Effects of maternal ethanol consumption and buspirone treatment on 5- HT(1A) and 5-HT(2A) receptors in offspring

Alcoholism: Clinical and Experimental Research

Volumn 21, Issue 7, 1997, Pages 1169-1178

  Kim, Jung Ae ^a   Gillespie, Roberta A ^a   Druse, Mary J ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

5 HT(1A) Receptor; 5 HT(2A) Receptor; Buspirone; Ethanol; Fetal Alcohol Syndrome; Serotonin

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ALCOHOL; BUSPIRONE; KETANSERIN; SEROTONIN; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; TRITIUM;

ADOLESCENT; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; FEMALE; NEWBORN; NONHUMAN; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; PROGENY; RAT; RECEPTOR BINDING; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALIA; TRITIUM;

EID: 0030758797     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1997.tb04434.x     Document Type: Article

References (72)

1. Abel EL, Sokol RJ: A revised conservative estimate of the incidence of FAS and its economic impact. Alcohol Clin Exp Res 15:514-524, 1991
2. Druse MJ: Effects of in utero ethanol exposure on the development of CNS neurotransrnitter systems, in Miller MW (ed): Development of the Central Nervous System. Effects of Alcohol and Opiates. New York, Wiley-Liss, 1992, pp 139-167
3. Druse MJ: Effects of maternal alcohol consumption on the developing nervous system, in Watson RR (ed); Alcohol and Neurobiology. Brain Development and Hormone Regulation. New York, CRC Press, 1992, pp 1-30
4. Druse MJ: Neurotransrnitter function: Changes associated with in utero alcohol exposure, in Abel EL (ed): Fetal Alcohol Syndrome. From Mechanisms to Prevention. New York, CRC Press, 1996, pp 171-189
5. Druse MJ, Kuo A, Tajuddin N: Effects of in utero ethanol exposure on the developing serotonergic system. Alcohol Clin Exp Res 15:678-684, 1991
6. Krsiak M, Elis N, Poschlova N, Masek K: Increased aggressiveness and lower brain serotonin levels in offspring of mice given alcohol during gestation. J Stud Alcohol 38:1696-1704, 1977
7. Rathbun W, Druse MJ: Dopamine, serotonin and acid metabolites in brain regions from the developing offspring of ethanol treated rats. J Neurochem 44:57-62, 1985
8. Druse MJ, Paul LH: Effects of in utero ethanol exposure on serotonin uptake in cortical regions. Alcohol 5:455-459, 1989
9. Kim J-A, Druse MJ: Protective effects of maternal buspirone treatment on serotonin reuptake sites in ethanol-exposed offspring. Dev Brain Res 92:190-198, 1996
10. 1 receptors. Alcohol 5:465-470. 1989
11. Chan AWK, Abel EL: Absence of long-lasting effects on brain receptors for neurotransmitters in rats prenatally exposed to alcohol. Res Commun Subst Abuse 3:219, 1982
12. 2 binding sites. Alcohol 5:465-470, 1989
13. 1 receptors following prenatal alterations in serotonin levels: Further evidence for functional fetal serotonin, receptors. Dev Brain Res 33:285-289, 1987
14. Haydon PG, McCobb DP, Kater SB: Serotonin selectively inhibits growth cone motility and synaptogenesis of specific identified neurons. Science 236:561-564, 1984
15. Haydon PG, McCobb DP, Kater SB: The regulation of neurite outgrowth, growth cone motility, and electrical synaptogenesis by serotonin. J Neurobiol 18:197-215, 1987
16. McCobb DP, Haydon PG, Kater SB: Dopamine and serotonin inhibition of neurite elongation of different identified neurons. J Neurosci Res 19:19-26, 1988
17. Whitaker-Azmitia PM, Azmitia EC: Stimulation of astroglial serotonin receptors produces culture media which regulates growth of scrotonergic neurons. Brain Res 497:80-85, 1989
18. 3H)-8-Hydroxy-2-(di-n-propylamino)tetralin binding to pre- and postsynaptic 5-hydroxytryptamine sites in various regions of the brain. J Neurochem 44:1685-1696, 1985
19. 2-receptor-bindiiig sites: Effects of neuronal lesions, in Mandel P, DeFeudis FV (eds): CNS Receptors-From Molecular Pharmacology to Behavior. New York, Raven Press. 1983. pp 373-383
20. Chuhakov AR, Gromova EA, Konovalov GV, Sarkisova EF, Chumasov EI: The effects of serotonin on the morpho-functional development of rat cerebral neocortex in tissue culture. Brain Res 369:285-297, 1986
