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Volumn 117, Issue 1, 1997, Pages 111-119

Degeneration of pre-labelled nigral neurons induced by intrastriatal 6-hydroxydopamine in the rat: Behavioural and biochemical changes and pretreatment with the calcium-entry blocker nimodipine

Author keywords

6 hydroxydopamine lesion; Dopamine; Parkinson's disease; Striatum; Substantia nigra

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; DIHYDROXYPHENYLACETIC ACID; DOPAMINE; FLUOROGOLD; HOMOVANILLIC ACID; NEUROTROPHIC FACTOR; NIMODIPINE; OXIDOPAMINE; TYROSINE 3 MONOOXYGENASE;

EID: 0030767710     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002210050204     Document Type: Article
Times cited : (19)

References (66)
  • 1
    • 0023130088 scopus 로고
    • Time course of adaptations in dopamine biosynthesis, metabolism, and release following nigrostriatal lesions: Implications for behavioral recovery from brain injury
    • Altar CA, Marien MR, Marshall JF (1987) Time course of adaptations in dopamine biosynthesis, metabolism, and release following nigrostriatal lesions: implications for behavioral recovery from brain injury. J Neurochem 48: 390-399
    • (1987) J Neurochem , vol.48 , pp. 390-399
    • Altar, C.A.1    Marien, M.R.2    Marshall, J.F.3
  • 3
    • 0002950780 scopus 로고
    • Nimodipine attenuates NMDA- and MDMA-induced toxicity of cultured fetal serotonergic neurons: Evidence for a generic model of calcium toxicity
    • Traber J, Gispen WH (eds) Schattauer, Stuttgart
    • Azmitia EC (1989) Nimodipine attenuates NMDA- and MDMA-induced toxicity of cultured fetal serotonergic neurons: evidence for a generic model of calcium toxicity. In: Traber J, Gispen WH (eds) Nimodipine and central nervous system function: new vistas. Schattauer, Stuttgart, pp 141-159
    • (1989) Nimodipine and Central Nervous System Function: New Vistas , pp. 141-159
    • Azmitia, E.C.1
  • 5
    • 0026081180 scopus 로고
    • Retrograde degeneration of nigrostriatal neurons induced by intrastriatal 6-hydroxydopamine injection in rats
    • Berger K, Przedborski S, Cadet JL (1991) Retrograde degeneration of nigrostriatal neurons induced by intrastriatal 6-hydroxydopamine injection in rats. Brain Res Bull 26: 301-307
    • (1991) Brain Res Bull , vol.26 , pp. 301-307
    • Berger, K.1    Przedborski, S.2    Cadet, J.L.3
  • 6
    • 0024822244 scopus 로고
    • The effects of dihydropyridine compounds in behavioral tests of dopamine activity
    • Bourson A, Gower AJ, Mir AK, Moser PC (1989) The effects of dihydropyridine compounds in behavioral tests of dopamine activity. Br J Pharmacol 98: 1312-1318
    • (1989) Br J Pharmacol , vol.98 , pp. 1312-1318
    • Bourson, A.1    Gower, A.J.2    Mir, A.K.3    Moser, P.C.4
  • 7
    • 0014848664 scopus 로고
    • Effect of 6-hydroxydopamine on brain norepinephrine and dopamine: Evidence for selective degeneration of catecholamine neurons
    • Breese GR, Traylor TD (1970) Effect of 6-hydroxydopamine on brain norepinephrine and dopamine: evidence for selective degeneration of catecholamine neurons. J Pharmacol Exp Ther 174: 413-420
    • (1970) J Pharmacol Exp Ther , vol.174 , pp. 413-420
    • Breese, G.R.1    Traylor, T.D.2
  • 8
    • 0003057732 scopus 로고
    • Functional effects of mesencephalic dopamine neurons and adrenal chromaffin cells grafted to the rodent striatum
    • Dunnett SB, Björklund A (eds) Raven Press, New York
