Report on the workshop entitled: 'Modeling chemically induced leukemia -Implications for benzene risk assessment'

Leukemia Research

Volumn 21, Issue 5, 1997, Pages 361-374

  Smith, Martyn T ^a   Fanning, Elinor W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENE;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; BLOOD TOXICITY; CANCER GENETICS; CANCER MODEL; CHEMICAL CARCINOGENESIS; CONFERENCE PAPER; HUMAN; LEUKEMOGENESIS; MYELODYSPLASTIC SYNDROME; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT;

ANIMALS; BENZENE; BIOTRANSFORMATION; CARCINOGENS; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKEMIA; LEUKEMIA, EXPERIMENTAL; MODELS, THEORETICAL; RISK ASSESSMENT;

EID: 0030799564     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(96)00122-1     Document Type: Conference Paper

References (47)

1. Snyder R., Witz G. and Goldstein B. D., The toxicology of benzene. Environ. Hlth Perspect, 1993, 100, 293.
2. Zhang L., Venkatesh P., Creek M. L. R. and Smith M. T., Detection of 1,2,4-benzenetriol induced aneuploidy and microtubule disruption by fluorescence in situ hybridization and immunocytochemistry. Mutat. Res., 1994, 320, 315.
3. Zhang L., Rothman N., Wang Y., Hayes R., Bechtold W., Venkatesh P., Yin S., Wang Y., Dosemeci M., Li G., Lu W. and Smith M. T., Interphase cytogenetics of workers exposed to benzene. Environ. Hlth Perspect. 1996, 104, Suppl. 6, in press.
4. Rothman N., Haas R., Hayes R. B., Li G. L., Wiemels J., Campleman S., Quintana P. J., Xi L. J., Dosemeci M., Titenko-Holland N., Meyer K. B., Lu W., Zhang L., Bechtold W., Wang Y. Z., Kolachana P., Yin S. N., Blot W. and Smith M. T., Benzene induces gene-duplicating but not gene-inactivating mutations at the glycophorin A locus in exposed humans. Proc. natn. Acad. Sci. U.S.A., 1995, 92, 4069.
5. Kolachana P., Subrahmanyam V. V., Meyer K. B., Zhang L. and Smith M. T., Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo. Cancer Res., 1993, 53, 1023.
6. Irons R. D., Stillman W. S., Colagiovanni D. B. and Henry V. A., Synergistic action of the benzene metabolite hydroquinone on myelopoietic stimulating activity of granulocyte/macrophage colony-stimulating factor in vitro. Proc. natn. Acad. Sci. U.S.A., 1992, 89, 3691.
7. Irons R. D. and Stillman W. S., Cell proliferation and differentiation in chemical leukemogenesis. Stem Cells (Dayt), 1993, 11, 235.
8. Green J. D., Snyder C. A., LoBue J., Goldstein B. D. and Albert R. E., Acute and chronic dose/response effects of inhaled benzene on multipotential hematopoietic stem (CFU-S) and granulocyte/macrophage progenitor (GM-CFU-C) cells in CD-1 mice. Toxic. appl. Pharmac., 1981, 58, 492.
9. Sabourin P. J., Betchold W. E., Griffith W. C., Birnbaum L. S., Lucier G. and Henderson R. F., Effect of exposure concentration, exposure rate, and route of administration on metabolism of benzene by F344 rats and B6C3F1 mice. Toxic. appl. Pharmac., 1989, 99, 421.
10. Medinsky M., Pharmacokinetic model of benzene metabolism and distribution. Environ. Hlth Perspect. 1996, 104, Suppl. 6, in press.
11. Yin S. N., Li G. L., Tain F. D., Fu Z. I., Jin C., Chen Y. J., Luo S. J., Ye P. Z., Zhang J. Z. and Wang G. C. et al., Leukaemia in benzene workers: a retrospective cohort study. Br. J. Ind. Med., 1987, 44, 124.
