The β-tubulin gene of Cryptosporidium parvum

Molecular and Biochemical Parasitology

Volumn 89, Issue 2, 1997, Pages 307-311

  Cacciò, Simone ^a   Rosa, Giuseppe La ^a   Pozio, Edoardo ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

tubulin gene; Apicomplexa; Coccidia; Cryptosporidium parvum

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; BETA TUBULIN;

ANIMAL EXPERIMENT; ARTICLE; CELL INVASION; CONTROLLED STUDY; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; CYTOSKELETON; DRUG TARGETING; HOST PARASITE INTERACTION; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, NEWBORN; CATTLE; CHROMOSOME MAPPING; CLONING, MOLECULAR; CRYPTOSPORIDIUM PARVUM; DNA, PROTOZOAN; GENE DOSAGE; GENES, PROTOZOAN; MOLECULAR SEQUENCE DATA; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; TUBULIN;

EID: 0030768731     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(97)00122-9     Document Type: Article

References (25)

1. Burns RG, Surridge CD. Tubulins: conservation and structure. In: Hyams JS, Lloyd CW, editors. Microtubules. New York: Wiley, 1994:3-33.
2. Lacey E. The role of the cytoskeletal protein, tubulin, in the mode of action and mechanism of drug resistance to benzimidazoles. Int J Parasitol 1988;18:885-936.
3. O'Donoghue PJ. Cryptosporidium and cryptosporidiosis in man and animals. Int J Parasitol 1995;25:139-95.
4. MacKenzie WR, Hoxie NJ, Proctor ME, et al. A massive outbreak in Milwaukee of Cryptosporidium infection transmitted through the public water supply. New Engl J Med 1994;331:161-7.
5. Tilney LG, Tilney MS. The cytoskeleton of protozoan parasites. Curr Opin Cell Biol 1996;8:43-8.
6. Russell DG, Sinden RE. The role of cytoskeleton in the motility of coccidian sporozoites. J Cell Sci 1981;50:345-59.
7. Kim K, Goozé L, Petersen C, Gut J, Nelson RG. Isolation, sequence and molecular karyotype analysis of the actin gene of Cryptosporidium parvum. Mol Biochem Parasitol 1992;50:105-14.
8. Edlind T, Visvesvara G, Li J, Katiyar S. Cryptosporidium and microsporidial β-tubulin sequences: predictions of benzimidazole sensitivity and phylogeny. J Euk Microbiol 1994;41:38S.
9. Nagel SD, Boothroyd JC. The α- and β-tubulins of Toxoplasma gondii are encoded by single-copy genes containing multiple introns. Mol Biochem Parasitol 1988;29:261-73.
10. Delves CJ, Ridley RG, Goman M, Holloway SP, Hyde JE, Scaife JG. Cloning of a β-tubulin gene from Plasmodium falciparum. Mol Microbiol 1989;3:1511-9.
11. Zhu G, Keithly JS. The beta tubulin gene of Eimeria tenella. Mol Biochem Parasitol 1996;76:315-9.
12. Vasquez JR, Goozé L, Kim K, Gut J, Petersen C, Nelson RG. Potential antifolate resistance determinants and genotypic variation in the bifunctional dihydrofolate reductase-thymidylate synthase gene from human and bovine isolates of Cryptosporidium parvum. Mol Biochem Parasitol 1996;79:153-65.
13. Khramtsov NV, Blunt DS, Montelone BA, Upton SJ. The putative acetyl-CoA synthethase gene of Cryptosporidium parvum and a new conserved protein motif in acetyl-CoA synthethases. J Parasitol 1996;82:423-7.
14. Burns RG. α-, β- and γ-tubulins: sequence comparisons and structural constraints. Cell Motil Cytoskeleton 1991;20:181-9.
15. Cleveland DW. Auto regulated instability of tubulin mRNAs: a novel eukaryotic regulatory mechanism. Trends Biochem Sci 1988;13:339-43.
16. Katiyar SK, Gordon VR, McLaughin GL, Edlind TD. Antiprotozoal activities of benzimidazoles and correlations with β-tubulin sequence. Antimicrob Agents Chemother 1994;38:2086-90.
17. Fayer R, Fetterer R. Activity of benzimidazoles against cryptosporidiosis in neonatal Balb/C mice. J Parasitol 1995;81:794-5.
18. Wiest PM, Johnson JH, Flanigan TP. Microtubule inhibitors block Cryptosporidium parvum infection of a human enterocyte cell line. Infect Immun 1993;61:4888-990.
19. Arrowood MJ, Mead JR, Xie L, You X. In vitro anticryptosporidial activity of dinitroaniline herbicides. FEMS Microbiol Lett 1996;136:245-9.
20. Chan MM, Fong D. Plant microtubule inhibitors against trypanosomatids. Parasitol Today 1994;10:448-51.
21. Francis PC, Emmerson JL, Adams ER, Owen NV. Oncogenicity study of trifluralin in B6C3F21 mice. Food Chem Toxicol 1991;29:549-55.
22. Garriott ML, Adams ER, Probst GS, et al. Genotoxicity studies on the preemergence herbicide trifluralin. Mutat Res 1991;260:187-93.
23. Fong D, Lee B. Beta tubulin gene of the parasitic protozoan Leishmania mexicana. Mol Biochem Parasitol 1988;31:97-106.
24. Escalante AA, Ayala FJ. Evolutionary origin of Plasmodium and other Apicomplexa based on rRNA genes. Proc Natl Acad Sci USA 1995;92:5793-7.
25. Fayer R, Speer CA, Dubey JP. General biology of Cryptosporidium. In: Dubey JP, Speer CA, Fayer R, editors. Cryptosporidiosis of Man and Animals. Boca Raton (FL): CRC Press, 1990:1-30.