    • Brundin P, Duan WM, Sauer H (1994) Functional effects of mesencephalic dopamine neurons and adrenal chromaffin cells grafted to the rodent striatum. In: Dunnett SB, Björklund A (eds) Functional neural transplantation. Raven Press, New York, pp 9-46
    • (1994) Functional Neural Transplantation , pp. 9-46
    • Brundin, P.1    Duan, W.M.2    Sauer, H.3
  • 9
    • 0025851603 scopus 로고
    • Long-term behavioral and biochemical effects of 6-hydroxydopamine injections in rat caudate-putamen
    • Cadet JL, Last R, Kostic V, Przedborski S, Jackson-Lewis V (1991) Long-term behavioral and biochemical effects of 6-hydroxydopamine injections in rat caudate-putamen. Brain Res Bull 26: 707-713
    • (1991) Brain Res Bull , vol.26 , pp. 707-713
    • Cadet, J.L.1    Last, R.2    Kostic, V.3    Przedborski, S.4    Jackson-Lewis, V.5
  • 10
    • 0027344407 scopus 로고
    • Role of dopamine autoxidation, hydroxyl radical generation, and calcium overload in underlying mechanisms involved in MPTP-induced Parkinsonism
    • Narabayashi H, Nagutsu T, Yanagisawa N, Mizuno Y (eds)
    • Chiueh CC, Miyake H, Peng M-T (1993) Role of dopamine autoxidation, hydroxyl radical generation, and calcium overload in underlying mechanisms involved in MPTP-induced Parkinsonism. In: Narabayashi H, Nagutsu T, Yanagisawa N, Mizuno Y (eds) Adv Neurol 60: 251-258
    • (1993) Adv Neurol , vol.60 , pp. 251-258
    • Chiueh, C.C.1    Miyake, H.2    Peng, M.-T.3
  • 11
    • 0023753142 scopus 로고
    • Calcium-mediated neurotoxicity: Relationship to specific channel types and role in ischemic damage
    • Choi DW (1988) Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci 11: 465-469
    • (1988) Trends Neurosci , vol.11 , pp. 465-469
    • Choi, D.W.1
  • 12
    • 0016378870 scopus 로고
    • The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents
    • Cohen G, Heikkila RE (1973) The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents. J Biol Chem 249: 2447-2452
    • (1973) J Biol Chem , vol.249 , pp. 2447-2452
    • Cohen, G.1    Heikkila, R.E.2
  • 13
    • 0021232402 scopus 로고
    • Spontaneous recovery from motor asymmetry in adult rats with 6-hydroxydopamine-induced partial lesions of the nigrostriatal pathway
    • Dravid A, Jaton AL, Enz A, Björklund A (1984) Spontaneous recovery from motor asymmetry in adult rats with 6-hydroxydopamine-induced partial lesions of the nigrostriatal pathway. Brain Res 311: 361-365
    • (1984) Brain Res , vol.311 , pp. 361-365
    • Dravid, A.1    Jaton, A.L.2    Enz, A.3    Björklund, A.4
  • 14
    • 0028885080 scopus 로고
    • Chronic effects of single intrastriatal injections of 6-hydroxydopamine or 1-methyl-4-phenyl-pyridinium studied by microdialysis in freely moving rats
    • Espino A, Cutillas B, Tortosa A, Ferrer I, Bartrons R, Ambrosio S (1995) Chronic effects of single intrastriatal injections of 6-hydroxydopamine or 1-methyl-4-phenyl-pyridinium studied by microdialysis in freely moving rats. Brain Res 695: 151-157
    • (1995) Brain Res , vol.695 , pp. 151-157
    • Espino, A.1    Cutillas, B.2    Tortosa, A.3    Ferrer, I.4    Bartrons, R.5    Ambrosio, S.6
  • 15
    • 0025105493 scopus 로고
    • Role of catechol autoxidation in the degeneration of dopamine neurons
    • Fornstedt B (1990) Role of catechol autoxidation in the degeneration of dopamine neurons. Acta Neurol Scand Suppl 129: 12-4
    • (1990) Acta Neurol Scand Suppl , vol.129 , pp. 12-14
    • Fornstedt, B.1
  • 16
    • 0028169155 scopus 로고
