The transforming growth factor β superfamily

Growth Factors and Cytokines in Health and Disease

Volumn 1, Issue C, 1996, Pages 357-393

  McPherron, Alexandra C ^a   Lee, Se Jin ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77957063704     PISSN: 18745687     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1874-5687(96)80016-4     Document Type: Article

References (181)

1. Albano R.M., Groome N., and Smith J.C. Activins are expressed in preimplantation mouse embryos and in ES and EC cells and are regulated on their differentiation. Development 117 (1993) 711-723
2. Alper J. Boning up: Newly isolated proteins heal bad breaks. Science 263 (1994) 324
3. 77]transforming growth factor-β1: Selective biological activity and receptor binding in mink lung epithelial cells. J. Biol. Chem. 269 (1994) 27687-27691
4. Asashima M., Nakano H., Shimada K., Kinoshita K., Ishii K., Shibai H., and Ueno N. Mesodermal induction in early amphibian embryos by activin A (erythroid differentiation factor). Roux's Arch. Dev. Biol. 198 (1990) 330-335
5. Barr P.J. Mammalian subtilisins: The long-sought dibasic processing endoproteases. Cell 66 (1991) 1-3
6. Barton D.E., Yang-Feng T.L., Mason A.J., Seeburg P.H., and Francke U. Mapping genes for inhibin subunits α, βa, and βB on human and mouse chromosomes and studies of jsd mice. Genomics 5 (1989) 91-99
7. Basier K., Edlund T., Jessell T.M., and Yamada T. Control of cell pattern in the neural tube: Regulation of cell differentiation by dorsalin-1, a novel TGFβ family member. Cell 73 (1993) 687-702
8. Behringer R.R. In: Pedersen R.A. (Ed). Current Topics in Developmental Biology Vol. 29 (1994), Academic Press, San Diego 171-187
9. Behringer R.R., Cate R.L., Froelick G.J., Palmiter R.D., and Brinster R.L.1990. Abnormal sexual development in transgenic mice chronically expressing Müllerian inhibiting substance. Nature 345 (1990) 167-170
10. Behringer R.R., Finegold M.J., and Cate R.L. Müllerian-inhibiting substance function during mammalian sexual development. Cell 79 (1994) 415-425
11. Blessing M., Nanney L.B., King L.E., Jones C.M., and Hogan B.L.M. Transgenic mice as a model to study the role of TGF-β-related molecules in hair follicles. Genes Dev. 7 (1993) 204-215
12. Boyer J., Pascolo S., Richard G.-F., and Dujon B. Sequence of a 7.8 kb segment on the left arm of yeast chromosome XI reveals four open reading frames, including the CAP1 gene, an intron-containing gene and a gene encoding a homolog to the mammalian UOG-1 gene. Yeast 9 (1993) 279-287
13. Broxmeyer H.E., Lu L., Cooper S., Schwall R.H., Mason A.J., and Nikolics K. Selective and indirect modulation of human multipotential and erythroid hematopoietic progenitor cell proliferation by recombinant human activin and inhibin. Proc. Natl. Acad. Sci. USA 85 (1988) 9052-9056
14. Brunner A.M., Lioubin M.N., Marquardt H., Malacko A.R., Wang W.-C., Shapiro R.A., Neubauer M., Cook J., Madisen L., and Purchio A.F. Site-directed mutagenesis of glycosylation sites in the transforming growth factor βl (TGFβl ) and TGFβ2 (414) precursors and of cysteine residues within mature TGFβ1: Effects on secretion and bioactivity. Mol. Endocrinol. 6 (1992) 1691-1700
15. Brunner A.M., Marquardt H., Malacko A.R., Lioubin M.N., and Purchio A.F. Site-directed mutagenesis of cysteine residues in the pro region of the transforming growth factor-β 1 precursor. J. Biol. Chem. 264 (1989) 13660-13664
16. Carré-Eusèbe D., Imbeaud S., Harbison M., New M.1., Josso N., and Picard J.-Y. Variants of the anti-Müllerian hormone gene in a compound heterozygote with the persistent Müllerian duct syndrome and his family. Hum. Genet. 90 (1992) 389-394
17. Cate R.L., Mattaliano R.J., Hession C., Tizard R., Farber N.M., Cheung A., Ninfa E.G., Frey A.Z., Gash D.J., Chow E.P., Fisher R.A., Bertonis J.M., Torres G., Wallner B.P., Ramachandran K.L., Ragin R.C., Manganaro T.F., MacLaughlin D.T., and Donahoe P.K. Isolation of the bovine and human genes for Müllerian inhibiting substance and expression of the human gene in animal cells. Cell 45 (1986) 685-698
18. Catlin E.A., Ezzell R.M., Donahoe P.K., Manganaro T.F., Ebb R.G., and MacLaughlin D.T. Müllerian inhibiting substance binding and uptake. Dev. Dyn. 193 (1992) 295-299
19. Catlin E.A., Manganaro T.F., and Donahoe P.K. Müllerian inhibiting substance depresses accumulation in vitro of disaturated phosphatidylcholine in fetal rat lung. Am. J. Obstet. Gynecol. 159 (1988) 1299-1303
