Ropivacaine

British Journal of Anaesthesia

Volumn 76, Issue 2, 1996, Pages 300-307

  McClure, John H ^a  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

Author keywords

Anaesthetic local; Ropivacaine

Indexed keywords

BUPIVACAINE; LOCAL ANESTHETIC AGENT; MEPIVACAINE; ROPIVACAINE;

BRACHIAL PLEXUS ANESTHESIA; CESAREAN SECTION; CHEMICAL STRUCTURE; CONVULSION; DRUG SAFETY; EPIDURAL ANESTHESIA; HUMAN; INTRATHECAL DRUG ADMINISTRATION; LIPID SOLUBILITY; LOCAL ANESTHESIA; NERVE BLOCK; OBSTETRIC ANALGESIA; PERIPHERAL NERVE; PHARMACODYNAMICS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVIEW; SPINAL ANESTHESIA; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030020458     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/76.2.300     Document Type: Article

References (88)

1. Aberg G. Toxicological and local anaesthetic effects of opticaily active isomers of two local anaesthetic compounds. Acta Pharmacologica et Toxicologica 1972; 31: 273-286.
2. Aberg G, Dhuner KG, Sydnes G. Studies on the duration of local anaesthesia: Structure/activity relationships in a series of homologous local anaesthetics. Acta Pharmacologica et Toxicologica 1977; 41: 432-434.
3. Af Ekenstam B, Egner B, Petersson G. Local anaesthetics: 1. N-alkyl pyrrolidine and N-alkyl piperidine carboxylic amides. Acta Chemica Scandinavica 1957; 11: 1183-1190.
4. Af Ekenstam B, Egner B, Ulfendahl K, Dhuner KG, Oljelund O. Trials with carbocaine, a new local anaesthetic agent. British Journal of Anaesthesia 1956; 28: 503-506.
5. Akerman B, Hellberg IB, Trossvik C. Primary evaluation of the local anaesthetic properties of the amino amide agent ropivacaine (LEA 103). Acta Anaesthesiologica Scandinavica 1988; 32: 571-578.
6. Alahuhta S, Rasanen J, Jouppila P, Kangas-Saarela T, Jouppila R, Westerling P, Hollmen AI. The effects of epidural ropivacaine and bupivacaine for Cesarean section on uteroplacental and fetal circulation. Anesthesiology 1995; 83: 23-32.
7. Albright GA. Cardiac arrest following regional anesthesia with etidocaine or bupivacaine. Anesthesiology 1979; 51: 285-287.
8. Arlock P. Actions of three local anaesthetics: lidocaine, bupivacaine and ropivacaine on guinea pig papillary muscle sodium channels (V(max)). Pharmacology and Toxicology 1988; 63: 96-104.
9. Arthur GR, Feldman HS, Covino BG. Comparative pharmacokinetics of bupivacaine and ropivacaine, a new amide local anesthetic. Anesthesia and Analgesia 1988; 67: 1053-1058.
10. Axelsson K., Hallgren S, Widman B, Olstrin P. A new method for measuring motor block in the lower extremities. Acta Anaesthesiologica Scandinavica 1985; 29: 72-78.
11. Bader AM, Datta S, Flanagan H, Covino BG. Comparison of bupivacaine-and ropivacaine-induced conduction blockade in the isolated rabbit vagus nerve. Anesthesia and Analgesia 1989; 68: 724-727.
12. Brockway MS, Bannister J, McClure JH, McKeown D, Wildsmith JAW. Comparison of extradural ropivacaine and bupivacaine. British Journal of Anaesthesia 1991; 66: 31-37.
13. Bromage PR. A comparison of the hydrochloride and carbon dioxide salt of lidocaine and prilocaine in epidural analgesia. Acta Anaesthesiologica Scandinavica 1965 (Suppl. XVI): 55-69.
14. Brown DL, Carpenter RL, Thompson GE. Comparison of 0.5% ropivacaine and 0.5% bupivacaine for epidural anesthesia in patients undergoing lower-extremity surgery. Anesthesiology 1990; 72: 633-636.
15. Calvey TN. Chirality in anaesthesia. Anaesthesia 1992; 47: 93-94.
