CSF 5-HIAA, testosterone, and sociosexual behaviors in free-ranging male rhesus macaques in the mating season

Psychiatry Research

Volumn 72, Issue 2, 1997, Pages 89-102

  Mehlman, Patrick T ^a   Higley, J Dee ^b   Fernald, Beth J ^a   Sallee, Floyd R ^c   Suomi, Stephen J ^b   Linnoila, Markku ^d  

^a LABS of Virginia Inc   (United States)

^b NIH Animal Center   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Macaca mulatta; Monkeys; Serotonin; Sexual behavior

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; MATING; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SEROTONIN RELEASE; SEXUAL BEHAVIOR; TESTOSTERONE RELEASE;

AGGRESSION; ANIMALS; BRAIN; GROOMING; HYDROXYINDOLEACETIC ACID; MACACA MULATTA; MALE; SEASONS; SEROTONIN; SEXUAL BEHAVIOR, ANIMAL; SOCIAL BEHAVIOR; SOCIAL ENVIRONMENT; TESTOSTERONE;

EID: 0030754745     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1781(97)00084-X     Document Type: Article

References (42)

1. Abraham, G.E., Buster, J.E., Teller, R.C., 1972. Radioimmunoassay of plasma cortisol. Analytical Letters 5, 757-766.
2. Åsberg, M., Träskman, L., Thorén, P., 1976. 5-HIAA in the cerebrospinal fluid -a biochemical suicide predictor. Archives of General Psychiatry 33, 1193-1197.
3. Brewerton, T.D., Berrettini, W.H., Nurnberger, J.I., Jr., Linnoila, M., 1988. Analysis of the seasonal fluctuations of CSF monoamine metabolites and neuropeptides in normal controls: findings with 5HIAA and HVA. Psychiatry Research 23, 257-265.
4. Brown, G.L., Ebert, M.H., Goyer, P.F., Jimerson, D.C., Klein, W.J., Bunney, W.E., Jr., Goodwin, F.K., 1982. Aggression, suicide, and serotonin: relationships to CSF amine metabolites. American Journal of Psychiatry 139, 741-746.
5. Brown, G.L., Goodwin, F.K., Ballenger, J.C., Goyer, P.F., Major, L.F., 1979. Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Research 1, 131-139.
6. Faustman, W.O., Ringo, D.L., Faull, K.F., 1993. An association between low levels of 5-HIAA and HVA in cerebrospinal fluid and early mortality in a diagnostically mixed psychiatric sample. British Journal of Psychiatry 163, 519-521.
7. Gordon, T.P., Rose, R.M., Bernstein, I.S., 1976. Seasonal rhythm in plasma testosterone levels in the rhesus monkey (Macaca mulatto): a three year study. Hormones and Behavior 7, 229-243.
8. Higley, J.D., Suomi, S.J., Linnoila, M., 1991. CSF monoamine metabolite concentrations vary according to age, rearing, and sex, and are influenced by the stressor of social separation in rhesus monkeys. Psychopharmacology 103, 551-556.
9. Higley, J.D., Mehlman, P., Taub, D., Higley, S.B., Vickers, J.H., Suomi, S.J., Linnoila, M., 1992a. Cerebrospinal fluid monoamine and adrenal correlates of aggression in free-ranging rhesus monkeys. Archives of General Psychiatry 49, 436-441.
10. Higley, J.D., Suomi, S.J., Linnoila, M., 1992b. A longitudinal assessment of CSF monoamine metabolite and plasma cortisol concentrations in young rhesus monkeys. Biological Psychiatry 32, 127-145.
11. Higley, J.D., Thompson, W.T., Champoux, M., Goldman, D., Hasert, M.F., Kraemer, G.W., Scanlan, J.M., Suomi, S.J., Linnoila, M., 1993. Paternal and maternal genetic and environmental contributions to cerebrospinal fluid monoamine metabolites in rhesus monkeys (Macaca mulatto). Archives of General Psychiatry 50, 615-623.
12. Higley, J.D., Linnoila, M., Suomi, S.J., 1994. Ethological contributions: experiential and genetic contributions to the expression and inhibition of aggression in primates. In: Hersen, M., Ammerman, R.T., Sisson, L. (Eds.), Handbook of Aggressive and Destructive Behavior in Psychiatric Patients. Plenum Press, New York, pp. 17-32.