20. Catlin E.A., Powell S.M., Manganaro T.F., Hudson P.L., Ragin R.C., Epstein J., and Donahoe P.K. Sex-specific fetal lung development and Müllerian inhibiting substance. Ann. Rev. Respir. Dis. 141 (1990) 466-470
21. Celeste A.J., Iannazzi J.A., Taylor R.C., Hewick R.M., Rosen V., Wang E.A., and Wozney J.M. Identification of transforming growth factor β family members present in bone-inductive protein purified from bovine bone. Proc. Natl. Acad. Sci., USA 87 (1990) 9843-9847
22. Centrella M., McCarthy T.L., and Canalis E. Activin-A binding and biochemical effects in osteoblast-enriched cultures from fetal-rat parietal bone. Mol. Cell. Biol. 11 (1991) 250-258
23. Chang S.C., Hoang B., Thomas J.T., Vukicevic S., Luyten F.P., Ryba N.J.P., Kozak C.A., Reddi A.H., and Moos J.M. Cartilage-derived morphogenetic proteins. J. Biol. Chem. 269 (1994) 28227-28234
24. Cohen-Haguenauer O., Picard J.Y., Mattei M.-G., Severo S., van Long N., de Tand M.-F., Guerrier D., Hors-Cayla M.-C., Josso N., and Frezal J. Mapping of the gene for anti-Müllerian hormone to the short arm of human chromosome 19. Cytogenet. Cell Genet. 44 (1987) 2-6
25. Cönlon F.L., Barth K.S., and Robertson E.J. A novel retrovirally induced embryonic lethal mutation in the mouse: assessment of the developmental fate of embryonic stem cells homozygous for the 413.d proviral integration. Development 111 (1991) 969-981
26. Coulombe J.N., Schwall R., Parent A.S., Eckenstein F.P., and Nishi R. Induction of somatostatin immunoreactivity in cultured ciliary ganglion neurons by activin in choroid cell- conditioned medium. Neuron 10 (1993) 899-906
27. Cox K., Holtrop M., D'Allesandro J.S., Wang E.A., Wozney J.M., and Rosen V. Histological and ultrastructural comparison of the in vivo activities of RHBMP 2 and RHBMP 5. J. Bone Min. Res. 6 (1991) S155
28. Crawford R.J., Hammond V.E., Evans B.A., Coghland J.P., Haralambidis J., Hudson B., Penschow J.D., Richards R.I., and Tregear G.W. Alpha-inhibin gene expression occurs in the ovine adrenal cortex, and is regulated by adrenocorticotropin. Mol. Endocrinol. 1 (1987) 699-706
29. Cunningham N.S., Paralkar V., and Reddi A.H. Osteogenin and recombinant bone morphoge- netic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor beta 1 mRNA expression. Proc. Natl. Acad. Sci., USA 89 (1992) 11740-11744
30. D'Allessandro J.S., Cox K.A., Israel D.I., LaPan P., Moutsatsos J.K., Nove J., Rosen V., Ryan M.C., Wozney J.M., and Wang E.A. Purification, characterization and activities of recombinant human bone morphogenetic protein 5. J. Bone Min. Res. 6 (1991) S153
31. D'mello N.P., Childress A.M., Franklin D.S., Kale S.P., Pinswasdi C., and Jazwinski S.M. Cloning and characterization of LAG1, a longevity-assurance gene in yeast. J. Biol. Chem. 269 (1994) 15451-15459
32. Daopin S., Piez K.A., Ogawa Y., and Davies D.R. Crystal structure of transforming growth factor-β2: An unusual fold for the superfamily. Science 257 (1992) 369-373
33. deMartin R., Haendler B., Hofer-Warbinek R., Gaugitsch H., Wrann M., Schlusener H., Seifert J.M., Bodmer S., Fontana A., and Hofer E. Complementary DNA for human glioblastoma- derived T-cell suppressor factor, a novel member of the transforming growth factor-β gene family. EMBO J. 6 (1987) 3673-3677
34. Derynck R., Jarrett J.A., Chen E.Y., Eaton D.H., Bell J.R., Assoian R.K., Roberts A.B., Sporn M.B., and Goeddel D.V. Human transforming growth factor β complementary DNA sequence and expression in normal and transformed cells. Nature 316 (1985) 701-705
35. Derynck R., Lindquist P.B., Lee A., Wen D., Tamm J., Graycar J.L., Rhee .L., Mason A.J., Miller D.A., Coffey R.J., Moses H.L., and Chen E.Y. A new type of transforming growth factor-β, TGF-β3. EMBO J. 7 (1988) 3737-3743
36. Dickinson M.E., Kobrin M.S., Silan C.M., Kingsley D.M., Justice M.J., Miller D.A., Ceci J.D., Lock L.F., Lee A., Buchberg A.M., Siracusa L.D., Lyons K.M., Derynck R., Hogan .BL.M., Copeland N.G., and Jenkins N.A. Chromosomal localization of seven members of the murine TGF-β superfamily suggests close linkage to several morphogenetic mutant loci. Genomics 6 (1990) 505-520
37. Drozdoff V., Wall N.A., and Pledger W.J. Expression and growth inhibitory effect of decapentaplegic Vg-related protein 6: Evidence for a regulatory role in keratmocyte differentiation. Proc. Natl. Acad. Sci. USA 91 (1994) 5528-5532
38. Dye R.B., Rabinovici J., and Jaffe R.B. Inhibin and activin in reproductive biology. Obstet. and Gynecol. Surv. 47 (1992) 173-185
