Rational design of nematode vaccines: Hidden antigens

International Journal for Parasitology

Volumn 27, Issue 4, 1997, Pages 359-366

  Munn, Edward A ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

H11; Hidden antigens; membrane proteins; nematodes; vaccination

Indexed keywords

ANTIGEN RECOGNITION; IMMUNE RESPONSE; NEMATODE; NEMATODIASIS; NONHUMAN; PARASITE CONTROL; REVIEW; VACCINATION;

ANIMALS; ANTIGENS, HELMINTH; NEMATODE INFECTIONS; VACCINES;

NEMATODA;

EID: 0030915642     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7519(97)00003-9     Document Type: Review

References (30)

1. Andrews S. J., Hole N. J. K., Munn E. A. & Rolph T. P. 1995 Vaccination of sheep against haemonchosis with H11, a gut-membrane-derived protective antigen from the adult parasite: prevention of the periparturient rise and colostral transfer of protective immunity. International Journal for Parasitology 25: 839-846.
2. Andrews, S. J., Rolph, T. P., Munn, E. A. & Taylor, M. A. Duration of protective immunity against ovine haemonchosis following vaccination with the nematode gut membrane antigen H11. Research in Veterinary Science. In press.
3. Emery D. L. & Wagland B. M. 1991. Vaccines against gastrointestinal nematode parasites of ruminants. Parasitology Today 7: 347-349.
4. Jasmer D. P., Perryman L. E. & McGuire T. C. 1996 Haemonchus cantor tus GAI antigens: related, phospholipase C-sensitive, apical gut membrane proteins encoded as a poly-protein and released from the nematode during infection. Proceedings of the National Academy of Sciences U.S.A. 93: 8642-8647.
5. Jasmer D. P., Perryman L. E., Conder G. A. & Crow S., McGuire T. 1993. Protective immunity to Haemonchus contortus induced by immunoaffinity isolated antigens that share a phylogenetically conserved carbohydrate gut surface epitope. Journal of Immunology 151: 5450-5460.
6. Johnson K. S., Harrison G. B., Lightowlers M. W., O'Hoy K. L., Cougle W. G., Dempster R. P., Lawrence S. B., Vinton J. G., Heath D. D. & Rickard M. D. 1989. Vaccination against cysticercosis using a defined recombinant antigen. Nature 338: 585-587.
7. Johnston L. A. Y., Kemp D. H. & Pearson R. D. 1986. Immunization of cattle against Boophilus microplus using extracts derived from adult female ticks: effects of induced immunity on tick populations. International Journal for Parasitology 16: 27-34.
8. Lightowlers M. W. & Rickard M. D. 1993. Vaccination against cestode parasites. Immunology and Cell Biology 71: 443-451.
9. Miller T. A. 1978. Industrial development and field use of the canine hookworm vaccine. Advances in Parasitology 16: 333-342.
10. Munn E. A. 1977. A helical, polymeric extracellular protein associated with the luminal surface of Haemonchus contortus intestinal cells. Tissue & Cell 9: 23-34.
11. Munn E. A. 1981. The endotube, a macroscopic intracellular structure from the syncytial intestine of the parasitic nematode Haemonchus contortus. Journal of Physiology London 319: 7-8.
12. Munn E. A. & Greenwood C. A. 1983. Endotube-brush-border complexes dissected from the intestines of Haemonchus contortus and Ancylostoma caninum. Parasitology 87: 129-137.
13. Munn E. A. & Greenwood C. A. 1984. The occurrence of submicrovillar endotube (modified terminal web) and associated cytoskeletal structures in the intestinal epithelia of nematodes. Philosophical Transactions of the Royal Society of London, Biological Sciences 306: 1-18.
14. Munn E. A., Greenwood C. A. & Coadwell J. W. 1987. Vaccination of young lambs by means of a protein fraction extracted from adult Haemonchus contortus. Parasitology 94: 385-397.