13. Higley, J.D., King, S.T., Hasert, M.F., Champoux, M., Suomi, S.J., Linnoila, M., 1996a. Stability of interindividual differences in serotonin function and its relationship to aggressive wounding and competent social behavior in rhesus macaque females. Neuropsychopharmacology 14, 67-76.
14. Higley, J.D., Mehlman, P.T., Higley, S.B., Fernald, B., Vickers, J., Lindell, S.G., Taub, D.M., Suomi, S.J., Linnoila, M., 1996b. Excessive mortality in young free-ranging male nonhuman primates with low cerebrospinal fluid 5-hydroxyindoleacetic acid. Archives of General Psychiatry 53, 537-543.
15. Higley, J.D., Mehlman, P.T., Poland, R.E., Faucher, I., Taub, D.T., Vickers, J., Suomi, S.J., Linnoila, M., 1996c. A nonhuman primate model of violence and assertiveness: CSF 5-HIAA and CSF testosterone correlate with different types of aggressive behaviors. Biological Psychiatry 40, 1067-1082.
16. Iyengar, B., 1994. Indoleamines and the UV-light-sensitive photoperiodic responses of the melanocyte network: a biological calendar? Experientia 50, 733-736.
17. Kaplan, J.R., Fontenot, M.B., Berard, J., Manuck, S.B., Mann, J.J., 1995. Delayed dispersal and elevated monoamine activity in free-ranging rhesus monkeys. American Journal of Primatology 35, 229-234.
18. Kaplan, J.R., Shively, C.A., Fontenot, M.B., Morgan, T.M., Howell, S.M., Manuck, S.B., Muldoon, M.F., Mann, J.J., 1994. Demonstration of an association among dietary cholesterol, central serotonergic activity, and social behavior in monkeys. Psychosomatic Medicine 56, 479-484.
19. Kraemer, G.W., Ebert, M.H., Schmidt, D.E., McKinney, W.T., 1989. A longitudinal study of the effect of different social rearing conditions on cerebrospinal fluid norepinephrine and biogenic amine metabolites in rhesus monkeys. Neuropsychopharmacology 2, 175-189.
20. Kruesi, M.J., 1990. Biological risk factors in the aetiology of childhood psychiatric disorders. In: Tonge, Burros, Werry (Eds.), Handbook of Studies on Child Psychiatry. Elsevier Science Publishers B.V., pp. 13-28.
21. Kruesi, M.J., Hibbs, E.D., Zahn, T.P., Keysor, C.S., Hamburger, S.D., Bartko, J.J., Rapoport, J.L., 1992. A 2-year prospective follow-up study of children and adolescents with disruptive behavior disorders. Prediction by cerebrospinal fluid 5-hydroxyindoleacetic acid, homovanillic acid, and autonomie measures? Archives of General Psychiatry 49, 429-435.
22. Lidberg, L., Tuck, J.R., Åsberg, M., Scalia-Tomba, G.P., Bertilsson, L., 1985. Homicide, suicide and CSF 5-HIAA. Acta Psychiatrica Scandinavica 71, 230-236.
23. Limson, R., Goldman, D., Roy, A., Lamparski, D., Ravitz, B., Adinoff, B., Linnoila, M., 1991. Personality and cerebrospinal fluid monoamine metabolites in alcoholics and controls. Archives of General Psychiatry 48, 437-441.
24. Linnoila, M., Virkkunen, M., Scheinin, M., Nuutila, A., Rimon, R., Goodwin, F.K., 1983. Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sciences 33, 2609-2614.
25. Mehlman, P., Higley, J.D., Faucher, I., Lilly, A.A.,Taub, D.M., Vickers, J.H., Suomi, S., Linnoila, M., 1995. Correlation of CSF 5-HIAA concentrations with sociality and the timing of emigration in free-ranging primates. American Journal of Psychiatry 152, 907-913.
26. Mehlman, P.T., Higley, J.D., Faucher, I., Corr, J., Taub, D.M., Dodson, A., Lilly, A., Linnoila, M., Suomi, S., 1992. CNS 5-HIAA and aggression in free-ranging adolescent rhesus males. American Journal of Primatology 27, 46-47.
