Direct approach for attenuating cocaine's effects on extracellular dopamine: Targeting the dopamine transporter

Synapse

Volumn 26, Issue 4, 1997, Pages 423-427

  Morgan, Alexander E ^a   Porter, Simone P ^a   Clarkson, Francis A ^a   Volkow, Nora D ^a   Fowler, Joanna S ^a   Dewey, Stephen L ^a  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

Cocaine; Dopamine; Dopamine transporter; Microdialysis; Nucleus accumbens; RTI 55

Indexed keywords

COCAINE; DOPAMINE TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DOPAMINE UPTAKE; DRUG EFFECT; GENE TARGETING; MICRODIALYSIS; NEUROTRANSMITTER RELEASE; NONHUMAN; NUCLEUS ACCUMBENS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY;

ANIMALS; CARRIER PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COCAINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; EXTRACELLULAR SPACE; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; NUCLEUS ACCUMBENS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN;

EID: 0030797532     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199708)26:4<423::AID-SYN10>3.0.CO;2-U     Document Type: Article

References (42)

1. Alexoff, D.L., Dewey, S.L., Chen, C.-E., Tedeschi, D.L., Straughter-Moore, R.M., D'Demilia, D., and Fowler, J.S. (1995) A novel system for simultaneous measurement of locomotor activity during microdialysis experiments in freely-moving rats. Soc. Neurosci. Abstr., 21:341.
2. Bergman, J., Madras, B.K., Johnson, S.E., and Spealman, R.D. (1989) Effects of cocaine and related drugs in nonhuman primates. III Self-administration by squirrel monkeys. J. Pharm. Exp. Ther., 251:150-155.
3. 125I]RTI-55: A potent ligand for dopamine transporters. Europ. J. Pharmacol., 194:133-134.
4. Boja, J.W., Mitchell, W.M., Patel, A., Kopajtic, T.A., and Carroll, F.I. (1992) High Affinity binding of [125I]RTI-55 to dopamine and serotonin transporters in rat brain. Synapse, 12:27.
5. 123I]B-CIT. Binding kinetics in the human brain. J. Neural. Transm. [GenSect], 94:137-146.
6. Carrera, M.R., Ashley, J.A., Parsons, L.H., Wirsching, P., Koob, G.F., and Janda, K.D. (1995) Suppression of psychoactive effects of cocaine by active immunization. Nature, 378:727-730.
7. Chen, C-E., Straughter-Moore, R.M., Tedeschi, D.L., Russo, N.B., Alexoff, D.L., Volkow, N.B., Fowler, J.S., Chaurasia, C.S., and Dewey, S.L. (1995) Pharmacologic modulation of cocaine-induced dopamine release and locomotor activity: A potential therapeutic strategy for cocaine abuse. Soc. Neuro. Sci. Abstr. 21:457.
8. 125I]RTI-55 to dopamine transporters: Pharmacology and regional distribution with autoradiography. Synapse, 12:37-46.
9. Dewey, S.L., Chaurasia, C.S., Chen, C-E., Volkow, N.B., Clarkson, F.A., Porter, S.P., Straughter-Moore, R.M., Alexoff, D.L., Tedeschi, D., Russo, N.B., Fowler, J.S., Brodie, J.B. (1997) GABAergic attenuation of cocaine-induced dopamine release and locomotor activity. Synapse 25:393-398.
10. Di Chara, G., and Imperato, A. (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc. Natl. Acad. Sci. USA, 85:5274-5278.
11. Di Chara, G., Acquas, E., Tanda, G., and Cadoni, C. (1993) Drugs of abuse: biochemical surrogates of specific aspects of natural reward? In: Neurochemistry of Drug Dependence. S. Wonnacott and G.G. Lunt, eds. Portland Press, London, pp. 65-81.
