Antagonistic effect of orphanin FQ on opioid analgesia in rat

Acta Pharmacologica Sinica

Volumn 19, Issue 1, 1998, Pages 10-14

  Zhu, Chong Bin ^a   Zhang, Xiu Lin ^b   Xu, Shao Fen ^a   Cao, Xiao Ding ^a   Wu, Gen Cheng ^a   Li, Mo Yi ^c   Cui, Da Fu ^c   Qi, Zheng Wu ^c  

^a FUDAN UNIVERSITY   (China)

^b Ji nan Mil Med Sch Shandong Prov   (China)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

Delta opioid receptor; Kappa opioid receptor; Mu opioid receptor; Nociceptors; Opioid analgesics; Orphanin FQ

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; DELTA OPIATE RECEPTOR; FENTANYL; KAPPA OPIATE RECEPTOR; LEUCINE ENKEPHALIN[2 DEXTRO SERINE 6 THREONINE]; MU OPIATE RECEPTOR; NOCICEPTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG MECHANISM; DRUG MIXTURE; HYPERALGESIA; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRATHECAL DRUG ADMINISTRATION; MALE; NOCICEPTION; NONHUMAN; PAIN THRESHOLD; RAT; TAIL FLICK TEST;

EID: 0031906417     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Mollereau C, Parmentier M, Mailleux P, Butour J-L, Moisand C, Chalon P, et al. ORL1, a novel member of the opioid receptor family: cloning, functional expression and localization. FEBS Lett 1994; 341; 33-8.
2. Bunzow JR, Saez C, Mortrud M, Bouvier C, Williams JT, Low M, et al. Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ, or κ opioid receptor type. FEBS Lett 1994; 347: 284-8.
3. Fukuda K, Kato S, Mori K, Nishi M, Takeshima H, Iwabe N, et al. cDNA cloning and regional distribution of a novel member of the opioid receptor family. FEBS Lett 1994; 342: 42-6.
4. Wick MJ, Minnerath SR, Lin X, Elde R, Law PY, Loh HH. Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned μ, δ, and κ opioid receptors. Mol Brain Res 1994; 27: 37-44.
5. Meunier J-C, Mollereau C, Toll L, Suaudeau C, Moisand C, Alvinerie P, et al. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature 1995; 377: 532-5.
6. Reinscheid RK, Nothacker H-P, Bourson A, Ardati A, Henningsen RA, Bunzow JR, et al. Orphanin FQ: A neuropeptide that activates an opioidlike G-protein-coupled receptor. Science 1995; 270: 792-4.
7. Yang HL, Luo RS, Wang LX, Zhu DX, Chi CW. Primary structure and disulfide bridge location of arrowhead double-headed proteinase inhibitors. J Biochem 1992; 111: 537-45.
8. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983; 16: 109-10.
9. Zhou, KR, Lu WX, Sheng MP, Xu SF. Intracerebroventricular injection of metorphamide induced hypotensive and bradycardia effects and their mechanism. Acta Phiysiol Sin 1988; 40: 43-51.
10. Yaksh TL, Rudy TA. Chronic catheterization of the spinal subarachnoid space. Physiol Behav 1976; 17: 1031-6.
11. Zhu CB, Liu YH, Xu SF. Increase in opioid receptor binding sites in rat brain during acupuncture analgesia enhanced by droperidol: an autoradiographic study. Chin J Neurosci 1995; 2: 7-13.
12. Rossi GC, Leventhal L, Pasternak GW. Naloxone sensitive orphanin FQ-induced analgesia in mice. Eur J Pharmacol 1996; 311: R7-8.
13. Noble F, Montiel JL, Cornille F, Fournié-Zaluski MC, Roques BP. Pharmacological study of orphanin: role in the pain control. 27th Meeting of the International Narcotics Research Conference; 1996 Jul 21-26; California, USA.
14. Reinscheid RK, Ardati A, Monsma FJ Jr, Civelli O. Structure-activity relationship studies on the novel neuropeptide orphanin FQ. J Biol Chem 1996; 271: 14163-8.
15. Zhu CB, Xu SF, Cao XD, Wu GC, Zhang XL, Li MY, et at. Antagonistic action of orphanin FQ on acupuncture analgesia in rat brain. Acupunct Electrother Res 1996; 21: 199-205.