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Volumn 32, Issue 4-5, 1997, Pages 363-374

Genetic control of programmed cell death and aging in the nematode Caenorhabditis elegans

Author keywords

Apoptosis; Biological clocks; Cell death genes; Dauer formation; Life span

Indexed keywords

ANIMAL CELL; APOPTOSIS; BIOLOGICAL RHYTHM; CAENORHABDITIS ELEGANS; CELL AGING; CELL DEATH; CELL SURVIVAL; CONFERENCE PAPER; CONTROLLED STUDY; GENETIC REGULATION; NONHUMAN; PRIORITY JOURNAL;

EID: 0030759779     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(96)00167-2     Document Type: Conference Paper
Times cited : (28)

References (64)
  • 2
    • 0023663870 scopus 로고
    • A cell that dies during wild-type C. Elegans development can function as a neuron in a ced-3 mutant
    • AVERY, L. and HORVITZ, H.R. A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant. Cell 51, 1071-1078, 1987.
    • (1987) Cell , vol.51 , pp. 1071-1078
    • Avery, L.1    Horvitz, H.R.2
  • 4
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • BRENNER, S. The genetics of Caenorhabditis elegans. Genetics 77, 71-94, 1974.
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 6
    • 0025950667 scopus 로고
    • Programmed cell death in the immune system
    • COHEN, J.J. Programmed cell death in the immune system. Adv. Immunol. 50, 55-85, 1991.
    • (1991) Adv. Immunol. , vol.50 , pp. 55-85
    • Cohen, J.J.1
  • 7
    • 0028807085 scopus 로고
    • The age-1 and daf-2 genes function in a common pathway to control the life span of Caenorhabditis elegans
    • DORMAN, J.B., ALBINDER, B., SHROYER, T., and KENYON, C. The age-1 and daf-2 genes function in a common pathway to control the life span of Caenorhabditis elegans. Genetics 141, 1399-1406, 1995.
    • (1995) Genetics , vol.141 , pp. 1399-1406
    • Dorman, J.B.1    Albinder, B.2    Shroyer, T.3    Kenyon, C.4
  • 8
    • 0022497852 scopus 로고
    • Genetic control of programmed cell death in the nematode
    • ELLIS, H.M. and HORVITZ, H.R. Genetic control of programmed cell death in the nematode. C. elegans. Cell 44, 817-829, 1986.
    • (1986) C. Elegans. Cell , vol.44 , pp. 817-829
    • Ellis, H.M.1    Horvitz, H.R.2
  • 9
    • 0026051936 scopus 로고
    • Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans
    • ELLIS, R.E., JACOBSON, D.M., and HORVITZ, H.R. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. Genetics 129, 79-94, 1991a.
    • (1991) Genetics , vol.129 , pp. 79-94
    • Ellis, R.E.1    Jacobson, D.M.2    Horvitz, H.R.3
  • 11
    • 0028225587 scopus 로고
    • Production of age-synchronous mass cultures of Caenorhabditis elegans
    • FABIAN, T.J. and JOHNSON, T.E. Production of age-synchronous mass cultures of Caenorhabditis elegans. J. Gerontol. 49, B145-B156, 1994.
    • (1994) J. Gerontol. , vol.49
    • Fabian, T.J.1    Johnson, T.E.2
  • 12
    • 0023831256 scopus 로고
    • A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility
    • FRIEDMAN, D.B. and JOHNSON, T.E. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 118, 75-86, 1988.
    • (1988) Genetics , vol.118 , pp. 75-86
    • Friedman, D.B.1    Johnson, T.E.2
  • 13
    • 0020557883 scopus 로고
    • Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans
    • HEDGECOCK, E.M., SULSTON, J.E., and THOMSON, J.N. Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans. Science 220, 1277-1279, 1983.
    • (1983) Science , vol.220 , pp. 1277-1279
    • Hedgecock, E.M.1    Sulston, J.E.2    Thomson, J.N.3
  • 14
    • 0028786075 scopus 로고
    • Viable maternal-effect mutations that affect the development of the nematode Caenorhabditis elegans
    • HEKIMI. S., BOUTIS, P., and LAKOWSKI, B. Viable maternal-effect mutations that affect the development of the nematode Caenorhabditis elegans. Genetics 141, 1351-1364, 1995.
