Clonal haemopoiesis in normal elderly women: Implications for the myeloproliferative disorders and myelodysplastic syndromes

British Journal of Haematology

Volumn 97, Issue 4, 1997, Pages 920-926

  Champion, Kim M ^a   Gilbert, James G R ^a   Asimakopoulos, Fotios A ^a   Hinshelwood, Stephen ^a   Green, Anthony R ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Clonality analysis; Elderly; HUMARA; Myelodysplastic syndromes; Myeloproliferative disorders

Indexed keywords

ADULT; AGED; AGING; ANALYTIC METHOD; ARTICLE; CELL TYPE; CLONAL ANERGY; CYTOGENETICS; DNA METHYLATION; FEMALE; GENE MUTATION; GENETIC TRANSCRIPTION; GRANULOCYTE; HEMATOPOIESIS; HUMAN; MAJOR CLINICAL STUDY; MYELODYSPLASTIC SYNDROME; MYELOPROLIFERATIVE DISORDER; POLYCLONAL ACTIVATION; PRIORITY JOURNAL; STEM CELL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; X CHROMOSOME LINKAGE;

EID: 0030800389     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1997.1933010.x     Document Type: Article

References (50)

1. Abkowitz, J., Catlin, S.N. & Guttorp, P. (1996a) Evidence that hematopoiesis may be a stochastic process in vivo. Nature Medicine, 2, 190-197.
2. Abkowitz, J.L., Persik, M., Shelton, G.H., Catlin, A.N., Guttorp, P. & Kiklvich, J.V. (1996b) Evidence that an X chromosome gene controls hematopoietic stem cell behaviour. Blood, 88, (Suppl 1) 445a.
3. Abkowitz, J.L., Persik, M., Shelton, G.H., Ott, R.L., Kiklvich, J.V., Catlin, A.N. & Guttorp, P. (1995) Behaviour of hematopoietic stem cells in a large animal. Proceedings of the National Academy of Sciences of the United States of America, 92, 2031-2035.
4. Abrahamson, G., Boultwood, J., Madden, J., Kelly, S., Oscier, D.G., Rack, K., Buckle, V. & Wainscoat, J. (1991) Clonality of cell populations in refractory anaemia using combined approach of gene loss and X-linked restriction length polymorphism-methylation analyses. British Journal of Haematology, 79, 550-555.
5. Adamson, J.W., Fialkow, P.J., Murphy, S., Prchal, J.F. & Steinman, L. (1976) Polycythemia vera; stem cell and probable clonal origin of the disease. New England Journal of Medicine, 295, 913-916.
6. Allen, R.C., Zoghbi, H.Y., Moseley, A.B., Rosenblatt, H.M. & Belmont, J.W. (1992) Methylation of HpaII and HHAIsites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation. American Journal of Human Genetics, 51, 1229-1239.
7. Anger, B., Janssen, J.W.G., Schrezenmeier, H., Hehlmann, R., Heimpel, H. & Bartram, C.R. (1990) Clonal analysis of chronic myeloproliferative disorders using X-linked DNA polymorphisms. Leukemia, 4, 258-261.
8. Asimakopoulos, F.A., Gilbert, J.G.R., Aldred, M.A., Pearson, T.C. & Green, A.R. (1996) Interstitial deletion constitutes the major mechanism for loss of heterozygosity on chromosome 20q in polycythemia vera. Blood, 88, 2690-2698.
9. Bartram, C.R., Ludwig, W.D., Hidderman, W., Lyons, J., Buschle, M., Ritter, J., Harbott, J., Frolich, A. & Janssen, J.W.G. (1989) Acute myeloid leukemia: analysis of ras gene mutation and clonality referred by polymorphic X-linked loci. Leukemia, 3, 247-256.
10. Busque, L., Mio, R., Mattioli, J., Brais, E., Blais, N., Lalonde, Y., Maragh, M. & Gilliland, D.G. (1996) Nonrandom X-inactivation patterns in normal females: Lyonization ratios vary with age. Blood, 88, 59-65.
11. Busque, L., Zhu, J., DeHart, D., Griffith, B., Willman, C., Carroll, R., McL.Black, P. & Gilliland, D.G. (1994) An expression based clonality assay at the human androgen receptor locus (HUMARA) on chromosome X. Nucleic Acids Research, 22, 697-698.
12. Conley, M.E., Brown, P., Pichard, A.R., Buckley, R.H., Miller, D.S., Raskin, W.H., Singer, J.W. & Fialkow, P.J. (1986) Expression of the gene defect in X-linked agammaglobulinemia. New England Journal of Medicine, 315, 564-567.
13. Culligan, D.J., Cachia, P., Whittaker, J., Jacobs, A. & Padua, R.A. (1992) Clonal lymphocytes are detectable in only some cases of MDS. British Journal of Haematology, 81, 346-352.