39. Eto Y., Tsuji T., Takezawa M., Takano S., Yokogawa Y., and Shibai H. Purification and characterization of erythroid differentiation factor (EDF) isolated from human leukemia cell line THP-1. Biochem. Biophys. Res. Commun. 142 (1987) 1095-1103
40. Farm M.-J., and Patterson P.H. Neuropoietic cytokines and activin A differentially regulate the phenotype of cultured sympathetic neurons. Proc. Natl. Acad. Sci. USA 91 (1994) 43-47
41. Ferguson E.L., and Anderson K.V. Localized enhancement and repression of the activity of the TGF-β family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo. Dev. 114 (1992) 583-597
42. Forage R.G., Ring J.M., Brown R.W., Mclnerney B.V., Cobon G.S., Gregson R.P., Robertson D.M., Morgan F.J., Hearn M.T.W., Findlay J.K., Wettenhall R.E.H., Burger H.G., and de K.D.M. Cloning and sequence analysis of cDNA species coding for the two subunits of inhibin from bovine follicular fluid. Proc. Natl. Acad. Sci., USA 83 (1986) 3091-3095
43. Galway A.B., Hsueh A.J.W., Daneshdoost L., Zhou H.-H., Pavlou S.N., and Snyder P.J. Gonadotroph adenomas in men produce biologically active follicle-stimulating hormone. J. Clin. Endocrinol. Metab. 71 (1990) 907-912
44. Gentry L.E., and Nash B.W. The pro domain of pre-pro-transforming growth factor β1 when independently expressed is a functional binding protein for the mature growth factor. Biochem. 29 (1990) 6851-6857
45. Graham A., Francis-West P., Brickell P., and Lumsden A. The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest. Nature 372 (1994) 684-686
46. Gray A.M., and Mason A.J. Requirement for activin A and transforming growth factor-β 1 proregions in homodimer assembly. Science 247 (1990) 1328-1330
47. Green E.L., and Green M.C. The development of three manifestations of the short ear gene in the mouse. J. Morphol. 70 (1942) 1-19
48. Green E.L., and Green M.C. Effect of the short ear gene on number of ribs and presacral vertebrae in the house mouse. Am. Nat. 80 (1946) 619-625
49. Green M.C. Further morphological effects of the short ear gene in the house mouse. J. Morphol. 88 (1951) 1-21
50. Green M.C. Effects of the short ear gene in the mouse on cartilage formation in healing bone fractures. J. Exp. Zool. 137 (1958) 75-88
51. Green M.C. Mechanism of the pleiotropic effects in the short-ear mutant gene in the mouse. J. Exp. Zool. 167 (1968) 129-150
52. Grüneberg H., and Lee A.J. The anatomy and development of brachypodism in the mouse. J. Embryol. Exp. Morphol. 30 (1973) 119-141
53. Hahn G.V., Cohen R.B., Wozney J.M., Levitz C.L., Shore E.M., Zasloff M.A., and Kaplan F.S. A bone morphogenetic protein subfamily: Chromosomal localization of human genes for BMP5, BMP6, and BMP7. Genomics 14 (1992) 759-762
54. Hammonds R.G., Schwall R., Dudley A., Berkemeier L., Lai C., Lee J., Cunningham N., Reddi A.H., Wood W.I., and Mason A.J. Bone-inducing activity of mature BMP-2b produced from a hybrid BMP-2a/2b precursor. Mol. Endocrinol. 5 (1991) 149-155
55. Harland R.M. The transforming growth factor β family and induction of the vertebrate mesoderm: Bone morphogenetic proteins are ventral inducers. Proc. Natl. Acad. Sci. USA 91 (1994) 10243-10246
56. Harris S.E., Harris M.A., Mahy P., Wozney J., Feng J.Q., and Mundy G.R. Expression of bone morphogenetic protein messenger RNAs by normal rat and human prostate and prostate cancer cells. Prostate 24 (1994) 204-211
57. Hashimoto M., Kondo S., Sakurai T., Yuzuru E., Shibai H., and Muramatsu M. Activin/EDF as an inhibitor of neural differentiation. Biochem. Biophys. Res. Comm. 173 (1990) 193-200
58. 3H]thymidine uptake by rat thymocytes and 3T3 cells in vitro. Mol. Cell. Endocrinol. 61 (1989) 133-138
59. Heikinheimo K. Stage-specific expression of decapentaplegic-Vg-related genes 2, 4, and 6 (Bone morphogenetic proteins 2, 4, and 6) during human tooth morphogenesis. J. Dent. Res. 73 (1994) 590-597
60. Hemmati-Brivanlou A., and Melton D.A. A truncated activin receptor dominantly inhibits mesoderm induction and formation of axial structures in Xenopus embryos. Nature 359 (1992) 609-614
61. Henderson C.E., Phillips H.S., Pollock R.A., Davies A.M., Lemeulle C., Armanini M., Simpson L.C., Moffet B., Vandlen R.A., Koliatsos V.E., and Rosenthal A. GDNF: A potent survival factor for motoneurons present in peripheral nerve and muscle. Science 266 (1994) 1062-1064
62. Hillier S.G., and Miró F. Inhibin, activin, and follistatin. Ann. NY Acad. Sci. 687 (1993) 29-38