    • 2+-indticed neurotoxicity in rat primary cortical cultures: Involvement of L-type calcium channel
    • 2+-indticed neurotoxicity in rat primary cortical cultures: involvement of L-type calcium channel. Brain Res 654: 257-264
    • (1994) Brain Res , vol.654 , pp. 257-264
    • Freund, W.-D.1    Reddig, S.2
  • 17
    • 0018872938 scopus 로고
    • The importance of calcium in amphetamine induced turning behavior in mice with unilateral nigrostriatal lesions
    • Fung YK, Uretsky NJ (1980) The importance of calcium in amphetamine induced turning behavior in mice with unilateral nigrostriatal lesions. Neuropharmacology 19: 555-560
    • (1980) Neuropharmacology , vol.19 , pp. 555-560
    • Fung, Y.K.1    Uretsky, N.J.2
  • 18
    • 0029845140 scopus 로고    scopus 로고
    • Animal models of Parkinson's disease: An empirical comparison with the phenomenology of the disease in man
    • Gerlach M, Riederer P (1996) Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man. J Neural Transm 103: 987-1041
    • (1996) J Neural Transm , vol.103 , pp. 987-1041
    • Gerlach, M.1    Riederer, P.2
  • 20
    • 0029691735 scopus 로고    scopus 로고
    • Molecular mechanisms for neurodegeneration: Synergism between reactive oxygen species, calcium, and excitotoxic amino acids
    • Gerlach M, Riederer P, Youdim MBH (1996) Molecular mechanisms for neurodegeneration: synergism between reactive oxygen species, calcium, and excitotoxic amino acids. Adv Neurol 69: 177-194
    • (1996) Adv Neurol , vol.69 , pp. 177-194
    • Gerlach, M.1    Riederer, P.2    Youdim, M.B.H.3
  • 22
    • 0018894295 scopus 로고
    • Circling behavior in rats with partial, unilateral nigro-striatal lesions: Effect of amphetamine, apomorphine, and I-DOPA
    • Hefti F, Melamed E, Suhakian BJ, Wurtman RJ (1980a) Circling behavior in rats with partial, unilateral nigro-striatal lesions: effect of amphetamine, apomorphine, and I-DOPA. Pharmacol Biochem Behav 12: 185-188
    • (1980) Pharmacol Biochem Behav , vol.12 , pp. 185-188
    • Hefti, F.1    Melamed, E.2    Suhakian, B.J.3    Wurtman, R.J.4
  • 23
    • 0018830236 scopus 로고
    • Partial lesions of the dopaminergic nigrostriatal system in the rat: Biochemical characterization
    • Hefti F, Melamed E, Wurtman RJ (1980b) Partial lesions of the dopaminergic nigrostriatal system in the rat: biochemical characterization. Brain Res 195: 209-217
    • (1980) Brain Res , vol.195 , pp. 209-217
    • Hefti, F.1    Melamed, E.2    Wurtman, R.J.3
  • 24
    • 0015231054 scopus 로고
    • Inhibition of biogenic amine uptake by hydrogen peroxide: A mechanism for toxic effects of 6-hydroxydopamine
    • Heikkila RE, Cohen G (1971) Inhibition of biogenic amine uptake by hydrogen peroxide: a mechanism for toxic effects of 6-hydroxydopamine. Science 172: 1257-1258
    • (1971) Science , vol.172 , pp. 1257-1258
    • Heikkila, R.E.1    Cohen, G.2
  • 25
    • 0021324534 scopus 로고
    • Evidence that apomorphine and pergolide induce rotation in rats by different actions on D1 and D2 receptors
    • Herrera-Marschitz M, Ungerstedt U (1984) Evidence that apomorphine and pergolide induce rotation in rats by different actions on D1 and D2 receptors. Eur J Pharmacol 98: 165-76
    • (1984) Eur J Pharmacol , vol.98 , pp. 165-176
    • Herrera-Marschitz, M.1    Ungerstedt, U.2
  • 26
    • 0026637866 scopus 로고
    • Why are nigral catecholaminergic neurons more vulnerable than other cells in Parkinson's disease?
