메뉴 건너뛰기




Volumn 12, Issue 4, 1997, Pages 427-437

Antiplatelet and antithrombin therapies in the acute coronary syndromes

Author keywords

[No Author keywords available]

Indexed keywords

ABCIXIMAB; ACETYLSALICYLIC ACID; ANTITHROMBIN; ANTITHROMBOCYTIC AGENT; CLOPIDOGREL; DALTEPARIN; ENOXAPARIN; EPTIFIBATIDE; FIBRINOGEN RECEPTOR ANTAGONIST; HEPARIN; HIRUDIN; HIRULOG; LAMIFIBAN; LOW MOLECULAR WEIGHT HEPARIN; REVIPARIN; THROMBIN INHIBITOR; TICLOPIDINE; TIROFIBAN; WARFARIN;

EID: 0030808952     PISSN: 02684705     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001573-199707000-00012     Document Type: Review
Times cited : (12)

References (46)
  • 1
    • 0027125530 scopus 로고
    • The pathogenesis of coronary artery disease and the acute coronary syndromes
    • Fuster V, Badmon J, Chesebro J: The pathogenesis of coronary artery disease and the acute coronary syndromes. N Engl J Med 1992, 326:242-250.
    • (1992) N Engl J Med , vol.326 , pp. 242-250
    • Fuster, V.1    Badmon, J.2    Chesebro, J.3
  • 2
    • 0023805341 scopus 로고
    • Randomized trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2
    • ISIS-2 (Second International Trial of Infarct Survival) Collaborative Group: Randomized trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. Lancet 1988, 2:349-360.
    • (1988) Lancet , vol.2 , pp. 349-360
  • 3
    • 0028120906 scopus 로고
    • Antiplatelet Trialists' Collaboration: Collaborative overview of randomized trials of anti-platelet therapy. I: Prevention of death, myocardial infarction, and stroke by prolonged anti-platelet therapy in various categories of patients
    • Antiplatelet Trialists' Collaboration: collaborative overview of randomized trials of anti-platelet therapy. I: Prevention of death, myocardial infarction, and stroke by prolonged anti-platelet therapy in various categories of patients. BMJ 1994, 308:81-106.
    • (1994) BMJ , vol.308 , pp. 81-106
  • 4
    • 0030590746 scopus 로고    scopus 로고
    • A randomized, blinded, trial of clopidogrel versus aspirin in patients at risk of ischemic events (CAPRIE)
    • CAPRIE Steering Committee: A randomized, blinded, trial of clopidogrel versus aspirin in patients at risk of ischemic events (CAPRIE). Lancet 1996, 348:1329-1339. The authors documented a modest, 8.7% reduction in death, myocardial infarction (MI), and vascular death with clopidogrel in patients after MI or stroke, or with peripheral vascular disease, with an acceptable side effect profile.
    • (1996) Lancet , vol.348 , pp. 1329-1339
  • 5
    • 2242477091 scopus 로고
    • Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty
    • The EPIC Investigators: Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty. N Engl J Med 1994, 330:956-961. The EPIC trial was the first trial to reveal a significant 35% reduction in death, myocardial infarction, and urgent revascularization in patients undergoing high-risk angioplasty who were treated with abciximab.
    • (1994) N Engl J Med , vol.330 , pp. 956-961
  • 8
    • 0342759568 scopus 로고    scopus 로고
    • Abciximab with reduced heparin dosing during coronary intervention: Final results of the EPILOG trial
    • Lincoff AM, Tcheng JE, Califf RM, Cabot CF, Miller DP, Booth JE, Montague EA, Anderson KM, Topol EJ: Abciximab with reduced heparin dosing during coronary intervention: final results of the EPILOG trial [abstract]. J Am Coll Cardiol 1997, 29:187A. The EPILOG trial, which revealed a 56% reduction in death, myocardial infarction, and urgent revascularization in all patients undergoing angioplasty, was also stopped due to early positive results, and extended the beneficial effects of abciximab to all patients undergoing angioplasty.
