Characterization of the Wtm proteins, a novel family of Saccharomyces cerevisiae transcriptional modulators with roles in meiotic regulation and silencing

Molecular and Cellular Biology

Volumn 17, Issue 8, 1997, Pages 4830-4841

  Pemberton, Lucy F ^a   Blobel, Günter ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE; MICROORGANISM PROTEIN; MUTANT PROTEIN;

ARTICLE; HAPLOIDY; MEIOSIS; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN TARGETING; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION;

SACCHAROMYCES CEREVISIAE;

EID: 0030744584     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.8.4830     Document Type: Article

References (62)

1. Aitchison, J. D., M. P. Rout, M. Marelli, G. Blobel, and R. W. Wozniak. 1995. Two novel related yeast nucleoporins Nup170p and Nupl57p: complementation with the vertebrate homologue Nupl55p and functional interactions with the yeast nuclear pore-membrane protein Pom 152p. J. Cell Biol. 131: 1133-1148.
2. Bartel, P. L., C. Chien, R. Sternglanz, and S. Fields. 1993. Using the two hybrid system to detect protein-protein interactions, p. 153-179. In D. A. Harley (ed.), Cellular interactions in development: a practical approach. IRL Press, Oxford, England.
3. Bowdish, K. S., and A. P. Mitchell. 1993. Bipartite structure of an early meiotic upstream activation sequence from Saccharomyces cerevisiae. Mol. Cell. Biol. 13:2172-2181.
4. Braunstein, M., A. B. Rose, S. G. Holmes, C. D. Allis, and J. R. Broach. 1993. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation. Genes Dev. 7:592-604.
5. Braunstein, M., R. E. Sobel, C. D. Allis, B. M. Turner, and J. R. Broach. 1996. Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern. Mol. Cell. Biol. 16:4349-4356.
6. Brownell, J. E., and C. D. Allis. 1996. Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation. Curr. Opin. Genet. Dev. 6:176-184.
7. Brownell, J. E., J. Zhou, T. Ranalli, R. Kobayashi, D. G. Edmondson, S. Y. Roth, and C. U. Allis. 1996. Tetrahymena hislone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell 84:843-851.
8. Buck, S. W., and D. Shore. 1995. Action of a RAPl C-terminal silencing domain reveals an underlying competition between HMR and telomeres in yeast. Genes Dev. 9:370-384.
9. Fassler, J. S., and F. Winston. 1989. The Saccharomyces cerevisiae SPTI3/ GAL11 gene has both positive and negative regulatory roles in transcription. Mol. Cell. Biol. 9:5602-5609.
10. Finley, D., E. Ozkaynak, and A. Varshavsky. 1987. The yeast polyubiquitin gene is essential for resistance to higher temperatures, starvation and other stresses. Cell 48:1035-1046.
11. Gotta, M., A. Formenton, L. Maillet, H. Scherthan, and S. Gasser. 1996. The clustering of telomeres and colocalization with Rapl, Sir3 and Sir4 proteins in wild-type Saccharomyces cerevisiae. J. Cell Biol. 134:1349-1363.
12. Gottschling, D. E., O. M. Aparicio, B. L. Billington, and V. A. Zakian. 1990. Position effect at S. cerevisiae telomeres: reversible repression of pol II transcription. Cell 63:751-762.
13. Hebbes, T. R., A. W. Thorne, and C. Crane-Robinson. 1988. A direct link between core histone acetylation and transcriptionally active chromatin. EMBO J. 7:1395-1402.
14. Hecht, A., S. Strahl-Bolsinger, and M. Grunstein. 1996. Spreading of transcriptional repressor SIR3 from telomeric heterochromatin. Nature 383:92-95.
15. Himmelfarb, H. J., J. Pearlberg, D. H. Last, and M. Ptashne. 1990. GAL11P: a yeast mutation that potentiates the effect of weak GAL4-derived activators. Cell 63:1299-1309.
16. Hollenberg, S. M., R. Sternglanz, P. F. Cheng, and H. Weintraub. 1995. Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. Mol. Cell. Biol. 15:3813-3822.
17. Kayne, P. S., U. J. Kim, M. Han, J. R. Mullen, F. Yoshizaki, and M. Grunstein. 1988. Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast. Cell 55:27-39.
