Solution structure of the transforming growth factor β-binding protein-like module, a domain associated with matrix fibrils

EMBO Journal

Volumn 16, Issue 22, 1997, Pages 6659-6666

  Yuan, Xuemei ^a,b   Downing, A Kristina ^a,b   Knott, Vroni ^b,c   Handford, Penny A ^b,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

8 cysteine domain; Human fibrillin 1; Marfan syndrome; NMR structure; TB domain

Indexed keywords

BINDING PROTEIN; FIBRILLIN; MUTANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CONSENSUS SEQUENCE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FIBER; HUMAN; HYDROPHOBICITY; MARFAN SYNDROME; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; STEREOCHEMISTRY;

AMINO ACID SEQUENCE; CELL ADHESION; EXTRACELLULAR MATRIX; HUMANS; MARFAN SYNDROME; MICROFILAMENT PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SOLUTIONS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0030781430     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Ades, L.C., Haan, E.A., Colley, A.F. and Richaids, R.I. (1996) Characterization of 4 novel fibrillin-1 (FBN1) mutations in Marfansyndrome. J. Med. Genet., 33, 665-671.
2. Ambrus, J.L. et al. (1993) Identification of a cDNA for a human highmolecular-weight B-cell growth-factor. Proc. Natl Acad. Sci. USA. 90, 6330-6334.
3. Aue, W.P., Bartholdi, E. and Ernst, R.R. (1976) Two-dimensional spectroscopy: application to nuclear magnetic resonance. J. Chem. Phys., 64, 2229-2246.
4. Bairoch, A. (1992) Prosite - a dictionary of sites and patterns in proteins. Nucleic Acids Res., 20, 2013-2018.
5. Barton, C.J. (1990) Protein multiple sequence alignment and flexible pattern-matching. Methods Enymol., 183, 403-428.
6. Bax, A. and Davis, D.G. (1985) MLHV-17-based two-dimensional homonuclcar magnetization transfer spectroscopy. J. Magn. Resonance, 65, 355-360.
7. Bork, P., Downing, A.K., Kieffer, B. and Campbell, I.D. (1996) Structure and distribution of modules in extracellular proteins. Q. Rev. Biophys., 29, 119-167.
8. Braunschweiler, I., and Ernst, R.R. (1983) Coherence transfer by Isotropic mixing - application to proton correlation spectroscopy. J. Magn. Resonance, 53, 521-528.
9. 1H NMR spectra in proteins. J. Mugn. Resonance. 77, 166-169.
10. Brünger, A.T. (1992) X-PLOR (Version 3.1): A System for X-ray Crystallography and NMR. Yale University Press. New Haven. CT. USA.
11. Collod-Béroud, G. et al. (1997) Marian database (second edition): software and database for the analysis of mutations in the human FUN1 gene. Nucleic Acids Res., 25, 147-150.
12. Dallas, S.L., Miyazono, K., Skerry, T.M. Mundy, G.R. and Bonewald, L.F. (1995) Dual role for the latent transforming growth factor-β binding protein in storage of latent TGF-β in the extracellular matrix and as a structural matrix protein. J. Cell Biol., 131, 539-549.
13. Dietz, H.C. and Pycritz, R.E. (1995) Mutations in the human gene for fibrillin-1 (FBN1) in the Marfan syndrome and related disorders. Hum. Mol. Genet., 4, 1799-1809.
14. Downing, A.K., Knott, V., Werner, M., Cardy, C.M., Campbell, I.D. and Handford, P.A. (1996) Solution structure of a pair of calcium-binding epidermal growth factor-like domains: Implications for the Marfan syndrome and other genetic disorders. Cell. 85, 597-605.
15. Garvey, K.J., Oberste, M.S., Elser, J.E., Braun, M.J. and Gonda, M.A. (1990) Nucleotide-sequence and genome organization of biologically active proviruses of the bovine immunodeficiency-like virus. Virology. 175, 391-109.