12. Segal G. M., Magenis R. E., Brown M., Keeble W., Smith T. D., Heinrich M. C. and Bagby G. C. Jr., Repression of Fanconi anemia gene (FACC) expression inhibits growth of hematopoietic progenitor cells. J. clin. Invest., 1994, 94, 846.
13. Whitney M. A., Royle G., Low M. J., Kelly M. A., Axthelm M. K., Reifsteck C., Olson S., Braun R. E., Heinrich M. C., Rathbun R. K., Bagby G. C. and Grompe M., Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene. Blood, 1996, 88, 49.
14. Raza A., Mundle S., Shetty V., Alvi S., Chopra H., Span L., Parcharidou A., Dar S., Venugopal P., Borok R., Gezer S., Showel J., Loew J., Robin E., Rifkin S., Alston D., Hernandez B., Shah R., Kaizer H. and Gregory S., Novel insights into the biology of myelodysplastic syndromes: excessive apoptosis and the role of cytokines. Int. J. Hematol., 1996, 63, 265.
15. Raza A., Gezer S., Mundle S., Gao X. Z., Alvi S., Borok R., Rifkin S., Iftikhar A., Shetty V. and Parcharidou A. et al., Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes. Blood, 1995, 86, 268.
16. Mehrotra B., George T. I., Kavanau K., Avet-Loiseau H., Moore Dn., Willman C. L., Slovak M. L., Atwater S., Head D. R. and Pallavicini M. G., Cytogenetically aberrant cells in the stem cell compartment (CD34+lin-) in acute myeloid leukemia. Blood, 1995, 86, 1139.
17. Le Beau M. M., Albain K. S., Larson R. A., Vardiman J. W., Davis E. M., Blough R. R., Golomb H. M. and Rowley J. D., Clinical and cytogenetic correlations in 63 patients with therapy-related myelodysplastic syndromes and acute nonlymphocytic leukemia: further evidence for characteristic abnormalities of chromosomes no. 5 and 7. J. clin. Oncol., 1986, 4, 325.
18. Pedersen-Bjergaard J. and Rowley J. D., The balanced and the unbalanced chromosome aberrations of acute myeloid leukemia may develop in different ways and may contribute differently to malignant transformation. Blood, 1994, 83, 2780.
19. Le Beau M. M., Espinosa R., Davis E. M., Eisenbart J. D., Larson R. A. and Green E. D., Cytogenetic and molecular delineation of a region of chromosome 7 commonly deleted in malignant myeloid diseases. Blood, 1996, 88, 1930.
20. Nagarajan L., Molecular analysis of the 5q-chromosome. Leuk. Lymphoma, 1995, 17, 361.
21. Tucker M. A., Coleman C. N., Cox R. S., Varghese A. and Rosenberg S. A., Risk of second cancers after treatment for Hodgkin's disease. N. Engl. J. Med., 1988, 318, 76.
22. Moran J. L., Siegel D., Sun X. M. and Ross D., Induction of apoptosis by benzene metabolites in HL-60 and CD34+ human bone marrow progenitor cells. Molec. Pharmac., 1996, 50, 610.
23. Moolgavkar S. H. and Luebeck G., Two-event model for carcinogenesis: biological, mathematical, and statistical considerations. Risk. Anal., 1990, 10, 323.
24. Steinbach K. H., Raffler H., Pabst G. and Fliedner T. M., A mathematical model of canine granulocytopoiesis. J. Math. Biol., 1980, 10, 1.
25. Cox L. A. Jr. and Ricci P. F., Reassessing benzene cancer risks using internal doses [see comments]. Risk Anal., 1992, 12, 401.
26. Jones T. D., Morris M. D. and Young R. W., Mathematical models of marrow cell kinetics: differential effects of protracted irradiations on stromal and stem cells in mice. Int. J. Radiat. Oncol. Biol. Phys., 1993, 26, 817.
27. Yin S.-N., Hayes R. and MS L. et al., A Cohort study of cancer among benzene-exposed workers in China: overall results. Am. J. Indust. Med., 1996, 29, 227.
28. Forni A., Chromosome studies in workers exposed to benzene or toluene or both. Arch. Environ. Hlth, 1971, 22, 373.
