The effects of GLP-1 on insulin release in young and old rats in the fasting state and during an intravenous glucose tolerance test

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 52, Issue 5, 1997, Pages

  De Ore, Kimberly ^a   Greig, Nigel H ^a   Holloway, Harold W ^a   Wang, Yihong ^a   Perfetti, Riccardo ^a   Egan, Josephine M ^a,b  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN;

AGED; AGING; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DRUG EFFECT; GLUCOSE BLOOD LEVEL; HORMONE ACTION; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESPONSE; INTRAVENOUS GLUCOSE TOLERANCE TEST; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0030768270     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/52A.5.B245     Document Type: Article

References (27)

1. Calles-Escandon, J.; Robbins, D.C. Loss of early phase of insulin release in humans impairs glucose tolerance and blunts thermic effect of glucose. Diabetes 36:1167-1177; 1987.
2. Cerasi, E.; Luft, R; Efendic, J. Decreased sensitivity of the pancreatic beta cells to glucose in prediabetic and diabetic subjects. Diabetes 21: 224-234; 1972.
3. Creutzfeldt, W.; Ebert, R. The enteroinsular axis. In: Go, V.L.W.; Lebenthal, E.; DiMagno, E.P.; Reber, H.A.; Gardner, L.D.; Scheele, G.A., eds. The pancreas: biology, pathobiology, and disease. 2d ed. New York: Raven Press, 1993:769-788.
4. Czech, M.P.; Clancy, B.M.; Pessino, A.; Woon, C-W.; Harrison, S.A. Complex regulation of simple sugar transport in insulin-responsive cells. Trends Biochem. Sci. 17:197-201; 1992.
5. De Fronzo, R.A. Glucose intolerance and aging. Diabetes Care 4:493-501; 1981.
6. Elahi, D.; Andersen, D.K.; Tobin, J.D.; Brown, J.C.; Andres, A. The enteric enhancement of glucose-stimulated insulin release: the role of GIP in aging, obesity, and non-insulin-dependent diabetes mellitus. Diabetes 33:950-957; 1984.
7. Elahi, D.; Muller, D.C.; Andersen, D.K.; Tobin, J.D.; Andres, A. The effect of age and glucose concentration on insulin secretion by the isolated perfused rat pancreas. Endocrinology 116:11-16; 1985.
8. Elahi, D.; McAloon-Dyke, M.; Fukagawa, N.K.; Meneilly, G.S.; Sclater, A.L.; Minaker, K.L.; Habener, J.F.; Andersen, D.K. The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects. Regulatory Peptides 51:63-74; 1994.
9. Fehmann, H-C.; Goke, R.; Goke, B. Glucagon-like peptide-1 (7-37)7(7-36) amide is a new incretin. Mol. Cell. Endocrinol. 85:C39-C44; 1992.
10. Gutniak, M.; Orskov, C.; Holst, J.J.; Ahren, B.; Efendic, S. Antidiabetogenic effect of glucagon-like peptide-1 (7-36) amide in normal subjects and patients with diabetes mellitus. N. Engl. J. Med. 326: 1316-1322; 1992.
11. Holz IV, G.G.; Kühtreiber, W.M.; Habener, J.F. Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1-(7-37). Nature 361:362-365; 1993.
12. Jackson, R.A. Mechanisms of age-related glucose intolerance. Diabetes Care 13:9-19; 1990.
13. Luft, R. Some aspects of the pathogenesis of type II diabetes. Endocrine Rev. 5:134-136; 1984.
14. Montrose-Rafizadeh, C.; Egan, J.M.; Roth, J. Incretin hormones regulate glucose dependent insulin secretion in RIN 1046-38 cells: mechanisms of action. Endocrinology 135:589-594; 1994.
15. Moore, B.; Edie, E.S.; Abram, J.H. On the treatment of diabetes mellitus by acid extract of duodenal mucus membrane. Biochem. J. 1:28-38; 1906.
16. Morley, J. E. Diabetes mellitus in elderly patients. Is it different? Am. J. Med. 88:533-544; 1987.
17. Nadiv, O.; Cohen, O.; Zick, Y. Defects in insulin's signal transduction in old rat livers. Endocrinology 130:1515-1524; 1992.
18. Nathan, D.M.; Schreiber, E.; Fogel, H.; Mosjov, S.; Habener, J. Insulinotropic action of glucagonlike peptide-1-(7-37) in diabetic and nondiabetic subjects. Diabetes Care 15:270-276; 1992.
19. Nauck, M.A.; Heimesaat, M.M.; Orskov, C.; Holst, J.J.; Eben, R.; Creutzfeldt, W. Preserved incretin activity of glucagon-like peptide 1 [7-36 Amide] but not of synthetic human gastric inhibitory polypeptide in patients with Type-2 diabetes mellitus. J. Clin. Invest. 91:301-307; 1993.
20. Olefsky, J.M. Insulin resistance and insulin action. Diabetes 30:148-162; 1981.
21. Palmer, J.P.; Ensinck, J.W. Acute-phase insulin secretion and glucose intolerance in young and aged normal men and diabetic patients. J. Clin. Endocrinol. Metab. 41:498-503; 1975.
22. Perfetti, R.; Montrose-Rafizadeh, C.; Liotta, A.S.; Egan, J.M. Age-dependent reduction in insulin secretion and insulin mRNA in isolated islets from rats. Am. J. Physiol. 32:E983-E990; 1995.
23. Reaven, E.P.; Gold, G.; Reaven, G.M. Effect of age on glucose-stimulated insulin release by the B-cell of the rat. J. Clin. Invest. 64:345-350; 1979.
24. Reaven, G.M.; Reaven, E.P. Effects of age on various aspects of glucose and insulin metabolism. Mol. Cell. Biochem. 31:37-47; 1980.
25. Srikanta, S.; Ganda, O.P.; Gleason, P.E.; Jackson, R.A.; Soeldner, J.S.; Eisenbarth, G.S. Pre-type 1 diabetes: linear loss of beta cell response to intravenous glucose. Diabetes 33:717-720; 1984.
26. Willms, B.; Werner, J.; Holst, J.J.; Orskov, C.; Creutzfeldt, W.; Nauck, M.A. Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in Type 2 (noninsulin-dependent) diabetic patients. J. Clin. Endocrinol. Metab. 81:327-332; 1996.
27. Zavaroni, I.; Dall'Aglio, F.; Bruschi, F.; Borona, E.; Alpi, O.; Pezzarossa, A.; Butturini, U. Effect of age and environmental factors on glucose and insulin secretion in a worker population. J. Am. Geriatr. Soc. 34: 271-275; 1986.