18. Keleher, C. A., M. J. Redd, J. Schultz, M. Carlson, and A. D. Johnson. 1992. Ssn6-Tupl is a general repressor of transcription in yeast. Cell 68:709-719.
19. Kilmartin, J. V., and A. E. Adams. 1982. Structural rearrangements of tubulin and actin during the cell cycle of the yeast Saccharomyces. J. Cell Biol. 98:922-933.
20. Kirn, Y.-J., S. Bjorklund, Y. Li, M. H. Sayre, and R. D. Kornberg. 1994. A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell 77:599-608.
21. Kingston, R. E., C. A. Bunker, and A. N. Imbalzano. 1996. Repression and activation by multiprotein complexes that alter chromatin structure. Genes Dev. 10:905-920.
22. Kipling, D., C. Tambini, and S. E. Kearsey. 1991. rar mutations which increase artificial chromosome stability in Saccharomyces cerevisiae identify transcription and recombination proteins. Nucleic Acids Res. 19:1385-1391.
23. Kraemer, D. M., C. Strambio-de-Castilia, G. Blobel, and M. P. Rout. 1995. The essential yeast nucleoporin NUP159 is located on the cytoplasmic side of the nuclear pore complex and serves in karyopherin-mediated binding of transport substrate. J. Biol. Chem. 270:19017-19021.
24. Kuo, M.-H., J. E. Brownell, R. E. Sobel, T. A. Ranalli, R. G. Cook, D. G. Edmondson, S. Y. Roth, and C. D. Allis. 1996. Transcription-linked acetylation by GCN5p of histones H3 and H4 at specific lysines. Nature 383:269-272.
25. Kyrion, G., K. Liu, C. Liu, and A, J. Lustig. 1993. RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae. Genes Dev. 7:1146-1159.
26. Li. Y., S. Bjorklund, Y. W. Jiang, Y. J. Kim, W. S. Lane, D. J. Stillman, and R. D. Kornberg. 1995. Yeast global transcriptional regulators Sin4 and Rgrl are components of mediator complex/RNA polymerase II holoenzyme. Proc. Natl. Acad. Sci. USA 92:10864-10868.
27. Marsh, J. L., M. Erfle, and E. J. Wykes. 1984. The pIC plasmid and phage vectors with versatile cloning sites for recombinant selection by insertional inactivation. Gene 32:481-485.
28. Mitchell, A. P. 1994. Control of meiotic gene expression in Saccharomyces cerevisiae. Microbiol. Rev. 58:56-70.
29. Moretti, P., K. Freeman, L. Coodley, and D. Shore. 1994. Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1. Genes Dev. 8:2257-2269.
30. Neer, E., and T. Smith. 1996. G protein heterodimers: new structures propel new questions. Cell 84:175-178.
31. Neer, E. J., C. J. Schmidt, R. Nambudripad, and T. Smith. 1994. The ancient regulatory-protein family of WD-repeat proteins. Nature 371:297-300.
32. Nisnizawa, M., Y. Suzuki, Y. Nogi, K. Matsumoto, and T. Fukasawa. 1990. Yeast Ga111 protein mediates the transcriptional activation signal of two different transacting factors, Gal4 and general regulatory factor I/repressor/ activator site binding protein I/translation upstream factor. Proc. Natl. Acad. Sci. USA 87:5373-5377.
33. Nogi, Y., and T. Fukasawa. 1983. A novel mutation that affects utilization of galactose in Saccharomyces cerevisiae. Curr. Genet. 2:115-120.
34. Park, E.-C., and J. W. Szostak. 1990. Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML. Mol. Cell. Biol. 10:4932-4934.
35. Parthun, M. R., J. Widom, and D. E. Gottschling. 1996. The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism. Cell 87:85-94.
36. Pemberton, L. F., M. P. Rout, and G. Blobel. 1995. Disruption of the nucleoporin gene NUP133 results in clustering of nuclear pore complexes. Proc. Natl. Acad. Sci. USA 62:1187-1191.
37. Qian, Y.-W., and E. Y.-H. P. Lee. 1995. Dual retinoblastoma-binding proteins with properties related to negative regulator of Ras in yeast. J. Biol. Chem. 270:25507-25513.
38. Qian, Y.-W., Y.-C. J. Wang, R. E. J. Hollingsworth, D. Jones, N. Ling, and E. Y.-H. P. Lee. 1993. A retinoblastoma-binding protein related to a negative regulator of Ras in yeast. Nature 364:648-652.
39. Rose, M. D., P. Novick, J. H. Thomas, D. Botstein, and G. R. Fink. 1987. A Saccharomyces cersvisiae genomic plasmid bank based on a centromeric-containing shuttle vector. Gene 60:237-243.
