Modified cytokeratins expressed on the surface of carcinoma cells undergo endocytosis upon binding of human monoclonal antibody and its recombinant Fab fragment

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 15, 1997, Pages 8110-8115

  Ditzel, Henrik J ^a,b,e   Garrigues, Ursula ^c   Andersen, Claus B ^a   Larsen, Morten K ^b   Garrigues, H Jacques ^c   Svejgaard, Arne ^a   Hellström, Ingegerd ^c   Hellström, Karl Erik ^c   Jensenius, Jens C ^d  

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c BRISTOL MYERS SQUIBB   (United States)

^d AARHUS UNIVERSITY   (Denmark)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Cancer; COU 1 antibody; Cytokeratin; Internalization; Phage display

Indexed keywords

ANTIBODY CONJUGATE; CYTOKERATIN; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY;

ANTIBODY DETECTION; ARTICLE; BINDING AFFINITY; CELL SURFACE; ENDOCYTOSIS; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; BACTERIOPHAGES; BINDING SITES, ANTIBODY; CELL LINE; COLON; COLONIC NEOPLASMS; ENDOCYTOSIS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; INTESTINAL MUCOSA; KERATINS; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS;

MURINAE;

EID: 0030800239     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.15.8110     Document Type: Article

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