Ex vivo cytokine expansion of peripheral blood 5-fluorouracil-treated CD34-positive chronic myeloid leukaemia cells increases the selection of Ph- negative cells

British Journal of Haematology

Volumn 98, Issue 2, 1997, Pages 467-473

  Mahon, François Xavier ^a   Pigeonnier Lagarde, Valérie ^a   Chahine, Hikmat ^a   Barbot, Caroline ^a   Jazwiec, Bozena ^a   Ripoche, Jean ^a   Reiffers, Josy ^a  

^a CNRS Bordeaux Segalen University   (France)

Author keywords

5 fluorouracil; Chronic myeloid leukaemia; Cytokine expansion; FLT3 ligand; Ph negative cells

Indexed keywords

CD34 ANTIGEN; CYTOKINE; FLUOROURACIL; INTERLEUKIN 1ALPHA; INTERLEUKIN 3; STEM CELL FACTOR;

ARTICLE; CANCER CHEMOTHERAPY; CHRONIC MYELOID LEUKEMIA; COLONY FORMING UNIT GM; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL; MYELOPROLIFERATIVE DISORDER; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; STEM CELL TRANSPLANTATION;

EID: 0030763720     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1997.2003017.x     Document Type: Article

References (43)

1. Bedi, A., Zehnbauer, B.A., Collector, M.I., Barber, J.P., Zicha, M.S., Sharkis, S.J. & Jones, R.J. (1993) BCR-ABL gene rearrangement and expression of primitive haemopoietic progenitors in chronic myeloid leukemia. Blood, 81, 2898-2902.
2. Beradi, A.C., Wang, A., Levine, J.D., Lopez, P. & Scadden, D.T. (1995) Functional isolation and characterization of human hemopoietic stem cells. Science, 267, 104-108.
3. Birg, F., Courcoul, M., Rosnet, O., Bardin, F., Pebusque, M.J., Marchetto, S., Tabilio, A., Mannoni, P. & Birnbaum, D. (1992) Expression of FMS/KIT-like gene FLT3 in human acute leukemia of the myeloid and lymphoid lineage. Blood, 80, 2584-2593.
4. Broxmeyer, H.E., Lu, L., Cooper, S., Ruggieri, L., Li, Z.H. & Lyman, S.D (1995) Flt3 ligand stimulates/costimulates the growth of myeloid stem/progenitor cells. Experimental Hematology, 12, 1121-1129.
5. Carlo-Stella, C., Mangoni, L., Piovani, G., Almici, C., Garau, D., Caramatti, C, & Rizzoli, V. (1991) In vitro marrow purging in chronic myelogenous leukemia: effect of mafosfamide and recombinant granulocyte-macrophage colony-stimulating factor. Bone Marrow Transplantation, 8, 265-272.
6. Carlo-Stella, C., Mangoni, L., Piovani, G., Garau, D., Almici, C. & Rizzoli, V. (1994) Identification of Philadelphia-negative granulocyte-macrophage colony-forming units generated by stroma-adherent cells from chronic myelogenous leukemia patients. Blood, 83, 1373-1380.
7. Carow, C.E., Levenstein, M., Kaufmann, S.H., Chen, J., Amin, S., Rockwell, P., Witte, L., Borowitz, J., Civin, C.I. & Small, D. (1996) Expression of the haemopoietic growth factor receptor FLT3(STK-1/Flk2) in human leukemias. Blood, 87, 1089-1096.
8. Coulombel, L., Kalousek, D.K., Eaves, C.J., Gupta, C.M. & Eaves, A.C. (1983) Long-term marrow culture reveals chromosomally normal haemopoietic progenitor cells in patients with Philadelphia chromosome-positive myelogenous leukemia. New England Journal of Medicine, 308, 1493-1498.
9. Deisseroth, A.B., Zu, Z., Claxton, D., Hanania, E.G., Fu, S., Ellerson, D., Goldberg, L., Thomas, M., Janicek, K., Anderson, W.F., Hester, J., Körbling, M., Durett, A., Moen, R., Berenson, R., Heimfeld, S., Hamer, J., Calvert, L., Tibbits, P., Talpaz, M., Kantarjian, H., Champlin, R. & Reading, C. (1994) Genetic marking shows that Ph+ cells present in autologous transplants of chronic myelogenous leukemia (CML) contribute to relapse after autologous bone marrow in CML. Blood, 83, 3068-3076.
