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Volumn 110, Issue 2, 1997, Pages 167-173

A double blind, placebo-controlled, crossover therapy study with natural human IL-2 (nhuIL-2) in combination with regular intravenous gammaglobulin (IVIG) infusions in 10 patients with common variable immunodeficiency (CVID)

Author keywords

Common variable immunodeficiency; IL 2; NhuIL 2 therapy

Indexed keywords

IMMUNOGLOBULIN; INTERLEUKIN 2; PLACEBO;

EID: 0030776087     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.1997.tb08313.x     Document Type: Article
Times cited : (23)

References (39)
  • 1
    • 0026710007 scopus 로고
    • Primary immunodeficiency diseases: Report of a WHO Scientific Group
    • WHO Scientific Group. Primary immunodeficiency diseases: report of a WHO Scientific Group. Immunodefic Rev 1992; 3:195-236.
    • (1992) Immunodefic Rev , vol.3 , pp. 195-236
  • 2
    • 0028985611 scopus 로고
    • Primary immunodeficiency diseases
    • WHO Scientific Group. Primary immunodeficiency diseases. Clin Exp Immunol 1995; 99 (Suppl. 1):10-19.
    • (1995) Clin Exp Immunol , vol.99 , Issue.1 SUPPL. , pp. 10-19
  • 5
    • 0024395025 scopus 로고
    • The failure of B cells in common variable immunodeficiency to transit from proliferation to differentiation is associated with altered B cell surface display
    • Saxon A, Giorgi JV, Sherr EH, Kagan JM. The failure of B cells in common variable immunodeficiency to transit from proliferation to differentiation is associated with altered B cell surface display. J Allergy Clin Immunol 1989; 841:44-55.
    • (1989) J Allergy Clin Immunol , vol.841 , pp. 44-55
    • Saxon, A.1    Giorgi, J.V.2    Sherr, E.H.3    Kagan, J.M.4
  • 7
    • 0025614055 scopus 로고
    • Cellular abnormalities in common variable immunodeficiency
    • Spickett GP, Webster ADB, Farrant J. Cellular abnormalities in common variable immunodeficiency. Immunodef Rev 1990; 2:199-219.
    • (1990) Immunodef Rev , vol.2 , pp. 199-219
    • Spickett, G.P.1    Webster, A.D.B.2    Farrant, J.3
  • 8
    • 0025771260 scopus 로고
    • Defects in proliferative responses of T cells from patients with common variable immunodeficiency on direct activation of protein kinase C
    • North ME, Spickett GP, Allsop J. Defects in proliferative responses of T cells from patients with common variable immunodeficiency on direct activation of protein kinase C. Clin Exp Immunol 1991; 85:198-201.
    • (1991) Clin Exp Immunol , vol.85 , pp. 198-201
    • North, M.E.1    Spickett, G.P.2    Allsop, J.3
  • 9
    • 0026672437 scopus 로고
    • Immunophenotypical alterations in a subset of patients with common variable immunodeficiency (CVID)
    • Baumert E, Wolff-Vorbeck G, Schlesier M, Peter HH. Immunophenotypical alterations in a subset of patients with common variable immunodeficiency (CVID). Clin Exp Immunol 1992; 90:25-30.
    • (1992) Clin Exp Immunol , vol.90 , pp. 25-30
    • Baumert, E.1    Wolff-Vorbeck, G.2    Schlesier, M.3    Peter, H.H.4
  • 10
    • 0028358766 scopus 로고
    • Failure in antigen responses by T cells from patients with common variable immunodeficiency (CVID)
    • Stagg AJ, Funauchi M, Knight SC, Webster ADB, Farrant J. Failure in antigen responses by T cells from patients with common variable immunodeficiency (CVID). Clin Exp Immunol 1994; 96:48-53.
    • (1994) Clin Exp Immunol , vol.96 , pp. 48-53
    • Stagg, A.J.1    Funauchi, M.2    Knight, S.C.3    Webster, A.D.B.4    Farrant, J.5
  • 11
    • 0028003720 scopus 로고
    • A defect in early phase of T-cell receptor-mediated T-cell activation in patients with common variable immunodeficiency
    • Fischer MB, Hauber I, Eggenbauer H et al. A defect in early phase of T-cell receptor-mediated T-cell activation in patients with common variable immunodeficiency. Blood 1994; 84:4234-41.
    • (1994) Blood , vol.84 , pp. 4234-4241
    • Fischer, M.B.1    Hauber, I.2    Eggenbauer, H.3