    • (1995) Genetics , vol.141 , pp. 1351-1364
    • Hekimi, S.1    Boutis, P.2    Lakowski, B.3
  • 15
    • 0026582702 scopus 로고
    • C. Elegans gene ced-9 protects cells from programmed cell death
    • HENGARTNER, M.O., ELLIS, R.E., and HORVITZ, H.R. C. elegans gene ced-9 protects cells from programmed cell death. Nature 356, 494-499, 1992.
    • (1992) Nature , vol.356 , pp. 494-499
    • Hengartner, M.O.1    Ellis, R.E.2    Horvitz, H.R.3
  • 16
    • 0028288277 scopus 로고
    • C. Elegans cell death gene ced-9 encodes a functional homolog of mammalian proto-oncogene bcl-2
    • HENGARTNER, M.O. and HORVITZ, H.R. C. elegans cell death gene ced-9 encodes a functional homolog of mammalian proto-oncogene bcl-2. Cell 76, 665-676, 1994a.
    • (1994) Cell , vol.76 , pp. 665-676
    • Hengartner, M.O.1    Horvitz, H.R.2
  • 17
    • 0028291141 scopus 로고
    • Activation of C. Elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved in Bcl-2
    • HENGARTNER, M.O. and HORVITZ, H.R. Activation of C. elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved in Bcl-2. Nature 369, 318-320, 1994b.
    • (1994) Nature , vol.369 , pp. 318-320
    • Hengartner, M.O.1    Horvitz, H.R.2
  • 19
    • 0024066438 scopus 로고
    • An endonuclease from Caenorhabditis elegans: Partial purification and characterization
    • HEVELONE, J. and HARTMAN, P.S. An endonuclease from Caenorhabditis elegans: Partial purification and characterization. Biochem. Genet. 26, 447-461, 1988.
    • (1988) Biochem. Genet. , vol.26 , pp. 447-461
    • Hevelone, J.1    Hartman, P.S.2
  • 20
    • 0028822875 scopus 로고
    • The nematode Caenorhabditis elegans and its genome
    • HODGKIN, J., PLASTERK, R.H., and WATERSTON, R.H. The nematode Caenorhabditis elegans and its genome. Science 270, 410-414, 1995.
    • (1995) Science , vol.270 , pp. 410-414
    • Hodgkin, J.1    Plasterk, R.H.2    Waterston, R.H.3
  • 22
    • 0030016821 scopus 로고    scopus 로고
    • Longevity, genes, and aging
    • JAZWINSKI, S.M. Longevity, genes, and aging. Science 273, 54-59, 1996.
    • (1996) Science , vol.273 , pp. 54-59
    • Jazwinski, S.M.1
  • 23
    • 0027771804 scopus 로고
    • C. Elegans mutant that lives twice as long as wild type
    • KENYON, C., CHANG, J., GENSCH, E., RUDNER, A., and TABTIANG, R. A C. elegans mutant that lives twice as long as wild type. Nature 366, 461-464, 1993.
    • (1993) Nature , vol.366 , pp. 461-464
    • Kenyon, C.1    Chang, J.2    Gensch, E.3    Rudner, A.4    Tabtiang, R.A.5
  • 24
    • 0018725140 scopus 로고
    • The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans
    • KIMBLE, J. and HIRSH, D. The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans. Dev. Biol. 70, 396-417, 1979.
    • (1979) Dev. Biol. , vol.70 , pp. 396-417
    • Kimble, J.1    Hirsh, D.2
  • 25
    • 0017301265 scopus 로고
    • Non-aging developmental variant of Caenorhabditis elegans
    • KLASS, M. and HIRSH, D. Non-aging developmental variant of Caenorhabditis elegans. Nature 260, 523-525, 1976.
    • (1976) Nature , vol.260 , pp. 523-525
    • Klass, M.1    Hirsh, D.2
  • 27
    • 0029069295 scopus 로고
    • ICE-like proteases in apoptosis
    • KUMAR, S. ICE-like proteases in apoptosis. Trends Biochem. Sci. 20, 198-202, 1995.
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 198-202
    • Kumar, S.1
  • 28
    • 0029776793 scopus 로고    scopus 로고
    • Determination of life-span in Caenorhabditis elegans by four clock genes
    • LAKOWSKI, B. and HEKIMI, S. Determination of life-span in Caenorhabditis elegans by four clock genes. Science 272, 1010-1013, 1996.
    • (1996) Science , vol.272 , pp. 1010-1013
    • Lakowski, B.1    Hekimi, S.2
  • 29
    • 0028930267 scopus 로고
    • Genes that regulate both development and longevity in Caenorhabditis elegans
    • LARSEN, P.L., ALBERT, P.S., and RIDDLE, D.L. Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139, 1567-1583, 1995.