12. Gatley, S.J., Volkow, N.B., Chen, R., Fowler, J.S., Carroll, F.I., and Kuhar, M.J. (1996) Displacement of RTI-55 from the dopamine transporter by cocaine. Europ. J. Pharm., 296:145-151.
13. Gatley, S.J., Volkow, N.D., Gifford, A.N., Ding, Y.-S., Logan, J., and Wang, G.-J. (1997) Model for estimating dopamine transporter occupancy and subsequent increases in synaptic dopamine using positron emission tomography and carbon-11-labeled cocaine. Biochem. Pharmacol., 53:43-52.
14. Guan, X.-M., and MeBride, W.J. (1989) Serotonin microinfusion into the ventral tegmental area increases accumbens DA release. Brain Res. Bull., 23:541-547.
15. Hurd, Y.L., Weiss, F., Koob, G.F., and Ungerstedt, U. (1989) Cocaine reinforcement and extracellular dopamine overflow in rat nucleus accumbens: An in vivo microdialysis study. Brain Res., 498:199-203.
16. Innes, R.B., Seibyl, J.P., Scanley, B.E., Laurelle, M., Abi-Dargham, A., Wallace E., Baldwin, R.M., Zea-Ponce, Y., Zoghbi, S.S., Wang, S., Guo, Y., Neumever, J.L., Charney, D.S., Hoffer, P.B., and Marek, K.L. (1993) Single photon emission computed tomographic imaging demonstrates loss of striatal dopamine transporters in Parkinson disease. Proc. Natl. Acad. Sci., 90:11965-11969.
17. Johnson, S.W., Mercuri, N.B., and North, R.A. (1992) 5-hydroxytryptamine 1B receptors block the GABAb synaptic potential in rat dopamine neurons. J. Neurosci., 39:196-199.
18. Kankaanpaa, A., Lillsunde, P., Ruotsalainen, M., Ahtee, L., and Seppala, T. (1996) 5-HT3 receptor antagonist MBL-72222 dose-dependently attenuates cocaine-induced and amphetamine-induced elevations of extracellular dopamine in the nucleus accumbens and the dorsal striatum. Pharmacol. Toxicol., 78:317-321.
19. Kelly, P.H., and Iversen, S.D. (1976) Selective 60HDA-induced destruction of mesolimbic dopamine neurons: Abolition of psychostimulant-induced locomotor activity in rats. Eur. J. Pharmacol., 40:45-56.
20. Kitayama, S., Shimada, S., Xu, H., Markham, L., Donovan, D.M., and Uhl, G.R. (1992) Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding. Proc. Natl. Acad. Sci. USA, 89:7782-7785.
21. Kuczenski, R., and Segal, D.S. (1992) Differential effects of amphetamine and dopamine uptake blockers (cocaine, nomifensine) on caudate and accumbens dialysate dopamine and 3-methoxytyramine. J. Pharm. Exp. Ther., 262:1085-94.
22. Kuczenski, R., Segal, D.S., and Aizenstein, M.L. (1991) Amphetamine, cocaine and fencamfamine: Relationship between locomotor and stereotypy response profiles and caudate and accumbens dopamine dynamics. J. Neurosci., 11:2703-12.
23. Kuhar, M.J., Ritz, M.C., and Boja, J.W. (1991) The dopamine hypothesis of the reinforcing properties of cocaine. Trends Neurosci., 14:299-302.
24. Laruelle, M., Baldwin, R.M., Malison, R.T., Zea-Ponce, Y., Zoghbi, S.S., Al-Tikriti, M.S., Sybirska, E.H., Zimmerman, R.C., Wisniewski, G., Neumeyer, J.L., Milius, R.A., Wang, S., Smith, E.G., Roth, R.H., Charney, D.S., Hoffer, P.B., and Innis, R. (1993) SPECT imaging of dopamine and serotonin transporters with [123I]B-CIT: Pharmacological characterization of brain uptake in nonhuman primates. Synapse, 13:295-309.
