Genetic analysis of the role of Eph receptors in the development of the mammalian nervous system

Cell and Tissue Research

Volumn 290, Issue 2, 1997, Pages 209-215

  Frisén, Jonas ^a,b   Barbacid, Mariano ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Axon fasciculation; Axon guidance; Cell migration; Topographic maps; Tyrosine kinase receptors

Indexed keywords

PROTEIN TYROSINE KINASE;

ARTICLE; CELL MIGRATION; GENETIC ANALYSIS; MOUSE; MOUSE MUTANT; NERVE FIBER; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; AXONS; CELL MOVEMENT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MICE; NERVOUS SYSTEM; NEURONS; RECEPTOR PROTEIN-TYROSINE KINASES;

MAMMALIA;

EID: 0030775337     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410050925     Document Type: Article

References (52)

1. Brambilla R, Schnapp A, Casagranda F, Labrador JP, Bergemann AD, Flanagan JG, Pasquale EB, Klein R (1995) Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine protein kinases. EMBO J 14:3116-3126
2. Brambilla R, Brückner K, Orioli D, Bergemann AD, Flanagan JG, Klein R (1996) Similarities and differences in the way transmembrane-type ligands interact with the Elk subclass of Eph receptors. Mol Cell Neurosci 8:199-209
3. Brennan C, Monschau B, Lindberg R, Guthrie B, Drescher U, Bonhoeffer F, Holder N (1997) Two Eph receptor tyrosine protein kinase ligands control axon growth and may be involved in the creation of the retinotectal map in the zebrafish. Development 124:655-664
4. Brückner K, Pasquale EB, Klein R (1997) Tyrosine phosphorylation of transmembrane ligands for eph receptors. Science 275:1640-1643
5. Chen J, Nachabah A, Scherer C, Ganju P, Reith A, Bronson R, Ruley HE (1996) Germ-line inactivation of the murine Eck receptor kinase by gene trap retroviral insertion. Oncogene 12:979-988
6. Cheng H-J, Nakamoto M, Bergemann AD. Flanagan JG (1995) Complementary gradients in expression and binding of Elf-1 and Mek4 in development of the topographic retinotectal projection map, Cell 82:371-381
7. Ciossek T, Millauer B, Ullrich A (1995) Identification of alternatively spliced mRNAs encoding variants of MDK1, a novel receptor tyrosine protein kinase expressed in the murine nervous system. Oncogene 11:97-108
8. Connor RJ, Pasquale EB (1995) Genomic organisation and alternatively processed forms of Cek5, a receptor protein-tyrosine protein kinase of the Eph subfamily. Oncogene 11:2429-2438
9. Davis S, Gale NW, Aldrich TH, Maisonpierre PC, Lhotak V, Pawson T, Goldfarb M, Yancopoulos GD (1994) Ligands for EPH-related receptor tyrosine protein kinases that require membrane attachment or clustering for activity. Science 266:816-819
10. Donoghue MJ, Lewis RM, Merlie JP, Sanes JR (1996) The Eph kinase ligand AL-1 is expressed by rostral muscles and inhibits outgrowth from caudal neurons. Mol Cell Neurosci 8:185-198
11. Drescher U, Kremoser C, Handwerker C, Löschinger J, Noda M, Bonhoeffer F (1995) In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine protein kinases. Cell 82:359-370
12. Ellis C, Kasmi F, Ganju P, Walls E, Panayotou G, Reith AD (1996) A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine protein kinase, Sek, mediates high affinity interaction with p59fyn. Oncogene 12:1727-1736
13. Eph Nomenclature committee (1997) Unified nomenclature for Eph family receptors and their ligands, the ephrins. Cell 90:403-404
14. Flenniken AM, Gale NW, Yancopoulos GD, Wilkinson DG (1996) Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine protein kinases during mouse embryo-genesis. Dev Biol 179:382-401
15. Friedman GC, O'Leary DMM (1996) Retroviral missexpression of engrailed genes in the chick optic tectum perturbs the topographic targeting of retinal axons. J Neuroscience 17:5498-55509
16. Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE, Henkemeyer M, Strebhardt K, Hirai H, Wilkinson DG. Pawson T, Davis S, Yancopoulos GD (1996) Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron 17:9-19
17. Gao P-P, Zhang J-H, Yokoyama M, Racey B, Dreyfus C F, Black I B, Zhou R (1996) Regulation of topographic projection in the brain: Elf-1 in the hippocamposeptal system. Proc Natl Acad Sci USA 93:11161-11166
18. Gurniak CB, Berg LJ (1996) A new member of the Eph family of receptors that lacks protein tyrosine protein kinase activity. Oncogene 13:777-786
19. Henkemeyer M, Orioli D, Henderson JT, Saxton TM, Roder J, Pawson T, Klein R (1996) Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell 86:35-46
20. Holash JA, Pasquale EB (1995) Polarized expression of the receptor protein tyrosine protein kinase Cek5 in the developing avian visual system. Dev Biol 172:683-693
21. Holland SJ, Gale NW, Mbamalu G, Yancopoulos GD, Henkemeyer M, Pawson T (1996) Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands. Nature 383:722-725
22. tasaki N, Nakamura H (1996) A role for gradient en expression in positional specification on the optic tectum. Neuron 16:55-62
23. IKenney D, Bronner-Fraser M, Marcelle C (1995) The receptor tyrosine protein kinase QEK5 mRNA is expressed in a gradient within the neural retina and the tectum. Dev Biol 172:708-716