    • Hirsch E (1992) Why are nigral catecholaminergic neurons more vulnerable than other cells in Parkinson's disease? Ann Neurol 32: 88-93
    • (1992) Ann Neurol , vol.32 , pp. 88-93
    • Hirsch, E.1
  • 27
    • 0015909166 scopus 로고
    • Specifity of 6-hydroxydopamine induced degeneration of central monoamine neurones: An electron and fluorescence microscopic study with special reference to intracerebral injection on the nigrostriatal dopamine system
    • Hökfelt T, Ungerstedt U (1973) Specifity of 6-hydroxydopamine induced degeneration of central monoamine neurones: an electron and fluorescence microscopic study with special reference to intracerebral injection on the nigrostriatal dopamine system. Brain Res 60: 269-297
    • (1973) Brain Res , vol.60 , pp. 269-297
    • Hökfelt, T.1    Ungerstedt, U.2
  • 28
    • 0027449341 scopus 로고
    • Correlation of apomorphine- and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats
    • Hudson JL, van Horne CG, Strömberg I, Brock S, Clayton J, Masserano J, Hoffer BJ, Gerhardt GA (1993) Correlation of apomorphine- and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats. Brain Res 626: 167-174
    • (1993) Brain Res , vol.626 , pp. 167-174
    • Hudson, J.L.1    Van Horne, C.G.2    Strömberg, I.3    Brock, S.4    Clayton, J.5    Masserano, J.6    Hoffer, B.J.7    Gerhardt, G.A.8
  • 29
    • 0025817092 scopus 로고
    • Degeneration of the nigral dopamine neurons after 6-hydroxydopamine injection into the rat striatum
    • Ichitani Y, Okamura H, Matsumoto Y, Nagatsu I, Ibata Y (1991) Degeneration of the nigral dopamine neurons after 6-hydroxydopamine injection into the rat striatum. Brain Res 549: 350-353
    • (1991) Brain Res , vol.549 , pp. 350-353
    • Ichitani, Y.1    Okamura, H.2    Matsumoto, Y.3    Nagatsu, I.4    Ibata, Y.5
  • 30
    • 0028610569 scopus 로고
    • Biochemical and immunocytochemical changes induced by intrastriatal 6-hydroxydopamine injection in the rat nigrostriatal dopamine neuron system: Evidence for cell death in the substantia nigra
    • Ichitani Y, Okamura H, Nakahara D, Nagatsu I, Ibata Y (1994) Biochemical and immunocytochemical changes induced by intrastriatal 6-hydroxydopamine injection in the rat nigrostriatal dopamine neuron system: evidence for cell death in the substantia nigra. Exp Neurol 130: 269-278
    • (1994) Exp Neurol , vol.130 , pp. 269-278
    • Ichitani, Y.1    Okamura, H.2    Nakahara, D.3    Nagatsu, I.4    Ibata, Y.5
  • 31
    • 0000340348 scopus 로고
    • Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: Uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity
    • Javitch JA, D'Amato RJ, Strittmatter SM, Snyder SH (1985) Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc Natl Acad Sci USA 82: 2173-2177
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 2173-2177
    • Javitch, J.A.1    D'Amato, R.J.2    Strittmatter, S.M.3    Snyder, S.H.4
  • 32
    • 0017281887 scopus 로고
    • Specificity of dopaminergic neuron degeneration induced by intracerebral injection of 6-hydroxydopamine in the nigrostriatal dopamine system
    • Javoy F, Sotelo C, Herbet A, Agid Y (1976) Specificity of dopaminergic neuron degeneration induced by intracerebral injection of 6-hydroxydopamine in the nigrostriatal dopamine system. Brain Res 102: 201-216
    • (1976) Brain Res , vol.102 , pp. 201-216