63. Hüsken-Hindi P., Tsuchida K., Park M., Corrigan A.Z., Vaughan J.M., Vale W.W., and Fischer W.H. Monomeric activin A retains high receptor binding affinity but exhibits low biological activity. J. Biol. Chem. 269 (1994) 19380-19384
64. Iannaccone P.M., Zhou X., Khokha M., Boucher D., and Kuehn M.R. Insertional mutation of a gene involved in growth regulation of the early mouse embryo. Dev. Dyn. 194 (1992) 198-208
65. Imbeaud S., Carré-Eusèbe D., Rey R., Belville C., Josso N., and Picard J.-Y. Molecular genetics of the persistent Müllerian duct syndrome: A study of 19 families. Hum. Mol. Gen. 3 (1994) 125-131
66. Itoh M., Igarashi M., Yamada K., Hasegawa Y., Seki M., Eto Y., and Shibai H. Activin A stimulates meiotic maturation of the rat oocyte in vitro. Biochem. Biophys. Res. Comm. 166 (1990) 1479-1484
67. Jaffe G.J., Harrison C.E., Lui G.M., Roberts W.L., Goldsmith P.C., Mesiano S., and Jaffe R.B. Activin expression by cultured human retinal pigment epithelial cells. Inv. Opthamol. Vis. Sci. 35 (1994) 2924-2931
68. Jones C.M., Lyons K.M., and Hogan B.L.M. Involvement of bone morphogenetic protein- 4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse. Development 111 (1991) 531-542
69. Jones C.M., Simon-Chazottes D., Guenet J.-L., and Hogan B.L.M. Isolation of Vgr-2, a novel member of the transforming growth factor-β-related gene family. Mol. Endocrinol. 6 (1992) 1961-1968
70. Josso N., Cate R.L., Picard J.-Y., Vigier B., di C., N .W., C .I., S.Pepinsky R., B .G., D .B., L .L., and L.Carré-Eusèbe D. Anti-Müllenan hormone: The Jost factor. Recent Prog. Horm. Res. 48 (1993) 1-59
71. Jost A. Recherches sur la différenciation sexuelle de l'embryon de lapin. Arch. Anat. Micro. Morph. Exp. 36 (1947) 271-315
72. Jost A., Vigier B., Prepin J., and Perchellet J.P. Studies on sex differentiation in mammals. Recent Prog. Horm. Res. 29 (1973) 1-41
73. King J.A., Marker P.C., Seung K.J., and Kingsley D.M. BMP 5 and the molecular, skeletal, and soft-tissue alterations in short ear mice. Development Biol. 166 (1994) 112-122
74. King T.R., Lee B.K., Behringer R.R., and Eicher E.M. Mapping anti-Müllerian hormone (Amh) and related sequences in the mouse: Identification of a new region of homology between MMU10 and HSA 19 p. Genomics 11 (1991) 273-283
75. Kingsley D.M. What do BMPs do in mammals? Clues from the mouse short-ear mutation. TIGS 10 (1994) 16-21
76. Kingsley D.M., Bland A.E., Grubber J.M., Marker P.C., Russell L.B., Copeland N., and Jenkins N.A.G. The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF β superfamily. Cell 71 (1992) 399-410
77. Knebelmann B., Boussin L., Guerrier D., Legeai L., Kahn A., Josso N., and Picard J.-Y. Anti-Müllerian hormone Bruxelles: A nonsense mutation associated with the persistent Müllerian duct syndrome. Proc. Natl. Acad. Sci. USA 88 (1991) 3767-3771
78. Knight P.G., Beard A.J., Wrathall J.H.M., and Castillo R.J. Evidence that the bovine ovary secretes large amounts of monomeric inhibin α subunit and its isolation from bovine follicular fluid. J. Mol. Endocrinol. 2 (1989) 189-200
79. Kojima I., Mogami H., Kawamura N., Yasuda H., and Shibata H. Modulation of growth of vascular smooth muscle cells by activin A. Exp. Cell Res. 206 (1993) 152-156
80. Landauer W. Brachypodism: A recessive mutation of house-mice. J. Hered. 43 (1952) 293-298
81. Lawrence D.A., Pircher R., and Jullien P. Conversion of a high molecular weight latent β-TGF from chicken embryo fibroblasts into a low molecular weight active β-TGF under acidic conditions. Biochem. Biophys. Res. Comm. 133 (1985) 1026-1034
82. Lee M.M., and Donahoe P.K. Müllerian inhibiting substance: A gonadal hormone with multiple functions. Endocrine Rev. 14 (1993) 152-164
83. Lee S.-J. Identification of a novel member of the transforming growth factor-β superfamily. 4. Mol. Endocrinol. (1990) 1034-1040
84. Lee S.-J. Expression of growth/differentiation factor 1 in the nervous system: Conservation of a bicistronic structure. Proc. Natl. Acad. Sci., U.S.A. 88 (1991) 4250-4254
85. Lefer A.M., Tsao P.S., Ma X.-L., and Sampath T.K. Anti-ischaemic and endothelial protective actions of recombinant human osteogenic protein (hOP-1). J. Mol. Cell. Cardiol. 24 (1992) 585-593
86. Lillie F.R. The theory of the free-martin. Science 43 (1916) 611-613
87. Lin L.-F.H., Doherty D.H., Lile J.D., Bektesh S., and Collins F. GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260 (1993) 1130-1132
