Noninvolvement of CYP2E1 in the (ω-1)-hydroxylation of fatty acids in rat kidney microsomes

Biochemical Pharmacology

Volumn 54, Issue 8, 1997, Pages 947-952

  Amet, Yolande ^a   Zerilli, Alain ^a   Goasduff, Thierry ^a   Dréano, Yvonne ^a   Berthou, François ^a  

^a FACULTÉ DE MÉDECINE ET DES SCIENCES DE LA SANTÉ   (France)

Author keywords

CYP2E1; CYP4A; Lauric acid; Microsomes; Rat kidney

Indexed keywords

4 NITROPHENOL; ALCOHOL; CHLORZOXAZONE; CYTOCHROME P450 ISOENZYME; FATTY ACID; LAURIC ACID;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; HYDROXYLATION; KIDNEY MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ALKANE 1-MONOOXYGENASE; ANIMALS; CHLORZOXAZONE; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; FATTY ACIDS; IMMUNOLOGIC TECHNIQUES; KIDNEY; MALE; MICROSOMES; MIXED FUNCTION OXYGENASES; NITROPHENOLS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030809752     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00257-8     Document Type: Article

References (32)

1. Nelson DR, Koymans L, Kamataki T, Stegeman JJ, Feyereisen R, Waxman DJ, Waterman MR, Gotoh O, Coon MJ, Estabrook R, Gunsalus IC and Nebert DW, P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 6: 1-42, 1996.
2. Imaoka S, Terrano Y and Funae Y, Expression of four phenobarbital inducible cytochrome P-450s in liver, kidney and lung of rats. J Biochem 105: 939-945, 1989.
3. Imaoka S, Nagashima K and Funae Y, Characterization of three cytochrome P450s purified from renal microsomes of untreated male rats and comparison with human renal cytochrome P450. Arch Biochem Biophys 276: 473-480, 1990.
4. Wu D and Cederbaum AI, Characterization of pyrazole and 4-methylpyrazole induction of cytochrome P450 2E1 in rat kidney. J Pharmacol Exp Ther 270: 407-413, 1994.
5. Zerilli A, Lucas D, Amet Y, Beaugé F, Volant A, Floch HH, Berthou F and Ménez JF, Cytochrome P-450 2E1 in rat liver, kidney and lung microsomes after chronic administration of ethanol either orally or by inhalation. Alcohol Alcohol 30: 357-365, 1995.
6. Gibson GG, Orton TC and Tamburini PP, Cytochrome P450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for 12 and 11-hydroxylation of dodecanoic acid (lauric acid). Biochem J 203: 161-168, 1982.
7. Amet Y, Berthou F, Goasduff T, Salaün JP, Le Breton L and Ménez JF, Evidence that cytochrome P450 2E1 is involved in the (ω-1)-hydroxylation of lauric acid in rat liver microsomes. Biochem Biophys Res Commun 203: 1168-1174, 1994.
8. Clarke SE, Baldwin SJ, Bloomer JC, Ayrton AD, Sozio RS and Chenery RJ, Lauric acid as a model substrate for the simultaneous determination of cytochromes P450 2E1 and 4A in hepatic microsomes. Chem Res Toxicol 7: 836-842, 1994.
9. Amet Y, Berthou F, Baird S, Dréano Y, Bail JP and Ménez JF, Validation of the (ω-1)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1. Biochem Pharmacol 50: 1775-1782, 1995.
10. Amet Y, Berthou F, Fournier G, Dréano Y, Bardou L, Clèdes J and Ménez JF, Cytochrome P450 4A and 2E1 expression in human kidney microsomes. Biochem Pharmacol 53: 765-771, 1997.
11. Berthou F, Ratanasavanh D, Riché C, Picart D, Voirin T and Guillouzo A, Comparison of caffeine metabolism by slices, microsomes and hepatocyte cultures from adult human liver. Xenobiotica 19: 401-417, 1989.
12. Peter R, Böcker R, Beaune P, Iwasaki M, Guengerich FP and Yang CS, Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P450 IIE1. Chem Res Toxicol 3: 566-573, 1990.
13. Carrière V, Goasduff T, Ratanasavanh D, Morel F, Gautier JC, Guillouzo A, Beaune P and Berthou F, Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazone. Chem Res Toxicol 6: 852-857, 1993.
