What can we learn from experimental ischemia research?

Cerebrovascular Diseases

Volumn 7, Issue 6, 1997, Pages 315-317

  Hossmann, K A ^a  

^a MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD FLOW; BRAIN INJURY; BRAIN ISCHEMIA; CEREBROVASCULAR DISEASE; EDITORIAL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; THERAPY;

EID: 0030780585     PISSN: 10159770     EISSN: 14219786     Source Type: Journal    
DOI: 10.1159/000108213     Document Type: Editorial

References (9)

1. Siesjö BK, Zhao Q, Pahlmark K, Siesjo P, Kat-sura K, Folbergrova J: Glutamalc, calcium, and free radicals as mediators of ischemic brain damage. Ann Thorac Surg 1995.59:1316-1320.
2. Choi DW: Calcium: Still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci 1995:18:58-60.
3. Chopp M, Li Y. Jiang N, Zhang RL, Prostak J: Antibodies against adhesion molecules reduce apoptosis after transient middle cerebral artery occlusion in rat brain. J Ccrcb Blood Flow Metab 1996:16:578-584.
4. Irikura K, Huang PL, Ma JY, Lee WS, Dalkara T, Fishman MC, Dawson TM, Snyder SH, Moskowitz MA: Cerebrovascular alterations in mice lacking neuronal nitric oxide synthase gene expression. Proc Nat Acad Sci USA 1995: 92:6823-6827.
5. Chan PH: Role of oxidants in ischemic brain damage. Stroke 1996;27:l 124.
6. Del Zoppo GJ: Why do all drugs work in animals but none in stroke patients? 1. Drugs promoting cerebral blood flow. J Intern Med 1995; 237:79-88.
7. Grotta J: Why do all drugs work in animals but none in stroke patients? 2. Neuroprolective therapy. J Intern Med 1995:237:89-94.
8. Xue D, Slivka A, Buchan AM: Tirilazad reduces cortical infarction alter transient but not permanent focal cerebral ischemia in rats. Stroke 1992:23:894-899.
9. Scott P, Barsan W, Frederiksen S, Kroniek S, Zink BJ, Domeier RM, Mitchincr JC, Judge FP, Levy RJ, et al: A randomized trial in tirilazad mesylate in patients with acute stroke (RANTTAS). Stroke 1996:27:1453-1458.