88. Ling N., Ying S.-Y., Ueno N., Shimasaki S., Esch F., Hotta M., and Guillemin R. Pituitary FSH is released by a heterodimer of the β-subunits from the two forms of inhibin. Nature 321 (1986) 779-782
89. Loeff D.S., Imbeaud S., Reyes H.M., Meiler J.L., and Rosenthal I.M. Surgical and genetic aspects of persistent Müllerian duct syndrome. J. Pediatr. Surg. 29 (1994) 61-65
90. Lu R.-Z., Matsuyama S., Nishihara M., and Takahashi M. Developmental expression of activin/inhibin βA, βB, and α subunits, and activin receptor-IIB genes in preimplantation mouse embryos. Biol. Reprod. 49 (1993) 1163-1169
91. Luvten F.P., Cunningham N.S., Ma S., Muthukumaran N., Hammonds R.G., Nevins W.B., Wood W.I., and Reddi A.H. Purification and partial amino acid sequence of osteogenin, a protein initiating bone differentiation. J. Biol. Chem. 264 (1989) 13377-13380
92. Lyons K., Graycar J.L., Lee A., Hashmi S., Lindquist P.B., Chen E.Y., Hogan B.L.M., and Derynck R. Vgr-1, a mammalian gene related to XenopusVg-1, is a member of the transforming growth factor β gene superfamily. Proc. Natl. Acad. Sci., USA 86 (1989) 4554-4558
93. Lyons K.M., Pelton R.W., and Hogan B.L.M. Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor- β-like genes coordinately regulate aspects of embryonic development. Genes Development 3 (1989) 1657-1668
94. Lyons K.M., Pelton R.W., and Hogan B.L.M. Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2a (BMP-2a). Development 109 (1990) 833-844
95. Lyons R.M., Keski-Oja J., and Moses H.L. Proteolytic activation of latent transforming growth factor-β from fibroblast-conditioned medium. J. Cell Biol. 106 (1988) 1659-1665
96. Malinina N.A., Kindiakov B.N., and Koniukhov B.V. Mutant gene expression in mouse aggregation chimeras. 3. The brachypodism-H gene. Ontogenez 15 (1984) 514-521
97. Manova K., Paynton B.V., and Bachvarova R.F. Expression of activins and TGFβ1 and β2 RNAs in early postimplantation mouse embryos and uterine decidua. Mech. Dev. 36 (1992) 141-152
98. Mason A.J., Niall H.D., and Seeburg P.H. Structure of two human ovarian inhibins. Biochem. Biophys. Res. Comm. 135 (1986) 957-964
99. Mason A.J. Functional analysis of the cysteine residues of activin A. Mol. Endocrinol. 8 (1994) 325-332
100. Mason A.J., Hayflick J.S., Ling N., Esch F., Ueno N., Ying S.-Y., Guillemin R., Niall H., and Seeburg P. Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homology with transforming growth factor. Nature 318 (1985) 659-663
101. Matzuk M.M., Finegold M.J., Mather J.P., Krummen L., Lu H., and Bradley A. Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice. Proc. Natl. Acad. Sci., USA 91 (1994) 8817-8821
102. Matzuk M.M., Finegold M.J., Su J.-G.J., Hsueh A.J.W., and Bradley A.H. Inhibin is a tumor-suppressor gene with gonadal specificity in mice. Nature 360 (1992) 313-319
103. Mayo K.E., Cerelli G.M., Spiess J., Rivier J., Rosenfeld M.G., Evans R.M., and Vale W. Inhibin A-subunit cDNA's from porcine ovary and human placenta. Proc. Natl. Acad. Sci., USA 83 (1986) 5849-5853
104. McCarthy S.A., and Bicknell R. Inhibition of vascular endothelial cell growth by activin-A. J. Biol. Chem. 268 (1993) 23066-23071
105. McCullagh D.R. Dual endocrine activity of the testes. Science 76 (1932) 19-20
106. McDonald N.Q., and Hendrickson W.A. A structural superfamily of growth factors containing a cystine knot motif. Cell 73 (1993) 421-424
107. McGrath S.A., Esquela A.F., and Lee S.-J. Oocyte-specific expression of growth/differentiation factor-9. Mol. Endocrinol. 9 (1995) 131-136
108. McPherron A.C., and Lee S.-J. GDF-3 and GDF-9: Two new members of the transforming growth factor-β superfamily containing a novel pattern of cysteines. J. Biol. Chem. 268 (1993) 3444-3449
109. Meunier H., Rivier C., Evans R.M., and Vale W. Gonadal and extragonadal expression of inhibin α, βA, and βB subunits in various tissues predicts diverse functions. Proc. Natl. Acad. Sci. USA 85 (1988) 247-251
110. Miyazono K., Hellman U., Wernstedt C., and Heldin C.-H. Latent high molecular weight complex of transforming growth factor βl. J. Biol. Chem. 263 (1988) 6407-6415
111. Moore A., Krummen L.A., and Mather J.P. Inhibins, activins, their binding proteins and receptors: Interactions underlying paracrine activity in the testis. Mol. Cell. Endocrinol. 100 (1994) 81-86
112. Murata M., Eto Y., Shibai H., Sakai M., and Muramatsu M. Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin βA chain. Proc. Natl. Acad. Sci., USA 85 (1988) 243