14. Dow, L.W. Martin, P., Moohr, J., Greenberg, M., Macdougall, L.G., Najfield, V. & Fialkow, P.J. (1985) Evidence for clonal development of childhood acute lymphoblastic leukemia. Blood, 66, 902-907.
15. El Kassar, N., Hetet, G., Li, Y., Briére, J. & Grandchamp, B. (1995) Clonal analysis of haemopoietic cells in essential thrombocythaemia. British Journal of Haematology, 90, 131-137.
16. Fearon, E.R., Burke, P.J., Schiffer, C.A., Zehnbauer, B.A. & Vogelstein, B. (1986) Differentiation of leukemia cells to polymorphonuclear leukocytes in patients with acute nonlymphocytic leukemia. New England Journal of Medicine, 315, 15-24.
17. Fearon, E.R., Koher, D.B., Winkelstein, J.A., Vogelstein, B. & Blasse, R.M. (1988) Carrier detection in the Wiskott-Aldrich syndrome. Blood, 72, 1735-1739.
18. Fey, M.F., Liechti-Gallati, S., von Rohr, A., Borisch, B., Theikäs, L., Schneider, V., Oestreicher, M., Nagel, S., Ziemiecki, A. & Tobler, A. (1994) Clonality and X-inactivation patterns in hematopoietic cell populations detected by the highly informative M27β DNA probe. Blood, 83, 931-938.
19. Fey, M.F., Peter, H.-J., Hinds, H.L., Zimmermann, A., Liechti-Gallati, S., Gerber, H., Suder, H. & Tobler, A. (1992) Clonal analysis of human tumors with M27β, a highly informative polymorphic X chromosomal probe. Journal of Clinical Investigation, 89, 1438-1444.
20. Fialkow, J.P., Faguet, G.B., Jacobson, R.J., Vaidya, K. & Murphy, S. (1981) Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell. Blood, 58, 916-919.
21. Fialkow, P., Gartler, S.M. & Yoshida, A. (1967) Clonal origin of chronic myelocytic leukemia in man. Proceedings of the National Academy of Sciences of the United States of America, 58, 1468-1471.
22. Fialkow, P.J. (1973) Primordial cell pool size and lineage relationships of five human cell types. Annuls of Human Genetics, 37, 39-48.
23. Fialkow, P.J., Singer, J.W., Raskind, W.H., Adamson, J.W., Jacobson, R.J., Bernstein, I.D., Dow, L.W., Najfield, V. & Veith, R. (1987) Clonal development, stem-cell differentiation, and clinical remissions in acute non-lymphocytic leukemia. New England Journal of Medicine, 317, 468-473.
24. Fraser, N.J., Boyd, Y., Brownlee, G.G. & Graig, I.W. (1987) Multiallelic RFLP for M27β, an anonymous single copy genomic clone at XpI 1.3-XCen [HGM9 provisional no. DXS255]. Nucleic Acids Research, 15, 9616.
25. Gale, R.E. & Linch, D.C. (1994) Interpretation of X-chromosome inactivation patterns. Blood, 84, 2376-2378.
26. Gale, R.E. & Wainscoat, J.S. (1993) Clonal analysis using X-linked DNA polymorphisms. British Journal of Haematology, 85, 2-8.
27. Gale, R.E., Wheadon, H., Boulos, P. & Linch, D.C. (1994) Tissue specificity of X-chromosome inactivation patterns. Blood, 83, 2899-2905.
28. Gale, R.E., Wheadon, H., Goldstone, A.H., Burnett, A.K. & Linch, D.C. (1993) Frequency of clonal remission in acute mycloid leukaemia. Lancet, 341, 138-142.
29. Gale, R.E., Wheadon, H. & Linch, D.C. (1991) X chromosome inactivation patterns using HPRT and PGK polymorphisms in haematologically normal and post-chemotherapy females. British Journal of Haematology, 79, 193-197.
30. Gale, R.E., Wheadon, H. & Linch, D.C. (1992) Assessment of X-chromosome inactivation patterns using the hypervariable probe M27β in normal hematopoietic cells and acute myeloid leukemia blasts. Leukemia, 6, 649-655.
31. Gilliland, D.G., Blanchard, K.L., Levy, J., Perrin, S. & Bunn, H.F. (1991) Clonality in myeloproliferative disorders: analysis by means of the polymerase chain reaction. Proceedings of the National Academy of Sciences of the United States of America, 88, 6848-6852.
32. Hirota, Y., Okamura, S., Kimura, N., Shibuya, T. & Niho, Y. (1988) Haematopoiosis in the aged as studied by in vitro colony assay. European Journal of Haematology, 40, 83-90.
