Computer model analysis of the relationship of ST-segment and ST-segment/heart rate slope response to the constituents of the ischemic injury source

Journal of Electrocardiology

Volumn 30, Issue 3, 1997, Pages 161-174

  Hyttinen, Jari ^a   Viik, Jari ^a   Lehtinen, Rami ^a   Plonsey, Robert ^b   Malmivuo, Jaakko ^a  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b Duke University   (United States)

Author keywords

Finite difference element method; Ischemia; Modeling; ST segment deviation; ST segment heart rate slope

Indexed keywords

ARTICLE; COMPUTER MODEL; COMPUTER SIMULATION; DIAGNOSTIC VALUE; ELECTROCARDIOGRAM; EXERCISE TEST; FINITE ELEMENT ANALYSIS; GEOMETRY; HEART MUSCLE ISCHEMIA; HEART RATE; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; ST SEGMENT; THEORY;

EID: 0030753341     PISSN: 00220736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-0736(97)80001-5     Document Type: Article

References (37)

1. Elamin M, Mary D, Smith D et al: Prediction of severity of coronary heart disease using slope of submaximal ST-segment/heart rate relationship. Cardiovasc Res 48:311, 1980
2. Okin PM, Kligfield P: Solid-angle theory and heart rate adjustment of ST-segment depression for the identification of coronary artery disease. Am Heart J 127:658, 1994
3. Sievänen H, Karhumäki L, Vuori I et al: Improved diagnostic performance of the exercise ECG test by computerized multivariate ST-segment/heart rate analysis. J Electrocardiol 24:129, 1991
4. Lehtinen R, Sievänen H, Uusitalo A et al: Performance characteristics of various exercise ECG classifiers in different clinical populations. J Electrocardiol 27:11, 1994
5. Holland RP, Brooks H, Lild B: Spatial and nonspatial influences on the TQ-ST segment deflection of ischemia. Theoretical and experimental analysis in the pig. J Clin Invest 60:197, 1977
6. Holland RP, Arnsdorf MF: Solid angle theory and the electrocardiogram: physiologic and quantitative interpretations. Prog Cardiovasc Dis 19:431, 1977
7. Kléber AG, Janse MJ, van Capelle FJL et al: Mechanism and time course of S-T and T-Q segment changes during acute regional myocardial ischemia in the pig heart determined by extracellular and intracellular recordings. Circ Res 42:603, 1978
8. Maehera K, Kyono H, Kitaoka S et al: A comparison of ST segment deviation and calculated solid angle during acute regional ischemia in the isolated canine heart at precordial, epicardial and intramyocardial lead surfaces. J Electrocardiol 19:235, 1986
9. Okin MP, Kligfield P: Heart rate adjustment of ST segment depression and performance of the exercise electrocardiogram: a critical review. J Am Coll Cardiol 25:1726, 1995
10. Malmivuo JA, Plonsey R: Bioelectromagnetism - principles and application of bioelectric and biomagnetic fields. Oxford University Press, New York, 1995
11. Janse MJ, van Capelle FJL, Morsink H et al: Flow of "injury" current of excitation during early ventricular arrhythmias in acute regional myocardial ischemia in isolated porcine and canine hearts. Evidence for two different arrhythmogenic mechanisms. Circ Res 47:151, 1980
12. Richeson JF, Akiyama T, Schenk E: A solid angle analysis of the epicardial ischemic ST-TQ deflection in the pig: a theoretical and experimental study. Circ Res 43:879, 1978
13. Mirvis DM, Keller FW, Ideker RE et al: Equivalent generator properties of acute ischemic lesions in the isolated rabbit heart. Circ Res 12:676, 1978
14. Vincent GM, Abildskov JA, Burgess MJ: Mechanism of ischemic ST-segment displacement: evaluation by direct current recordings. Circulation 56:559, 1977
15. Rush S: Inhomogeneities as a cause of multiple peaks of heart potential on the body surface: theoretical studies. IEEE Trans Biomed Eng 18:115, 1971
16. Gulrajani RM, Mailloux GE: A simulation study of the effects of torso inhomogeneities on electrocardiographic potentials using realistic heart and torso models. Circ Res 52:45, 1983