16. Cederholm I, Akerman B, Evers H. Local analgesic and vascular effects of intradermal ropivacaine and bupivacaine in various concentrations with and without addition of adrenaline in man. Acta Anaesthesiologica Scandinavica 1994; 38: 322-327.
17. Cederholm I, Anskar S, Bengtsson M. Sensory, motor, and sympathetic block during epidural analgesia with 0.5 % and 0.75 % ropivacaine with and without epinephrine. Regional Anesthesia 1994; 19: 18-33.
18. Cederholm I, Evers H, Lofstrom JB. Effect of intradermal injection of saline or a local anaesthetic agent on skin blood flow - a methodological study in man. Acta Anaesthesiologica Scandinavica 1991; 35: 208-215.
19. Cederholm I, Evers H, Lofstrom JB. Skin blood flow after intradermal injection of ropivacaine in various concentrations with and without epinephrine evaluated by laser Doppler flowmetry. Regional Anesthesia 1992; 17: 322-328.
20. Concepcion M, Arthur GR, Steele SM, Bader AM, Covino BG. A new local anesthetic, ropivacaine. Its epidural effects in humans. Anesthesia and Analgesia 1990; 70: 80-85.
21. Datta S, Camann W, Bader A, VanderBurgh L. Clinical effects and maternal and fetal plasma concentrations of epidural ropivacaine versus bupivacaine for cesarean section. Anesthesiology 1995; 82: 1346-1352.
22. Duthie AM, Wyman JB, Lewis GA. Bupivacaine in labour: its use in lumbar extradural analgesia. Anaesthesia 1968; 23: 20-26.
23. Ekblom L, Widman B. A comparison of the properties of LAC-43, prilocaine and mepivacaine in extradural anaesthesia. Acta Anaesthesiologica Scandinavica 1966 (Suppl. XXI): 33-43.
24. Erichsen CJ, Vibits H, Dahl JB, Kehlet H. Wound infiltration with ropivacaine and bupivacaine for pain after inguinal herniotomy. Acta Anaesthesiologica Scandinavica 1995; 39: 67-70.
25. Federsel H, Jaksch P, Sandberg R. An efficient synthesis of a new, chiral 2′, 6′-pipecoloxylidide local anaesthetic agent. Acta Chemica Scandinavica 1987; B41: 757-761.
26. Feldman HS, Arthur GR, Covino BG. Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine, bupivacaine, and lidocaine in the conscious dog. Anesthesia and Analgesia 1989; 69: 794-801.
27. Feldman HS, Arthur GR, Pitkanen M, Hurley R, Doucette AM, Covino BG. Treatment of acute systemic toxicity after the rapid intravenous injection of ropivacaine and bupivacaine in the conscious dog. Anesthesia and Analgesia 1991; 73: 373-384.
28. Feldman HS, Covino BG. Comparative motor-blocking effects of bupivacaine and ropivacaine, a new amino amide local anesthetic, in the rat and dog. Anesthesia and Analgesia 1988; 67: 1047-1052.
29. Griffin RP, Reynolds F. Extradural anaesthesia for Caesarean section: A double-blind comparison of 0.5 % ropivacaine with 0.5% bupivacaine. British Journal of Anaesthesia 1995; 74: 512-516.
30. Guinard JP, Nadir B, Carpenter RL, Owens BD. Original article. Comparison between ropivacaine and bupivacaine after subcutaneous injection in pigs: Cutaneous blood flow and surgical bleeding. Regional Anesthesia 1991; 16: 268-271.
31. Heath ML. Deaths after intravenous regional anaesthesia. British Medical Journal 1982; 285: 913-914.
32. Hickey R, Blanchard J, Hoffman J, Sjovall J, Ramamurthy S. Plasma concentrations of ropivacaine given with or without epinephrine for brachial plexus block. Canadian Journal of Anaesthesia 1990; 37: 878-882.
33. Hickey R, Candido KD, Ramamurthy S, Winnie AP, Blanchard J, Raza SM, Hoffman J, Durrani Z, Masters RW. Brachial plexus block with a new local anaesthetic: 0.5 per cent ropivacaine. Canadian Journal of Anaesthesia 1990; 37: 732-738.