21. Lauder JM, Krebs H: Serotonin as a differentiation signal in early neurogenesis. Dev Neurosci 1:15-30, 1978
22. Lauder JM, Towlc AC, Patrick K, Henderson P, Krebs H: Decreased serotonin content of embryonic raphe neurons following maternal administration of p-chlorophcnylalanine: A quantitative immunocyto-chemical study. Dev Brain Res 20:107-114, 1985
23. Lauder JM: Ontogeny of the serotonergic system in the rat: serotonin as a developmental signal. Ann NY Acad Sci 600:297-313, 1990
24. Shemer AV, Whitaker-Azmitia PM, Azmitia EC: Effects of prenatal 5-methoxytryptamine and parachlorophenylalaninc on serotonergic uptake and behavior in the neonatal rat. Pharmacol Biochem Behav 30:547-581, 1988
25. Shemer AV, Azmitia EC, Whitaker-Azmitia PM: Dose-related effects of prenatal 5-methoxytryptaminc (5-MT) on development of serotonin terminal density and behavior. Dev Brain Res 59:59-63, 1991
26. Tajuddin NF, Druse MJ: Treatment of pregnant alcohol-consuming rats with buspirone: Effects of serotonin and 5-hydroxyindolcacctic acid content in offspring. Alcohol Clin Exp Res 17:110-114, 1993
27. Whitaker-Azmitia PM, Azmitia EC: Autoregulation of fetal serotonergic neuronal development: Role of high affinity serotonin receptors Neurosci Lett 67:307-312. 1986
28. 1A receptors to astroglial cells in adult rats: Implications for neuronalglial interactions and psychoactive drug mechanism of action. Synapse 14:201-205, 1993
29. 1A receptors S-100 beta in development and plasticity. Perspect Rev Ncurobiol 2:233-238, 1994
30. Wallace JA, Lauder JM: Development of the serotonergic system in the rat embryo: An immunocytochemical study. Brain Res Bull 10:459-479, 1983
31. Lidov HWG, Molliver ME: Immunohistochemieal study of the development of serotonergic neurons in the rat CNS. Brain Res Bull 9:559-604, 1982
32. 1A receptor gene followed by PCR. Biochem Biophys Res Commun 191:991-997, 1993
33. Noronha AB, Druse MJ: Maternal ethanol consumption and synaptic membrane glycoproteins in offspring. J Neurosci Res 8:83-97, 1982
34. Van de Kar LD: Neuroendocrine pharmacology of serotonergic neurons. Annu Rev Pharmacol Toxicol 31:289-320, 1991
35. Bruinink A, Lichtensteiger W, Schlumpf M: Pre- and postnatal ontogeny and characterization of dopaminergic D2, serotonergic S2, and spiradecanone binding sites in rat forebrain. J Neurochem 40:1227-1236, 1983
36. Paxinos G, Watson C: The Rat Brain in Stereotaxic Coordinates. Perth, Western Australia, Academic Press, 1986
37. 2 receptors in the rat spinal cord. Brain Res 550:15-23, 1991
38. Hall MD, Gozlan H, Emerit MB, El Mestikawy S, Pichat L, Hamon M: Differentiation of pre- and postsynaptic high affinity serotonin binding sites using physico-chemical parameters and modifying agents. Neurochem Res 11:891-912, 1986
39. 3H-5-hydroxytryptamine binding site subtype in bovine brain membranes. J Neurosci 7:894-903, 1987
40. Pazos A, Cortes R, Palacios JM: Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors. Brain Res 346:231-249, 1985
41. Fletcher PJ, Davies M: The involvement of 5-hydroxytryptaminergic and dopaminergic mechanisms in the eating induced by buspirone, gepirone and ipsapirone. Br J Pharmacol 99:519-525, 1990
42. 1A binding in rat brain - A combined in situ hybridisation/in vitro receptor autoradiography study. Brain Res 561:51-60, 1991
43. Hrdina PV, Thu BV: Chronic fluoxetine treatment upregulates 5-HT uptake sites and 5-HT, receptors in rat brain: An autoradiographic study. Synapse 14:324-331, 1993
44. McBride WJ, Chernet E, Rabold JA, Lumeng L, Li T-K: Serotonin-2 receptors in the CNS of alcohol-preferring rats. Pharmacol Biochem Behav 46:631-636, 1993
45. Noble EP, Ritchie T: Prenatal ethanol exposure reduces the effects of excitatory amino acids in the rat hippocampus. Life Sci 45:803-810, 1989
46. Wigal SB, Amsel A, Wilcox RE: Fetal ethanol exposure diminishes hippocampal beta-adrenergic receptor density while sparing muscarinic receptors during development. Brain Res Dev Brain Res 55:161-169, 1990
47. 3H]-glutamate binding site density in 45-day-old rats. Alcohol 8:193-201, 1991
48. Tanaka H, Nasu F, Inomata K: Fetal alcohol effects: Decreased synaptic formations in the field CA3 of fetal hippocampus. Int J Dev Neurosci 9:509-517, 1991