    • Javoy, F.1    Sotelo, C.2    Herbet, A.3    Agid, Y.4
  • 33
    • 0026740057 scopus 로고
    • New insights into the cause of Parkinson's disease
    • Jenner P, Schapira AHV, Marsden CD (1992) New insights into the cause of Parkinson's disease. Neurology 42: 2241-2250
    • (1992) Neurology , vol.42 , pp. 2241-2250
    • Jenner, P.1    Schapira, A.H.V.2    Marsden, C.D.3
  • 34
    • 0029018424 scopus 로고
    • 6-Hydroxydopamine lesion of the rat substantia nigra: Time course and morphology of cell death
    • Jeon BS, Jackson-Lewis V, Burke RE (1995) 6-Hydroxydopamine lesion of the rat substantia nigra: time course and morphology of cell death. Neurodegeneration 4: 131-137
    • (1995) Neurodegeneration , vol.4 , pp. 131-137
    • Jeon, B.S.1    Jackson-Lewis, V.2    Burke, R.E.3
  • 36
    • 0018851399 scopus 로고
    • Chemical neurotoxins as denervation tools in neurobiology
    • Jonsson G (1980) Chemical neurotoxins as denervation tools in neurobiology. Annu Rev Neurosci 3: 169-187
    • (1980) Annu Rev Neurosci , vol.3 , pp. 169-187
    • Jonsson, G.1
  • 37
    • 0028241877 scopus 로고
    • Influence of dihydropyridines on the recovery of sensory function after caudal nerve crush in the rat
    • Kappelle AC, Biessels G, Van Buren T, Brakkee JH, Gispen WH (1994) Influence of dihydropyridines on the recovery of sensory function after caudal nerve crush in the rat. Restor Neurol Neurosci 6: 271-276
    • (1994) Restor Neurol Neurosci , vol.6 , pp. 271-276
    • Kappelle, A.C.1    Biessels, G.2    Van Buren, T.3    Brakkee, J.H.4    Gispen, W.H.5
  • 38
    • 0028916715 scopus 로고
    • Free radical-generated neurotoxicity of 6-hydroxydopamine
    • Kumar R, Agarwal AK, Seth PK (1995) Free radical-generated neurotoxicity of 6-hydroxydopamine. J Neurochem 64: 1703-1707
    • (1995) J Neurochem , vol.64 , pp. 1703-1707
    • Kumar, R.1    Agarwal, A.K.2    Seth, P.K.3
  • 41
    • 0030601952 scopus 로고    scopus 로고
    • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in non-human primates is antagonized by pretreatment with nimodipine at the nigral, but not at the striatal level
    • Kupsch A, Sautter J, Schwarz J, Riederer P, Gerlach M, Oertel WH (1996) 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in non-human primates is antagonized by pretreatment with nimodipine at the nigral, but not at the striatal level. Brain Res 741: 185-196
    • (1996) Brain Res , vol.741 , pp. 185-196
    • Kupsch, A.1    Sautter, J.2    Schwarz, J.3    Riederer, P.4    Gerlach, M.5    Oertel, W.H.6
  • 43
    • 0025063609 scopus 로고
    • Excitatory amino acid neurotoxicity and neurodegenerative disease
    • Meldrum B, Garthwaite J (1990) Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Neuropharmacol 11: 379-387
    • (1990) Trends Neuropharmacol , vol.11 , pp. 379-387
    • Meldrum, B.1    Garthwaite, J.2
  • 45
    • 0028183348 scopus 로고
    • Bioanalytics of nimodipine: An overview of methods
    • Mück W, Bode H (1994) Bioanalytics of nimodipine: an overview of methods. Pharmazie 49: 130-139
    • (1994) Pharmazie , vol.49 , pp. 130-139
    • Mück, W.1    Bode, H.2
  • 46
    • 0030031457 scopus 로고    scopus 로고
    • The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons
    • Nirenberg MJ, Vaughan RA, Uhl GR, Kuhar MJ, Pickel VM (1996) The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons. J Neurosci 15: 436-447