15. Munn E. A., Smith T. S., Graham M., Greenwood C. A., Tavernor A. S. & Coetzee G. 1993a. Vaccination of merino lambs against haemonchosis with membrane-associated proteins from the adult parasite. Parasitology 106: 63-66.
16. Munn E. A., Smith T. S., Graham M., Tavernor A. S. & Greenwood C. A. 1993b. The potential value of integral membrane proteins in vaccination of lambs against Haemonchus contortus. International Journal for Parasitology 23: 261-269.
17. Munn E. A., Smith T. S., Smith H., James F. M., Smith F. C. & Andrews S. J. Vaccination against Haemonchus contortus with denatured forms of the protective antigen H11. Parasite Immunology. In press.
18. Newton S. E. 1995. Progress on vaccination against Haemonchus contortus. International Journal for Parasitology 25: 1281-1289.
19. Newton S. E., Morrish L. E., Martin P. J., Montague P. E. & Rolph T. P. 1995. Protection against multple drug-resistant and geographically distant strains of Haemonchus cantortus by vaccination with H11, a gut membrane-derived protective antigen. International Journal for Parasitology 25: 511-521.
20. Peacock, R. & Poynter, D. 1980. Field experience with a bovine lungworm vaccine. In: Vaccines against Parasites (Edited by Taylor A. E. R. & Muller R.), Symposia of the British Society for Parasitology, Vol. 18, pp. 141-148. Blackwell Scientific Publications, Oxford.
21. Rand K. N., Moore T., Sriskantha A., Spring K., Tellam R., Willadsen P. & Cobon G. S. 1989. Cloning and expression of a protective antigen from cattle tick Boophilus microplus. Proceedings of the National Academy of Sciences U.S.A. 86: 9657-9661.
22. Smith T. S. & Munn E. A. 1990. Strategies for vaccination against gastro-intestinal nematodes. Revue Scientifique et Technique Office International des Epizooties 9: 577-593.
23. Smith, T. S., Graham, M., Munn, E. A., Newton, S. E., Knox, D. P., Coadwell, W. J., McMichael-Phillips, D., Smith, H., Smith, W. D. & Oliver. J. J. Cloning and characterization of a microsomal aminopeptidase from the parasitic nematode Haemonchus contortus. Biochimica et Biophysica Acta. In press.
24. Smith T. S., Munn E. A., Graham M., Tavernor A. S. & Greenwood C. A. 1993. Purification and evaluation of the integral membrane protein H11 as a protective antigen against Haemonchus contortus. International Journal for Parasitology 23: 271-280.
25. Smith W. D. & Smith S. K. 1993. Evaluation of aspects of the protection afforded to sheep immunised with a gut membrane protein of Haemonchus contortus. Research in Veterinary Science 55: 1-9.
26. Smith W. D., Smith S. K. & Murray J. M. 1994. Protection studies with membrane fractions of Haemonchus contortus. Parasite Immunology 16: 231-241.
27. Tavernor A. S., Smith T. S., Langford C. F., Graham M. & Munn E. A. 1992. Immune response of Clun Forest sheep to vaccination with membrane glycoproteins from Haemonchus contortus. Parasite Immunology 14: 671-675.
28. Tavernor A. S., Smith T. S., Langford C. F., Munn E. A. & Graham M. 1992. Vaccination of young Dorset lambs against haemonchosis. Parasite Immunology 14: 645-655.
29. Willadsen P., McKenna R. V. & Riding G. A. 1988. Isolation from the cattle tick, Boophilus microplus, of antigenic material capable of eliciting a protective immunological response in the bovine host. International Journal for Parasitology 18: 183-189.
30. Willadsen P., Riding G. A., McKenna R. V., Kemp D. H., Tellam R. L., Nielsen J. N., Lahnstein J., Cobon G. S. & Gough J. M. 1989. Immunological control of a parasitic arthropod. Identification of a protective antigen from Boophilus microplus. Journal of Immunology 143: 1346-1351.