Nonactivated astrocytes downregulate T cell receptor expression and reduce antigen-specific proliferation and cytokine production of myelin basic protein (MBP)-reactive T cells

Journal of Neuroimmunology

Volumn 78, Issue 1-2, 1997, Pages 69-78

  Sun, Deming ^a   Coleclough, Christopher ^b   Whitaker, John N ^a  

^a Dept Neurol Ctr N ^*  (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Antigen presenting cell; Experimental autoimmune encephalomyelitis; Glial cells; T cell activation; TCR downregulation

Indexed keywords

CYTOKINE; MYELIN BASIC PROTEIN; T LYMPHOCYTE RECEPTOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANTIBODY PRODUCTION; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; ASTROCYTE; CELL PROLIFERATION; DEMYELINATION; GLIA CELL; IMMUNE RESPONSE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; T LYMPHOCYTE ACTIVATION; TISSUE INJURY;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS; ASTROCYTES; DOWN-REGULATION; EPITOPES; HISTOCOMPATIBILITY ANTIGENS CLASS II; INTERFERON TYPE II; LYMPHOCYTE ACTIVATION; MYELIN BASIC PROTEINS; RATS; RATS, INBRED LEW; RECEPTORS, ANTIGEN, T-CELL; SPLEEN; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030764894     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(97)00083-0     Document Type: Article

References (44)