34. Hickey R, Hoffman J, Ramamurthy S. A comparison of ropivacaine 0.5 % and bupivacaine 0.5 % for brachial plexus block. Anesthesiology 1991; 74: 639-642.
35. Hickey R, Rowley CL, Candido KD, Hoffman J, Ramamurthy S, Winnie AP. A comparative study of 0.25 % ropivacaine and 0.25 % bupivacaine for brachial plexus block. Anesthesia and Analgesia 1992; 75: 602-606.
36. Johansson B, Glise H, Hallerback B, Dalman P, Kristoffersson A. Preoperative local infiltration with ropivacaine for postoperative pain relief after cholecystectomy. Anesthesia and Analgesia 1994; 78: 210-214.
37. Kasten GW. High serum bupivacaine concentrations produce rhythm disturbances similar to torsades de pointes in anesthetised dogs. Regional Anesthesia 1986; 11: 20-25.
38. Katz JA, Bridenbaugh PO, Knarr DC, Helton SH, Denson DD. Pharmacodynamics and pharmacokinetics of epidural ropivacaine in humans. Anesthesia and Analgesia 1990; 70: 16-21.
39. Katz JA, Knarr D, Bridenbaugh PO. A double-blind comparison of 0.5% bupivacaine and 0.75% ropivacaine administered epidurally in humans. Regional Anesthesia 1990; 15: 250-252.
40. Katz JA, Sehlhorst CS, Thompson GA, Denson DD, Coyle D, Bridenbaugh PO. Pharmacokinetics of intravenous and epidural ropivacaine in the Rhesus monkey. Biopharmaceutics and Drug Disposition 1993; 14: 579-588.
41. Kerkkamp HEM, Gielen MJM. Cardiovascular effects of epidural local anaesthetics. Comparison of 0.75% bupivacaine and 0.75% ropivacaine, both with adrenaline. Anaesthesia 1991; 46: 361-365.
42. Kerkkamp HEM, Gielen MJM, Edstrom HH Comparison of 0.75 % ropivacaine with epinephrine and 0.75 % bupivacaine with epinephrine in lumbar epidural anesthesia. Regional Anesthesia 1990; 15: 204-207.
43. Kopacz DJ, Carpenter RL, Mackey DC. Effect of ropivacaine on cutaneous capillary blood flow in pigs. Anesthesiology 1989; 71: 69-74.
44. Kopacz DJ, Emanuelsson BM, Thompson GE, Carpenter RL, Stephenson CA. Pharmacokinetics of ropivacaine and bupivacaine for bilateral intercostal blockade in healthy male volunteers. Anesthesiology 1994; 81: 1139-1148.
45. Lanz E, Theiss D, Kellner G, Zimmer M, Staudte H. Assessment of motor blockade during epidural anesthesia. Anesthesia and Analgesia 1983; 62: 889-893.
46. Lee A, Fagan D, Lamont M, Tucker GT, Halldin M, Scott DB. Disposition kinetics of ropivacaine in humans. Anesthesia and Analgesia 1989; 69: 736-738.
47. Luduena FP. Duration of local anesthesia. Annual Review of Pharmacology 1969; 9: 503-520.
48. Marx GF. Cardiotoxicity of local anesthetics - the plot thickens. Anesthesiology 1984; 60: 3-5.
49. McCrae AF, Jozwiak H, McClure JH. Comparison of ropivacaine and bupivacaine in extradural analgesia for the relief of pain in labour. British Journal of Anaesthesia 1995; 74: 261-265.
50. Moller R, Covino BG. Cardiac electrophysiologic properties of bupivacaine and lidocaine compared with those of ropivacaine, a new amide local anesthetic. Anesthesiology 1990; 72: 322-329.
51. Moller RA, Covino BG. Effect of progesterone on the cardiac electrophysiologic alterations produced by ropivacaine and bupivacaine. Anesthesiology 1992; 77: 735-741.
52. Morishima HO, Pedersen H, Finster M, Hiraoka H, Tsuji A, Feldman HS, Arthur GR, Covino BG. Bupivacaine toxicity in pregnant and non-pregnant ewes. Anesthesiology 1985; 63: 134-139.
53. Morrison LMM, Emanuelsson BM, McClure JH, Pollok AJ, McKeown DW, Brockway M, Jozwiak H, Wildsmith JAW. Efficacy and kinetics of extradural ropivacaine: Comparison with bupivacaine. British Journal of Anaesthesia 1994; 72: 164-169.