24. Kilpatrick TJ, Brown A, Lai C, Gassman M, Goulding M, Lemke G (1996) Expression of the Tyro4/Mek4/Cek4 gene specifically marks a subset of embryonic motor neurons and their muscle targets. Mol Cell Neurosci 62-74
25. Kiyokawa E, Takai S, Tanaka M, Iwaso I, Suzuki M, Xiang YY, Naito Y, Yamada K, Sugimura H, Kino I (1994) Overexpression of ERK, an EPH family receptor protein tyrosine protein kinase, in various human tumors. Cancer Res 54:3645-3650
26. Krumlauf R (1994) Hox genes in vertbrate development. Cell 78:191-201
27. Lhotak V, Pawson T (1993) Biological and biochemical activities of a chimeric epidermal growth factor-elk receptor tyrosine protein kinase. Mol Cell Biol 13:7071-7079
28. Logan C, Wizenmann A, Drescher U, Monschau B, Bonhoeffer F, Lumsden A (1996) Rostral optic tectum acquires caudal characteristics following ectopic Engrailed expression. Curr Biol 6:1006-1014
29. Lumsden A, Krumlauf R (1996) Patterning the vertebrate neuraxis. Science 274:1109-1115
30. Monschau B, Kremoser C, Ohta K, Tanaka H, Kaneko T, Yamada T, Handwerker C, Hornberger M, Löschinger J, Pasquale EB, Siever DA, Verderame MF, Muller BK. Bonhoeffer F, Drescher V (1997) Shared and unique functions of RAGS and ELF-1 in guiding retinal axons. EMBO J 16:1258-1267
31. Nakamoto M, Cheng H-J, Friedman GC, McLaughlin T, Hansen MJ, Yoon CH, O'Leary DMM, Flanagan JG (1996) Topographically specific effects of Elf-1 on retinal axon guidance in vitro and retinal mapping in vivo. Cell 86:755-766
32. Nieto MA, Gilardi-Hebenstreit P, Charnay P, Wilkinson DG (1992) A receptor protein tyrosine protein kinase implicated in the segmental patterning of the hindbrain and mesoderm. Development 116:1137-1150
33. Ohta K, Nakamura M, Hirokawa K, Tanaka S, Iwama A, Suda T, Ando M, Tanaka H (1996) The receptor tyrosine protein kinase, Cek8, is transiently expressed on subtypes of motoneurons in the spinal cord during development. Mech Dev 54:59-69
34. O'Leary DDM and Koester SE (1993) Development of projection neuron types, axon pathways, and patterned connections of the mammalian cortex. Neuron 10 991-1006
35. Orioli D, Henkemeyer M, Lemke G, Klein R, Pawson T (1996) Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. EMBO J 15:6035-6049
36. Pandey A, Lazar DF, Saltiel AR, Dixit VM (1994) Activation of the Eck receptor protein tyrosine protein kinase stimulates phosphatidylinositol 3-kinase activity. J Biol Chem 269:30154-30157
37. Pandey A, Duan H, Dixit VM (1995) Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine protein kinase. J Biol Chem 270 19201-19204
38. Pandey A, Shao H, Marks RM, Polverini PJ, Dixit VM (1995) Role of B61, the ligand for the Eek receptor tyrosine protein kinase, in TNF-a-induced angiogenesis. Science 268:567-569
39. Park S, Sánchez MP (1997) The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands. Oncogene 14:533-542
40. Park S, Frisén J, Barbacid M (1997) Aberrant axonal projections in mice lacking Eek tyrosine protein kinase receptors. EMBO J 16:3106-3114
41. Rétaux S, McNeill L, Harris WA (1996) Engrailed, retinotectal targeting, and axonal patterning in the midbrain during xenopus development: and antisense study. Neuron 16:63-75
42. Sajjadi FG, Pasquale EB, Subramani S (1991) Identification of a new eph-related receptor tyrosine protein kinase gene from mouse and chicken that is developmentally regulated and encodes at least two forms of the receptor. New Biol 3:769-778
43. Soans C, Holash JA, Pavlova Y, Pasquale EB (1996) Developmental expression and distinctive tyrosine phosphorylation of the Eph-related receptor tyrosine protein kinase Cek9. J Cell Biol 135:781-795
44. Sperry RW (1963) Chemoaffinity in the orderly growth of nerve fiber patterns and connections. Proc Natl Acad Sci USA 50 703-710
45. Taneja R, Thisse B, Rijli FM, Thisse C, Bouillet P, Dolle P, Chambon P (1996) The expression pattern of the mouse receptor tyrosine protein kinase gene Mdk1 is conserved through evolution and requires Hoxa-2 for rhombomere-specific expression in mouse embryos. Dev Biol 177:397-412
46. Tessier-Lavigne M, Goodman C S (1996) The molecular biology of axon guidance. Science 274:1123-1133
47. Tsuchida T, Ensini M, Morton S B, Baldassare M, Edlund T, Jessel T M, Pfaff S L (1994) Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes. Cell 79:957-970
48. Valenzuela DM, Rojas E, Griffiths JA, Compton DL, Gisser M, Ip NY, Goldfarb M, Yancopoulos GD (1995) Identification of full-length and truncated forms of Ehk-3, a novel member of the Eph receptor tyrosine protein kinase family. Oncogene 10 1573-1580
49. Varela-Echavarria A, Guthrie S (1997) Molecules making waves in axon guidance. Genes and Dev 11:545-557
50. Wang HU, Anderson DJ (1997) Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth. Neuron 18:383-396
51. Winslow JW, Moran P, Valverde J, Shih A, Yuan JQ, Wong SC, Tsai SP, Goddard A, Henzel W J, Hefti F, Beck KD, Caras IW (1995) Cloning of AL-1, a ligand for an eph-related tyrosine protein kinase receptor involved in axon bundle formation. Neuron 14:973-981
52. Xu Q, Alldus G, Macdonald R, Wilkinson DG, Holder N (1996) Function of the Eph-related kinase rtkI in patterning of the zebrafish forebrain. Nature 381:319-322