  • 13
    • 0024567143 scopus 로고
    • The role of lymphokines in common variable hypogammaglobulinemia
    • Spickett GP, Farrant J. The role of lymphokines in common variable hypogammaglobulinemia. Immunol Today 1989; 6:192-4.
    • (1989) Immunol Today , vol.6 , pp. 192-194
    • Spickett, G.P.1    Farrant, J.2
  • 14
    • 0024391052 scopus 로고
    • Peripheral blood lymphocytes of patients with common variable immunodeficiency (CVID) produce reduced levels of interleukin 4, interleukin 2 and interferon-gamma, but proliferate normally upon activation by mitogens
    • Pastorelli G, Roncarlo MG, Touraine JL, Peronne G, Tovo PA, De Vries JE. Peripheral blood lymphocytes of patients with common variable immunodeficiency (CVID) produce reduced levels of interleukin 4, interleukin 2 and interferon-gamma, but proliferate normally upon activation by mitogens. Clin Exp Immunol 1989; 78:334-40.
    • (1989) Clin Exp Immunol , vol.78 , pp. 334-340
    • Pastorelli, G.1    Roncarlo, M.G.2    Touraine, J.L.3    Peronne, G.4    Tovo, P.A.5    De Vries, J.E.6
  • 15
    • 0027254675 scopus 로고
    • Defective interleukin-2 and interferon-γ gene expression in response to antigen in a subgroup of patients with common variable immuno-deficiency
    • Fischer MB, Hauber I, Vogel E, Wolf HM, Mannhalter JW, Eibl MM. Defective interleukin-2 and interferon-γ gene expression in response to antigen in a subgroup of patients with common variable immuno-deficiency. J Allergy Clin Immunol 1993; 92:340-52.
    • (1993) J Allergy Clin Immunol , vol.92 , pp. 340-352
    • Fischer, M.B.1    Hauber, I.2    Vogel, E.3    Wolf, H.M.4    Mannhalter, J.W.5    Eibl, M.M.6
  • 17
    • 0028827446 scopus 로고
    • Alterations in interleukin secretion (IL-2 and IL-4) by CD4 and CD4 CD45RO cells from common variable immunodeficiency (CVI) patients
    • Ferrer JM, Iglesias J, Hernandez M, Matamoros N. Alterations in interleukin secretion (IL-2 and IL-4) by CD4 and CD4 CD45RO cells from common variable immunodeficiency (CVI) patients. Clin Exp Immunol 1995; 102:286-9.
    • (1995) Clin Exp Immunol , vol.102 , pp. 286-289
    • Ferrer, J.M.1    Iglesias, J.2    Hernandez, M.3    Matamoros, N.4
  • 18
    • 0028935638 scopus 로고
    • Reduced IL-2 expression upon antigen stimulation is accompanied by deficient IL9 gene expression in T cells of patients with CVID
    • Hauber I, Fischer MB, Maris M, Eibl MM. Reduced IL-2 expression upon antigen stimulation is accompanied by deficient IL9 gene expression in T cells of patients with CVID. Scand J Immunol 1995; 41:215-9.
    • (1995) Scand J Immunol , vol.41 , pp. 215-219
    • Hauber, I.1    Fischer, M.B.2    Maris, M.3    Eibl, M.M.4
  • 19
    • 0026710448 scopus 로고
    • Possible role of IL2 deficiency for hypogammaglobulinemia in patients with common variable immunodeficiency
    • Rump JA, Jahreis A, Schlesier M, Dräger R, Melchers I, Peter HH. Possible role of IL2 deficiency for hypogammaglobulinemia in patients with common variable immunodeficiency. Clin Exp Immunol 1992; 89:204-10.
    • (1992) Clin Exp Immunol , vol.89 , pp. 204-210
    • Rump, J.A.1    Jahreis, A.2    Schlesier, M.3    Dräger, R.4    Melchers, I.5    Peter, H.H.6
  • 20
    • 0027323830 scopus 로고
    • Interleukin 10 and immune restoration in common variable immunodeficiency
    • Zielen S, Bauscher P, Hofmann D, Meuer SC. Interleukin 10 and immune restoration in common variable immunodeficiency. Lancet 1993; 342:750-1.
    • (1993) Lancet , vol.342 , pp. 750-751
    • Zielen, S.1    Bauscher, P.2    Hofmann, D.3    Meuer, S.C.4
  • 21
    • 0031024697 scopus 로고    scopus 로고
    • IL-4 synergizes with IL-10 and anti-CD40 MoAbs to induce B-cell differentiation in patients with common variable immunodeficiency
    • Punnonen J, Kainulainen L, Ruuskanen O, Nikoskelainen J, Arvilommi H. IL-4 synergizes with IL-10 and anti-CD40 MoAbs to induce B-cell differentiation in patients with common variable immunodeficiency. Scand J Immunol 1997; 45:203-12.