33. Hitzeroth, H.W. & Bender, K. (1981) Age-dependency of somatic selection in South African Negro G-6-PD heterozygotes. Human Genetics, 58, 338-343.
34. Janssen, J.W.G., Buschle, M., Layton, B.M., Drexler, H.G., Lyons, J., van den Berghe, H., Heimpel, H., Kubanek, B., Kleihauer, E., Mufti, G.J. & Bartram, C.R. (1989) Clonal analysis of myelodysplastic syndromes: evidence of multipotent stem cell origin. Blood, 73, 248-254.
35. Kreipe, H., Jaquet, K., Felgner, J., Radzun, H.-J. & Parwaresch, M.R. (1991) Clonal granulocytes and bone marrow cells in the cellular phase of agnogenic myeloid metaplasia. Blood, 78, 1814-1817.
36. Linder, D. & Gartler, S.M. (1965) Glucose-6-phosphate dehydrogenase mocaicism: utilization as a cell marker in the study of leiomyomas. Science, 150, 67-69.
37. Lucas, G.S., Padua, R.A., Masters, G.S., Oscier, D.G. & Jacobs, A. (1989) The application of X-chromosome gene probes to the diagnosis of myeloproliferative disease. British Journal of Haematology, 72, 530-533.
38. Luzzatto, L., Usanga, E.A., Bienzle, U., Esan, G.F.J. & Fasuan, F.A. (1979) Imbalance in X-chromosome expression: evidence for a human X-linked gene affecting growth of hemopoietic cells. Science, 205, 1418-1420.
39. Morrison, S.J., Wandycz, A.M., Akashi, K., Globerson, A. & Weissman, I.L. (1996) The aging of hematopoietic stem cells. Nature Medicine, 2, 1011-1016.
40. Nilsson-Ehle, H., Swolin, B. & Westin, J. (1995) Bone marrow progenitor cell growth and karyotype changes in healthy 88-year-old subjects. European Journal of Haematology, 55, 14-18.
41. Prchal, J.T. & Guan, Y.L. (1993) A novel clonality assay based on transcriptional analysis of the active X chromosome. Stem Cells, 11, 62-65.
42. Tan, S.S., Williams, E.A. & Tarm, P.P.L. (1993) X-chromosome inactivation occurs at different times in different tissues of the post-implantation mouse embryo. Nature Genetics, 3, 170-174.
43. Tefferi, A., Thibodeau, S.N. & Solberg, L.A. (1990) Clonal studies in the myelodysplastic syndrome using X-linked restriction fragment length polymorphisms. Blood, 75, 1770-1773.
44. Tsukamoto, N., Morita, K., Maehara, T., Okamoto, K., Sakai, H., Karasawa, M., Naruse, T. & Omine, M. (1944) Clonality in chronic myeloproliferative disorders defined by X-chromosome linked probes: demonstration of heterogeneity in lineage involvement. British Journal of Haematology, 86, 253-258.
45. Turhan, A.G., Humphries, R.K., Phillips, G.L., Eaves, A.C. & Eaves, D.J. (1989) Clonal hematopoiesis demonstrated by X-linked DNA polymorphisms after allogeneic bone marrow transplantation. New England Journal of Medicine, 320, 1655-1661.
46. van Kamp, H., Fibbe, W.E., Janssen, R.P.M., van der Keur, M., Graaff, E., Willemze, R. & Landegent, J.E. (1992) Clonal involvement of granulocytes and monocytes, but not T and B lymphocytes and natural killer cells in patients with myelodysplasia: analysis by X-linked restriction length polymorphisms and polymerase chain reaction of the phosphoglycerate kinase gene. Blood, 80, 1774-1780.
47. Vogelstein, B., Fearon, E.R., Hamilton, S.R. & Fienberg, A.P. (1985) Use of restriction fragment length polymorphisms to determine the clonal origin of human tumors. Science, 227, 642-645.
48. Vogelstein, B., Fearon, E.R., Hamilton, S.R., Preisinger, A.C., Willard, H.F., Michelson, A.M., Riggs, A.D. & Orkin, S.H. (1987) Clonal analysis using recombinant DNA probes from the X-chromosome. Cancer Research, 47, 4806-4813.
49. Wiggans, R.G., Jacobson, R.J., Fialkow, P.J., Wooley, P.V., Macdonald, J.S. & Schein, P.S. (1978) Probable clonal origin of acute myeloblastic leukemia following radiation and chemotherapy of colon cancer. Blood, 52, 659-663.
50. Yu, R.C., Chu, C., Buluwela, L. & Chu, A.C. (1994) Clonal proliferation of Langerhans cells in Langerhans cell histiocytosis. Lancet, 343, 767-768.