113. Nakao K., Kosaka M., and Saito S. Effects of erythroid differentiation factor (EDF) on proliferation and differentiation of human hematopoietic progenitors. Exp. Hematol. 19 (1991) 1090-1095
114. Nakase T., Nomura S., Yoshikawa H., Hashimoto J., Hirota S., Kitamura Y., Oikawa S., Ono K., and Takaoka K. Transient and localized expression of bone morphogenetic protein 4 messenger RNA during fracture healing. J. Bone Min. Res. 9 (1994) 651-659
115. Nishi Y., Haji M., Tanaka S., Yanase T., Takayanagi R., Etoh Y., and Nawata H. Human recombinant activin-A modulates the steroidogenesis of cultured bovine adrenocortical cells. J. Endocrinol. 132 (1992) R1-R4
116. Niswander L., and Martin G.R. FGF-4 and BMP-2 have opposite effects on limb growth. Nature 361 (1993) 68-71
117. O W.-S., Robertson D.M., and de K.D.M. Inhibin as an oocyte meiotic inhibitor. Mol. Cell. Endocrinol. 62 (1989) 307-311
118. Ogawa K., Abe K., Kurosawa N., Kurohmaru M., Sugino H., Takahashi M., and Hayashi Y. Expression of a, βA and βB subunits of inhibin or activin and follistatin in rat pancreatic islets. FEBS Lett. 319 (1993) 217-220
119. Ogawa Y., Schmidt D.K., Nathan R.M., Armstrong R.M., Miller K.L., Sawamura S.J., Ziman J., M .E., K.L. d.L., E .R.R., D .M.S., S .M.G., C.B.Chang R.-Y., Corrigan A.Z., and Vale W. Bovine bone activin enhances bone morphogenetic protein- induced ectopic bone formation. J. Biol. Chem. 267 (1992) 14233-14237
120. Owens E.M., and Solursh M. Cell-cell interaction by mouse limb cells during in vitro chondrogenesis: Analysis of the brachypod mutation. Development Biol. 91 (1982) 376-388
121. Özkaynak E., Rueger D.C., Drier E.A., Corbett C., Ridge R.J., Sampath T.K., and Oppermann H. OP-1 cDN A encodes an osteogenic protein in the TGF-β family. EMBO J. 7 (1990) 2085-2093
122. Özkaynak E., Schnegelsberg P.N.J., Jin D.F., Clifford G.M., Warren F.D., Drier E.A., and Opperman H. Osteogenic protein-2, a new member of the transforming growth factor-β superfamily expressed early in embryogenesis. J. Biol. Chem. 267 (1992) 25220-25227
123. Özkaynak E., Schnegelsberg P.N.J., and Opperman H. Munne osteogenic protein (OP-1): High levels of mRNA in kidney. Biochem. Biophys. Res. Comm. 179 (1991) 116-123
124. Padgett R.W., St .J., and R.D.Gelbart W.M. A transcript from a Dwsophila pattern gene predicts a protein homologous to the transforming growth factor-β family. Nature 325 (1987) 81-84
125. Paralkar V.M., Weeks B.S., Yu Y.M., Kleinman H.K., and Reddi A.H. Recombinant human bone morphogenetic protein-2B stimulates PC 12 cell differentiation: Potentiation and binding to type IV collagen. J. Cell Biol. 119 (1992) 1721-1728
126. Pepinsky R.B., Sinclair L.K., Chow E.P., Mattaliano R.J., Manganaro T.F., Donahoe P.K., and Cate R.L. Proteolytic processing of Müllerian inhibiting substance produces a trans- forming growth factor-β-like fragment. J. Biol. Chem 263 (1988) 18961-18964
127. Perides G., Safran R.M., Downing L.A., and Charness M.E. Regulation of neural cell adhesion molecule and Ll by the transforming growth factor-β superfamily. J. Biol. Chem. 269 (1994) 765-770
128. Perides G., Safran R.M., Rueger D.C., and Charness M.E. Induction of the neural cell adhesion molecule and neuronal aggregation by osteogenic protein 1. Proc. Natl. Acad. Sci., USA 89 (1992) 10326-10330
129. Petraglia F., Sacerdote P., Cossarizza A., Angioni S., Genazani A.D., Franceschi C., Muscettola M., and Grasso G. Inhibin and activin modulate human monocyte chemotaxis and human lymphocyte interferon-γ production. J. Clin. Endocrinol. Metab. 72 (1991) 496-502
130. Picon R. Action du testicule foetal, sur le développement in vitro des canaux de Müller chez le rat. Arch. Anat. Micro. Morph. Exp. 58 (1969) 1-19
131. Rao V.V.N.G., Loffler C., Wozney J.M., and Hansmann I. The gene for BMP 2A is localized to human chromosome 20pl2 by radioactive and nonradioactive in situ hybridization. Hum. Genet. 90 (1992) 299
132. Reddi A.H. Cell biology and biochemistry of endochrondral bone development. Coll. Res. 1 (1981) 209-226
133. Roberts V.J., Sawchenko P.E., and Vale W. Expression of inhibin/activin subunit messenger ribonucleic acids during rat embryogenesis. Endocrinol. 128 (1991) 3122-3129
134. Robertson D.M., Foulds L.M., Prisk M., and Hedger M.P. Inhibin/activin β-subunit monomer: Isolation and characterization. Endocrinol. 130 (1992) 1680-1687