49. Martin D, Savage DD, Swartzwelder HS: Effects of prenatal ethanol exposure on hippocampal ionotropic-quisqualate and kainate receptors. Alcohol Clin Exp Res 16:816-821, 1992
50. Savage DD, Queen SA, Sanehez CF, Paxton LL, Mahoney JC, Goodlctt CR, West JR: Prenatal ethanol exposure during the last third of gestation in rat reduces hippocampal NMDA agonist binding site density in 45-day-old offspring. Alcohol 9:37-41, 1992
51. Queen SA, Sanchez CG, Lopez SR, Paxton LL, Savage DD: Dose-and age-dependent effects of prenatal ethanol exposure on hippocampal metabotropic-glutamate receptor-stimulated phosphoinositide hydrolysis. Alcohol Clin Exp Res 17:887-893, 1993
52. Heaton MB, Paiva M, Swanson DJ, Walker DW: Prenatal ethanol exposure alters neurotrophic activity in the developing rat hippocampus. Neurosci Lett 188:132-136, 1995
53. Swanson DJ, King MA, Walker DW, Heaton MB: Chronic prenatal ethanol exposure alters the normal ontogeny of choline acetyltransferase activity in the rat septohippocampal system. Alcohol Clin Exp Res 19: 252-1260, 1995
54. Verge D, Daval G, Marcinkiewicz M, Patey A, el Mestikawy S, Gozlan H, Hamon M: Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control and 5,7-dihydroxytryplamine-treated rats. J Neurosci 6:3473-3482, 1986
55. IB agonists. Synapse 1:3-9, 1987
56. Mueller RA, Towle A, Breesc GR: Serotonin turnover and super-sensitivity after neonatal 5,7-dihydroxytryptamine. Pharmacol Biochem Behav 22:221-225, 1985
57. 1A receptor mRNA in rat forebrain and cerebellum. Dev Brain Res 80:149-157, 1994
58. Whitaker-Azmitia PM, Shemer AV, Caruso J, Molino L, Azmitia EC: Role of high affinity serotonin receptors in neuronal growth. Ann NY Acad Sci 600:315-330, 1990
59. B but not NGF, EGF, insulin or calmodulin is a CNS serotonergic growth factor. Brain Res 516:354-356, 1990
60. Kim J-A, Druse MJ: Deficiency of essential neurotrophic factors in conditioned media produced by ethanol-exposed cortical astrocyles. Dev Brain Res 96:1-10, 1996
61. Feighner JP, Merideth CH, Hendrickson GA: A double-blind comparison of buspirone and diazepam in outpatients with generalized anxiety disorder. J Clin Psychiatry 43:103-108, 1982
62. 1A receptors, Biol Psychiatry 20:971-979, 1985
63. 3H]buspirone binding in rat brain by autoradiography, in Tunnicliff G, Eison AS, Taylor DP (eds): Buspirone: Mechanisms and Clinical Aspects. San Diego, Academic Press, 1991, pp 163-176
64. VanderMaelen CP, Matheson GK, Wilderman RC, Patterson LA: Inhibition of serotonergic dorsal raphe neurons by systemic and iontophoretic administration of buspirone, a non-benzodiazepine anxiolytic drug. Eur J Pharmacol 129:123-130, 1986
65. Andrade R, Nicoll RA: Novel anxiolytics discriminate between postsynaptic serotonin receptors mediating different physiological responses on single neurons of the rat hippocampus. Naunyn-Schmiedebergs Arch Pharmacol 336:5-10, 1987
66. Riblet LA, Taylor DP, Eison MS, Stanton HC: Pharmacology and neurochemistry of buspirone. J Clin Psychiatry 43:11-16, 1982
67. Riblet LA, Eison AS, Eison MS, Taylor DP, Temple DL, Vander-Maelen CP: Neuropharmacology of buspirone. Psychopathology 17:69-78, 1984
68. Rimele TJ, Henry DE, Lee DKH, Geiger G, Heaslip RJ, Grimes D: Tissue-dependent alpha adrenoceptor activity of buspirone and related compounds. J Pharmacol Exp Ther 241:771-778, 1987
69. Meltzer HY, Gudelsky GA, Lowy MT, Nash JF, Koenig JI: 1991 Neuroendocrine effects of buspirone: Mediation by dopaminergic and serotonergic mechanisms, in Tunnicliff G, Eison AS, Taylor DP (eds): Buspirone: Mechanisms and Clinical Aspects. San Diego, Academic Press, 1991, pp 163-176
70. 1A receptor subtype increases rat plasma ACTH concentration. Eur J Pharmacol 147:431-439, 1988
71. Davila-Garcia MI, Azmitia EC: Neuropeptides as positive neuronal growth regulatory factors: effects of ACTH and leu-enkephalin on cultured serotonergic neurons, in Lauder JM (ed): Molecular Aspects of Development and Aging of the Nervous System. New York, Plenum Press, 1990, pp 75-92
72. Gillespie RA, Eriksen J, Hao H-L, Druse MJ: Effects of maternal ethanol consumption and buspirone treatment on dopamine and norepinephrine reuptake sites and D1 receptors in offspring. Alcohol Clin Exp Res 21:452-459, 1997