Prospective multicenter study on subcutaneous concentrated desmopressin for home treatment of patients with von Willebrand disease and mild or moderate hemophilia A

Thrombosis and Haemostasis

Volumn 76, Issue 5, 1996, Pages 692-696

  Rodeghiero, Francesco ^a   Castaman, Giancarlo ^b   Mannucci, Pier Mannuccio ^b  

^a SAN BORTOLO HOSPITAL   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DESMOPRESSIN; PROCOAGULANT;

ADOLESCENT; ADULT; ARTICLE; BLEEDING; CLINICAL TRIAL; DRUG EFFICACY; DRUG SAFETY; DRUG SELF ADMINISTRATION; FEMALE; FLUSHING; GASTROINTESTINAL HEMORRHAGE; HEADACHE; HEMOPHILIA A; HOME CARE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENORRHAGIA; MULTICENTER STUDY; PRIORITY JOURNAL; QUESTIONNAIRE; SCHOOL CHILD; SUBCUTANEOUS DRUG ADMINISTRATION; THORAX PAIN; TREATMENT FAILURE; VON WILLEBRAND DISEASE;

EID: 0029909162     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0038-1650645     Document Type: Article

References (20)

1. Rodeghiero F, Castaman G, Mannucci PM. Clinical indications for desmopressin (DDAVP) in congenital and acquired von Willebrand disease. Blood Reviews 1991; 5: 155-61.
2. Rodeghiero F, Castaman G, Dini E. Epidemiological investigation of the prevalence of von Willebrand's disease. Blood 1987; 69: 454-9.
3. Castaman G, Rodeghiero F. Current management of von Willebrand's disease. Drugs 1995; 50: 602-14.
4. Mannucci PM. Desmopressin: a nontransfusional form of treatment for congenital and acquired bleeding disorders. Blood 1988; 72: 1449-55.
5. Lethagen S, Harris AS, Nilsson IM. Intranasal desmopressin (DDAVP) by spray in mild haemophilia A and von Willebrand's disease type I. Blut 1990; 60: 187-91.
6. Rose EH, Aledort LM. Nasal spray desmopressin (DDAVP) for mild hemophilia A and von Willebrand disease. Ann Intern Med 1991; 114: 563-8.
7. Lethagen S, Ragnarson Tennvall G. Self-treatment with desmopressin intranasal spray in patients with bleeding disorders: effect on bleeding symptoms and socioeconomic factors. Ann Hematol 1993; 66: 257-60.
8. Ghirardini A, Mariani G, Iacopino G, Tirindelli MC, Solinas S, Moretti T. Concentrated DDAVP: further improvement in the management of mild factor VIII deficiencies. Thromb Haemost 1987; 58: 896-8.
9. Ghirardini A, Chistolini A, Tirindelli MC, Di Paolantonio T, Iacopino G, Mariani P, Chirletti P, Agrestini F, Mariani G. Clinical evaluation of subcutaneously administered DDAVP. Thromb Res 1988; 49: 363-72.
10. Mannucci PM, Vicente V, Alberca I, Sacchi E, Longo G, Harris AS, Lindquist A. Intravenous and subcutaneous administration of desmopressin (DDAVP) to hemophiliacs: pharmacokinetics and factor VIII responses. Thromb Haemost 1987; 58: 1037-9.
11. Mannucci PM, Ruggeri ZM, Pareti FI, Capitanio A. DDAVP: a new pharmacological approach to the management of haemophilia and von Willebrand's disease. Lancet 1977; 1: 869-72.
12. Mariani G, Mannucci PM, Cattaneo M (eds). Desmopressin in bleeding disorders. Plenum Press, New York, 1993
13. Kohler M, Hellstern P, Miyashita C, von Blohn G, Wenzel E. Comparative study of intranasal, subcutaneous and intravenous administration of desamino-D-arginine vasopressin (DDAVP). Thromb Haemost 1986; 55: 108-11.
14. Lethagen S, Harris AS, Sjorin E, Nilsson IM. Intranasal and intravenous administration of desmopressin: effect on FVIII/vWF, pharmacokinetics and reproducibility. Thromb Haemost 1987; 58: 1033-6.
15. Smith TJ, Gill JC, Ambroso DR, Hathaway WE. Hyponatremia and seizures in young children given DDAVP. Am J Hematol 1989; 31: 199-202.
16. Weinstein RE, Bona RD, Altman AJ, Quinn JJ, Weisman SJ, Bartolomeo A, Rickles FR. Severe hyponatremia after repeated intravenous administration of desmopressin. Am J Hematol 1989; 32: 258-61.
17. Mannucci PM, Lusher JM. Desmopressin and thrombosis. Lancet 1989; 2: 675-6.
18. Bond L, Bevan DU. Myocardial infarction in a patient with hemophilia treated with DDAVP. N Engl J Med 1988; 318: 121.
19. Hartmann S, Reinhart W. Fatal complication of desmopressin. Lancet 1995; 1: 1302-3.
20. Mariani G, Ghirardini A, Schinaia N. Epidemiology of mild and moderate hemophilia A and von Willebrand's disease. In Mariani G, Mannucci PM, Cattaneo M (eds). Desmopressin in bleeding disorders. Plenum Press, New York, 1993, 233-8.