17. Hyttinen JAK, Malmivuo JA, Walker SJ: Lead field of ECG-leads calculated with a computer thorax model - an application of reciprocity. p. 241. In Proceedings of the 20th Computers in Cardiology Meeting, London, May 8-9, 1993. IEEE Computer Society Press, Los Alamitos, CA, 1993
18. Hyttinen J, Kauppinen P, Heinonen T et al: Application of the visible human man data for modelling of the human thorax as a volume conductor. Proceedings 23rd International Conference on Electrocardiology, Cleveland, OH, July 31-August 4, 1996, 4p.
19. Walker SJ, Kilpatrick D: Forward and inverse electrocardiographic calculations using resistor network models of the human torso. Circ Res 61:504, 1987
20. Hyttinen JAK: Development of regional aimed ECG leads especially for myocardial ischemia diagnosis. Ph.D. Thesis, Tampere University of Technology, Tampere, Finland, 1994, 162 pp.
21. Chung E: Exercise electrophysiology - practical approach. Willams & Wilkins, Baltimore, 1979
22. Viik J, Lehtinen R, Malmivuo J: Capability of the single ECG leads of the 12-lead system to discriminate patients with CAD and without CAD - ROC analysis approach. p. 234. In Van Oosterom A, Oostendorp T, Oijen G (eds): 22nd International Congress on Electrocardiology. University of Nijmegen, Nijmegen, Netherlands, 1995
23. Fuchs RM, Achuff SC, Grunwald L et al: Electrocardiographic localization of coronary artery narrowings: studies during myocardial ischemia and infarction in patients with one-vessel disease. Circulation 66:1168, 1982
24. Kurata C, Tawarahara K, Okayama K et al: Localization of exercise-induced myocardial ischemia with ST depression. Intern Med 31:583, 1992
25. Dunn RF, Freedman B, Bailey IK et al: Localization of coronary artery disease with exercise electrocardiography: correlation with thallium-201 myocardial perfusion scanning. Am J Cardiol 48:837, 1981
26. Fox RM, Hakki A-H, Iskandrian AS et al: Relation between electrocardiographic and scintigraphic location of myocardial ischemia during exercise in one-vessel coronary artery disease. Am Heart J 53:1529, 1984
27. Kligfield P, Ameisen O, Okin PM: Heart rate adjustment of ST segment for improved detection of coronary artery disease. Circulation 79:245, 1989
28. Lehtinen R, Sievänen H, Viik J et al: Accurate detection of coronary artery disease by integrated analysis of the ST segment depression/heart rate patterns during the exercise and recovery phases of the exercise electrocardiography test. Am J Cardiol 78:1002, 1996
29. Herpin D, Ferrandis J, Couderq C et al: Usefulness of a quantitative analysis of the recovery phase patterns of the ST-segment depression in the diagnosis of coronary artery disease. Am J Med 101:592, 1996
30. Walker SJ: Epicardial potential distributions calculated from body surface measurements using multiple torso models. Ph.D. Thesis, University of Tasmania. 1985, 235 p.
31. Laarne P, Eskola H, Hyttinen J et al: Validation of a detailed model of the electrical fields in the brain. J Med Eng Technol 19:84, 1995
32. Huiskamp GJ, van Oosterom A: Heart position and orientation in forward and inverse electrocardiography. Med Biol Eng Comput 30:613, 1992
33. Van Oosterom A, Huiskamp GJM: The effect of torso inhomogeneities on body surface potentials quantified using "tailored" geometry. J Electrocardiol 22:53, 1989
34. Johnson CR, MacLeod RS, Dutson A: Effects of the inhomogeneity on electrocardiographic fields: a finite element study. p. 2009. In Morucci JP, Plonsey R, Coatreaux JL et al (eds): Proceedings of the 14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Service Center, Piscataway, NJ, 1992
35. Smith GT, Geary GG, Blanchard W et al: An electrocardiographic model of myocardial ischemic injury. J Electrocardiol 16:223, 1983
36. Rush S, Abildskov JA, McFee R: Resistivity of body tissues at low frequencies. Circulation 22:40, 1963
37. Geddes LA, Baker LE: The specific resistance of biological material - a compendium of data for the biomedical engineer and physiologist. Med Biol Eng Comput 5:271, 1967