Do 'lefthanders' make better local anaesthetics? The relevance of chirality in clinical practice as shown by new local anaesthetics;Sind 'Linkshander' bessere Lokalanasthetika? Zur Relevanz der Stereoisomerie in der klinischen Praxis am Beispiel neuer Lokalanasthetika

Anaesthesist

Volumn 46, Issue 7, 1997, Pages 622-626

  Wulf, H ^a,b  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

Author keywords

cardiotoxicity; chirality; levobupivacaine; local anaesthetics; ropivacaine

Indexed keywords

LEVOBUPIVACAINE; ROPIVACAINE; UNCLASSIFIED DRUG; AMIDE; LOCAL ANESTHETIC AGENT;

ARTICLE; CARDIOTOXICITY; CHIRALITY; DRUG EFFICACY; DRUG SAFETY; DRUG TOXICITY; EPIDURAL DRUG ADMINISTRATION; HUMAN; LOCAL ANESTHESIA; MOTOR NERVE BLOCK; NERVE BLOCK; OBSTETRICS; POSTOPERATIVE PAIN; CHEMISTRY; REVIEW; STEREOISOMERISM;

AMIDES; ANESTHETICS, LOCAL; HUMANS; STEREOISOMERISM;

EID: 0030743117     PISSN: 00032417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001010050447     Document Type: Article

References (32)

