Induction of autoimmunity. A role for the idiotypic network

Annals of the New York Academy of Sciences

Volumn 815, Issue , 1997, Pages 342-346

  Shoenfeld, Yehuda ^a,b   George, Jacob ^a,b  

^a SHEBA MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; CARDIOLIPIN ANTIBODY; DNA ANTIBODY; GLOMERULUS BASEMENT MEMBRANE ANTIBODY; NEUTROPHIL CYTOPLASMIC ANTIBODY; RIBONUCLEOPROTEIN ANTIBODY; THYROGLOBULIN ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPHOSPHOLIPID SYNDROME; AUTOIMMUNITY; CONFERENCE PAPER; DISEASE PREDISPOSITION; ENDOTHELIUM CELL; ETIOLOGY; IMMUNE SYSTEM; IMMUNIZATION; MOUSE; NONHUMAN; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALIA; GLOMERULUS;

EID: 0030753789     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb52080.x     Document Type: Conference Paper

References (26)

1. SHOENFELD, Y. & D. A. ISENBERG. 1989. The mosaic of autoimmunity. Immunol. Today 10: 123-126.
2. ROSE, N. R. & C. BONA. 1993. Defining criteria for autoimmune diseases: Witebsky's criteria revisited. Immunol. Today 14:426-430.
3. SHOENFELD, Y. 1994. Idiotypic induction of autoimmunity: a new aspect of the idiotypic network. FASEB J. 8: 1296-1303.
4. MENDLOVIC, S., S. BROCKE, Y. SHOENFELD, et al. 1988. Induction of SLE-like disease in mice by a common anti-DNA idiotype. Proc. Natl. Acad. Sci. U.S.A. 85: 2260-2264.
5. BLANK, M., S. MENDLOVIC, E. MOSES, er al. 1989. Induction of SLE-like disease in naive mice with monoclonal anti-DNA antibody derived from a patient with polymyositis carrying 16/6 Id. J. Autoimmun. 1: 683-691.
6. BLANK, M., M. KRUP, S. MENDLOVIC, H. FRICK, E. MOSES, N. TALAL, A. R. M. COATES & Y. SHOENFELD. 1990. The importance of the pathogenic 16/6 idiotype in the induction of SLE in naive mice. Scand. J. Immunol. 31:45-52.
7. BLANK, M., I. KRAUSE, M. BEN-BASSAT & Y. SHOENFELD. 1992. Induction of antiphospholipid associated with SLE following immunization with human monoclonal pathogenic anti-DNA idiotype. J. Autoimmun. 5:495-509.
8. BLANK, M., S. MENDLOVIC, E. MOSES, A. R. M. COATES & Y. SHOENFELD. 1991. Induction of SLE in naive mice with T cell lines specific for human anti-DNA antibody SA-1 (16/6+ Id) and for mouse tuberculous antibody (16/6+ Id). Clin. Immunol. Immunopathol. 60:471483.
9. BLANK, M., M. BEN-BASSAT & Y. SHOENFELD. 1991. Modulation of SLE induction in naive mice by specific T cells with suppressor activity to pathogenic anti-DNA idiotype. Cell. Immunol. 137:474-486.
10. BAKIMER, R., P. FISHMAN, M. BLANK, B. SRENDI, M. DJALDETTI & Y. SHOENFELD. 1992. Induction of primary anti-phospholipid syndrome in naive mice by immunization with a human monoclonal anti-cardiolipin antibody. J. Clin. Invest. 89: 1558-1563.
11. COHEN, J., R. BAKIMER, M. BLANK, G. VALESINI & Y. SHOENFELD. 1994. Pathogenic anticardiolipin antibodies: the experience from monoclonal gammopathy. Clin. Exp. Immunol. 97: 181-186.
12. BLANK, M., Y. TOMER, M. STEIN, J. KOPOLOVIC, A. WIIK, P. L. MERONI, G. CONFORTI & Y. SHOENFELD. 1995. Immunization with anti-neutrophil cytoplasmic antibody (ANCA) induces the production of mouse ANCA and perivascular lymphocyte infiltration. Clin. Exp. Immunol. 102: 120-130.
