Human and rat lung biotransformation of cyclosporin A and its derivatives using slices and bronchial epithelial cells

Drug Metabolism and Disposition

Volumn 25, Issue 7, 1997, Pages 873-880

  Vickers, Alison E M ^a   Jimenez, Rosa M ^b   Spaans, M Carina ^b   Pflimlin, Veronique ^b   Fisher, Robyn L ^b   Brendel, Klaus ^b  

^a NOVARTIS PHARMA AG   (Switzerland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; ESTERASE;

ANIMAL TISSUE; ARTICLE; BRONCHUS MUCOSA; DRUG CLEARANCE; DRUG DEGRADATION; DRUG HYDROXYLATION; DRUG OXIDATION; DRUG TRANSFORMATION; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; LUNG CLEARANCE; NONHUMAN; PRIORITY JOURNAL;

ADULT; ANIMALS; BIOTRANSFORMATION; BRONCHI; CHILD; CYCLOSPORINS; EPITHELIAL CELLS; EPITHELIUM; ESTERASES; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LUNG; MALE; MIDDLE AGED; OXIDATION-REDUCTION; RATS; RATS, WISTAR;

ANIMALIA; BRONCHUS;

EID: 0030756219     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. A. Kumar and W. W. Busse: Airway inflammation in asthma. Science (Washington, DC) Med. March/April, 38-47 (1995).
2. E. P. Trulock: Management of lung transplant rejection. Chest 103, 1566-1576 (1993).
3. M. Denis, Y. Cormier, and M. Laviolette: Murine hypersensitivity pneumonitis: a study of cellular infiltrates and cytokine production and its modulation by cyclosporin A. Am. J. Respir. Cell Mol. Biol. 6, 68-74 (1992).
4. J. Merely: Cyclosporin A in asthma therapy: a pharmacological rationale. J. Autoimmunity 5, 265-269 (1992).
5. I. Chapman and L. Mazzoni: Mechanisms of inhibition by cyclosporin A on pulmonary leukocyte accumulation. Trends Pharmacol. Sci. 15, 99-101 (1994).
6. C. J. Corrigan, P. H. Brown, N. C. Barnes. J. J. Tsai, A. J. Frew, and A. B. Kay: Glucocorticoid resistance in chronic asthma: peripheral blood T-lymphocyte activation and comparison of the T-lymphocyte inhibitory effects of glucocorticoids and cyclosporin A. Am. Rev. Respir. Dis. 144, 1026-1032 (1991).
7. T. Sano, Y. Nakamura, Y. Matsunaga, T. Takahashi, M. Azuma, Y. Okano, E. Shimizu, F. Ogushi, S. Sone, and T. Ogura: FK506 and cyclosporin A inhibit granulocyte/macrophage colony-stimulating factor production by mononuclear cells in asthma. Eur. Respir. J. 8, 1473-1478 (1995).
8. A. G. Alexander, N. C. Barnes, and A. B. Kay: Trial of cyclosporin in corticosteroid-dependent chronic severe asthma. Lancet 339, 324-328 (1992).
9. A. G. Alexander, N. C. Barnes, A. B. Kay, and C. J. Corrigan: Clinical response to cyclosporin in chronic severe asthma is associated with reduction in serum soluble interleukin-2 receptor concentrations. Eur. Respir. J. 8, 574-578 (1995).
10. R. D. Dowling, M. Zenati, G. J. Burckart, S. A. Youssem, M. Schaeper, R. L. Simmons, R. L. Hardesty, and B. P. Griffith: Aerosolized cyclosporine as single agent immunotherapy in canine lung allografts. Surgery 108, 198-205 (1990).
11. R. J. Keenan, A. J. Duncan, S. A. Youssem, M. Zenati, M. Schaeper, R. D. Dowling, Y. Alarie, G: J. Burckart, and B. P. Griffith: Improved immunosuppression with aerosolized cyclosporine in experimental transplantation. Transplantation 53, 20-25 (1992).
12. T. G. O'Riordan, A. Iacono, R. J. Keenan, S. R. Duncan, G. J. Burckart, B. P. Griffith, and G. C. Smaldone: Delivery and distribution of aerosolized cyclosporine in lung allograft recipients. Am. J. Respir. Crit. Care 151, 516-521 (1995).
13. P. Donatsch, J. Mason, B. P. Richardson, and B. Ryffel: Toxicologic evaluation of the new cyclosporin derivative, SDZ IMM 125, in a comparative, subchronic toxicity study in rats. Transplant. Proc. 24, 39-42 (1992).
14. A. Bruelisauer, R. Kawai, P. Misslin, and M. Lemaire: Absorption and disposition of SDZ IMM 125, a new cyclosporin derivative, in rats after single and repeated administration. Drug Metab. Dispos. 22, 194-199 (1994).
15. J. Baron, and J. M. Voigt: Localization, distribution, and induction of xenobiotic-metabolizing enzymes and aryl hydrocarbon hydroxylase activity within lung. Pharmacol. Ther. 47, 419-445 (1990).