135. Robertson D.M., Giacometti M., Foulds L.M., Lahnstein J., Goss N.H., Hearn M.T.W., and de K.D.M. Isolation of inhibin α-subunit precursor proteins from bovine follicular fluid. Endocrinol. 125 (1989) 2141-2149
136. Sakai R., Eto Y., Ohtsuka M., Hirafuji M., and Shinoda H. Activin enhances osteoclast-hke cell formation in vitro. Biochem. Biophys. Res. Comm. 195 (1993) 39-46
137. Sampath T.K., Coughlin J.E., Whetstone R.M., Banach D., Corbett C., Ridge R.J., Özkaynak E., Oppermann H., and Rueger D.C. Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-β superfamily. J. Biol. Chem. 265 (1990) 13198-13205
138. Sampath T.K., Maliakal J.C., Hauschka P.V., Jones W.K., Sasak H., Tucker R.F., White K.H., Coughlin J.E., Tucker M.M., Pang R.H.L., Corbett C., Özkaynak E., Oppermann H., and Rueger D.C. Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro. J. Biol. Chem. 267 (1992) 20352-20362
139. Sampath T.K., and Reddi A.H. Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation. Proc. Natl. Acad. Sci., USA 78 (1981) 7599-7603
140. Sawchenko P.E., Plotsky P.M., Pfeiffer S.W., Cunningham E.T., Vaughan J., Rivier J., and Vale W. Inhibin β in central neural pathways involved in the control of oxytocin secretion. Nature 334 (1988) 615-617
141. Schaar D.G., Sieber B.-A., Dreyfus C.F., and Black I.B. Regional and cell-specific expression of GDNF in rat brain. Exp. Neurol. 124 (1993) 368-371
142. Schlunegger M.P., and Grütter M.G. An unusual feature revealed by the crystal structure at 2.2 A resolution of human transforming growth factor-β2. Nature 358 (1992) 430-434
143. Schubert D., Kimura H., LaCorbiere M., Vaughan J., Karr D., and Fischer W.H. Activin is a nerve cell survival molecule. Nature 344 (1990) 868-870
144. Schwall R.H., Robbins K., Jardieu P., Chang L., Lai C., and Terrell T.G. Activin induces cell death in hepatocytes in vivo and in vitr. Hepatol. 18 (1993) 347-356
145. Shimell M.J., Ferguson E.L., Childs S.R., and O'Connor M.B. The Drosophila dorsal-ventral patterning gene tolloid is related to human bone morphogenetic protein 1. Cell 67 (1991) 469-481
146. Shiozaki M., Sakai R., Tabuchi M., Eto Y., Kosaka M., and Shibai H. In vivo treatment with erythroid differentiation factor (EDF/Activin A) increases erythroid precursors (CFU-E and BFU-E) in mice. Biochem. Biophys. Res. Comm. 165 (1989) 1155-1161
147. Shiozaki M., Sakai R., Tabuchi M., Nakamura T., Sugino K., Sugino H., and Eto Y. Evidence for the participation of endogenous activin A/erythroid differentiation factor in the regulation of erythropoiesis. Proc. Natl. Acad. Sci. USA 89 (1992) 1553-1556
148. Smith J.C., Price B.M.J., van N., and K.Huylebroeck D. Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A. Nature 345 (1990) 729-731
149. Spencer S.J., Rabinovici J., and Jaffe R.B. Human recombinant activin-A inhibits proliferation of human fetal adrenal cells in vitro. J. Clin. Endocnnol. Metab. 71 (1990) 1678-1680
150. Spencer S.J., Rabinovici J., Mesiano S., Goldsmith P.C., and Jaffe R.B. Activm and inhibin in the human adrenal gland. J. Clin. Invest. 90 (1992) 142-149
151. Springer J.E., Mu X., Bergmann L.W., and Trojanowski J.Q. Expression of GDNF mRNA in rat and human nervous tissue. Exp. Neurol. 127 (1994) 167-170
152. Storm E.E., Huynh T.V., Copeland N.G., Jenkins N.A., Kingsley D.M., and Lee S.-J. Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamily. Nature 368 (1994) 639-643
153. Strömberg I., Bjorklund L., Johansson M., Tomac A., Collins F., Olson L., Hoffer B., and Humpel C. Glial cell line-derived neurotrophic factor is expressed in the developing but not adult striatum and stimulates developing dopamine neurons in vivo. Exp. Neurol. 124 (1993) 401-412
154. Tabas J.A., Hahn G.V., Cohen R.B., Seaunez H.N., Mosi W.S., Wozney J.M., Zasloff M., and Kaplan F.S. Chromosomal assignment of the human gene for bone morphogenetic protein 4. Clin. Orthopaed. Rel. Res. 293 (1993) 310-316
155. Tabas J.A., Zasloff M., Wasmuth J.J., Emanuel B.S., Altherr M.R., McPherson J.D., Wozney J.M., and Kaplan F.S. Bone morphogenetic protein: Chromosomal localization of human genes for BMP1, BMP2A, and BMP3. Genomics 9 (1991) 283-289
156. Takahashi M., Koide S.S., and Donahoe P.K. Miillerian inhibiting substance as oocyte meiosis inhibitor. Mol. Cell. Endocrinol. 47 (1986) 225-234
157. ten D., P .H., P .I., K .K.P., and C.Foulkes J.G. Identification of another member of the transforming growth factor type β gene family. Proc. Natl. Acad. Sci., USA 85 (1988) 4715-4719