25. Lew, R., Sabol, K.E., Chou, C., Vosmer, G.L., Richards, J., and Seiden, L.S. (1996) Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. Part II: Radioligand binding and autoradiography studies. J. Pharm Exp Ther, 276:855-65.
26. Li, M.-Y., Yan, Q.-S., Coffey, L.L., and Reith, M.E.A. (1996) Extracellular DA, norepinephrine, and serotonin in the NACC of freely moving rats during intracerebral dialysis with cocaine and other mono-amine uptake blockers. J. Neurochem., 66:559-568.
27. Morgan, A.E., and Dewey, S.L. (1997) Effects of pharmacologic increases in brain GABA levels on cocaine-induced changes in extracellular dopamine. Synapse, (in press).
28. Oades, R.J., and Halliday, G.M. (1987) Ventral tegmental (A10) system: Neurobiology. 1. Anatomy and connectivity. Brain Res. Rev., 12:117-165.
29. Paxinos, G., and Watson, C. (1986) The Rat Brain in Stereotaxic Coordinates. Academic Press, San Diego.
30. Pettit, H.O., and Justice, J.B., Jr. (1989) Dopamine in the nucleus accumbens during cocaine self-administration as studied by in vivo microdialysis. Pharmacol. Biochem. Behav., 34:899-904.
31. Pettit, H.O., and Justice, J.B., Jr. (1991) Effect of dose on cocaine self-administration behavior and dopamine levels in the nucleus accumbens. Brain Res., 539:94-102.
32. Pijnenberg, A.J.J., and Van Rossum, J. (1973) Stimulation of locomotor activity following injection of dopamine into the nucleus accumbens. J. Pharm. Pharmacol., 25:1003-1005.
33. Rinne, J.O., Laihinen, A., Nagren, K., Ruottinen, H., Ruotsalainen, U., and Rinne, U.K. (1995) PET examination of the monoamine transportr with [11C]B-CIT and [11C]B-CIT in early Parkinson's Disease. Synapse, 21:97-103.
34. Ritchie, J.M., and Greene, N.M. (1985) Local anesthetics. In: The Pharmacological Basis of Therapeutics. Alfred Gilman and Louis Goodman, eds. Macmillan, New York, pp. 309-310.
35. Ritz, M.C., and Kuhar, M.J. (1993) Psychostimulant drugs and a dopamine hypothesis regarding addiction: Update on recent research. In: Neurochemistry of Drug Dependence. S. Wonnacott and G.G.Lunt, eds. Portland Press, London, pp. 51-64.
36. Ritz, M.C., Lamb, R.J., Goldberg, S.R., and Kuhar, M.J. (1987) Cocaine receptors on dopamine transporters are related to self administration of cocaine. Science, 237:1219-1223.
37. Roberts, D.C.S., and Zito, K.A. (1987) Interpretation of lesion effects on stimulant self-administration. In: Methods of Assessing the Reinforcing Properties of Abused drugs. M.A. Bozarth, ed. Springer-Verlag, New York, pp. 87-104.
38. Rothman, R.B. (1990) High affinity dopamine reuptake inhibitors as potential cocaine antagonists: A strategy for drug development. Life Sci., 46:PL-17-PL-21.
39. Rothman, R.B., Mele, A., Reid, A.A., Akunne, H., Greig, N., Thurkauf, A., Rice, K.C., and Pert, A. (1989) Tight binding dopamine reuptake inhibitors as cocaine antagonists: A strategy for drug development. FEBS Lett., 257:341-344.
40. Schad, C.A., Justice, J.B., and Holtzman, S.G. (1995) Naloxone reduces the neurochemical and behavioral effects of amphetamine but not those of cocaine. Eur. J. Pharmacol., 275:9-16.
41. 123/125I]RTI-55. an in vivo label for the serotonin transporter. Synapse, 11:134-139.
42. Tricklebank, M.D. (1989) Interactions between dopamine and 5-HT3 receptors suggest new treatment for psychosis and drug addiction. Trends Neurosci., 10:127-129.