16. F. P. Guengerich: Purification and characterization of xenobiotic-metabolizing enzymes from lung tissue. Pharmacol. Ther. 45, 299-307 (1990).
17. A. R. Dahl and J. L. Lewis: Respiratory tract uptake of inhalants and metabolism of xenobiotics. Annu. Rev. Pharmacol. Toxicol. 32, 383-407 (1993).
18. S. Kudo: Differentiation of Clara cells and pneumocytes of the rat by means of enzyme immunohistochemistry. Anat. Rec. 238, 49-56 (1994).
19. G. I. Murray and M. D. Burke: Immunohistochemistry of drug-metabolizing enzymes. Biochem. Pharmacol. 50, 895-903 (1995).
20. G. M. Pacifici, M. Franchi, C. Bencini, F. Repetti, N. Di Lascio, and G. B. Muraro: Tissue distribution of drug-metabolizing enzymes in human. Xenobiotica 18, 849-856 (1988).
21. T. Shimada, H. Yamazaki, M. Mimura, N. Wakamiya, Y.-F. Ueng, F. P. Guengerich, and Y. Inui: Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal livers and adult lungs. Drug Metab. Dispos. 24, 515-522 (1996).
22. M. S. Stefaniak, C. L. Krumdiek, R. D. Spall, A. J. Gandolfi, and K. Brendel: Biochemical and histological characterization of agar-filled precision cut rat lung slices in dynamic organ culture as an in vitro tool. In Vitro Toxicol. 5, 7-19 (1992).
23. R. L. Fisher, M. S. Smith, S. J. Hasal, K. S. Hasal, A. J. Gandolfi, and K. Brendel: The use of human lung slices in toxicology. Hum. Exp. Toxicol. 13, 466-471 (1994).
24. A. E. M. Vickers, V. Fischer, S. Connors, R. L. Fisher, J. P. Baldeck, G. Maurer, and K. Brendel: Cyclosporin A metabolism in human liver, kidney, and intestine slices: comparison to rat and dog slices and human cell lines. Drug Metab. Dispos. 20, 802-809 (1992).
25. M. M. Bradford: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254 (1976).
26. A. E. M. Vickers, R. L. Fisher, K. Brendel, J. Guertler, R. Dannecker, B. Keller, and V. Fischer: Sites of biotransformation for the cyclosporin derivative SDZ IMM 125 using human liver and kidney slices and intestine: comparison with rat liver slices and cyclosporin A. Drug Metab. Dispos. 23, 327-333 (1995).
27. R. L. Fisher. R. P Shaughnessy, P. M. Jenkins, M. L. Austin, G. L. Roth, A. J. Gandolfi, and K. Brendel: Dynamic organ culture is superior to multiwell plate culture for maintaining precision-cut tissue slices: optimization of tissue slice culture. Part 1. Toxicol. Methods 5, Nr.2, 99-113 (1995).
28. F. L. S. Tse and J. M. Jaffe: Appendixes I-V. In "Preclinical Drug Disposition" (F.L.S. Tse and J. M. Jaffe. eds.). pp. 154-155. Marcel Dekker. Inc., New York, 1991.
29. V. J. Desmet: Organizational Principles. In "The Liver: Biology and Pathobiology," 3rd Ed. (I. M. Arias, J. L. Boyer, N. Fausto, W. B. Jakoby, D. A. Schachter, and D. A. Shafritz, eds.), pp. 3-14. Raven Press. Ltd., New York, 1994.
30. T. J. Prendergast and S. J. Ruoss: Pulmonary disease. In "Pathophysiology of Disease, An Introduction to Clinical Medicine" (S. J. McPhee, V. R. Lingappa, W. F. Ganong, and J. D. Lange, eds.), pp. 135-172. Appleton and Lange, East Norwalk, CT, 1995.
31. T. Kronbach, V. Fischer, and U. A. Meyer: Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs, Cliin. Pharmacol. Ther. 43, 630-635 (1988).
32. A. E. M. Vickers, E. Meyer. R. Dannecker, B. Keller, R. Tynes, and G. Maurer: Human liver cytochrome P4503A biotransformation of the cyclosporin derivative SDZ IMM 125. Drug Metab. Dispos. 23, 321-326 (1995).
33. W. M. Haschek, and H. R. Witschi: Respiratory System. In 'Handbook of Toxicologic Pathology' (W. M. Haschek and C. G. Rousseaux, eds.), pp. 761-827. Academic Press, Inc., San Diego, CA, 1991.
34. O. Wagner, E. Schreier, F. Heita, and G. Maurer: Tissue distribution, disposition, and metabolism of cyclosporine in rats. Drug Metab. Dispos. 15, 377-383 (1987).
35. R. J. Price, A. B. Renwick, J. A. Beamand, F. Esclangon, P. T. Wield, D. G. Walters, and B. G. Lake: Comparison of the metabolism of 7-ethoxycoumarin and coumarin in precision-cut rat liver and lung slices. Food Chem. Toxicol. 33, No.3, 233-237 (1995).