27. Mehlman, P.T., Higley, J.D., Faucher, I., Lilly, A.A., Taub, D.M., Suomi, S., Linnoila, M., 1994. Low CSF 5-HIAA concentrations and severe aggression and impaired impulse control in nonhuman primates. American Journal of Psychiatry 151, 1485-1491.
28. Nankai, M., Yamada, S., Toru, M., 1991. Down regulation of serotonin uptake sites in rat brain induced by concomitant chronic administration of desipramine and repeated stress. Japanese Journal of Psychiatry and Neurology 45, 105-106.
29. Rahe, R.H., Karson, S., Howard, N.S.J., Rubin, R.T., Poland, R.E., 1990. Psychological and physiological assessments on American hostages freed from captivity in Iran. Psychosomatic Medicine 52, 1-16.
30. Raleigh, M.J., 1987. Differential behavioral effects of tryptophan and 5-hydroxytryptophan in vervet monkeys: influence of catecholaminergic systems. Psychopharmacology 93, 44-50.
31. Raleigh, M.J., Brammer, G.L., McGuire, M.T., 1983a. Male dominance, serotonergic systems, and the behavioral and physiological effects of drugs in vervet monkeys (Cercopithecus aethiops sabaeus). In: Miczek, K.A. (Ed.), Ethopharmacology: Primate Models of Neuropsychiatrie Disorders. Alan R. Liss, New York, pp. 185-197.
32. Raleigh, M.J., Brammer, G.L., McGuire, M.T., Pollack, D.B., Yuwiler, A., 1992. Individual differences in basal cisternal cerebrospinal fluid 5-HIAA and HVA in monkeys. The effects of gender, age, physical characteristics, and matrilineal influences. Neuropsychopharmacology 7, 295-304.
33. Raleigh, M.J., Brammer, G.L., McGuire, M.T., Yuwiler, A., Geller, E., Johnson, C.K., 1983b. Social status related differences in the behavioral effect of drugs in vervet monkeys (Cercopithecus aethiops sabaeus). In: Steklis, H.D., Kling, A.S. (Eds.), Hormones, Drugs and Social Behavior in Primates. SP Medical and Scientific Books, New York, pp. 83-105.
34. Raleigh, M.J., Brammer, G.L., Yuwiler, A., Flannery, J.W., McGuire, M.T., 1980. Serotonergic influences on the social behavior of vervet monkeys (Cercopithecus aethiops sabaeus). Experimental Neurology 68, 322-334.
35. Raleigh, M.J., McGuire, M.T., 1994. Serotonin, aggression, and violence in vervet monkeys. In: Masters, R.D., McGuire, M.T. (Eds.), The Neurotransmitter Revolution. Southern Illinois University Press, Carbondale, pp. 129-145.
36. Roonwal, M.L., Mohnot, S.M., 1977. Primates of South Asia. Harvard University Press, Cambridge, MA.
37. Scheinin, M., Chang, W.H., Kirk, K.L., Linnoila, M., 1983. Simultaneous determination of 3-methoxy-4-hydroxyphenylglycol, 5-hydroxyindoleacetic acid, and homovanillic acid in cerebrospinal fluid with high-performance liquid chromatography using electrochemical detection. Analytical Biochemistry 131, 246-253.
38. Taub, D.M., Mehlman, P.T., 1989. Development of the Morgan Island Rhesus Monkey colony. Puerto Rico Health Sciences Journal 8, 159-169.
39. Thurmond, J.B., Heishman, S.J., 1984. Effect of catecholamine precursors on stress-induced changes in motor activity, exploration, and brain monoamines in young and aged mice. Behavioral Neuroscience 98, 506-517.
40. Virkkunen, M., Kallio, E., Rawlings, R., Tokola, R., Poland, R.E., Guidotti, A., Nemeroff, C., Bissette, G., Kalogeras, K., Karonen, S.L., Linnoila, M., 1994. Personality profiles and state aggressiveness in Finnish alcoholic, violent offenders, fire setters, and healthy volunteers. Archives of General Psychiatry 51, 28-33.
41. Virkkunen, M., Linnoila, M., 1993. Brain serotonin, type II alcoholism and impulsive violence. Journal of Studies on Alcohol (Supplement) 11, 163-169.
42. Wehr, T.A., 1992. Seasonal vulnerability to depression. Implications for etiology and treatment. Encephale 18 (4), 479-483.