    • (1995) Genetics , vol.139 , pp. 1567-1583
    • Larsen, P.L.1    Albert, P.S.2    Riddle, D.L.3
  • 30
    • 0030057982 scopus 로고    scopus 로고
    • Mechanisms and evolution of aging
    • LITHGOW, G.J. and KIRKWOOD, T.B. Mechanisms and evolution of aging. Science 273, 80, 1996.
    • (1996) Science , vol.273 , pp. 80
    • Lithgow, G.J.1    Kirkwood, T.B.2
  • 31
  • 32
    • 0029123058 scopus 로고
    • Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress
    • LITHGOW, G.J., WHITE, T.M., MELOV, S., and JOHNSON, T.E. Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc. Nad. Acad. Sci. USA. 92, 7540-7544, 1995.
    • (1995) Proc. Nad. Acad. Sci. USA , vol.92 , pp. 7540-7544
    • Lithgow, G.J.1    White, T.M.2    Melov, S.3    Johnson, T.E.4
  • 33
    • 0030007767 scopus 로고
    • Genetics analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans dauer formation
    • MALONE, E.A., INOUE, T., and THOMAS, J.H. Genetics analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans dauer formation. Genetics 143, 1193-1205, 1995.
    • (1995) Genetics , vol.143 , pp. 1193-1205
    • Malone, E.A.1    Inoue, T.2    Thomas, J.H.3
  • 34
    • 0025942107 scopus 로고
    • Efficient gene transfer in C. Elegans: Extrachromosomal maintenance and integration of transforming sequences
    • MELLO, C.C., KRAMER, J.M., STINCHCOMB, D.T., and AMBROS, V. Efficient gene transfer in C. elegans: Extrachromosomal maintenance and integration of transforming sequences. EMBO J. 10, 3959-3970, 1991.
    • (1991) EMBO J. , vol.10 , pp. 3959-3970
    • Mello, C.C.1    Kramer, J.M.2    Stinchcomb, D.T.3    Ambros, V.4
  • 35
    • 0029768753 scopus 로고    scopus 로고
    • A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
    • MORRIS, J.Z., TISSENBAUM, H.A., and RUVKUN, G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 381, 536-539, 1996.
    • (1996) Nature , vol.381 , pp. 536-539
    • Morris, J.Z.1    Tissenbaum, H.A.2    Ruvkun, G.3
  • 36
    • 0030014296 scopus 로고    scopus 로고
    • A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans
    • MURAKAMI, S. and JOHNSON, T.E. A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans. Genetics 143, 1207-1218, 1996.
    • (1996) Genetics , vol.143 , pp. 1207-1218
    • Murakami, S.1    Johnson, T.E.2
  • 37
    • 0030267395 scopus 로고    scopus 로고
    • Telling cells their time is up
    • NAGATA, S. Telling cells their time is up. Curr. Biol. 6, 1241-1243, 1996.
    • (1996) Curr. Biol. , vol.6 , pp. 1241-1243
    • Nagata, S.1
  • 38
    • 0028040019 scopus 로고
    • Bcl-2 and the regulation of programmed cell death
    • REED, J.C. Bcl-2 and the regulation of programmed cell death. J. Cell Biol. 124, 1-6, 1994.
    • (1994) J. Cell Biol. , vol.124 , pp. 1-6
    • Reed, J.C.1
  • 39
    • 0002716751 scopus 로고
    • The dauer larva
    • Wood, W.B. (Editor), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • RIDDLE, D.L. The dauer larva. In: The Nematode Caenorhabditis elegans., Wood, W.B. (Editor), pp. 393-412, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1988.
    • (1988) The Nematode Caenorhabditis Elegans , pp. 393-412
    • Riddle, D.L.1
  • 40
    • 0019496482 scopus 로고
    • Interacting genes in nematode dauer larva formation
    • RIDDLE, D.L., SWANSON, M.M., and ALBERT, P.S. Interacting genes in nematode dauer larva formation. Nature 290, 668-671, 1981.
    • (1981) Nature , vol.290 , pp. 668-671
    • Riddle, D.L.1    Swanson, M.M.2    Albert, P.S.3
  • 41
    • 0020059258 scopus 로고
    • Morphology of programmed cell death in the ventral nerve cord of Caenorhabditis elegans larvae
    • ROBERTSON, A. and THOMSON, N. Morphology of programmed cell death in the ventral nerve cord of Caenorhabditis elegans larvae. J. Embryol. Exp. Morphol. 67, 89-100, 1982.
