G mismatches at a mutational hotspot in the p53 gene is more efficient than base excision repair of T:G mismatches in extracts of human colon tumors. Cancer Res., 55: 3742-3746, 1995.
45. Kane, M. F., Loda, M., Gaida, G. M., Lipman, J., Mishra, R., Goldman, H., Jessup, M. A., and Kolodner, R. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res., 57: 808-811, 1997.
46. Meyers, M., Theodosiou, M., Acharya, S., Odegaard, E., Wilson, T., Lewis, J. E., Davis, T. W., Vanpatten, C. W., Fishel, R., and Boothman, D. A. Cell cycle regulation of the human DNA mismatch repair genes HMSH2, hMLH1, and hPMS2. Cancer Res., 57: 206-208, 1997.
47. Gallinari, P., and Jiricny, J. A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase. Nature (Lond.), 383: 735-738, 1996.
48. Ehrlich, M., Gama, S. M., Huang, L. H., Midgett, R. M., Kuo, K. C., McCune, R. A., and Gehrke, C. Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells. Nucleic Acids Res., 10: 2709-2721, 1982.
49. Horst, J. P., and Fritz, H. J. Counteracting the mutagenic effect of hydrolytic deamination of DNA 5-methylcytosine residues at high temperature: DNA mismatch N-glycosylase Mig.Mth of the thermophilic archaeon Methanobacterium thermoautotrophicum THF. EMBO J., 15: 5459-5469, 1996.