16. Genetics Computing Group (1994) Program manual for the GCG package, version 8. University of Wisconsin. Madison. WI. USA.
17. Gibson, M.A., Hatzinikolas, G., Davis, E.C., Baker, E., Sutherland, G.R. and Mecham, R.P. (1995) Bovine latent transforming growth factor β-binding protein 2: Molecular cloning. identification of tissue isoforms and immunolocalization to elaslin-associated microfibrils. Mol. Cell. Biol., 15, 6932-6942.
18. Gleizcs, P.-E., Beavis, R.C., Mazaeri, R., Shen, B. and Rifkin, D.B. (1996) Identification and characterization of an eight-cysteine repeat of the latent transforming growth factor-β binding protein-1 that mediates bonding to the latent transforming growth factor-β1. J. Biol. Chem., 271, 29891-29896.
19. Grzesiek, S. and Bax, A. (1993) Amino-acid type determination in the sequential assignment procedure of uniformly C-13/N-15-enriched proteins. J. Biomol. NMR. 3, 185-204.
20. Handford, P.A., Baron, M., Mayhew, M., Willis, A., Beesley, T., Brownlce, G.G. and Campbell, I.D. (1990) The first EGF-like domain from human factor IX contains a high-affinity calcium binding site. EMBO J., 9, 475-480.
21. Jeener, J., Meier, B.H., Bachmann, P. and Ernst, R.R. (1979) Investigation of exchange processes by two-dimensional NMR spectroscopy. J. Chem. Phys., 71, 4546-4553.
22. Kanzaki, T.A., Olofsson.A., Moren, A., Wernstedt, C., Hellman, U., Miyazono, K., Claesson-Welsh, I., and Heldin, C.-H. (1990) TGF-β1 binding protein: a component of the large latent complex of TGF-β1 with multiple repeat sequences. Cell. 61, 1051-1061.
23. Kay, L.E. and Bax.A. (1990) New methods for the measurement of NHC-alpha-H coupling-constants in N-15-labeled proteins. J. Magn. Resonance, 96, 110-126.
24. Kay, L.E., Marion, D. and Bax, A. (1989) Practical aspects of 3D heteronuclear NMR of proteins. J. Magn. Resonance. 84, 72-84.
25. Kay, L.E., Keifer, P. and Saarinen, T. (1992) Pure absorption gradient-enhanced heteronuclear single quantum correlation spectroscopy with improved sensitivity. J. Am. Chem. Soc., 114, 10663-10665.
26. Knott, V., Downing, A.K., Cardy, C.M. and Handford, P. (1996) Calcium binding properties of an epidermal growth factor-like domain pair. J. Mol. Biol. 255, 22-27.
27. Koslowsky, D.J., Bhat, G.J., Perrollaz, A.L., Feagin, J.E. and Stuart, K. (1990) The murf 3 gene of Trypanosoma brucei contains multiple domains of extensive editing and is homologous to a subunit of NADH dehydrogenase. Cell. 62, 901-911.
28. Kraulis, P.J. (1991) MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallogr., 24, 946-950.
29. Li, X., Yin, W., Perez-Jurado, L., Bonadio, J. and Francke, U. (1995) Mapping of human and murine genes for latent TGF-β binding protein2 (LTBP-2). Mamm. Genome, 6, 42-45.
30. Macura, S., Huang, Y. Suter, D. and Ernst, R.R. (1981) 2-dimensional chemical-exchange and cross-relaxation spectroscopy of coupled nuclear spins. J. Magn. Resonance. 43, 259-281.
31. McPherron, A.C. and Lee, S.-J. (1996) In LeRoith, D. and Bondy, C. (eds). Greenwich Factors and Cytokines in Health and Disease. Vol. IB. JAI. Greenwich, pp. 357-393.
32. Merritt, E.A. and Murphy, M.E.P. (1994) Raster3D, version 2.0: a program for photorealistic molecular graphics. Acta Crystallogr., 50, 869-873.
33. Moren, A. et al. (1994) Identification and characterization of LTBP-2. a novel latent transforming growth factor-β binding protein. J. Biol. Chem., 269, 32469-32478.