    • (1982) J. Embryol. Exp. Morphol. , vol.67 , pp. 89-100
    • Robertson, A.1    Thomson, N.2
  • 42
    • 43949172708 scopus 로고
    • Phagocyte recognition of cells undergoing apoptosis
    • SAVILL, J., FADOK, V., HENSON, P., and HASLETT, C. Phagocyte recognition of cells undergoing apoptosis. Immunol. Today 14, 131-136, 1993.
    • (1993) Immunol. Today , vol.14 , pp. 131-136
    • Savill, J.1    Fadok, V.2    Henson, P.3    Haslett, C.4
  • 43
    • 0030602837 scopus 로고    scopus 로고
    • An alternatively spliced C. Elegans ced-4 RNA encodes a novel cell death inhibitor
    • SHAHAM, S. and HORVITZ, H.R. An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitor. Cell 86, 201-208, 1996a.
    • (1996) Cell , vol.86 , pp. 201-208
    • Shaham, S.1    Horvitz, H.R.2
  • 44
    • 0030012008 scopus 로고    scopus 로고
    • Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities
    • SHAHAM, S. and HORVITZ, H.R. Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities. Genes Dev. 10, 578-591, 1996b.
    • (1996) Genes Dev. , vol.10 , pp. 578-591
    • Shaham, S.1    Horvitz, H.R.2
  • 45
    • 0028929328 scopus 로고
    • Mechanisms and genes of cellular suicide
    • STELLER, H. Mechanisms and genes of cellular suicide. Science 267, 1445-1449, 1995.
    • (1995) Science , vol.267 , pp. 1445-1449
    • Steller, H.1
  • 46
    • 0029115508 scopus 로고
    • dad-1, an endogenous programmed cell death suppressor in Caenorhabditis elegans and vertebrates
    • SUGIMOTO, A., HOZAK, R.R., NAKASHIMA, T., NISHIMOTO, T., and ROTHMAN, J.H. dad-1, an endogenous programmed cell death suppressor in Caenorhabditis elegans and vertebrates. EMBO J. 14, 4434-4441, 1995.
    • (1995) EMBO J. , vol.14 , pp. 4434-4441
    • Sugimoto, A.1    Hozak, R.R.2    Nakashima, T.3    Nishimoto, T.4    Rothman, J.H.5
  • 47
    • 0017303612 scopus 로고
    • Post-embryonic development in the ventral cord of Caenorhabditis elegans
    • SULSTON, J.E. Post-embryonic development in the ventral cord of Caenorhabditis elegans. Philos. Trans. R. Soc. London B Biol. Sci. 275, 287-297, 1976.
    • (1976) Philos. Trans. R. Soc. London B Biol. Sci. , vol.275 , pp. 287-297
    • Sulston, J.E.1
  • 48
    • 0017618537 scopus 로고
    • Post-embryonic cell lineages of the nematode, Caenorhabditis elegans
    • SULSTON, J.E. and HORVITZ, H.R. Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev. Biol. 56, 110-156, 1977.
    • (1977) Dev. Biol. , vol.56 , pp. 110-156
    • Sulston, J.E.1    Horvitz, H.R.2
  • 49
    • 0020858899 scopus 로고
    • The embryonic cell lineage of the nematode Caenorhabditis elegans
    • SULSTON, J.E., SCHIERENBERG, E., WHITE, J.G., and THOMSON, J.N. The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev. Biol. 100, 64-119, 1983.
    • (1983) Dev. Biol. , vol.100 , pp. 64-119
    • Sulston, J.E.1    Schierenberg, E.2    White, J.G.3    Thomson, J.N.4
  • 50
    • 0027268170 scopus 로고
    • Evidence for parallel processing of sensory information controlling dauer formation in Caenorhabditis elegans
    • THOMAS, J.H., BIRNBY, D. A., and VOWELS, J.J. Evidence for parallel processing of sensory information controlling dauer formation in Caenorhabditis elegans. Genetics 134, 1105-1117, 1993.
    • (1993) Genetics , vol.134 , pp. 1105-1117
    • Thomas, J.H.1    Birnby, D.A.2    Vowels, J.J.3
  • 51
    • 0026614114 scopus 로고
    • Production of sperm reduces nematode life span
    • VAN VOORHIES, W.A. Production of sperm reduces nematode life span. Nature 360, 456-458, 1992.