    • (1996) J Neurosci , vol.15 , pp. 436-447
    • Nirenberg, M.J.1    Vaughan, R.A.2    Uhl, G.R.3    Kuhar, M.J.4    Pickel, V.M.5
  • 47
    • 0027454020 scopus 로고
    • Dopamine transporter expression confers cytotoxicity to low doses of parkinsonism-inducing neurotoxin 1-methyl-4-phenyl-pyridinium
    • Pifl C, Giros B, Caron MG (1993) Dopamine transporter expression confers cytotoxicity to low doses of parkinsonism-inducing neurotoxin 1-methyl-4-phenyl-pyridinium. J Neurosci 13: 4246-4253
    • (1993) J Neurosci , vol.13 , pp. 4246-4253
    • Pifl, C.1    Giros, B.2    Caron, M.G.3
  • 50
    • 0028293038 scopus 로고
    • Time course of recovery of extracellular dopamine following partial damage to the nigrostriatal system
    • Robinson TE, Mocsary Z, Camp DM, Wishaw IQ (1994) Time course of recovery of extracellular dopamine following partial damage to the nigrostriatal system. J Neurosci 14: 2687-2696
    • (1994) J Neurosci , vol.14 , pp. 2687-2696
    • Robinson, T.E.1    Mocsary, Z.2    Camp, D.M.3    Wishaw, I.Q.4
  • 51
    • 0028220834 scopus 로고
    • Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemical study in the rat
    • Sauer H, Oertel WH (1994) Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat. Neuroscience 59: 401-415
    • (1994) Neuroscience , vol.59 , pp. 401-415
    • Sauer, H.1    Oertel, W.H.2
  • 52
    • 0029047329 scopus 로고
    • GDNF but not TGFβ prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion
    • Sauer H, Rosenblad C, Björklund A (1995) GDNF but not TGFβ prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion. Proc Natl Acad Sci USA 92: 8935-8939
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8935-8939
    • Sauer, H.1    Rosenblad, C.2    Björklund, A.3
  • 53
    • 0021000670 scopus 로고
    • Intracerebral grafting of neuronal cell suspensions. III. Activity of intrastriatal nigral suspension implants as assessed by measurements of dopamine synthesis and metabolism
    • Schmidt RH, Björklund A, Stenevi U, Dunnett SB, Gage FH (1983) Intracerebral grafting of neuronal cell suspensions. III. Activity of intrastriatal nigral suspension implants as assessed by measurements of dopamine synthesis and metabolism. Acta Physiol Scand Suppl 522: 19-28
    • (1983) Acta Physiol Scand Suppl , vol.522 , pp. 19-28
    • Schmidt, R.H.1    Björklund, A.2    Stenevi, U.3    Dunnett, S.B.4    Gage, F.H.5
  • 54
    • 0015803674 scopus 로고    scopus 로고
    • Injection of 6-hydroxydopamine in the substantia nigra of the rat. I. Morphological study
    • 9973
    • Sotelo C, Javoy F, Agid Y, Glowinski J (9973) Injection of 6-hydroxydopamine in the substantia nigra of the rat. I. Morphological study. Brain Res 58: 269-290
    • Brain Res , vol.58 , pp. 269-290
    • Sotelo, C.1    Javoy, F.2    Agid, Y.3    Glowinski, J.4
  • 55
    • 0030175747 scopus 로고    scopus 로고
    • In vivo protection against NMDA-induced neurodegeneration by Mk-801 and nimodipine: Combined therapy and temporal course of protection
    • Stuiver BT, Douma BRK, Bakker R, Nyakas C, Luiten PGM (1996) In vivo protection against NMDA-induced neurodegeneration by Mk-801 and nimodipine: combined therapy and temporal course of protection. Neurodegeneration 5: 153-159
    • (1996) Neurodegeneration , vol.5 , pp. 153-159
    • Stuiver, B.T.1    Douma, B.R.K.2    Bakker, R.3    Nyakas, C.4    Luiten, P.G.M.5
  • 57