    • (1997) J Am Coll Cardiol , vol.29
    • Lincoff, A.M.1    Tcheng, J.E.2    Califf, R.M.3    Cabot, C.F.4    Miller, D.P.5    Booth, J.E.6    Montague, E.A.7    Anderson, K.M.8    Topol, E.J.9
  • 10
    • 0030071380 scopus 로고    scopus 로고
    • EPILOG and CAPTURE trials halted because of positive interim results
    • Ferguson JJ: EPILOG and CAPTURE trials halted because of positive interim results. Circulation 1996, 93:637.
    • (1996) Circulation , vol.93 , pp. 637
    • Ferguson, J.J.1
  • 11
    • 0029928477 scopus 로고    scopus 로고
    • More evidence for a beneficial effect of platelet glycoprotein IIb/IIIa-blockade during coronary interventions: Latest results from the EPILOG and CAPTURE trials
    • Van de Werf F: More evidence for a beneficial effect of platelet glycoprotein IIb/IIIa-blockade during coronary interventions: latest results from the EPILOG and CAPTURE trials. Eur Heart J 1996, 17:325-326
    • (1996) Eur Heart J , vol.17 , pp. 325-326
    • Van De Werf, F.1
  • 13
    • 0000656559 scopus 로고    scopus 로고
    • Effect of competitive platelet glycoprotein IIb/IIIa inhibition with Integrilin in reducing complications of percutaneous coronary interventions: Results of the randomized clinical trial IMPACT-II
    • The IMPACT-II Investigators: Effect of competitive platelet glycoprotein IIb/IIIa inhibition with Integrilin in reducing complications of percutaneous coronary interventions: results of the randomized clinical trial IMPACT-II. Lancet 1997, 349:1422-1428. This trial of the glycoprotein IIb/IIIa antagonist Integrilin in patients undergoing angioplasty did not document significant durable benefit at the dose studied.
    • (1997) Lancet , vol.349 , pp. 1422-1428
  • 15
    • 16944362255 scopus 로고    scopus 로고
    • Combined accelerated tissue-plasminogen activator and platelet glycoprotein IIb/IIIa integrin receptor blockade with Integrilin in acute myocardial infarction: Results of a randomized, placebo-controlled, dose-ranging trial
    • Ohman EM, Kleiman NS, Gacioch G, Worley S, Talley JD, Navetta FI, Talley JD, Anderson HV, Ellis SG, Cohen M, Spriggs D, Miller M, , Dereiakes D, Yakubov S, Kitt MM, Sigmon KN, Califf RM, Krucoff M, Topol EJ. for the IMPACT-AMI Investigators: Combined accelerated tissue-plasminogen activator and platelet glycoprotein IIb/IIIa integrin receptor blockade with Integrilin in acute myocardial infarction: results of a randomized, placebo-controlled, dose-ranging trial. Circulation 1997, 98:846-854. Integrilin to Manage Platelet Activation to Prevent Coronary Thrombosis in Acute Myocardial Infarction I (IMPACT-AMI), a dose-finding trial of the short-acting glycoprotein IIb/IIIa inhibitor Integrilin, documented improved TIMI 3 flow in patients with acute myocardial infarction who were treated with Integrilin in conjuction with thrombolysis.
    • (1997) Circulation , vol.98 , pp. 846-854
    • Ohman, E.M.1    Kleiman, N.S.2    Gacioch, G.3    Worley, S.4    Talley, J.D.5    Navetta, F.I.6    Talley, J.D.7    Anderson, H.V.8    Ellis, S.G.9    Cohen, M.10    Spriggs, D.11    Miller, M.12    Dereiakes, D.13    Yakubov, S.14    Kitt, M.M.15    Sigmon, K.N.16    Califf, R.M.17    Krucoff, M.18    Topol, E.J.19
  • 16
    • 0030879876 scopus 로고    scopus 로고
    • Adjunctive antiplatelet therapy in acute myocardial infarction: The road to improved infarct-related artery patency
    • in press
    • Alexander JH, Harrington RA: Adjunctive antiplatelet therapy in acute myocardial infarction: the road to improved infarct-related artery patency. J Thromb Thrombol 1997, in press.
    • (1997) J Thromb Thrombol
    • Alexander, J.H.1    Harrington, R.A.2
  • 17
    • 0000440354 scopus 로고    scopus 로고
    • A randomized trial of potent platelet IIb/IIIa antagonism, heparin, or both in patients with unstable angina: The PARAGON study
    • PARAGON Investigators: A randomized trial of potent platelet IIb/IIIa antagonism, heparin, or both in patients with unstable angina: the PARAGON study [abstract]. Circulation 1996, 94(suppl):I-553.
