Improved antitumor activity of a recombinant anti-Lewisy immunotoxin not requiring proteolytic activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 3, 1996, Pages 974-978

  Kuan, Chien Tsun ^a   Pastan, Ira ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cancer therapy; Disulfide stabilized Fv fragment; Monoclonal antibody B1 Fv fragment; Protein engineering; Pseudomonas exotoxin

Indexed keywords

IMMUNOTOXIN; IMMUNOTOXIN B1 PE33; IMMUNOTOXIN B1 PE38; MONOCLONAL ANTIBODY; PSEUDOMONAS EXOTOXIN; RECOMBINANT IMMUNOTOXIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; TUMOR REGRESSION;

ADENOCARCINOMA; ADP RIBOSE TRANSFERASES; ANIMALS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; BACTERIAL TOXINS; BASE SEQUENCE; BREAST NEOPLASMS; CELL SURVIVAL; DNA PRIMERS; EXOTOXINS; FEMALE; HUMANS; IMMUNOTOXINS; L CELLS (CELL LINE); LEUKEMIA, T-CELL; LEWIS BLOOD-GROUP SYSTEM; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POLYMERASE CHAIN REACTION; PROSTATIC NEOPLASMS; PSEUDOMONAS AERUGINOSA; RECOMBINANT PROTEINS; STOMACH NEOPLASMS; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED; VIRULENCE FACTORS;

EID: 0030021956     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.3.974     Document Type: Article

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