NANC transmitters in the female pig urethra - localization and modulation of release via α2-adrenoceptors and potassium channels

British Journal of Pharmacology

Volumn 121, Issue 8, 1997, Pages 1605-1612

  Werkström, Viktoria ^a   Persson, Katarina ^a   Andersson, Karl Erik ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Adrenoceptors; Capsaicin; Neurotransmission; Non adrenergic non cholinergic; Potassium channels; Presynaptic; Relaxation; Smooth muscle; Urethra; Vasoactive intestinal polypeptide

Indexed keywords

4 AMINOPYRIDINE; ADENOSINE; ADENOSINE TRIPHOSPHATE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; APAMIN; BRIMONIDINE; CALCITONIN GENE RELATED PEPTIDE; CALCIUM ION; CAPSAICIN; CARBACHOL; CHARYBDOTOXIN; DENDROTOXIN; GLIBENCLAMIDE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE 27; IBERIOTOXIN; N(G) NITROARGININE; NEUROTRANSMITTER; OXIDOPAMINE; PIRENZEPINE; POTASSIUM CHANNEL; POTASSIUM ION; PRAZOSIN; PROSTAGLANDIN E2; RAUWOLSCINE; SCOPOLAMINE; SEROTONIN; TETRYLAMMONIUM CHLORIDE; UNINDEXED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE;

ADRENERGIC SYSTEM; ANIMAL TISSUE; ARTICLE; CHEMICAL SYMPATHECTOMY; CONTROLLED STUDY; DENERVATION; ELECTRIC FIELD; FEMALE; MODULATION; NEUROTRANSMITTER RELEASE; NONADRENERGIC NONCHOLINERGIC NERVE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE RELAXATION; SMOOTH MUSCLE TONE; SWINE; URETHRA;

ANIMALS; ELECTRIC STIMULATION; FEMALE; MUSCLE RELAXATION; NEUROTRANSMITTER AGENTS; OXIDOPAMINE; PEPTIDES; POTASSIUM CHANNELS; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, MUSCARINIC; SWINE; URETHRA;

EID: 0030759361     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701308     Document Type: Article

References (30)