    • (1996) Circulation , vol.94 , Issue.SUPPL.
  • 18
    • 0000888542 scopus 로고    scopus 로고
    • Delaying and preventing ischemic events in patients with acute coronary syndromes using the platelet glycoprotein IIb/IIIa inhibitor lamifiban
    • Harrington RA, Moliterno DJ, Van de Werf F, Keech A, Kleiman N, Bhapkar M, Rames A, Peek M, Topol EJ, Califf RM, Armstrong PW, for the PARAGON Investigators: Delaying and preventing ischemic events in patients with acute coronary syndromes using the platelet glycoprotein IIb/IIIa inhibitor lamifiban [abstract]. J Am Coll Cardiol 1997, 29:409A. In PARAGON-A, a dose-finding trial of lamifiban in patients with unstable angina and non-Q wave myocardial infarction, there was no singificant benefit seen at 30 days; however, there was a significant reduction in death or myocardial reinfarction seen at 6-month follow-up.
    • (1997) J Am Coll Cardiol , vol.29
    • Harrington, R.A.1    Moliterno, D.J.2    Van De Werf, F.3    Keech, A.4    Kleiman, N.5    Bhapkar, M.6    Rames, A.7    Peek, M.8    Topol, E.J.9    Califf, R.M.10    Armstrong, P.W.11
  • 19
    • 0001145269 scopus 로고
    • Randomized, placebo-controlled study of lamifiban with thrombolytic therapy for the treatment of acute myocardial infarction: Rationale and design for the Platelet Aggregation Receptor Antagonist Dose Investigation and reperfusion Gain in Myocardial infarction (PARADIGM) study
    • Moliterno DJ, Harrington RA, Califf RM, Rapold HJ, Topol EJ, for the PARADIGM Investigators: Randomized, placebo-controlled study of lamifiban with thrombolytic therapy for the treatment of acute myocardial infarction: rationale and design for the Platelet Aggregation Receptor Antagonist Dose Investigation and reperfusion Gain in Myocardial infarction (PARADIGM) study. J Thromb Thrombol 1995, 2:165-169.
    • (1995) J Thromb Thrombol , vol.2 , pp. 165-169
    • Moliterno, D.J.1    Harrington, R.A.2    Califf, R.M.3    Rapold, H.J.4    Topol, E.J.5
  • 21
    • 0031058514 scopus 로고    scopus 로고
    • Perspectives on large-scale cardiovascular clinical trials for the new millennium
    • Topol EJ, Califf RM, Van de Werf F, Simoons M, Hampton J, Lee KL, White H, Simes J, Armstrong PW, for the Virtual Coordinating Center for Global Collaborative Cardiovascular Research (VIGOUR) Group: Perspectives on large-scale cardiovascular clinical trials for the new millennium. Circulation 1997, 95:1072-1082. Reviews the importance of large randomized clinical trials for documenting the efficacy of new therapies in cardiovascular disease.
    • (1997) Circulation , vol.95 , pp. 1072-1082
    • Topol, E.J.1    Califf, R.M.2    Van De Werf, F.3    Simoons, M.4    Hampton, J.5    Lee, K.L.6    White, H.7    Simes, J.8    Armstrong, P.W.9
  • 22
    • 0029798675 scopus 로고    scopus 로고
    • Glycoprotein IIb/IIIa receptor inhibitors-putting the EPIC, IMPACT II, RESTORE, and EPILOG trials into perspective
    • Tcheng JE: Glycoprotein IIb/IIIa receptor inhibitors-putting the EPIC, IMPACT II, RESTORE, and EPILOG trials into perspective. Am J Cardiol 1996, 78(suppl 3A):35-40.
    • (1996) Am J Cardiol , vol.78 , Issue.SUPPL. 3A , pp. 35-40
    • Tcheng, J.E.1
  • 23
    • 0010353643 scopus 로고    scopus 로고
    • First experience with chronic platelet GPIIb/IIIa receptor blockade: A pilot study of xemlofiban an orally active antagonist in unstable angina patients eligible for PTCA
    • Simpfendorfer C, Kottke-Marchant K, Topol EJ: First experience with chronic platelet GPIIb/IIIa receptor blockade: a pilot study of xemlofiban an orally active antagonist in unstable angina patients eligible for PTCA [abstract]. J Am Coll Cardiol 1996, 27:242A.
