Rabbit RAG-2 UTRs: Characterization of an unusually large 3' untranslated region

Immunogenetics

Volumn 46, Issue 4, 1997, Pages 267-275

  Hu, Lei ^a   Epstein, Lloyd M ^a   Roux, Kenneth H ^a  

^a FLORIDA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; EXON; GENE MAPPING; GENE SEQUENCE; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; MOLECULAR GENETICS; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECOMBINATION ACTIVATING GENE 2; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOTTING, NORTHERN; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; HUMANS; INTRONS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; RABBITS; RNA, MESSENGER; SPECIES SPECIFICITY;

ANIMALIA; ORYCTOLAGUS CUNICULUS; VERTEBRATA;

EID: 0030800320     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002510050272     Document Type: Article

References (47)

1. Aguilera, A. and Klein, H.L. HRP1, a novel yeast gene that prevents intrachoromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene. Mol Cell Biol 10: 1439-1451, 1990
2. a allotype gene that is deleted in Alicia mutants; somatic hypermutation/conversion may play a major role in generating the heterogeneity of rabbit heavy chain variable region sequences. Eur J Immunol 21: 411-417, 1991
3. Barnes, W.M. PCR amplification of up to 35-kb DNA with high fidelity and high yield from λ bacteriophage templates. Proc Natl Acad Sci USA 91: 2216-2220, 1994
4. Becker, R.S. and Knight, K.L. Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversions in rabbits. Cell 63: 987-997, 1990
5. Beelman, C.A. and Parker, R. Degradation of mRNA in eukaryotes. Cell 81: 179-183, 1995
6. Campbell, J.J. and Hashimoto, Y. Recombinase activating gene expression in thymic subpopulations. J Immunol 150: 1307-1313, 1993
7. Carlson, L.M., Oettinger, M.A., Schatz, D.G., Masteller, E.L., Hurley, E.A., McCormack, W.T., Baltimore, D., and Thompson, C.B. Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion. Cell 64: 201-208, 1991
8. Casillas, A.M., Thompson, A.D., Cheshier, S., Hernandez, S., and Aguilera, R.J. RAG-1 and RAG-2 gene expression and V(D)J recombinase activity are enhanced by protein phosphatase 1 and 2A inhibition in lymphocyte cell lines. Mol Immunol 32: 167-175, 1995
9. Coats, S.R., Zhang, Y., and Epstein, L.M. Transcription of satellite 2 DNA from the newt is driven by a snRNA type of promoter. Nucleic Acids Res 22: 4697-4704, 1994
10. Curtis, D., Lehmann, R., and Zamore, P.D. Translational regulation in development. Cell 81: 171-178, 1995
11. D'Aquila, R.T., Bechtel, L.J., Videler, J.A., Eron, J.J., Gorczyca, P., and Kalpan, J.C. Maximizing sensitivity and specificity of PCR by preamplification heating. Nucleic Acids Res 19: 3749-3749, 1991
12. Don, R.H., Cox, P.T., Wainwright, B.J., Baker, K., and Mattick, J.S. "Touchdown" PCR to circumvent spurious priming during gene amplification. Nucleic Acids Res 19: 4008-4008, 1991
13. Forney, J.D., Epstein, L.M., Preer, L.B., Rudman, B.M., Widmayer, J., Klein, W.H., and Preer, J.R. Jr. Structure and expression of genes for surface proteins in Paramecium. Mol Cell. Biol: 466-474, 1983.
14. Fuschiotti, P., Harindranath, N., Mage, R.G., McCormack, W.T., Dhanarajan, P., and Roux, K.H. Recombination activating genes-1 and -2 of the rabbit: cloning and characterization of germline and expressed genes. Mol Immunol 30: 1021-1032, 1993
15. Gil, A. and Proudfoot, N.J. Position-dependent sequence elements downstream of AAUAAA are required for efficient rabbit β-globin mRNA 3′ end formation. Cell 49: 399-406, 1987
16. Graur, D., Duret, L., and Gouy, M. Phylogenetic position of the order Lagomorpha (rabbits, hares and allies). Nature 379: 333-335, 1996
17. Grawunder, U., Leu, T.M.J., Schatz, D.G., Werner, A., Rolink, A.G., Melchers, F., and Winkler, T. H. Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement. Immunity 3: 601-608, 1995
18. Greenhalgh, P. and Steiner, L.A. Recombination activating gene 1 (RAG1) in zebrafish and shark. Immunogenetics 41: 54-55, 1995
19. Greenhalgh, P., Olesen, C. E. M., and Steiner, L. A. Characterization and expression of recombination activating genes (RAG-1 and RAG-2) in Xenopus laevis. J Immunol 151: 3100-3110, 1993
20. Hansen, J.D. and Kaattari, S.L. The recombination activating gene 2 (RAG2) of the rainbow trout Oncorhvnchus mykiss. Immunogenetics 44: 203-211, 1996