13. TOMER, Y, B. GILBURD, M. BLANK, O. LIDER, R. HERSHKOVIZ, P. FISHMAN, R. ZIGELMAN, P. L. MERONI, A. WllK & Y. SHOENFELD. 1995. Characterization of biologically active antineutrophil cytoplasmic antibodies induced in mice. Arthritis Rheum. 38: 1375-1381.
14. TOMER, Y, B. GILBURD, J. SACK, T. F. DAVIES, A. MESHORER, C. L. BUREK, N. R. ROSE &Y. SHOENFELD. 1996. Induction of thyroid autoantibodies in naive mice by idiotypic manipulation. Clin. Immunol. Immunopathol. In press.
15. SHOENFELD, Y, B. GILBURD, M. HOJNIC, M. DAMIANOVICH, S. HACHAM, Y. KOPOLOVIC, S. POLAK-CHARCON, I. GOLDBERG, A. AFEC, L. HuN-Ciu & J. B. PETER. 1996. Induction of Goodpasture antibodies to noncollagenous domain (NC1) of type IV collagen in mice by idiotypic manipulation. Hum. Antib. Hybrid. 6: 122-128.
16. GILBURD, B., J. GEORGE, A. AFEC, M. DAMIANOVICH, A. DORIA, S. TODESCO & Y. SHOENFELD. 1996. "Autoantibody dominance" pattern following idiotypic manipulation of naive mice with different epitope-specific anti-UlRNP antibodies. Submitted.
17. DAMIANOVICH, M., B. GILBURD, J. GEORGE, N. DEL PAPA, A. AFEC, I. GOLDBERG, Y. KOPOLOVIC, D. ROTH, G. BARKAI, P. L. MERONI & Y. SHOENFELD. 1996. Pathogenic role of antiendothelial cell antibodies (AECA) in vasculitis: an idiotypic experimental model. J. Immunol. 156:4946-4951.
18. PlERANGELI, S. S. & E. N. HARRIS. 1993. Induction of phospholipid antibodies in mice and rabbits by immunization with human beta-2 glycoprotein-1 or anticardiolipin antibodies alone. Clin. Exp. Immunol. 93: 269.
19. TINCANI, A., G. BALESTRIERI, F. ALLEGRI, R. CATTANEO, A. FORNASIERI, M. Li, A. SINICO & G. D'AMICO. 1993. Induction of experimental SLE in naive mice by immunization with human polyclonal anti-DNA antibody carrying the 16/6 idiotype. Clin. Exp. Rheumatol. 11: 129-134.
20. ROMBACH, E., D. A. STETLER & J. C. BROWN. 1992. Rabbits produce SLE-like anti-RNA polymerase I and anti-DNA autoantibodies in response to immunization with either human or murine SLE anti-DNA antibodies. Autoimmunity 13: 291-302.
21. DANG, H., N. OGAWA, M. TAKEI, K. LAZARIDIS & N. TALAL. 1993. Induction of lupusassociated autoantibodies by immunization with native and recombinant Ig polypeptides expressing a cross-reactive idiotype 4B4. J. Immunol. 151: 7260.
22. JERNE, N. K. 1974. Towards a network theory of the immune system. Ann. Immunol. (Paris) 125c: 373-389.
23. BAKIMER, R., B. GILBURD, N. ZURGIL & Y. SHOENFELD. 1993. The effect of intravenous y-globulin on the induction of experimental antiphospholipid syndrome. Clin. Immunol. Immunopathol. 69: 97-102.
24. KRAUSE, I., M. BLANK, J. KOPOLOVIC, A. APEC, I. GOLDBERG, Y. TOMER & Y. SHOENFELD. 1995. Abrogation of experimental systemic lupus erythematosus and primary antiphospholipid syndrome with intravenous gamma globulin. J. Rheumatol. 22: 1068-1074.
25. BLANK, M., J. MANSROI, Y. TOMER, A. MANSROI, J. KOPOLOVIC, S. POLAK-CHARCO.M & Y. SHOENFELD. 1994. Suppression of experimental SLE with specific anti-idiotypic antibodysaporin conjugate. Clin. Exp. Immunol. 98:434-441.
26. SHOENFELD, Y. & E. MOSES. 1990. Pathogenic idiotypes of antibodies and autoimmunity: lessons from new experimental models of SLE. FASEB J. 4: 2646-2651.