    • (1996) J Am Coll Cardiol , vol.27
    • Simpfendorfer, C.1    Kottke-Marchant, K.2    Topol, E.J.3
  • 24
    • 1842630672 scopus 로고    scopus 로고
    • Evaluation of the oral glycoprotein IIb/IIIa antagonist Ro 48-3657 in patients post acute coronary syndrome: Primary results of the TIMI 12 trial
    • Cannon CP, Novotny WF, McCabe CH, Tischler MD, Borzak S, Henry TD, Feldman R, Hamilton S, Rothman JM, Braunwald E, and the TIMI 12 Investigators: Evaluation of the oral glycoprotein IIb/IIIa antagonist Ro 48-3657 in patients post acute coronary syndrome: primary results of the TIMI 12 trial [abstract]. Circulation 1996, 94(suppl):I-552.
    • (1996) Circulation , vol.94 , Issue.SUPPL.
    • Cannon, C.P.1    Novotny, W.F.2    McCabe, C.H.3    Tischler, M.D.4    Borzak, S.5    Henry, T.D.6    Feldman, R.7    Hamilton, S.8    Rothman, J.M.9    Braunwald, E.10
  • 28
    • 9044243412 scopus 로고    scopus 로고
    • Low-molecular weight heparin during instability in coronary artery disease
    • Fragmin During Instability in Coronary Artery Disease (FRISC) Study Group: Low-molecular weight heparin during instability in coronary artery disease. Lancet 1996, 347:561-568. Documented a significant early reduction in death or myocardial infarction, which was attenuated at 40 days, in patients with unstable angina treated with dalteparin.
    • (1996) Lancet , vol.347 , pp. 561-568
  • 29
    • 0031576804 scopus 로고    scopus 로고
    • Meeting highlights
    • Ferguson JJ, Fox R: Meeting highlights. Circulation 1997, 95:763. Reviews the presentation of the ESSENCE trial results showing a significant reduction in death, MI, and recurrent angina in patients with unstable angina or non-Q wave myocardial infarction who were treated with enoxaparin.
    • (1997) Circulation , vol.95 , pp. 763
    • Ferguson, J.J.1    Fox, R.2
  • 31
    • 0029101260 scopus 로고
    • A comparison of hirudin with heparin in the prevention of restenosis after coronary angioplasty
    • Serruys PW, Herrman JR, Simon R, Rutsch W, Bode C, Laarman GJ, Dijk RV, Van Den Bos AA, Umans VAWM, Fox KAA, Close P, Deckers JW, for the HELVETICA Investigators: A comparison of hirudin with heparin in the prevention of restenosis after coronary angioplasty. N Engl J Med 1995, 333:757-763. In HELVETICA, although patients receiving hirudin had a significant reduction in early death, myocardial infarction, or revascularization, there was no benefit seen at 7-month follow-up.
    • (1995) N Engl J Med , vol.333 , pp. 757-763
    • Serruys, P.W.1    Herrman, J.R.2    Simon, R.3    Rutsch, W.4    Bode, C.5    Laarman, G.J.6    Dijk, R.V.7    Van Den Bos, A.A.8    Umans, V.A.W.M.9    Fox, K.A.A.10    Close, P.11    Deckers, J.W.12
  • 33
    • 0028037517 scopus 로고    scopus 로고
    • Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes
    • The Global Use Of Strategies To Open Occluded Coronary Arteries (GUSTO) IIa Investigators: Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes. Circulation 1996, 90:1631-1637. This trial, along with HIT-III (Neuhaus er al.: Circulation 1994, 90:1638-1642) and TIMI-9A (Antman et al.: Circulation 1994, 90:1624-1630) documented the narrow therapeutic window of the antithrombins hirudin and heparin, with aggressive dosing being associated with an increased risk of bleeding.