158. Thomsen G., Woolf T., Whitman M., Sokol S., Vaughan J., Vale W., and Melton D.A. Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures. Cell 63 (1990) 485-493
159. Thomsen G.H., and Melton D.A. Processed Vgl protein is an axial mesoderm inducer in Xenopus. Cell 74 (1993) 433-441
160. Totsuka Y., Tabuchi M., Kojima I., Shibai H., and Ogata E. A novel action of activin A: Stimulation of insulin secretion in rat pancreatic islets. Biochem. Biophys. Res. Comm. 156 (1988) 335-339
161. Urist M.R. Bone: Formation by autoinduction. Science 150 (1965) 893-899
162. Urist M.R. In: Urist M.R., O'Conner B.T., and Burwell R.G. (Eds). Bone Grafts, Derivatives and Substitutes (1994), Butterworth Heinemann, London 315-362
163. Vainio S., Karavanova I., Jowett A., and Thesleff I. Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell 75 (1993) 45-58
164. Vale W., Hsueh A., Rivier C., and Yu J. In: Sporn M.B., and Roberts A.B. (Eds). Peptide Growth Factors and Their Receptors: Handbook of Experimental Pharmacology (1991), Springer-Verlag, Berlin 211-248
165. Vale W., Rivier J., Vaughan J., McClintock R., Corrigan A., Woo W., Karr D., and Spiess J. Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid. Nature 321 (1986) 776-779
166. van d.E.-v.R.A.J.M., Feijen A., Lawson K.A., and Mummery C.L. Differential expression of inhibin subunits and follistatin, but not of activin receptor type II, during early murine embryonic development. Dev. Biol. 154 (1992) 356-365
167. Vassalli A., Matzuk M.M., Gardner H.A.R., and Lee K.-F. Activin/inhibin βB subunit gene disruption leads to defects in eyelid development and female reproduction. Genes Dev. 8 (1994) 414-427
168. Vigier B., Watrin F., Magre S., Tran D., and Josso N. Purified bovine AMH induces a characteristic freemartin effect in fetal rat prospective ovaries exposed to it in vitro. Development 100 (1987) 43-55
169. Vukicevic S., Helder M.N., and Luyten F.P. Developing human lung and kidney are major sites for synthesis of bone morphogenetic protein-3 (Osteogenin). J. Histochem. Cytochem. 42 (1994) 869-875
170. Wang E.A., Rosen V., D'Alessandro J.S., Bauduy M., Cordes P., Harada T., Israel D.I., Hewick R.M., Kerns K.M., LaPan P., Luxenberg D.P., McQuaid D., Moutsatsos I.K., Nove J., and Wozney J.M. Recombinant human bone morphogenetic protein induces bone formation. Proc. Natl. Acad. Sci., USA 87 (1990) 2220-2224
171. Wilson C.A., di C., N .E., C .P., R .B.J., N .V., and B.Cate R.L. Müllerian inhibiting substance requires its N-terminal domain for maintenance of biological activity, a novel finding within the transforming growth factor-β superfamily. Mol. Endocrinol. 7 (1993) 247-257
172. Wozney J.M. The bone morphogenetic protein family and osteogenesis. Mol. Reprod. Dev. 32 (1992) 160-167
173. Int. Patent Application No. PCT/US92/05374. Wozney J.M., and Celeste A.J. BMP-9 Compositions (1993)
174. Wozney J.M., Rosen V., Celeste A.J., Mitsock L.M., Whitters M.J., Kriz R.W., Hewick R.M., and Wang E.A. Novel regulators of bone formation: Molecular clones and activities. Science 242 (1988) 1528-1534
175. Yamashita N., Nakajima T., Takahashi H., Kaneoka H., Mizushima Y., and Sakane T. Effects of activin A on IgE synthesis and cytokine production by human peripheral mononuclear cells. Clin. Exp. Immunol. 94 (1993) 214-219
176. Yasuda H., Inoue K., Shibata H., Takeuchi T., Eto Y., Hasegawa Y., Sekine N., Totsuka Y., Mine T., Ogata E., and Kojima I. Existence of activin-A in A- and D-cells of rat pancreatic islet. Endocrinol. 133 (1993) 624-630
177. Yasuda H., Mine T., Shibata H., Eto Y., Hasegawa Y., Takeuchi T., Asano S., and Kojima I. Activin A: An autocrine inhibitor of initiation of DNA synthesis in rat hepatocytes. J. Clin. Invest. 92 (1993) 1491-1496
178. Yu J., Shao L.-E., Lemas V., Yu A.L., Vaughan J., Rivier J., and Vale W. Importance of FSH-releasing protein and inhibin in erythrodifferentiation. Nature 330 (1987) 765
179. Yu J., Shao L.-E., Vaughan J., Vale W., and Yu A.L. Characterization of the potentiation effect of activin on human erythroid colony formation in vitro. Blood 73 (1989) 952-960
180. Zhou B., Watts L.M., and Hutson J.M. Germ cell development in neonatal mouse testes in vitro requires Müllerian inhibiting substance. J. Urol. 150 (1993) 613-616
181. Zhou X., Sasaki H., Lowe L., Hogan B.L.M., and Kuehn MR. Nodal is a novel TGF-β-like gene expressed in the mouse node during gastrulation. Nature 361 (1993) 543-547