    • (1997) Scand J Immunol , vol.45 , pp. 203-212
    • Punnonen, J.1    Kainulainen, L.2    Ruuskanen, O.3    Nikoskelainen, J.4    Arvilommi, H.5
  • 22
    • 0027729826 scopus 로고
    • Ami-CD28 enhances defective mitogen responses by mononuclear cells from patients with common variable immunodeficiency
    • North ME, Akbar A, Borthwick N, Webster ADB. Ami-CD28 enhances defective mitogen responses by mononuclear cells from patients with common variable immunodeficiency. Immunodeficiency 1993; 4:17-18.
    • (1993) Immunodeficiency , vol.4 , pp. 17-18
    • North, M.E.1    Akbar, A.2    Borthwick, N.3    Webster, A.D.B.4
  • 23
    • 0028229768 scopus 로고
    • Co-stimulation with anti-CD28 (Kolt-2) enhance DNA synthesis by defective T-cells in common variable immunodeficiency
    • North ME, Akbar AN, Borthwick N, Sagawa K, Funauchi M, Webster ADB. Co-stimulation with anti-CD28 (Kolt-2) enhance DNA synthesis by defective T-cells in common variable immunodeficiency. Clin Exp Immunol 1994; 95:204-8.
    • (1994) Clin Exp Immunol , vol.95 , pp. 204-208
    • North, M.E.1    Akbar, A.N.2    Borthwick, N.3    Sagawa, K.4    Funauchi, M.5    Webster, A.D.B.6
  • 24
    • 0028228596 scopus 로고
    • The costimulatory signal CD28 is fully functional but cannot correct the impaired antigen response in T cells of patients with common variable immuno-deficiency
    • Fischer MB, Wolf HM, Eggenbauer H et al. The costimulatory signal CD28 is fully functional but cannot correct the impaired antigen response in T cells of patients with common variable immuno-deficiency. Clin Exp Immunol 1994; 95:209-14.
    • (1994) Clin Exp Immunol , vol.95 , pp. 209-214
    • Fischer, M.B.1    Wolf, H.M.2    Eggenbauer, H.3
  • 25
    • 0031060671 scopus 로고    scopus 로고
    • Transient CD80 expression defect in a patient with variable immunodeficiency and cyclic neutropenia
    • Moser C, Schlesier M, Dräger R, Eibel H, Peter HH. Transient CD80 expression defect in a patient with variable immunodeficiency and cyclic neutropenia. Int Arch Allergy Immunol 1997; 112:96-99.
    • (1997) Int Arch Allergy Immunol , vol.112 , pp. 96-99
    • Moser, C.1    Schlesier, M.2    Dräger, R.3    Eibel, H.4    Peter, H.H.5
  • 26
    • 0028011077 scopus 로고
    • CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency
    • Farrington M, Grosmaire LS, Nonoyama S et al. CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency. Proc Natl Acad Sci USA 1994; 91:1099-103.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 1099-1103
    • Farrington, M.1    Grosmaire, L.S.2    Nonoyama, S.3
  • 27
    • 0028024701 scopus 로고
    • Effect on immunoglobulin production by anti-CD40-activated human B cells: Synergistic effect with IL-10 and antagonistic effect with IL-4
    • Nonoyama S, Farrington ML, Ochs HD. Effect on immunoglobulin production by anti-CD40-activated human B cells: synergistic effect with IL-10 and antagonistic effect with IL-4. Clin Immunol Immunopathol 1994; 72:373-9.
    • (1994) Clin Immunol Immunopathol , vol.72 , pp. 373-379
    • Nonoyama, S.1    Farrington, M.L.2    Ochs, H.D.3
  • 29
    • 0025353943 scopus 로고
    • Classification of patients with common variable immuno-deficiency by B cell secretion of IgM and IgG in response to anti-IgM and interleukin-2
    • Bryant A, Calver NC, Toubi E, Webster ADB, Farrant J. Classification of patients with common variable immuno-deficiency by B cell secretion of IgM and IgG in response to anti-IgM and interleukin-2. Clin Immunol Immunopathol 1990; 56:239-48.
    • (1990) Clin Immunol Immunopathol , vol.56 , pp. 239-248
    • Bryant, A.1    Calver, N.C.2    Toubi, E.3    Webster, A.D.B.4    Farrant, J.5
  • 30
    • 0023907493 scopus 로고
    • Interleukin-2: Inception impact and implications
