The palladium catalyzed allylic alkylation of bis(trimethylsilyl) substituted propenyl acetates or carbonates in the presence of chiral ligands

Tetrahedron Letters

Volumn 38, Issue 50, 1997, Pages 8659-8662

  Romero, Donna L ^a   Fritzen, Edward L ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROPIONIC ACID DERIVATIVE;

ALKYLATION; ARTICLE; CATALYSIS; CHIRALITY; DRUG SYNTHESIS; ENANTIOMER; IN VITRO STUDY; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030786789     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)10380-X     Document Type: Article

References (18)

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12. We have previously used this approach to direct alkylation proximal to the phenyl group in the synthesis of 5,6-dihydro-4-hydroxy-2-pyrone HIV protease inhibitors: Thaisrivongs, S., et al. J. Med. Chem. 1996, 39, 4630-4642.
13. Another approach which accomplishes the same overall transformation uses W as catalyst: Lloyd-Jones, G.C.; Pfaltz, A. Angew. Chem. Int. Ed. Eng. 1995, 34, 462-463.
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