1. Arnold B., Schönrich G., Hämmerling G.J. Multiple levels of peripheral tolerance. Immunol. Today. 14:1993;12-14.
2. Azuma M., Cayabyab M., Buck D., Phillips J.H., Lanier L.L. CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes. J. Exp. Med. 175:1992;353-360.
3. Babbitt B.P., Allen P., Matsueda G., Haber E., Unanue E. The binding of immunogenic peptides to Ia histocompatibility molecules. Nature. 317:1985;359-361.
4. Ben-Nun A., Wekerle H., Cohen I.R. The rapid isolation of clonable,antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur. J. Immunol. 11:1981;195-204.
5. Bo L., Mork S., Kong P.A., Nyland H., Pardo C.A., Trapp B.D. Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active multiple sclerosis lesions. J. Neuroimmunol. 51:1994;135-146.
6. Burns J., Rosenzweig A., Zweiman B., Lisak R.P. Isolation of myelin basic protein-reactive T-cell lines from normal human blood. Cell. Immunol. 81:1983;435-440.
7. Cohen I.R. Regulation of autoimmune disease: Physiological and therapeutic. Immunol. Rev. 94:1986;5-21.
8. Fierz W., Endler B., Reske K., Wekerle H., Fontana A. Astrocytes as antigen presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune interferon and its effect on antigen presentation. J. Immunol. 134:1985;3785-3794.
9. Flick D.A., Gifford G.E. Comparison of in vitro cytotoxic assays for tumor necrosis factor. J. Immunol. Methods. 68:1984;167-175.
10. Fontana A., Fierz W., Wekerle H. Astrocytes present myelin basic protein to encephalitogenic T-cell lines. Nature. 307:1984;273-276.
11. Fontana A., Frei K., Bodmer S., Hofer E. Immune-mediated encephalitis: On the role of antigen-presenting cells in brain tissue. Immunol. Rev. 100:1987;185-201.
12. Hayakawa K., Hardy R.R. Murine CD4+ T cell subsets defined. J. Exp. Med. 168:1989;1825-1840.
13. Hünig T., Wallny H., Hartley J.K., Lawetzky A., Tiefenhaler G. A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induced T cell activation. J. Exp. Med. 169:1989;73-86.
14. Joly E., Mucke L., Oldstone M.B.A. Viral persistence in neurones explained by lack of major histocompatibility class I expression. Science. 253:1991;1283-1285.
15. Massa P.T., Dörries R., ter Meulen V. Viral particles induce Ia antigen expression on astrocytes. Nature. 320:1986;543-545.
16. Massa P.T., ter Meulen V., Fontana A. Hyperinducibility of Ia antigen on astrocytes correlates with strain-specific susceptibility to experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA. 84:1987;4219-4223.
17. McMaster W.R., Williams A.F. Identification of Ia glycoproteins in rat thymus and purification from rat spleen. Eur. J. Immunol. 9:1979;426-434.
18. Meinl E., Aloisi F., Ertl B., Weber F., De Waal Malefyt R., Wekerle H., Hohlfeld R. Multiple sclerosis. Immunomodulatory effects of human astrocytes on T cells. Brain. 117:1994;1323-1332.
19. Möller G. T-cell-tolerance, Mls and MHC antigen. Immunol. Rev. 107:1989;1-16.
20. Mueller D.L., Jenkins M.K., Schwartz R.H. An accessory cell-derived costimulatory signal acts independently of protein kinase C activation to allow T cell proliferation and prevent the induction of unresponsiveness. J. Immunol. 142:1989;2617-2627.
21. Panek R.B., Lee Y.-J., Itoh-Lindstrom Y., Ting J.P.-Y., Benveniste E.N. Characterization of astrocyte nuclear proteins involved in IFN-gamma- and TNF-α-mediated class II MHC gene expression. J. Immunol. 153:1994;4555-4564.
22. Pette M., Fujita K., Kitze B., Whitaker J.N., Albert E., Kappos L., Wekerle H. Myelin basic protein-specific T lymphocyte lines from MS patients and healthy individuals. Neurology. 40:1990;1770-1776.
23. Ridge J.P., Fuchs E.J., Matzinger P. Neonatal tolerance revisited: Turning on newborn T cells with dendritic cells. Science. 271:1996;1723-1726.
24. Risau W., Engelhardt B., Wekerle H. Immune function of the blood-brain barrier: Incomplete presentation of protein (auto-)antigens by rat brain microvascular endothelium in vitro. J. Cell Biol. 110:1990;1757-1766.
25. Schwartz R.H. T-lymphocyte recognition in association with gene products of the major histocompatibility complex. Ann. Rev. Immunol. 3:1985;237-261.
26. Sun D. Enhanced interferon-gamma-induced Ia-antigen expression by glial cells after previous exposure to this cytokine. J. Neuroimmunol. 34:1991;205-214.
27. Sun D., Wekerle H. Ia-restricted encephalitogenic T lymphocytes mediating EAE lyse autoantigen-presenting astrocytes. Nature. 320:1986;70-72.
28. Sun D., Myermann R., Wekerle H. Up- and down-regulatory activities of astrocyte clones. Ann. N.Y. Acad. Sci. 430:1988;463-465.
29. Sun D., Le J., Coleclough C. Diverse T cell receptor β chain usage by rat encephalitogenic T cells reactive to residues 68-88 of myelin basic protein. Eur. J. Immunol. 23:1993;494-498.
30. Sun D., Le J., Yang S., Malotkey M., Coleclough C. Major role of antigen-presenting cells in the response of rat encephalitogenic T cells to myelin basic proteins. J. Immunol. 151:1993;111-118.
31. Sun D., Coleclough C., Hu X. Heterogeneity of rat encephalitogenic T cells elicited by variants of the MBP(68-88) peptide. Eur. J. Immunol. 25:1995;1687-1692.
32. Sun D., Hu X., Coleclough C. The clonal composition of myelin basic protein-reactive encephalitogenic T cell populations is influenced both by the structure of relevant antigens and the nature of antigen-presenting cells. Eur. J. Immunol. 25:1995;69-74.
33. Sun D., Hu X., Shah R., Coleclough C. The pattern of cytokine gene expression induced in rat T cells specific for myelin basic protein depends on the type and quality of antigenic stimulus. Cell. Immunol. 166:1995;1-8.
34. Sun D., Hu X., Shah R., Zhang L., Coleclough C. Production of tumor necrosis factor-α as a result of glia-T cell interaction correlates with the pathogenic activity of myelin basic protein-reactive T cells in experimental autoimmune encephalomyelitis. J. Neurosci. Res. 45:1996;400-409.
35. Swain S.L. T cell subsets and the recognition of MHC class. Immunol. Rev. 74:1983;129-144.
36. Swanborg R.H., Swierkosz J.E., Saieg R.G. Studies on the species-variability of experimental allergic encephalomyelitis in guinea pig and rats. J. Immunol. 112:1974;594-600.
37. Traugott U. Multiple sclerosis: Relevance of class I and class II MHC-expressing cells to lesion development. J. Neuroimmunol. 16:1987;283-302.
38. Van Noort J.M., Van Sechel A., Boon J., Boersma W.J.A., Polman C.H., Lucas C.J. Minor myelin proteins can be major targets for peripheral blood T cells from both multiple sclerosis patients and healthy subjects. J. Neuroimmunol. 46:1993;67-72.
39. Vass K., Lassmann H., Wekerle H., Wisniewski H.M. the distribution of Ia antigen in the lesion of rat acute experimental allergic encephalomyelitis. Acta Neuropathol. 70:1986;149-160.
40. Weber F., Meinl E., Aloisi F., Nevinny-Stickel C., Albert E., Wekerle H., Hohlfeld R. Human astrocytes are only partially competent antigen presenting cells. Possible implications for lesion development in multiple sclerosis. Brain. 117:1994;59-69.
41. Wekerle H., Sun D. Immune reactivity in the nervous system: Modulation of T lymphocyte activation by glial cells. J. Exp. Biol. 132:1987;43-57.
42. Wong G.M.W., Bartlett P.F., Clark-Lewis I., Schrader J.W. Inducible expression of H-2 and Ia antigens on brain cells. Nature. 310:1984;688-691.
43. Zamvil S., Nelson P., Trotter J., Mitchell D., Knobler R., Fritz R., Steinman L. T cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination. Nature. 317:1985;355-358.
44. Zinkernagel R., Doherty P.C. H-2-compatibility requirement for T cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus: Different cytotoxic T cell specificities are associated with structures from H-2K or H-2D. J. Exp. Med. 141:1975;1427-1436.