Peripheral blood from human immunodeficiency virus type 1-infected patients displays diminished T cell generation capacity

Journal of Infectious Diseases

Volumn 176, Issue 3, 1997, Pages 649-654

  Clark, Dawn R ^b   Ampel, Neil M ^c   Hallett, Carrie A ^c   Yedavalli, Venkat R K ^c   Ahmad, Nafees ^c   DeLuca, Dominick ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b CENTRAL LABORATORY   (Netherlands)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; DIDANOSINE; LAMIVUDINE; ZALCITABINE; ZIDOVUDINE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FETUS; HEMATOPOIESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; PERIPHERAL CIRCULATION; PRIORITY JOURNAL; STEM CELL; T LYMPHOCYTE ACTIVATION;

EID: 0030800088     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/514086     Document Type: Article

References (20)

1. Joshi VV, Oleske JM. Pathologic appraisal of the thymus gland in acquired immunodeficiency syndrome in children. A study of four cases and a review of the literature. Arch Pathol Lab Med 1985;109:142-6.
2. Grody WW, Fligiel S, Naeim F. Thymus involution in the acquired immunodeficiency syndrome. Am J Clin Pathol 1985;84:85-95.
3. Rosenzweig M, Clark DP, Gaulton GN. Selective thymocyte depletion in neonatal HIV-1 thymic infection. AIDS 1993;7:1601-5.
4. +) hematopoietic progenitor cells by human immunodeficiency virus. Blood 1992;79:2680-7.
5. Steinberg HN, Crumpacker CS, Chatis PA. In vitro suppression of normal human bone marrow progenitor cells by human immunodeficiency virus. J Virol 1991;65:1765-9.
6. + bone marrow cells are infected with HIV in a subset of seropositive individuals. J Immunol 1992;149:689-97.
7. Aldrovandi GM, Feuer G, Gao L, et al. The SCID-hu mouse as a model for HIV-1 infection. Nature 1993;363:732-6.
8. Bonyhadi ML, Su L, Auten J, McCune JM, Kaneshima H. Development of a human thymic organ culture model for the study of HIV pathogenesis. AIDS Res Hum Retroviruses 1995;11:1073-80.
9. + single-positive T cells in murine fetal thymus organ culture. Proc Natl Acad Sci USA 1993;90:10778-82.
10. Greiner DL, Shultz LD, DeLuca D, Leif JH, Christianson SW, Hesselton RAM. HIV-1 infectivity of human T cells maturing in a murine fetal thymic organ culture system. In vivo 1996;10:33-8.
11. DeLuca D, Bluestone JA, Shultz LD, Sharrow SO, Tatsumi Y. Programmed differentiation of murine thymocytes during fetal thymus organ culture. J Immunol Methods 1995;178:13-29.
12. Ahmad N, Venkatesan S. Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTR. Science 1988;241:1481-5.
13. Ahmad N, Maitra RK, Venkatesan S. Rev-induced modulation of Nef protein underlies temporal regulation of human immunodeficiency virus replication. Proc Natl Acad Sci USA 1989;86:6111-5.
14. Koot M, van't Wout AB, Kootstra NA, de Goede REY, Tersmette M, Schuitemaker H. Relation between changes in cellular load, evolution of viral phenotype, and the clonal composition of virus populations in the course of human immunodeficiency virus type I infection. J Infect Dis 1996;173:349-54.
15. Finkel TH, Banda NK. Indirect mechanisms of HIV pathogenesis: how does HIV kill T cells? Curr Opin Immunol 1994;6:605-15.
16. Salzar-Gonzalez JF, Moody DJ, Giorgi JV, Maza OM, Mitsuyasu RT, Fahey J. Reduced ecto-5′-nucleotidase activity and enhanced OKT10 and HLA-DR expression of CD8 (T suppressor/cytotoxic) lymphocytes in the acquired immune deficiency syndrome: evidence of CD8 cell immaturity. J Immunol 1985;135:1778-85.
17. + cytotoxic T cells express CD38 and HLA-DR antigens. J Immunol 1993;150:3070-9.
18. + hematopoietic progenitor cells by human immunodeficiency virus 1 or gp120 mediated by endogenous transforming growth factor β1. J Exp Med 1996;183:99-108.
19. + human hematopoietic progenitor cells through different cell kinetic mechanisms depending on the applied stimulus. Exp Hematol 1994;22:903-9.
20. Selvakumaran M, Lin HK, Miyashita T, et. al. Immediate early up-regulation of Bax expression by p53 but not TGF-β 1: a paradigm for distinct apoptotic pathways. Oncogene 1994;9:1791-8.