1. Akerman B, Hellberg IB, Trossvik C (1988) Primary evaluation of the local anaesthetic properties of the aminoamide agent ropivacaine (LEA103). Acta Anaesthesiol Scand 32:571-578
2. Albright GA (1979) Cardiac arrest following regional anesthesia with etidocaine or bupivacaine (editorial). Anesthesiology 51:285-287
3. Biscoping J, Bachmann-Mennenga B (1996) Ropivacain. In: Alon E (Hrsg) Anästhesie und Schmerzlinderung in der Geburtshilfe. Huber, Bern
4. Brockway MS, Bannister J, McClure JH, McKeown D, Wildsmith JA (1991) Comparison of extradural ropivacaine and bupivacaine. Br J Anaesth 66:31-37
5. Butterworth JF, Brownlow RC, Leith JP, Prielipp RC, Cole RL (1993) Bupivacaine inhibits cyclic-3′,5′-adenosine monophosphate production. Anesthesiology 79:88-95
6. Clarkson CW, Hondeghem LM (1985) Mechanism for bupivacaine depression of cardiac conduction: fast block of sodium channels during action potential with slow recovery from block during diastole. Anesthesiology 62:396-405
7. Coyle DE, Sperelakis N (1987) Bupivacaine and lidocaine blockade of calcium-mediated slow action potentials in guinea pig ventricular muscle. J Pharmacol Exp Therap 242:1001-1005
8. Datta S, Camann W, Bader A, VanderBurgh L (1995) Clinical effects and maternal and fetal plasma concentrations of epidural ropivacaine versus bupivacaine for caesarean section. Anesthesiology 82:1346-1352
9. De la Coussaye JE, Bassoul B, Albat B, Peray BA, Gagnol JP, Eledjam JJ, Sassine A (1992) Experimental evidence in favor of role of intracellular actions of bupivacaine in myocardial depression. Anesth Analg 74:698-702
10. Eledjam JJ, Coussaye JE de la, Brugada J, Masse C, Desh G, dÁthis F, Sassine A (1989) In vitro study on mechanisms of bupivacaine-induced depression of myocardial contractility. Anesth Analg 69:732-735
11. Feldman HS, Arthur GR, Covino BG (1989) Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine, bupivacaine, and lidocaine in the concious dog. Anesth Analg 69:794-801
12. Feldman HS, Arthur GR, Pitkanen M, Hurley R, Doucette AM, Covino BG (1991) Treatment of acute systemic toxicity after the rapid intravenous injection of ropivacaine and bupivacaine in the concious dog. Anesth Analg 73:373-384
13. Heavner JE (1986) Cardiac dysrhythmias induced by infusion of local anesthetics into the lateral cerebral ventricle of cats. Anesth Analg 65:133-138
14. Lee-Son S, Wang GK, Concu A, Crill E, Strichartz G (1990) Stereoselective inhibition of neuronal sodium channels by local anesthetics. Evidence for two sites of action? Anesthesiology 77:324-335
15. McClure JH (1996) Ropivacaine. Br J Anaesth 76:300-307
16. Moller R, Covino BG (1990) Cardiac electrophysiologic properties of bupivacaine and lidocaine compared with those of ropivacaine, a new amide local anesthetic. Anesthesiology 72:322-329
17. Niesel HC, Eilingsfeld T, Hornung M, Kaiser H (1993) Ropivacain 1% versus Bupivacain 0,75% ohne Vasokonstriktor. Vergleichende Untersuchung zur Epiduralanästhesie bei orthopädischen Eingriffen. Anaesthesist 42:605-611
18. Nigrovic V, Diefenbach Ch, Mellinghoff H (1997) Ester und Stereoisomere. Anaesthesist 46:282-286
19. Quitmann J, Wulf H, Bauer H, Hägglöf B (1996) Unpublished observation (Multicenterstudie Ropivacaine 95Ro93)
20. Reiz S, Haggmark S, Johansson G, Nath S (1989) Cardiotoxicity of ropivacaine - a new amide local anaesthetic agent. Acta Anaesthesiol Scand 33:93-98
21. Rosenberg PH, Heinonen E (1983) Differential sensitivity of A and C nerve fibres to long-acting amide local anaesthetics. Br J Anaesth 55:163-167
22. Sanchez-Chapula J (1988) Effects of bupivacaine on membrane currents of guinea-pig ventricular myocytes. Eur J Pharmacol 156:303-308
23. Santos AC, Pedersen H, Harmon TW, Morishima HO, Finster M, Arthur GR, Covino BG (1989) Does pregnancy alter the systemic toxicity of local anesthetics? Anesthesiology 70:991-995
24. Santos AC, Arthur GR, Pedersen H, Morishima HO, Finster M, Covino BG (1991) Systemic toxicity of ropivacaine during ovine pregnancy. Anesthesiology 75:137-141
25. Scott DB, Lee A, Fagan D, Bowler GM, Bloomfield P, Lundh R (1989) Acute toxicity of ropivacaine compared with that of bupivacaine. Anesth Analg 69:563-569
26. Tucker GT (1996) Chirality and its relevance to local anaesthetics. In: Keneally JP (ed) 150 years on - a selection of papers presented at the 11th WCA. WFSALondon, pp 97-101
27. Vanhoutte F, Vereecke J, Verbeke N, Carmeliet M (1991) Stereoselective effects of bupivacaine on the electrophysiological properties of the guinea pig papillary muscle. Br J Pharmacol 103:1275-1281
28. Wahedi W, Nolte H, Trombitas G, Wehking M (1990) Zur Frage der Äquipotenz von Ropivacain, Bupivacain und Etidocain. Anaesthesist/Reg Anaesth 13:66-72
29. Wulf H, Münstedt P, Maier C (1991) Plasma protein binding of bupivacaine in pregnant women at term. Acta Anaesthesiol Scand 35:129-133
30. Wulf H, Petry A, Gödicke J (1993) Die Potentialabhängigkeit der Wirkung von Bupivacain und Ropivacain am Herzen. In vitro-Untersuchungen zur Wirkung der Lokalanästhetika auf die Kontraktionskraft und das Aktionspotential. Anaesthesist 42:516-520
31. Wulf H, Gödicke J, Herzig S (1994) Functional interaction between local anaesthetics and calcium antagonists in guinea-pig myocardium: 2. Electrophysiologic studies with bupivacaine and nifedipine on the mechanism of action. Br J Anaesth 73:364-370
32. Wulf H (1996) Die kardialen Effekte der Lokalanästhetika: Wirkmechanismen und Interaktionen mit anderen Pharmaka. Arcis, München