Identification and characterization of an auto-activating MEK kinase from bovine brain: Phosphorylation of serine-298 in the proline-rich domain of the mammalian MEKs

International Journal of Biochemistry and Cell Biology

Volumn 29, Issue 8-9, 1997, Pages 1071-1083

  Wang, Jingxiong ^a,b   Vantus, Tibor ^a,c   Merlevede, Wilfried ^a   Vandenheede, Jackie R ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b Xinjiang Medical College   (China)

^c SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

Author keywords

Autophosphorylation; Mammalian; MAP kinase pathway; MEK; Protein kinase; Signal transduction

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE; SERINE; THREONINE;

ANIMAL TISSUE; ARTICLE; AUTOPHOSPHORYLATION; BRAIN; CATTLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME CHEMISTRY; ENZYME PHOSPHORYLATION; ENZYME PURIFICATION; MAMMAL; NONHUMAN; PROTO ONCOGENE;

AMINO ACID SEQUENCE; ANIMALS; BRAIN; CATTLE; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PHOSPHOSERINE; PROLINE; PROTEIN DENATURATION; PROTEIN-SERINE-THREONINE KINASES; SUBSTRATE SPECIFICITY;

ANIMALIA; BOS TAURUS; BOVINAE; MAMMALIA;

EID: 0030778364     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(97)00054-X     Document Type: Article

References (26)

1. Beyaert R., Cuenda A., Vanden Berghe W., Plaisance S., Lee J. C., Haegeman G., Cohen P. and Fiers W. (1996) The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumour necrosis factor. EMBO J. 15, 1914-1925.
2. Bokemeyer D., Sorokin A. and Dunn M. J. (1996) Multiple intracellular MAP kinase signaling cascades. Kidney Int. 49, 1187-1198.
3. Brewster J. L., de Valoir T., Dwyer N. D., Winter E. and Gustin M. C. (1993) An osmo-sensing signal transduction pathway in yeast. Science 259, 1760-1763.
4. Catling A. D., Schaeffer H.-J., Reuter C. W. M., Reddy G. R. and Weber M. J. (1995) A proline-rich sequence unique to MEK1 and MEK2 is required for Raf binding and regulates MEK function. Mol. Cell. Biol. 15, 5214-5225.
5. Cicirelli M., Pelech S. L. and Krebs E. G. (1988) Activation of multiple protein kinases during the burst in protein phosphorylation that precedes the first meiotic cell division in Xenopus oocytes. J. Biol. Chem. 263, 2009-2019.
6. Derijard B., Hibi M., Wu I.-H., Barret T., Su B., Deng T., Karin M. and Davis R. J. (1994) JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76, 1025-1037.
7. Errede B., Cade R. M., Yashar B. M., Kamada Y., Levin D. E., Irie K. and Matsumoto K. (1995) Dynamics and organization of MAP kinase signal pathways. Mol. Reprod. Dev. 42, 477-485.
8. Gotoh Y., Nishida E., Yamashita T., Hoshi M., Kawakami M. and Sakai H. (1990) Microtubule-associated-protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells. Identity with the mitogen-activated MAP kinase of fibroblastic cells. Cell Regul. 2, 663-673.
9. Guo H., Reddy S. A. G. and Damuni Z. (1993) Purification and characterization of an autophosphorylation-activated protein serine threonine kinase that phosphorylates and inactivates protein phosphatase 2A. J. Biol. Chem. 268, 11193-11198.
10. Han J., Lee J.-D., Bibbs L. and Ulevitch R. J. (1994) A MAP kinase targeted by endotoxin and hyperosmolality in mammalian cells. Science 265, 808-811.
11. 2--inhibitable protein kinase that phosphorylates microtubule-associated protein 2 in vitro by growth factors, phorbol esters, and serum in quiescent cultured human fibroblasts. J. Biol. Chem. 263, 5396-5401.
12. Kyriakis J. M., Bannerjee P., Nikolakaki E., Dai T., Ruble E. A., Ahmad M. F., Avruch J. and Woodgett J. R. (1994) The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369, 165-170.
13. Kyriakis J. M., Force T. L., Rapp U. R., Bonventre J. V. and Avruch J. (1993) Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase. J. Biol. Chem. 268, 16009-16019.
14. Pelech S. L. and Charest D. L. (1995) MAP kinase-dependent pathways in cell cycle control. Progr. Cell Cycle Res. 1, 33-51.
15. Pelech S. L., Tombes R. M., Meijer L. and Krebs E. G. (1988) Activation of myelin basic protein kinases during echinoderm oocyte maturation and egg fertilization. Dev. Biol. 130, 28-36.
16. Posada J., Sanghera J. S., Pelech S. L., Aebersold R. and Cooper J. (1991) Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts. Mol. Cell. Biol. 11, 2517-2528.
17. Raingeaud J., Gupta S., Rogers J. S., Dickens M., Han J., Ulevitch R. J. and Davis R. J. (1995) Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270, 7420-7426y.
18. Ray L. B. and Sturgill T. W. (1987) Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro. Proc. Natl. Acad. Sci. U.S.A. 84, 1502-1506.
19. Rossomando A. J., Dent P., Sturgill T. W. and Marshak D. R. (1994) Mitogen-activated protein kinase kinase 1 (MKK1) is negatively regulated by threonine phosphorylation. Mol. Cell. Biol. 14, 1594-1602.
20. Sutherland C. and Cohen P. (1994) The α-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro. FEBS Lett. 338, 37-42.
21. Sutherland C., Leighton I. A. and Cohen P. (1993) Inactivation of glycogen synthase kinase-3β by phosphorylation: new kinase connections in insulin and growth-factor signalling. Biochem. J. 296, 15-19.
22. Tung L. H. Y., Resink T. J., Hemmings B. A., Shenolikar S. and Cohen P. (1984) The catalytic subunits of protein phosphatase-1 and protein phosphatase 2A are distinct gene products. Eur. J. Biochem. 138, 635-641.
23. Van Lint J., Van Damme J., Billiau A., Merlevede W. and Vandenheede J. R. (1993) Interleukin-8 activates microtubule-associated protein 2 kinase (ERK1) in human neutrophils. Mol. Cell. Biochem. 127/128, 171-177.
24. Wu J., Harrison J. K., Dent P., Lynch K. R., Weber M. J. and Sturgill T. W. (1993) Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2. Mol. Cell. Biol. 13, 5439-5448.
25. 2 + -independent protein kinase in the brain. J. Biol. Chem. 262, 7034-7040.
26. Yashar B., Irie K., Printen J. A., Stevenson B. J., Sprague G. F., Matsumoto K. and Errede B. (1995) Yeast MEK-dependent signal transduction: response thresholds and parameters affecting fidelity. Mol. Cell. Biol. 15, 6545-6553.