40. Roth, S. Y. 1995. Chromatin mediated transcriptional repression. Curr. Opin. Genet. Dev. 5:168-173.
41. Rout, M. P., and G. Blobel. 1993. Isolation of the yeast nuclear pore complex. J. Cell Biol. 123:771-783.
42. Ruggieri, R., K. Tanaka, M. Nakafuku, Y. Kaziro, A. Toh-e, and K. Matsumoto. 1989. MS11, a negative regulator of the RAS-cAMP pathway in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 86:8778-8782.
43. Rundlett, S. E., A. A. Carmen, R. Kobayashi, S. Bavykin, B. M. Turner, and M. Grunstein. 1996. HDA1 and RPD3 are members of distinct yeast deacetylase complexes that regulate silencing and transcription. Proc. Natl. Acad. Sci. USA 93:14503-14508.
44. Sherman, F., G. R. Fink, and J. B. Hicks (ed.). 1986. Methods in yeast genetics. Cold Spring Harbor Laboratory. Cold Spring Harbor, N.Y.
45. Shore, D. 1995. Telomere position effects and transcriptional silencing in the yeast Saccharomyces cerevisiae, p. 139-191. In E. H. Blackburn and C. W. Greider (ed.), Telomeres. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
46. Strich, R., R. T. Surosky, C. Steber, E. Dubois, F. Messenguy, and R. E. Esposito. 1994. UME6 is a key regulator of nitrogen repression and meiotic development. Genes Dev. 8:796-810.
47. Struhl, K. 1996. Chromatin structure and RNA polymerase II connection: implications for transcription. Cell 84:179-182.
48. Sussel, L., and D. Shore. 1991. Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length. Proc. Natl. Acad. Sci. USA 88:7749-7753.
49. Sussel, L., D. Vannier, and D. Shore. 1993. Epigenetic switching of transcriptional states: cis- and trans-acting factors affecting establishment of silencing at the HMR locus in Saccharomyces cerevisiae. Mol. Cell. Biol. 13:3919-3928.
50. Sussel, L., D. Vannier, and D. Shore. 1995. Suppressors of defective silencing in yeast: effects on transcriptional repression at the HMR locus, cell growth, and telomere structure. Genetics 141:873-888.
51. Taunton, J., C. A. Hassig, and S. L. Schreiber. 1996. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272:408-411.
52. Thomas, B. J., and R. Rothstein. 1989. Elevated recombination rates in transcriptionally active DNA. Cell 56:619-630.
53. Thompson, C. A., A. J. Koleske, D. M. Chao, and R. A. Young. 1993. A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast. Cell 73:1361-1375.
54. Tyler, J. K., M. Bulger, R. Kamakaka, R. Kobayashi, and J. T. Kadonaga. 1996. The p55 subunit of Drosophila Chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein. Mol. Cell. Biol. 16:6149-6159.
55. Valuer, L. G., and M. Carlson. 1991. New SNF genes, GAL11 and GRR1 affect SUC2 expression in Saccharomyces cerevisiae. Genetics 129:675-684.
56. Vannier, D., D. Balderes, and D. Shore. 1996. Evidence that the transcrip tional regulators SIN3 and RPD3. and a novel gene (SDS3) with similar functions, are involved in transcriptional silencing in S. cerevisiae. Genetics 144:1343-1353.
57. Verreault, A., P. D. Kaufman, R. Kobayashi, and B. Slillman. 1997. Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4. Cell 87:95-104.
58. Vidai, M., and R. F. Gaber. 1991. RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae. Mol. Cell. Biol. 11:6317-6327.
59. Vidai, M., R. Strich, R. E. Esposito, and R. F. Gaber. 1991. RPD1(SIN3/ UME4) is required for maximal activation and repression of diverse yeast genes. Mol. Cell. Biol. 11:6306-6316.
60. Wang, H., and D. J. Stillman. 1993. Transcriptional repression in Saccharomyces cerevisiae by a SIN3-LexA fusion protein. Mol. Cell. Biol. 13:1805-1814.
61. Wente, S. R., M. P. Rout, and G. Blobel. 1992. A new family of yeast nuclear pore complex proteins. J. Cell Biol. 119:705-723.
62. Wotton, D., and D. Shore. 1997. A novel Rap1p-interacting factor. Rif2p, cooperates with Rif1p to regulate telomere length in S. cerevisiae. Genes Dev. 11:748-760.