SIV/HIV-1 hybrid virus expressing the reverse transcriptase gene of HIV-1 remains sensitive to HIV-1-specific reverse transcriptase inhibitors after passage in rhesus macaques

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

Volumn 15, Issue 1, 1997, Pages 1-4

  Balzarini, Jan ^a   De Clercq, Erik ^a   Überla, Klaus ^b,c  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Reverse transcriptase gene; Reverse transcriptase inhibitors; SIV HIV hybrid virus

Indexed keywords

3 [(4,7 DICHLORO 2 BENZOXAZOLYLMETHYL)AMINO] 5 ETHYL 6 METHYL 2(1H) PYRIDONE; 9 CHLORO 4,5,6,7 TETRAHYDRO 5 METHYL 6 (3 METHYL 2 BUTENYL)IMIDAZO[4,5,1 JK][1,4]BENZODIAZEPINE 2(1H) THIONE; ADEFOVIR; DELAVIRDINE; DIDANOSINE; LAMIVUDINE; NEVIRAPINE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TALVIRALINE; THIOCARBOXANILIDE DERIVATIVE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; GENE EXPRESSION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SIMIAN IMMUNODEFICIENCY VIRUS; VIROGENESIS; VIRUS HYBRID; VIRUS MUTATION;

ANIMALS; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; HYBRIDIZATION, GENETIC; MACACA MULATTA; MUTATION; REVERSE TRANSCRIPTASE INHIBITORS; SIMIAN IMMUNODEFICIENCY VIRUS;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA; MACACA MULATTA; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS; SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0030795003     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042560-199705010-00001     Document Type: Article

References (10)

1. De Clercq E. Non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment of human immunodeficiency virus type 1 (HIV-1) infections: strategies to overcome drug resistance development. Med Res Rev 1996;16:125-57.
2. Überla K, Stahl-Hennig C, Böttiger D, et al. Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors. Proc Natl Acad Sci USA 1995;92:8210-4.
3. Balzarini J, Weeger M, Camarasa MJ, De Clercq E, Überla K. Sensitivity/resistance profile of a simian immunodeficiency virus containing the reverse transcriptase gene of human immunodeficiency virus type 1 (HIV-1) toward the HIV-1-specific nonnucleoside reverse transcriptase inhibitors. Biochem Biophys Res Commun 1995;211:850-6.
4. Potts BJ. Mini reverse transcriptase (RT) assay. In: Aldovini A, Walker BD, eds. Techniques in HIV research. New York: Stockton Press, 1990:103-6.
5. Regier DA, Desrosiers RC. The complete nucleotide sequence of a pathogenic molecular clone of simian immunodeficiency virus. AIDS Res Hum Retroviruses 1990;6:1221-31.
6. Kaluz S, Kolble K, Reid KB. Directional cloning of PCR products using exonuclease III. Nucleic Acids Res 1992;20:4369-70.
7. Balzarini J, Pérez-Pérez MJ, Velázquez S, et al. Suppression of the breakthrough of human immunodeficiency virus type 1 (HIV-1) in cell culture by thiocarboxanilide derivatives when used individually or in combination with other HIV-1-specific inhibitors (i.e., TSAO derivatives). Proc Natl Acad Sci USA 1995;92:5470-4.
8. Myers G, Wain-Hobson S, Korber B, Smith RF, Pavlakis GN. Human retroviruses and AIDS 1995. Los Alamos, NM: Los Alamos National Laboratory, 1995.
9. St. Clair MH, Martin JL, Tudor-Williams G, et al. Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase. Science 1991;253:1557-9.
10. Eron JJ, Chow YK, Caliendo AM, et al. Pol mutations conferring zidovudine and didanosine resistance with different effects in vitro yield multiply resistant human immunodeficiency virus type 1 isolates in vivo. Antimicrob Agents Chemother 1993;37:1480-7.