    • 0029114190 scopus 로고
    • Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult
    • Tomac A, Widenfalk J, Lin L-FH, Kohno T, Ebendahl T, Hoffer BJ, Olson L (1995) Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult. Proc Natl Acad Sci USA 92: 8274-8278
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8274-8278
    • Tomac, A.1    Widenfalk, J.2    Lin, L.-F.H.3    Kohno, T.4    Ebendahl, T.5    Hoffer, B.J.6    Olson, L.7
  • 59
    • 0014376793 scopus 로고
    • 6-Hydroxydopamine induced degeneration of central monoamine neurons
    • Ungerstedt U (1968) 6-Hydroxydopamine induced degeneration of central monoamine neurons. Eur J Pharmacol 5: 107-110
    • (1968) Eur J Pharmacol , vol.5 , pp. 107-110
    • Ungerstedt, U.1
  • 60
    • 0015176277 scopus 로고
    • Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behavior
    • Ungerstedt U (1971a) Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behavior. Acta Physiol Scand Suppl 367: 49-68
    • (1971) Acta Physiol Scand Suppl , vol.367 , pp. 49-68
    • Ungerstedt, U.1
  • 61
    • 0015184103 scopus 로고
    • Postsynaptic supersensitivity after 6-hydroxydopamine induced degeneration of the nigrostriatal dopamine system
    • Ungerstedt U (1971b) Postsynaptic supersensitivity after 6-hydroxydopamine induced degeneration of the nigrostriatal dopamine system. Acta Physiol Scand Suppl 367: 69-93
    • (1971) Acta Physiol Scand Suppl , vol.367 , pp. 69-93
    • Ungerstedt, U.1
  • 62
    • 0014954436 scopus 로고
    • Quantitative recording of rotational behaviour in rats after 6-hydroxydopamine lesions of the nigrostriatal dopamine system
    • Ungerstedt U, Arbuthnott GW (1970) Quantitative recording of rotational behaviour in rats after 6-hydroxydopamine lesions of the nigrostriatal dopamine system. Brain Res 24: 485-493
    • (1970) Brain Res , vol.24 , pp. 485-493
    • Ungerstedt, U.1    Arbuthnott, G.W.2
  • 63
    • 0022482024 scopus 로고
    • Simultaneous measurement of dopamine release and rotational behaviour in 6-hydroxydopamine denervated rats using intracerebral dialysis
    • Zetterström T, Herrrera-Marschitz M, Ungerstedt U (1986) Simultaneous measurement of dopamine release and rotational behaviour in 6-hydroxydopamine denervated rats using intracerebral dialysis. Brain Res 376: 1-7
    • (1986) Brain Res , vol.376 , pp. 1-7
    • Zetterström, T.1    Herrrera-Marschitz, M.2    Ungerstedt, U.3
  • 64
    • 0021235482 scopus 로고
    • Neurochemical compensation after nigrostriatal bundle injury in an animal model of preclinical parkinsonism
    • Zigmond MJ, Acheson AL, Stachowiak MK, Stricker EM (1984) Neurochemical compensation after nigrostriatal bundle injury in an animal model of preclinical parkinsonism. Arch Neurol 41: 856-861
    • (1984) Arch Neurol , vol.41 , pp. 856-861
    • Zigmond, M.J.1    Acheson, A.L.2    Stachowiak, M.K.3    Stricker, E.M.4
  • 66
    • 0026784401 scopus 로고
    • Neurochemical responses to 6-hydroxydopamine and 1-dopa therapy: Implications for Parkinson's disease
    • Zigmond MJ, Hastings TG, Abercrombie ED (1992) Neurochemical responses to 6-hydroxydopamine and 1-dopa therapy: implications for Parkinson's disease. Ann NY Acad Sci 648: 71-86
    • (1992) Ann NY Acad Sci , vol.648 , pp. 71-86
    • Zigmond, M.J.1    Hastings, T.G.2    Abercrombie, E.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.