    • Smith KA. Interleukin-2: inception impact and implications. Science 1988; 240:1169-76.
    • (1988) Science , vol.240 , pp. 1169-1176
    • Smith, K.A.1
  • 31
    • 0024390798 scopus 로고
    • Pleiotropy and redundancy: T cell-derived lymphokines in the immune response
    • Paul WE. Pleiotropy and redundancy: T cell-derived lymphokines in the immune response. Cell 1989; 57:521-4.
    • (1989) Cell , vol.57 , pp. 521-524
    • Paul, W.E.1
  • 33
    • 0027293065 scopus 로고
    • Activated B cells from patients with common variable immunodeficiency proliferate and synthesize immunoglobulin
    • Nonoyama S, Farrington M, Ishida H, Howard M, Ochs HD. Activated B cells from patients with common variable immunodeficiency proliferate and synthesize immunoglobulin. J Clin Invest 1993; 92:1282-7.
    • (1993) J Clin Invest , vol.92 , pp. 1282-1287
    • Nonoyama, S.1    Farrington, M.2    Ishida, H.3    Howard, M.4    Ochs, H.D.5
  • 34
    • 0024585663 scopus 로고
    • Low dose interleukin 2 induces systemic immune responses against HbsAg in immunodeficient non responders to hepatitis B vaccination
    • Meuer SC, Dumann H, Meyer zum Büschelfelde KH, Kohler H. Low dose interleukin 2 induces systemic immune responses against HbsAg in immunodeficient non responders to hepatitis B vaccination. Lancet 1989; 1:15-17.
    • (1989) Lancet , vol.1 , pp. 15-17
    • Meuer, S.C.1    Dumann, H.2    Meyer Zum Büschelfelde, K.H.3    Kohler, H.4
  • 35
    • 0026683682 scopus 로고
    • Restoration of immunoglobulin secretion in vitro in common variable immuno-deficiency by in vivo treatment with polyethylene glycol-conjugated human recombinant interleukin-2
    • Cunningham-Rundles C, Mayer L, Sapira E, Mendelsohn L. Restoration of immunoglobulin secretion in vitro in common variable immuno-deficiency by in vivo treatment with polyethylene glycol-conjugated human recombinant interleukin-2. Clin Immunol Immunopathol 1992; 64:46-56.
    • (1992) Clin Immunol Immunopathol , vol.64 , pp. 46-56
    • Cunningham-Rundles, C.1    Mayer, L.2    Sapira, E.3    Mendelsohn, L.4
  • 36
    • 0027770890 scopus 로고
    • Potential use of polyethyleneglycol conjugated recombinant IL-2 in common variable immunodeficiency
    • Cunningham-Rundles C, Kasbay K, Mayer L. Potential use of polyethyleneglycol conjugated recombinant IL-2 in common variable immunodeficiency. Immunodeficiency 1993; 4:31-36.
    • (1993) Immunodeficiency , vol.4 , pp. 31-36
    • Cunningham-Rundles, C.1    Kasbay, K.2    Mayer, L.3
  • 37
    • 0028024183 scopus 로고
    • Brief report: Enhanced humoral immunity in common variable immunodeficiency after long-term treatment with polyethyleneglycol conjugated interleukin-2
    • Cunningham-Rundles C, Kazbay K, Hassett J, Zhou Z, Mayer L. Brief report: enhanced humoral immunity in common variable immunodeficiency after long-term treatment with polyethyleneglycol conjugated interleukin-2. N Engl J Med 1994; 331:918-21.
    • (1994) N Engl J Med , vol.331 , pp. 918-921
    • Cunningham-Rundles, C.1    Kazbay, K.2    Hassett, J.3    Zhou, Z.4    Mayer, L.5
  • 38
    • 0028168333 scopus 로고
    • Ligation of leucocyte function-associated (LFA) molecule-1 provides an accessory signal for T-cell activation with pokeweed mitogen
    • Wallays G, Ceuppens JL. Ligation of leucocyte function-associated (LFA) molecule-1 provides an accessory signal for T-cell activation with pokeweed mitogen. Scand J Immunol 1994; 39:137-43.
    • (1994) Scand J Immunol , vol.39 , pp. 137-143
    • Wallays, G.1    Ceuppens, J.L.2
  • 39
    • 0024538472 scopus 로고
    • Clinical and immunologic analyses of 103 patients with common variable immunodeficiency
    • Cunningham-Rundles C. Clinical and immunologic analyses of 103 patients with common variable immunodeficiency. J Clin Immunol 1989; 9:22-33.
    • (1989) J Clin Immunol , vol.9 , pp. 22-33
    • Cunningham-Rundles, C.1


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