1. ALM, P., UVELIUS, B., EKSTRÖM, J., HOLMQUIST, B.I., LARSSON, B. & ANDERSSON, K.-E. (1995). Nitric oxide-containing neurons in rat parasympathetic, sympathetic and sensory ganglia: a comparative study. Histochem. J., 27, 819-831.
2. ANDERSSON, K.-E. (1993). Pharmacology of lower urinary tract smooth muscles and penile erectile tissues. Pharmacol. Rev., 45, 253-308.
3. BEVAN, S. & SZOLCSÁNYI, J. (1990). Sensory neuron-speciuc actions of capsaicin: mechanisms and applications. Trends Pharmacol. Sci., 11, 330-333.
4. BOECKXSTAENS, G.E., DE MAN, J.G., PELCKMANS, P.A., HERMAN, A.G. & VAN MAERCKE, Y.M. (1992). α-Adrenoceptor-mediated modulation of the nitrergic innervation of the canine isolated ileocolic junction. Br. J. Pharmacol., 109, 1079-1084.
5. BRIDGEWATER, M. & BRADING, A.F. (1993). Evidence for a non-nitrergic inhibitory innervation in the pig urethra. Neurourol. Urodyn., 12, 357-358.
6. BRIDGEWATER, M., DAVIES, J.R. & BRADING, A.F. (1995). Regional variations in the neural control of the female pig urethra. Br. J. Urol., 76, 730-740.
7. BRIDGEWATER, M., MACNEIL, H.F. & BRADING, A.F. (1993). Regulation of tone in pig urethral smooth muscle. J. Urol., 150, 223-228.
8. CAULFIELD, M.P. (1993). Muscarinic receptors- characterization, coupling and function. Pharmacol. Ther., 58, 319-379.
9. DALZIEL, H.H. & WESTFALL, D.P. (1994). Receptors for adenine nucleotides and nucleosides: subclassification, distribution and molecular characterization. Pharmacol. Rev., 46, 449-466.
10. 2adrenoceptor activation on the release of nitric oxide from non-adrenergic non-cholinergic nerves. Br. J. Pharmacol., 112, 341-345.
11. DE MAN, J.G., BOECKXSTAENS, G.E., PELCKMANS, P.P. & DE WINTER, B.Y. (1993). Prejunctional modulation of the nitrergic innervation of the canine ileocolic junction via potassium channels. Br. J. Pharmacol., 110, 559-564.
12. GARCIA-PASQUAL, A., COSTA, G., GARCIA-SACRISTAN, A. & ANDERSSON, K.-E. (1991). Relaxation of sheep urethral muscle induced by electrical stimulation of nerves: involvement of nitric oxide. Acta Physiol. Scand., 141, 531-539.
13. HASHIMOTO, S., KIGOSHI, S. & MURAMATSU, I. (1993). Nitric oxide-dependent and -independent neurogenic relaxation of isolated dog urethra. Eur. J. Pharmacol., 231, 209-214.
14. HILLS, J., MELDRUM, L.A., KLARSKOV, P. & BURNSTOCK, G. (1984). A novel non-adrenergic, non-cholinergic nerve-mediated relaxation of the pig bladder neck: and examination of possible neurotransmitter candidates. Eur. J. Pharmacol., 99, 287-293.
15. KLARSKOV, P. (1988). Lower urinary tract smooth muscle inhibitory nerve responses. Neurourol. Urodyn., 7, 307-326.
16. 2-adrenoceptor agonist, UK-14 304. Br. J. Pharmacol., 107, 256-261.
17. MATTIASSON, A., ANDERSSON, K.-E., ANDERSSON, P.-O., LARSSON, B., SJÖGREN, C. & UVELIUS, B. (1989). Nerve-mediated functions in the circular and longitudinal muscle layers of the proximal female rabbit urethra. J. Urol., 143, 155-160.
18. MATTIASSON, A., ANDERSSON, K.-E. & SJÖGREN, C. (1988). Inhibitory α-adrenoceptors on cholinergic axon terminals in the urethra of rabbit and man. Neurourol. Urodyn., 6, 449-456.
19. MILLER, R.J. (1990). Receptor-mediated regulation of calcium channels and neurotransmitter release. FASEB J., 4, 3291-3299.
20. PARLANI, M., CONTE, B., GOSO, C., SZALLASI, A. & MANZINI, S. (1993). Capsaicin-induced relaxation in the rat isolated external urethral sphincter: characterization of the vanilloid receptor and mediation by CGRP. Br. J. Pharmacol., 110, 989-994.
21. PERSSON, K. & ANDERSSON, K.-E. (1992). Nitric oxide and relaxation of pig lower urinary tract. Br. J. Pharmacol., 106, 416-422.
22. PERSSON, K., JOHANSSON, K., ALM, P., LARSSON, B. & ANDERSSON, K.-E. (1997). Morphological and functional evidence against a sensory and sympathetic origin of nitric oxide synthase-containing nerves in the rat lower urinary tract. Neuroscience, 77, 271-281.
23. 1 muscarinic receptor-mediated facilitation of acetylcholine release in the rat urinary bladder. J. Physiol., 480, 81-89.
24. TANAGHO, E.A. & MILLER, E.R. (1970). Initiation of voiding. Br. J. Urol., 42, 175-183.
25. VIZZARD, M.A., ERDMAN, S.L., FÖRSTERMANN, U. & DE GROAT, W.C. (1994). Differential distribution of nitric oxide synthase in neural pathways to the urogenital organs (urethra, penis, urinary bladder) of the rat. Brain Res., 646, 279-291.
26. WERKSTRÖM, V., NY, L., PERSSON, K. & ANDERSSON, K.-E. (1997a). Carbon monoxide-induced relaxation and distribution of haem oxygenase isoenzymes in the pig urethra and oesophagogastric junction. Br. J. Pharmacol., 120, 318-322.
27. WERKSTRÖM, V., NY, L., PERSSON, K. & ANDERSSON, K.-E. (1997b). Neurotransmitter release evoked by α-latrotoxin in the smooth muscle of the female pig urethra. Naunyn-Schmiedeberg's Arch. Pharmacol., (in press).
28. WERKSTRÖM, V., PERSSON, K., NY, L., BRIDGEWATER, M., BRADING, A.F. & ANDERSSON, K.-E. (1995). Factors involved in the relaxation of female pig urethra evoked by electrical field stimulation. Br. J. Pharmacol., 116, 1599-1604.
29. WESTFALL, T.C. & MARTIN, J.R. (1991). Presynaptic receptors in the peripheral and central nervous system. In Presynaptic Regulation of Neurotransmitter Release; a Handbook. ed. Feigenbaum, J. & Hanini, M. pp. 311-370. London: Freund Publishing house, Ltd.
30. ZYGMUNT, P.K.E., HÖGESTÄTT, E.D. & ANDERSSON, K.-E. (1996). Effects of potassium channel inhibitors on nitrergic and adrenergic neurotransmission in lamina propria of the female rabbit urethra. Naunyn-Schmiedeberg's Arch. Pharmacol., 354, 336-342.