14. Koop DR, Hydroxylation of p-nitrophenol by rabbit ethanol-inducible cytochrome P-450 isozyme 3a. Mol Pharmacol 291: 399-404, 1986.
15. Tassaneeyakul W, Veronese ME, Birkett DJ, Gonzalez FJ and Miners JO, Validation of 4-nitrophenol as an in vitro substrate probe for human liver CYP2E1 using cDNA expression and microsomal kinetic techniques. Biochem Pharmacol 46: 1975-1981, 1993.
16. Amet Y, Berthou F and Ménez JF, Simultaneous radiometric and fluorimetric detection of lauric acid metabolites using high-performance liquid chromatography following esterification with 4-bromomethyl-6,7-dimethoxycoumarin in human and rat liver microsomes. J Chromatogr B 681: 233-239, 1996.
17. Laemmli UK, Change of structural proteins during the assembly of bacteriophage T4. Nature 227: 680-685, 1970.
18. Towbin H, Staehelin T and Gordon J, Electrophoretic transfer of proteins from polyacrylamide gel to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76: 4350-4354, 1979.
19. Zou AP, Ma YH, Sui ZH, Ortiz de Montellano PR, Clarke JE, Masters BS and Roman RA. Effects of 17-octadecynoic acid, a suicide substrate inhibitor of cytochrome P450 fatty acid ω-hydroxylase, on renal function in rats. J Pharmacol Exp Ther 268: 474-481, 1994.
20. Newton DJ, Wang RW and Lu AYH, Cytochromes P450 inhibitors: evaluation of specificities in the in vitro metabolism of therapeutic agents by human liver microsomes. Drug Metab Dispos 23: 154-158, 1995.
21. Guengerich FP, Kim DH and Iwasaki M, Role of human cytochrome P450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem Res Toxicol 4: 168-179, 1991.
22. De Waziers I, Cugnenc PH, Yang CS, Leroux JP and Beaune PH, Cytochrome P-450 isoenzyme, epoxide hydrolase and glutathione transferases in rat and human hepatic and extra-hepatic tissues. J Pharmacol Exp Ther 253: 387-393, 1990.
23. Goasduff T, Bellec G, Amet Y, Dréano Y, Ménez JF and Berthou F, P450 2E1 expression in liver, kidney and lung of rats treated with single or combined inducers. Alcohol 13: 301-308, 1996.
24. Sharma RK, Lake BG, Makowski R, Bradshaw T, Earnshaw D, Dale JW and Gibson GG, Differential induction of peroxisomal and microsomal fatty-acid-oxidising enzymes by peroxisome proliferators in rat liver and kidney: characterisation of a renal cytochrome P-450 and implications for peroxisome proliferation. Eur J Biochem 184: 69-78, 1989.
25. Laω). J Biol Chem 262: 801-810, 1987.
26. Imaoka S, Tanaka S and Funae Y, ω and (ω-1)-hydroxylation of lauric and arachidonic acid by rat renal cytochrome P-450. Biochem Int 18: 731-740, 1989.
27. Chen W, Peter RM, McArdle S, Thummel KE, Sigle RO and Nelson SD, Baculovirus expression and purification of human and rat cytochrome P450 2E1. Arch Biochem Biophys 335: 123-130, 1996.
28. Muerhoff AS, Williams DE, Reich NO, CaJacob CA, Ortiz de Montellano PR and Masters BSS, Prostaglandin and fatty acid ω-and (ω-1)-oxidation in rabbit lung: acetylenic fatty acid mechanism-based inactivators as specific inhibitors. J Biol Chem 264: 749-756, 1989.
29. Ortiz de Montellano PR and Reich NO, Specific inactivation of hepatic fatty acid hydroxylases by acetylenic fatty acids. J Biol Chem 259: 4136-4141, 1984.
30. Ortiz de Montellano PR, Suicide substrates of drug metabolizing enzymes: mechanisms and biological consequences. In: Progress in drug metabolism. (Ed. Gibson GG), Vol. 11, pp. 99-148, Taylor & Francis Ltd., London, 1989.
31. Jayyosi Z, Knoble D, Muc M, Erick J, Thomas PE and Kelley M, Cytochrome P450 2E1 is not the sole catalyst of chlorzoxazone hydroxylation in rat liver microsomes. J Pharmocol Exp Ther 273: 1156-1161, 1995.
32. Imaoka S, Yamazoe Y, Kato R and Funae Y, Hormonal regulation of rat renal cytochrome P450s by androgen and the pituitary. Arch Biochem Biophys 299: 179-184, 1992.