34. Nilges, M. (1995) Calculation of protein structures with ambiguous distance restraints. Automated assignment of ambiguous NOE crosspeaks and disullide connectivities. J. Mol. Biol., 245, 645-660.
35. Nilges, M., Clore, G.M. and Gronenborn, A.M. (1988) Determination of three-dimensional structures of proteins from interproton distance data by dynamical simulated annealing from a random array of atoms. FEBS Lett., 239, 129-136.
36. Nilges, M., Kuszewski, J. and Brunger, A.T. (1991) Sampling properties of simulated annealing and distance geometry. In Hoch J.C. et al. (eds). Computational Aspects of the Study of Biological Moromolecules by Nuclear Magnetic Resonaance Spectroscopy. Plenum Press. New York. pp. 451-455.
37. Pereira, I., Dalessio, M., Ramirez, F., Lynch, J.R., Sykes, B., Pangilinan, T. and Bonadio J. (1993) Genomic organization of the sequence coding for fibrillin, the defective gene-product in Marfan-syndrome. Hum. Mol. Genel., 2, 961-968.
38. Pfaff, M., Reinhardt, D.P., Sakai, L.Y. and Timpl, R. (1996) Cell-adhesion and integrin binding to recombinant human fibrillin-1. FEBS Lett., 384, 247-250.
39. Raleigh, E.A. et al. (1988) Mcra and mcrb restriction phenotypes of some Escherichia coli strains and implications for gene cloning. Nucleic Acids Res., 16, 1563-1575.
40. 2+ -binding epidermal growth factor-like domain: Its role in protein-protein interactions. Cell. 82, 131-141.
41. Reinhardt, D.P., Keene, D.R., Corson, G.M., Poschl, E., Bachinger, H.P., Giambec, J.K. and Sakai, L.Y. (1996) Fibrillin-1: Organization in microfibrils and structural properties. J. Mol. Biol., 258, 104-116.
42. Russell, R.B. and Barton, G.J. (1992) Multiple protein-sequence alignment from tertiary structure comparison-assignment of global and residue confidence levels. Proteins. 14, 309-323.
43. Saharinen, J., Taipale, J. and Keski-OjaJ. (1996) Association of the small latent transforming growth-factor-β with an 8-cysteine repeat of its binding-protein LTBP-1. EMBO J., 15, 245-253.
44. Sakai, L.Y. and Keene, D.R. (1994) Fibrillin: Monomers and microfibrils. Methods Enzymol., 245, 29-52.
45. Sakai, L.Y., Keene, D.R., Glanville, R.W. and Bachinger, H.P. (1991) Purification and partial characterisation of fibrillin. a cysteine-rich structural component of connective-tissue microfibrils. J. Biol. Chem., 266, 14763-14770.
46. Sakamoto, H., Broekelmann, T., Cheresh, O.A., Ramirez, F., Rosenbloom, J. and Mecham, R.P. (1996) Cell-type specific recognition of RGD- and non-RGU-containing cell binding domains in fihrillin-l. J. Biol. Chem., 271, 4916-4922.
47. Swart, I., S. and Haylett, T. (1973) Studies on the high-sulphur proteins of reduced merino wool: amino acid sequence of protein SCMKB-IIIA3. Biochem. J., 133, 641-654.
48. Taipale, J., Saharinen, J., Hedman, K. and Keski-Oja, J. (1996) Latent transforming growth factor-β l and its binding protein arc components of extracellular matrix microfibrils. J. Histochem. Cytochem., 44, 875-889.
49. Thurmond, F.A. and Trotler, J.A. (1996) Morphology and biomechanics of the microfibrillar network of sea cucumber dermis. J. Exp. Biol., 199, 1817-1828.
50. Wüthrich, K. (1986) NMR of Proteins and Nucleic Acids. John Wiley and Sons. Inc., New York.
51. Yin.W., Smiley, E., Germiller, J., Mecham, R.P., Florer, J.B., Wenstrup, R.J. and Bonodio, J. (1995) Isolation of a novel latent transforming growth factor-β binding protein gene (LTBP-3). J. Biol. Chem., 270, 10147-10160.