10. De Klein, A., Geurts van Kessel, A., Grosveld, G., Bartram, C.R., Hagemeijer, A., Bootsma, D., Spurr, N.K., Heisterkamp, N., Groffen, J. & Stephenson, J.R. (1982) A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature, 300, 765-767.
11. Diamond, J., Goldman, J.M. & Melo, J. (1995) BCR-ABL, ABL-BCR, BCR and ABL genes are all espressed in individual CFU-GM colonies derived from blood of patients with chronic myeloid leukemia. Blood, 85, 2171-2175.
12. Drexler, H.G. (1996) Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells. Leukemia, 10, 588-599.
13. Emerson, S. (1996) Ex vivo expansion of hemopoietic precursors, progenitors, and stem cells: the next generation of cellular therapeutics. Blood, 87, 3082-3088.
14. Fialkow, P.J., Jacobson, R.J. & Papayannopoulou, T. (1977) Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. American Journal of Medicine, 63, 125-130.
15. Gabbianelli, M., Pelosi, E., Montesoro, E., Valtieri, M., Luchetti, L., Samoggia, P., Vitelli, L., Barberi, T., Testa, U. & Lyman, S. & Peschle, R. (1995) Multi-level effects of FLT3 ligand on human hematopoiesis: expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors. Blood, 86, 1661-1670.
16. Goldman, J.M., Apperley, J.F., Jones, L., Marcus, R., Goolden, A.W.G., Batchelor, R., Hale, G., Waldman, H. Reid, C.D., Hows, J., Gordon-Smith, E., Catovsky, D. & Galton, D.A.G. (1986) Bone marrow transplantation for patients with chronic myeloid leukemia. New England Journal of Medicine, 314, 202-207.
17. Groffen, J., Stephenson, J.R., Heisterkamp, N., De Klein, A., Bartram, C.R. & Grosveld, G. (1984) Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell, 36, 93-99.
18. + chronic phase chronic myeloid leukaemia (CP-CML) cells in liquid culture with cytokines. (Abstract). British Journal of Haematology, 93, (Suppl. 2), 628.
19. Hudak, S., Hunte, B., Culpepper, J., Menon, S., Hannum, C., Thompson-Snipes, L. & Rennick, D. (1995) FLT3/FLK2 ligand promote the growth of murine stem cells and the expansion of colony-forming cells and spleen colony-forming units. Blood, 85, 2747-2755.
20. + cell population from peripheral blood of CML patients contains Bcr-Abl negative progenitor cells. Experimental Hematology, 23, 1509-1514.
21. + cells arising from hemopoietic progenitors in chronic myeloid leukemia. Blood, 83, 1744-1747.
22. lo population in chronic myeloid leukemia: an analysis using interphase fluorescence in situ hybridization. Blood, 86, 737-743.
23. Lange, W., Henschler, R. & Mertelsmann, R. (1996) Biological and clinical advances in stem cell expansion. Leukemia, 10, 943-945.
24. Leemhuis, T., Leibowitz, D., Cox, G., Silver, R., Srour, E.F., Tricot, G. & Hoffman, R. (1993) Identification of BCR/ABL negative primitive hemopoietic progenitor cells within chronic myeloid leukemia marrow. Blood, 81, 801-807.
25. + cells from patients with chronic myeloid leukemia. Blood, 88, 1796-1804.
26. Malinge, M.C. Mahon, F.X., Delfau, M.H., Daheron, L., Kitzis, A., Guilhot, K. Tanzer, J., Grandchamp B. (1992) Quantitative determination of the hybrid Bcr-Abl RNA in patients with chronic myelogenous leukaemia under interferon therapy. British Journal of Haematology, 82, 701-707.