29. Forni A., Chromosome changes and benzene exposure. A review. Rev. Environ. Hlth, 1979, 3, 5.
30. Bonassi S., Abbondandolo A., Camurri L., Dal Pra L., De Ferrari M., Degrassi F., Forni A., Lamberti L., Lando C. and Padovani P. et al., Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an Italian cohort study. Cancer Genet. Cytogenet., 1995, 79, 133.
31. Eastmond D. A., Smith M. T. and Irons R. D., An interaction of benzene metabolites reproduces the myelotoxicity observed with benzene exposure. Toxic. appl. Pharmac., 1987, 91, 85.
32. Robertson M. L., Eastmond D. A. and Smith M. T., Two benzene metabolites, catechol and hydroquinone, produce a synergistic induction of micronuclei and toxicity in cultured human lymphocytes. Mutat. Res., 1991, 249, 201.
33. Bois F. Y., Smith M. T. and Spear R. C., Mechanisms of benzene carcinogenesis: application of a physiological model of benzene pharmacokinetics and metabolism. Toxic. Lett., 1991, 56, 283.
34. Travis C. C., Quillen J. L. and Arms A. D., Pharmacokinetics of benzene. Toxic. appl. Pharmac., 1990, 102, 400.
35. Medinsky M. A., Sabourin P. J., Lucier G., Birnbaum L. S. and Henderson R. F., A physiological model for simulation of benzene metabolism by rats and mice. Toxic. appl. Pharmac., 1989, 99, 193.
36. Bois F. Y., Jackson E. T., Pekari K. and Smith M. T., Population toxicokinetics of benzene. Environ. Hlth Perspect. 1996, 104, Suppl. 6, in press.
37. Pekari K., Vainiotalo S., Heikkila P., Palotie A., Luotamo M. and Riihimaki V., Biological monitoring of occupational exposure to low levels of benzene. Scand. J. Work Environ. Hlth, 1992, 18, 317.
38. ATSDR, Toxicological Profile for Benzene (update), Draft for public comment. Agency for Toxic Substances and Disease Registry, Atlanta, Georgia, 1996.
39. Schattenberg D. G., Stillman W. S., Gruntmeir J. J., Helm K. M., Irons R. D. and Ross D., Peroxidase activity in murine and human hematopoietic progenitor cells: potential relevance to benzene-induced toxicity. Molec. Pharmac., 1994, 46, 346.
40. Eastmond D. A., Induction of micronuclei and aneuploidy by the quinone-forming agents benzene and o-phenyl-phenol. Toxic. Lett., 1993, 67, 105.
41. Irons R. D. and Neptun D. A., Effects of the principal hydroxy-metabolites of benzene on microtubule polymerization. Arch. Toxic., 1980, 45, 297.
42. Dean B. J., Recent findings on the genetic toxicology of benzene, toluene, xylenes and phenols. Mutat. Res., 1985, 154, 153.
43. Smith M. T., The mechanism of benzene-induced leukemia: a hypothesis and speculations on the causes of leukemia. Environ. Hlth Perspect. 1996, 104, Suppl. 6, in press.
44. Aksoy M., Benzene Carcinogenicity. CRC Press, Boca Raton, Florida, 1988.
45. Thomas D. J., Reasor M. J. and Wierda D., Macrophage regulation of myelopoiesis is altered by exposure to the benzene metabolite hydroquinone [published erratum appears in Toxic. appl. Pharmac. 99, 376]. Toxic. appl. Pharmac., 1989, 97, 440.
46. Niculescu R., Bradford H. N., Colman R. W. and Kalf G. F., Inhibition of the conversion of pre-interleukins-1 alpha and 1 beta to mature cytokines by p-benzoquinone, a metabolite of benzene. Chem. biol. Interact., 1995, 98, 211.
47. Lewis J. G., Odom B. and Adams D. O., Toxic effects of benzene and benzene metabolites on mononuclear phagocytes. Toxic. appl. Pharmac., 1988, 92, 246.