    • (1996) Circulation , vol.90 , pp. 1631-1637
  • 34
    • 0028117846 scopus 로고
    • The Global Use Of Strategies To Open Occluded Coronary Arteries (GUSTO) IIa Investigators: Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes. Circulation 1996, 90:1631-1637. This trial, along with HIT-III (Neuhaus er al.: Circulation 1994, 90:1638-1642) and TIMI-9A (Antman et al.: Circulation 1994, 90:1624-1630) documented the narrow therapeutic window of the antithrombins hirudin and heparin, with aggressive dosing being associated with an increased risk of bleeding.
    • (1994) Circulation , vol.90 , pp. 1638-1642
    • Neuhaus1
  • 35
    • 0028092111 scopus 로고
    • The Global Use Of Strategies To Open Occluded Coronary Arteries (GUSTO) IIa Investigators: Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes. Circulation 1996, 90:1631-1637. This trial, along with HIT-III (Neuhaus er al.: Circulation 1994, 90:1638-1642) and TIMI-9A (Antman et al.: Circulation 1994, 90:1624-1630) documented the narrow therapeutic window of the antithrombins hirudin and heparin, with aggressive dosing being associated with an increased risk of bleeding.
    • (1994) Circulation , vol.90 , pp. 1624-1630
    • Antman1
  • 36
    • 0028092111 scopus 로고
    • Hirudin in acute myocardial infarction: Safety report from the thrombolysis and thrombin inhibition in myocardial infarction (TIMI) 9A trial
    • Antman EM, for the TIMI 9A Investigators: Hirudin in acute myocardial infarction: safety report from the thrombolysis and thrombin inhibition in myocardial infarction (TIMI) 9A trial. Circulation 1994, 90:1624-1630.
    • (1994) Circulation , vol.90 , pp. 1624-1630
    • Antman, E.M.1
  • 37
    • 0029835392 scopus 로고    scopus 로고
    • A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes
    • The Global Use Of Strategies To Open Occluded Coronary Arteries Investigators: A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes. N Engl J Med 1996, 335:775-782. This large trial documented only a modest benefit of the direct antithrombin hirudin in patients with acute coronary syndromes.
    • (1996) N Engl J Med , vol.335 , pp. 775-782
  • 38
    • 0029788104 scopus 로고    scopus 로고
    • Hirudin in acute myocardial infarction: Thrombolysis and thrombin inhibition in myocardial infarction (TIMI) 9B trial
    • Antman EM, for the TIMI-9B Investigators: Hirudin in acute myocardial infarction: thrombolysis and thrombin inhibition in myocardial infarction (TIMI) 9B trial. Circulation 1996, 94:911-921.
    • (1996) Circulation , vol.94 , pp. 911-921
    • Antman, E.M.1
  • 39
    • 0000873489 scopus 로고    scopus 로고
    • Impact of hirudin versus heparin on mortality and (re)infarction in patients with acute coronary syndromes: A prospective meta-analysis of the GUSTO-IIb and TIMI-9b trials
    • Simes RJ, Granger CB, Antman EM, Califf RM, Braunwald E, Topol EJ: Impact of hirudin versus heparin on mortality and (re)infarction in patients with acute coronary syndromes: a prospective meta-analysis of the GUSTO-IIb and TIMI-9b trials [abstract]. Circulation 1996, 94(suppl):I-430. This prospective meta-analysis of hirudin in patients with acute myocardial infarction documented no benefit of this direct antithrombin when used in combination with thrombolytic therapy.
    • (1996) Circulation , vol.94 , Issue.SUPPL.
    • Simes, R.J.1    Granger, C.B.2    Antman, E.M.3    Califf, R.M.4    Braunwald, E.5    Topol, E.J.6
  • 40
    • 0013613431 scopus 로고    scopus 로고
    • Streptokinase and hirudin reduce death and reinfarction in acute myocardial infarction compared with Streptokinase and heparin: Results from GUSTO IIb
    • Metz BK, Granger CB, White HD, Simes J, Topol EJ, for the Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb Investigators: Streptokinase and hirudin reduce death and reinfarction in acute myocardial infarction compared with Streptokinase and heparin: results from GUSTO IIb [abstract]. Circulation 1996, 94(suppl):I-430.
    • (1996) Circulation , vol.94 , Issue.SUPPL.