27. McGlave, P.B., De Fabritiis, P., Deisseroth, A., Goldman, J., Barnett, M., Reiffers, J., Simonsson, B., Carella, C. & Aepli, D. (1994) Autologous transplants for chronic myelogenous leukaemia: results from eight transplant groups. Lancet, 343, 1486-1488.
28. + hematopoietic progenitor cells. Blood, 86, 3413-3420.
29. Melo, J. (1996) The molecular biology of chronic myeloid leukemia. Leukemia, 10, 751-756.
30. - cells maintained in serum-free cytokine-supplemented medium under conditions that stimulate extensive amplification of normal LTC-IC. (Abstract). Blood, 86, 601.
31. -) human haemopoietic cells: novel responses to Flt3-ligand and thrombopoietin. Journal of Experimental Medicine, 183, 2551-2555.
32. Reiffers, J., Mahon, F.X., Boiron, J.M., Fabères, C., Cony-Makhoul, P. & Braustet, A. (1996) Autografting in chronic myeloid leukemia: an overview. Leukemia, 10, 385-388.
33. Rice, A., Boiron, J-M., Barbot, C., Dupouy, M., Dubosc-Marchenay, N., Dumain, P., Lacombe, F. & Reiffers, J. (1995) Cytokine-mediated expansion of 5-FU-resistant peripheral blood stem cells. Experimental Hematology, 23, 303-308.
34. Rosnet, O., Behring, H.J., Marchetto, S., Rappold, I., Lavagna, C., Sainty, D., Arnoulet, C., Chabannon, C., Kanz, L., Hannum, C. & Birnbaum, D. (1996) Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hemopoietic cells. Leukemia, 10, 238-248.
35. + bone marrow progenitor cells in vitro. Blood, 87, 1317-1325.
36. - cells and maintains progenitor cells in vitro. Blood, 87, 3563-3570.
37. Sirard, C., Lapidot, T., Vormoor, J., Cashman, J.D., Doedens, M., Murdoch, B., Jamal, N., Messner, H., Addey, L., Minden, M., Laraya, P., Keating, A., Eaves, A., Lansdorp, P.M., Eaves, C.J. & Dick, J.E. (1996) Normal and leukaemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis. Blood, 87, 1539-1548.
38. + human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proceedings of the National Academy of Sciences of the United States of America, 91, 459-463.
39. Thomas, E.D., Clift, R.A., Fefer, A., Appelbaum, F.R., Beatty, P., Bensinger, W.I., Buckner, C.D., Cheever, M.A., Deeg, H.J., Doney, K., Flournoy, N., Greenberg, P., Hansen, J.A., Martin, P., McGuffin, R., Ramberg, R., Sanders, J.E., Singer, J., Stevart, P., Storb, R. Sullivan, K., Weiden, P.L. & Witherspoon, R. (1986) Marrow transplantation for the treatment of chronic myelogenous leukemia. Annals of Internal Medicine, 104, 155-162.
40. Turhan, A.G., Humphries, R.K., Eaves, C.J., Barnett, M.J., Phillips, G.L., Kalousek, D.K., Klingemann, H.G., Lansdorp, P.L., Reece, D.E., Shepherd, J.D. & Eaves, A.C. (1990) Detection of breakpoint cluster region-negative and nonclonal hematopoiesis in vitro and in vivo after transplantation of cells selected in cultures of chronic myeloid leukemia marrow. Blood, 76, 2404-2410.
41. Udomsakdi, C., Eaves, C.J., Lansdorp, P.M. & Eaves, A.C. (1992a) Phenotypic heterogeneity of primitive leukemic hemopoietic cells in patients with chronic myeloid leukemia. Blood, 80, 2522-2550.
42. Udomsakdi, C., Eaves, C.J., Swolin, B., Reid, D.S., Barnett, M.J. & Eaves, A.C. (1992b) Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level. Proceedings of the National Academy of Sciences of the United States of America, 89, 6192-6196.
43. Verfaillie, C.M., Miller, W.J., Boylan, K. & McGlave, P.B. (1992) Selection of benign primitive hemopoietic progenitors in chronic myelogenous leukemia on the basis of HLA-DR antigen expression. Blood, 79, 1003-1010.