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Volumn 36, Issue 13-14, 1997, Pages 1541-1542

Selective Inhibition of Receptor Tyrosine Kinases by Synthetic Analogues of Aeroplysinin

Author keywords

Aeroplysinin; Bioorganic chemistry; Enzyme inhibitors; Kinases

Indexed keywords


EID: 0030767596     PISSN: 05700833     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.199715411     Document Type: Article
Times cited : (15)

References (33)
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    • For recent studies of tyrosine kinase inhibitors, see for example a) E. Buchdunger, J. Zimmermann, H. Mett, T. Meyer, M. Mÿller, U. Regenass, N. B. Lydon, Proc. Natl. Acad. Sci. USA 1995, 92, 2558; b) J. Zimmermann, E. Buchdunger, H. Mett, T. Meyer, N. B. Lydon, P. Traxler, Bioorg. Med. Chem. Lett. 1996, 6, 1221; c) J. Kobayashi, T. Madono, H. Shigemoni, Tetrahedron 1995, 51, 10867; d) K. Alvi, M. C. Diaz, P. Crews, D. L. Slate, R. H. Lee, R. Moretti, J. Org. Chem. 1992, 57, 6604, and citations in ref. [5].
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    • Buchdunger, E.1    Zimmermann, J.2    Mett, H.3    Meyer, T.4    Mÿller, M.5    Regenass, U.6    Lydon, N.B.7
  • 14
    • 0029951570 scopus 로고    scopus 로고
    • For recent studies of tyrosine kinase inhibitors, see for example a) E. Buchdunger, J. Zimmermann, H. Mett, T. Meyer, M. Mÿller, U. Regenass, N. B. Lydon, Proc. Natl. Acad. Sci. USA 1995, 92, 2558; b) J. Zimmermann, E. Buchdunger, H. Mett, T. Meyer, N. B. Lydon, P. Traxler, Bioorg. Med. Chem. Lett. 1996, 6, 1221; c) J. Kobayashi, T. Madono, H. Shigemoni, Tetrahedron 1995, 51, 10867; d) K. Alvi, M. C. Diaz, P. Crews, D. L. Slate, R. H. Lee, R. Moretti, J. Org. Chem. 1992, 57, 6604, and citations in ref. [5].
    • (1996) Bioorg. Med. Chem. Lett. , vol.6 , pp. 1221
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    • For recent studies of tyrosine kinase inhibitors, see for example a) E. Buchdunger, J. Zimmermann, H. Mett, T. Meyer, M. Mÿller, U. Regenass, N. B. Lydon, Proc. Natl. Acad. Sci. USA 1995, 92, 2558; b) J. Zimmermann, E. Buchdunger, H. Mett, T. Meyer, N. B. Lydon, P. Traxler, Bioorg. Med. Chem. Lett. 1996, 6, 1221; c) J. Kobayashi, T. Madono, H. Shigemoni, Tetrahedron 1995, 51, 10867; d) K. Alvi, M. C. Diaz, P. Crews, D. L. Slate, R. H. Lee, R. Moretti, J. Org. Chem. 1992, 57, 6604, and citations in ref. [5].
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    • and citations in ref. [5]
    • For recent studies of tyrosine kinase inhibitors, see for example a) E. Buchdunger, J. Zimmermann, H. Mett, T. Meyer, M. Mÿller, U. Regenass, N. B. Lydon, Proc. Natl. Acad. Sci. USA 1995, 92, 2558; b) J. Zimmermann, E. Buchdunger, H. Mett, T. Meyer, N. B. Lydon, P. Traxler, Bioorg. Med. Chem. Lett. 1996, 6, 1221; c) J. Kobayashi, T. Madono, H. Shigemoni, Tetrahedron 1995, 51, 10867; d) K. Alvi, M. C. Diaz, P. Crews, D. L. Slate, R. H. Lee, R. Moretti, J. Org. Chem. 1992, 57, 6604, and citations in ref. [5].
    • (1992) J. Org. Chem. , vol.57 , pp. 6604
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    • (+)-Aeroplysinin was kindly supplied by Prof. Proksch, Lehrstuhl für Pharmazeutische Biologie, Universität Würzburg (Germany)
    • (+)-Aeroplysinin was kindly supplied by Prof. Proksch, Lehrstuhl für Pharmazeutische Biologie, Universität Würzburg (Germany).
  • 26
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    • Aldehyde 3 is commercially available
    • Aldehyde 3 is commercially available.
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    • For recent applications of the Becker-Adler oxidation in natural-product synthesis, see a) E. J. Corey, J. P. Dittami, J. Am. Chem. Soc. 1985, 107, 256; b) S. Danishefsky, M. D. Shair, J. Org. Chem. 1996, 61, 16.
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    • Corey, E.J.1    Dittami, J.P.2
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    • For recent applications of the Becker-Adler oxidation in natural-product synthesis, see a) E. J. Corey, J. P. Dittami, J. Am. Chem. Soc. 1985, 107, 256; b) S. Danishefsky, M. D. Shair, J. Org. Chem. 1996, 61, 16.
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    • The NIH-3T3-β-PDGFR cells were kindly supplied by Prof. Dr. A. Ullrich, Max-Planck-Institut für Biochemie, Martinsried (Germany)
    • The NIH-3T3-β-PDGFR cells were kindly supplied by Prof. Dr. A. Ullrich, Max-Planck-Institut für Biochemie, Martinsried (Germany).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.