    • Metz, B.K.1    Granger, C.B.2    White, H.D.3    Simes, J.4    Topol, E.J.5
  • 41
    • 0029103184 scopus 로고
    • Treatment with bivalirudin (hirulog) as compared with heparin during coronary angioplasty for unstable angina or postinfarction angina
    • Bittl JA, Strony J, Brinker JA, Ahmed WH, Mecke CR, Chaitman BR, Maraganore J, Deutch E, Adelman B, for the Hirulog Angioplasty Study Investigators: Treatment with bivalirudin (hirulog) as compared with heparin during coronary angioplasty for unstable angina or postinfarction angina. N Engl J Med 1995, 333:764-769.
    • (1995) N Engl J Med , vol.333 , pp. 764-769
    • Bittl, J.A.1    Strony, J.2    Brinker, J.A.3    Ahmed, W.H.4    Mecke, C.R.5    Chaitman, B.R.6    Maraganore, J.7    Deutch, E.8    Adelman, B.9
  • 42
    • 0030771823 scopus 로고    scopus 로고
    • A randomized, double-blind comparison of hirulog versus heparin in patients receiving Streptokinase and aspirin for acute myocardial infarction (HERO)
    • in press
    • White H, Aylward P, Frey M, Adgey AAJ, Nair R, Hillis WS, Shalev Y, Brown M, French JK, Collins R, Maraganore J, Adelman B, on behalf of the Hirulog Early Reperfusion/Occlusion (HERO) Trial Investigators: A randomized, double-blind comparison of hirulog versus heparin in patients receiving Streptokinase and aspirin for acute myocardial infarction (HERO). Circulation 1997, in press.
    • (1997) Circulation
    • White, H.1    Aylward, P.2    Frey, M.3    Adgey, A.A.J.4    Nair, R.5    Hillis, W.S.6    Shalev, Y.7    Brown, M.8    French, J.K.9    Collins, R.10    Maraganore, J.11    Adelman, B.12
  • 43
    • 0028082271 scopus 로고
    • Combination antithrombotic therapy in unstable rest angina and non-Q-wave infarction in nonprior aspirin users: Primary end points. Analysis from the ATACS trial
    • Cohen M, Adams PC, Parry G, et al.: Combination antithrombotic therapy in unstable rest angina and non-Q-wave infarction in nonprior aspirin users: primary end points. Analysis from the ATACS trial. Circulation 1994, 89:81-88.
    • (1994) Circulation , vol.89 , pp. 81-88
    • Cohen, M.1    Adams, P.C.2    Parry, G.3
  • 44
    • 8544241421 scopus 로고    scopus 로고
    • A randomized, double-blind study of fixed low-dose warfarin plus aspirin in post myocardial infarction patients: The Coumadin Aspirin Reinfarction Study (CARS)
    • in press
    • The CARS Investigators: A randomized, double-blind study of fixed low-dose warfarin plus aspirin in post myocardial infarction patients: the Coumadin Aspirin Reinfarction Study (CARS). Lancet 1997, in press. Fixed low-dose warfarin, in combination with aspirin, afforded no clinical benefit in patients after myocardial infarction.
    • (1997) Lancet
  • 45
    • 0031030620 scopus 로고    scopus 로고
    • The effects of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation on obstructive changes in saphenous-vein coronary-artery bypass grafts
    • The Post Coronary Artery Bypass Graft Trial Investigators: The effects of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation on obstructive changes in saphenous-vein coronary-artery bypass grafts. N Engl J Med 1997, 336:153-162.
    • (1997) N Engl J Med , vol.336 , pp. 153-162
  • 46
    • 10544245025 scopus 로고    scopus 로고
    • Distinct effects of recombinant desulfatohirudin (Revasc) and heparin on plasma levels of fibrinopeptide a and prothrombin fragment F1.2 in unstable angina: A multicenter trial
    • Rao AK, Sun L, Chesebro JH, Fuster V, Harrington RA, Schwartz D, GaIIo P, Matos D, Topol EJ: Distinct effects of recombinant desulfatohirudin (Revasc) and heparin on plasma levels of fibrinopeptide A and prothrombin fragment F1.2 in unstable angina: a multicenter trial. Circulation 1996, 94:2389-2395.
    • (1996) Circulation , vol.94 , pp. 2389-2395
    • Rao, A.K.1    Sun, L.2    Chesebro, J.H.3    Fuster, V.4    Harrington, R.A.5    Schwartz, D.6    Gaiio, P.7    Matos, D.8    Topol, E.J.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.