21. Hecker, K.H. and Roux, K.H. High and low annealing temperatures increase both specificity and yield in touchdown and stepdown PCR. BioTechniques 20: 478-486, 1996
22. Hostomsky, Z., Hostomska, Z., and Mathews, D. A. In S.M. Linn, R.S. Lloy, and R.J. Roberts (eds.): Nucleases, pp. 341 -346, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 1993
23. Ichihara, Y., Hirai, M., and Kurosawa, Y. Sequence and chromosome assignment to 11p13-p12 of human RAG genes. Immunol Lett 33: 277-284, 1992
24. Jackson, R.J. and Standart, N. Do the Poly(A) tail and 3′ untranslated region control mRNA translation? Cell 62: 15-24, 1990
25. Jackson, R.J. Cytoplasmic regulation of mRNA function: The importance of the 3′ untranslated region. Cell 74: 9-14, 1993
26. Kuhn-Hallek, I., Sage, D.R., Stein, L., Groelle, H., and Fingeroth, J.D. Expression of recombination activating genes (RAG-1 and RAG-2) in Epstein-Barr-Virus- bearing B cells. Blood 85: 1289-1299, 1995
27. Leu, T.M.J. and Schatz, D. G. Rag-1 and Rag-2 are components of a high-molecular-weight complex, and association of rag-2 with this complex is rag-1 dependent. Mol Cell Biol 15: 5657-5670, 1995
28. Ma, A., Fisher, P., Dildrop, R., Oltz, E., Rathbun, G., Achacosco, P., Stall, A., and Alt, F.W. Surface IgM mediated regulation of RAG gene expression in Eμ-N-myc B cell lines. EMBO J 11: 2727-2734, 1992
29. McBlane, J.F., van Gent, D.C., Ramsden, D.A., Romeo, C., Cuomo, C. A., Gellert, M., and Oettinger, M.A. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83: 387-395, 1995
30. Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S., and Papaioannou, V. E. RAG-1 deficient mice have no mature B and T lymphocytes. Cell 54: 453-460, 1992
31. Muegge, K., Vila, M. P., and Durum, S. K. Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor β gene. Science 261: 93-95, 1993
32. Oettinger, M.A., Schatz, D.G., Gorka, C., and Baltimore, D. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248: 1517-1523, 1990
33. Roux, K.H. Optimization and troubleshooting in PCR. PCR Methods Appl 4: S185-194, 1995
34. 2 rabbit evidence for gene conversion at both the germline and somatic levels. J Immunol 146: 2027-2036, 1991
35. Sambrook, J., Fritsch, E.F., and Maniatis, T. Molecular Cloning: A Laboratory Manual (2nd edn), Cold Spring Harbor Laboratory, Cold Spring Harbor, 1989
36. Schatz, D.G., Oettinger, M.A., and Baltimore, D. The V(D)J recombination activating gene RAG-1. Cell 59: 1035-1048, 1989
37. Shinkai, Y., Rathbun, G., Lam, K.-P., Oltz, E.M., Stewart, V., Mendelsohn, M., Charron, J., Datta, M., Young, F., Stall, A.M., and Alt, F.W. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68: 855-867, 1992
38. Spanopoulou, E., Cortes, P., Shih, C., Huang, C.-H., Silver, D.P., Svec, P., and Baltimore, D. Localization, interaction, and RNA binding properties of the V(D)J recombination-activating proteins RAG1 and RAG2. Immunity 3: 715-726, 1995
39. Takahama, Y. and Singer, A. Post-transcriptional regulation of early T cell development by T cell receptor signals. Science 258: 1456-1462, 1992
40. Takeda, S., Masteller, E.L., Thompson, C.B., and Buerstedde, J-M. RAG-2 expression is not essential for chicken immunoglobulin gene conversion. Immunology 89: 4023-4027, 1992
41. Thompson, C.B. New insights into V(D)J recombination and its role in the evolution of the immune system. Immunity 3: 531-539, 1995
42. Turka, L.A., Schatz, D.G., Oettinger, M.A., Chun, J.J.M., Gorka, C., Lee, K., McCormack, W.T., and Thompson, C.B. Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking. Science 253: 778-781, 1991
43. Van Gent, D.C., McBlane, J.F., Ramseden, D.A., Sadofsky, M.J., Hesse, J.E., and Gellert, M. Initiation of V(D)J recombination in a cell free system. Cell 81: 925-934, 1995
44. Wahle, E. and Keller, W. The biochemistry of 3′-end cleavage and polyadenylation of messenger RNA precursors. Annu Rev Biochem 61: 419-440, 1992
45. Wang, J.C., Caron, P.R., and Kim, R.A. The role of DNA topoisomerase in recombination and genome stability: a double edged sword? Cell 62: 403-406, 1990
46. Wilson, A.C., Ochman, H., and Prager, E.M. Molecular time scale for evolution. Trends Genet 3: 241-247, 1987
47. Wysocki, L.J. and Gefter, M.L. Gene conversion and the generation of antibody diversity. Annu Rev Biochem 58: 509-531, 1989