Hyperhomocysteinemia following oral methionine load is associated with increased lipid peroxidation

Thrombosis Research

Volumn 87, Issue 4, 1997, Pages 411-416

  Domagala, Teresa B ^a   Libura, Magdalena ^a   Szczeklik, Andrzej ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Atherosclerosis; Homocysteine; Lipid peroxidation; Methionine loadind test

Indexed keywords

HOMOCYSTEINE; LOW DENSITY LIPOPROTEIN; METHIONINE;

ADULT; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CLINICAL ARTICLE; DIAGNOSTIC TEST; FEMALE; HUMAN; HYPERHOMOCYSTEINEMIA; LIPID PEROXIDATION; LOADING TEST; MALE; PRIORITY JOURNAL; RISK FACTOR; VASCULAR ENDOTHELIUM;

ADULT; FEMALE; HOMOCYSTEINE; HUMANS; LIPID PEROXIDATION; MALE; METHIONINE;

EID: 0030763280     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(97)00145-X     Document Type: Article

References (21)

1. BOUSHEY, C.J., BERESFORD, S.A.A., OMENN, G.S. and MOTULSKY, A.G. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. JAMA 174, 1049-1057, 1995.
2. MUDD, S.H., LEVY H.L. and SKOSBY F. Disorders of transsulfuration. In: The Metabolic and Molecular Bases of Inherited Disease. Seriver C.R., Beaudet A.L., Sly W.S., Valle D. (eds.), pp. 1279-1327, McGraw-Hill Inc; New York (1995).
3. KANG, S.S., WONG P.W.K., BOCK, H.G., HORWITZ, A. and GRIX, A. Intermediate hyperhomocysteinemia resulting from compound heterozygosity of methylene-tetrahydrofolate reductase mutation. Am J Hum Genet 48, 546-551, 1991.
4. KANG, S.S. and WONG, P.W.K. Genetic and nongenetic factors for moderate hyperhomocyst(e)inemia. Atherosclerosis 119, 135-138, 1996.
5. MALINOW, M.R., KANG, S.S., TAYLOR, L.M., WONG, P.W.K., COULL, B. and INAHARA, T. Prevalence of hyperhomocyst(e)inemia in patients with peripheral arterial occlusive disease. Circulation 79, 1180-1188, 1989.
6. BOSTOM, A.G., JACQUES, P.F., NADEAU, M.R., WILLIAMS, R.R., ELLISON, R.C. and SELHUB J. Post-methionine load hyperhomocysteinemia in persons with normal fasting total plasma homocysteine: initial results from The NHLBI Family Heart Study. Atherosclerosis 116, 147-151, 1995.
7. HARKER, L.A., ROSS, R., SLICHTER, S.J. and SCOTT, C.R. Homocysteine-induced atherosclerosis: The role of endothelial cell injury and platelet response in its genesis. J Clin Invest 58, 731-741, 1976.
8. REES, M.M. and RODGERS, G.M. Homocysteinemia: Association of metabolic disorder with vascular disease and thrombosis. Thromb Res 71, 337-359, 1993.
9. HEINECKE, J.W., KAWAMURA, M., SUZUKI, L. and CHAIT, A. Oxidation of low density lipoprotein by thiols. Superoxide-dependent and independent mechanism., J Lipid Res 34, 345-360, 1993.
10. WARE, J.A. and HEISTAD, D.D. Platelet endothelium interactions. New Engl J Med 328, 628-633, 1993.
11. ANDERSSON, A., BRATTSTROM, L., ISRAWLSSON B., ISAKSSON A. and HULTBERG B. The effect of excess daily methionine intake on plasma homocysteine after a methionine loading test in humans. Clin Chim Acta 192, 69-76, 1990.
12. MANSOOR, M.A., BERGMARK, C., SVARDAL, A.M., LONNING, P.E. and UELAND, P.M. Redox status and protein binding of plasma homocysteine and other aminothiols in patients with early-onset peripheral vascular disease. Arterioscl Thromb Vasc Biol 15, 232-240, 1995.
13. MANSOOR, M.A., SVARDAL, A.M. and UELAND, P.M. Determination of the in vivo redox status of cysteine, cysteinglycine, homocysteine and glutathione in human plasma. Anal Biochem 200, 218-229, 1992.
14. NYGARD, O., REFSUM.H., UELAND, P.M., SVENSOLD, I., NORDREHAUG, J.E., GUNNAR, K. and VOLLSET S.E. Coffee consumption and plasma total homocysteine. The Hordaland Homocysteine Study. Amer J Clin Nutr 65, 136-143, 1997.
15. WASOWICZ, W., NEVE, J. and PERETZ, A. Optimized steps in fluorimetric determination of thiobarbituric acid-reactive substance in serum importance of extraction pH and influence of sample preservation and storage. Clin Chem 39, 2522-2526, 1993.
16. WALL, R.T., HARLAM, J.M., HARKER, L.A. and STRIKER, G.E. Homocyst(e)ine -induced endothelial cell injury in vitro a model for the study of vascular injury. Thromb Res 18, 113-121, 1980.
17. STARKEBAUM, G. And HARLAM, J.M. Endothelial cell injury due to cooper-catalyzed hydrogen peroxide generation from homocysteine. J Clin Invest 77, 1370-1376, 1986.
18. SCHONEICH, C., DILLINGER, U., BRUCHAUSEN, F. and ASMUS, K.D. Oxidation of polyunsaturated fatty acids and lipids through thiyl and sulfonyl radicals: reaction kinetics, and influence of oxygen and structure of thiol radicals. Arch Biochem Biophys 292, 456-467, 1992.
19. HIRANO, K., OGIHARA, T., MIKI, M., YASUDA, H., TAMAI, H., KAWAMURA, N., and MINO, M. Homocysteine induces iron-catalyzed lipid peroxidation of low-density lipoprotein that is prevented by alpha-tocopherol. Free Radical Res 27, 267-276, 1994.
20. BLOM. H.J., ENGELEN, D.P.E., BOERS, G.H.J., STADHOUDERS, A.M., SENGERS, R.C.A., DE ABREU, R., TEPOELE-POTHOFF, M.T.W.B., and TRUBELS, J.M.F. Lipid peroxidation in homocysteinaemia. J Inher Metab 75, 419-422, 1992.
21. BLOM, H.J., KLEINVELD, H.A., BOERS, G.H.J., DEMACKER, P.M.N., HAKLEMMERS, H.L.M., TE POELE-POTHOFF, M.T.W.B. and TRIJBELS, J.M.F. Lipid peroxidation and susceptibility of low-density lipoprotein to in vitro oxidation in hyperhmocysteinemia. Eur J Clin Invest 25, 149-154, 1995.