    • (1992) Nature , vol.360 , pp. 456-458
    • Van Voorhies, W.A.1
  • 52
    • 0029042690 scopus 로고
    • The Caenorhabditis elegans spe-26 gene is necessary to form spermatids and encodes a protein similar to the actin-associated proteins kelch and scruin
    • VARKEY, J.P., MUHLRAD, P.J., MINNITI, A.N., DO, B., and WARD, S. The Caenorhabditis elegans spe-26 gene is necessary to form spermatids and encodes a protein similar to the actin-associated proteins kelch and scruin. Genes Dev. 9, 1074-1086, 1995.
    • (1995) Genes Dev. , vol.9 , pp. 1074-1086
    • Varkey, J.P.1    Muhlrad, P.J.2    Minniti, A.N.3    Do, B.4    Ward, S.5
  • 53
    • 0027050145 scopus 로고
    • Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2
    • VAUX, D.L., WEISSMAN, I.L., and KIM, S.K. Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2. Science 258, 1955-1957, 1992.
    • (1992) Science , vol.258 , pp. 1955-1957
    • Vaux, D.L.1    Weissman, I.L.2    Kim, S.K.3
  • 54
    • 0028540186 scopus 로고
    • Endonuclease activities, chromatin structure, and DNA degradation in apoptosis
    • WALKER, P.R. and SIKORSKA, M. Endonuclease activities, chromatin structure, and DNA degradation in apoptosis. Biochem. Cell Biol. 72, 615-623, 1994.
    • (1994) Biochem. Cell Biol. , vol.72 , pp. 615-623
    • Walker, P.R.1    Sikorska, M.2
  • 56
    • 0028950419 scopus 로고
    • Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing
    • WONG, A., BOUTIS, P., and HEKIMI, S. Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. Genetics 139, 1247-1259, 1995.
    • (1995) Genetics , vol.139 , pp. 1247-1259
    • Wong, A.1    Boutis, P.2    Hekimi, S.3
  • 57
    • 0018830636 scopus 로고
    • Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
    • WYLLIE, A.H. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284, 555-556, 1980.
    • (1980) Nature , vol.284 , pp. 555-556
    • Wyllie, A.H.1
  • 58
  • 59
    • 0029056059 scopus 로고
    • Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein
    • XUE, D. and HORVITZ, H.R. Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein. Nature 377, 248-251, 1995.
    • (1995) Nature , vol.377 , pp. 248-251
    • Xue, D.1    Horvitz, H.R.2
  • 60
    • 0029880987 scopus 로고    scopus 로고
    • The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease
    • XUE, D., SHAHAM, S., and HORVITZ, H.R. The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease. Genes Dev. 10, 1073-1083, 1996.
    • (1996) Genes Dev. , vol.10 , pp. 1073-1083
    • Xue, D.1    Shaham, S.2    Horvitz, H.R.3
  • 61
    • 0026448963 scopus 로고
    • The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death
    • YUAN, J. and HORVITZ, H.R. The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death. Development 116, 309-320, 1992.
    • (1992) Development , vol.116 , pp. 309-320
    • Yuan, J.1    Horvitz, H.R.2
  • 62
    • 0025255636 scopus 로고
    • The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death
    • YUAN, J. and HORVITZ, H.R. The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death. Dev. Biol. 138, 33-41, 1990.
    • (1990) Dev. Biol. , vol.138 , pp. 33-41
    • Yuan, J.1    Horvitz, H.R.2
  • 63
    • 0027525104 scopus 로고
    • The C. Elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1beta converting enzyme
    • YUAN, J., SHAHAM, S., LEDOUX, S., ELLIS, H.M., and HORVITZ, H.R. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1beta converting enzyme. Cell 75, 641-652, 1993.
    • (1993) Cell , vol.75 , pp. 641-652
    • Yuan, J.1    Shaham, S.2    Ledoux, S.3    Ellis, H.M.4    Horvitz, H.R.5
  • 64
    • 0027328348 scopus 로고
    • Target-selected gene inactivation in Caenorhabditis elegans by using a frozen transposon insertion mutant bank
    • ZWAAL, R.R., BROEKS, A., VAN MEURS, J., GROENEN, J.T., and PLASTERK, R.H. Target-selected gene inactivation in Caenorhabditis elegans by using a frozen transposon insertion mutant bank. Proc. Natl. Acad. Sci. USA 90, 7431-7435, 1993.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 7431-7435
    • Zwaal, R.R.1    Broeks, A.2    Van Meurs, J.3    Groenen, J.T.4    Plasterk, R.H.5


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