Synthesis and activity of C2-substituted analogs of influenza neuraminidase inhibitor GS 4071

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 14, 1997, Pages 1847-1850

  Zhang, Lijun ^a   Williams, Matthew A ^a   Mendel, Dirk B ^a   Escarpe, Paul A ^a   Kim, Choung U ^a  

^a GILEAD SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 ACETAMIDO 5 AMINO 3 (1 ETHYLPROPOXY) 1 CYCLOHEXENE 1 CARBOXYLIC ACID; SIALIDASE; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; IN VITRO STUDY; INFLUENZA VIRUS A; LIPOPHILICITY; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

INFLUENZA VIRUS; INFLUENZAVIRUS A;

EID: 0030743224     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00331-4     Document Type: Article

References (7)

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3. Kim, C. U.; Lew, W.; Williams, M. A.; Zhang, L.; Swaminathan, S.; Bischofberger, N.; Chen, M. S.; Mendel, D. B.; Li, W.; Tai, L.; Escarpe, P.; Cundy, K. C.; Eisenberg, E. J.; Lacy, S.; Sidwell, R. W.; Stevens, R. C.; Laver, W. G. 1996. New Potent, Orally Active Neuraminidase Inhibitors as Anti-Influenza Agents: In Vitro and In Vivo Activity of GS 4071 and Analogs, abstract H44, P171. In Abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Washington, D.C.
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