54. Nakamura K, Toda H, Kakuyama M, Nishiwada M, Yamamoto M, Hatano Y, Mori K. Direct vascular effect of ropivacaine in femoral artery and vein of the dog. Acta Anaesthesiologica Scandinavica 1993; 37: 269-273.
55. Nancarrow C, Rutten AJ, Runciman WG, Mather LE, Carapetis RJ, McLean CF, Hipkins SF. Myocardial and cerebral drug concentrations and the mechanisms of death after fatal intravenous doses of lidocaine, bupivacaine, and ropivacaine in the sheep. Anesthesia and Analgesia 1989; 69: 276-283.
56. Niesel HC, Eilingsfeld T, Hornung M, Kaiser H. Ropivacain 1 % versus bupivacain 0.75% ohne vasokonstriktor. Vergleichende untersuchung zur epiduralanasthesie bei orthopadischen eingriffen. Plain ropivacaine 1% versus bupivacaine 0.75 % in epidural anaesthesia. A comparative study in orthopaedic surgery. Anaesthesist 1993; 42: 605-611.
57. Niesel HC, Eilingsfeld T, Kaiser H, Klimpel L. Ropivacain zur periduralanasthesia. Untersuchungen zur dosiswirkungsrelation bei orthopadischen eingriffen. Ropivacaine in epidural analgesia. Dose-response study in orthopaedic surgery. Anaesthetist - Regional Anaesthesia 1990; 13: 73-77.
58. Nolte H, Fruhstorfer H, Edstrom HH. Local anesthetic efficacy of ropivacaine (LEA 103) in ulnar nerve block. Regional Anesthesia 1990; 15: 118-124.
59. Nydahl P, Axelsson K, Hallgren S, Larsson P, Leissner P, Philipson L. Evaluation of motor blockade by isometric force measurement and electromyographic recording during epidural anaesthesia - a methodological study. Acta Anaesthesiologica Scandinavica 1988; 32: 477-484.
60. Pitkanen M, Covino BG, Feldman HS, Arthur GR. Chronotropic and inotropic effects of ropivacaine, bupivacaine, and lidocaine in the spontaneously beating and electrically paced isolated, perfused rabbit heart. Regional Anesthesia 1992; 17: 183-192.
61. Reiz S, Haggmark S, Johansson G, Nath S. Cardiotoxicity of ropivacaine - A new amide local anaesthetic agent. Acta Anaesthesiologica Scandinavica 1989; 33: 93-98.
62. Reiz S, Nath S. Cardiotoxicity of local anaesthetic agents. British Journal of Anaesthesia 1986; 58: 736-746.
63. Rosenberg PH, Heinonen E. Differential sensitivity of A and C nerve fibres to long-acting amide local anaesthetics. British Journal of Anaesthesia 1983; 55: 163-167.
64. Rosenberg PH, Kytta J, Alila A. Absorption of bupivacaine, etidocaine, lignocaine and ropivacaine into n-heptane, rat sciatic nerve, and human extradural and subcutaneous fat. British Journal of Anaesthesia 1986; 58: 310-314.
65. Rubin AP, Lawson DIF. A controlled trial of bupivacaine: a comparison with lignocaine. Anaesthesia 1968; 23: 327-330.
66. Rutten AJ, Mather LE, Nancarrow C, Sloan PA, McLean CF. Cardiovascular effects and regional clearances of intravenous ropivacaine in sheep. Anesthesia and Analgesia 1990; 70: 577-582.
67. Rutten AJ, Nancarrow C, Mather LE, Ilsley AH, Runciman WB, Upton RN. Hemodynamic and central nervous system effects of intravenous bolus dose of lidocaine, bupivacaine, and ropivacaine in sheep. Anesthesia and Analgesia 1989; 69: 291-299.
68. Santos AC, Arthur GR, Pedersen H, Morishima HO, Finster M, Covino BG. Systemic toxicity of ropivacaine during ovine pregnancy. Anesthesiology 1991; 75: 137-141.
69. Santos AC, Arthur GR, Wlody D, De Armas P, Morishima HO, Finster M. Comparative systemic toxicity of ropivacaine and bupivacaine in nonpregnant and pregnant ewes. Anesthesiology 1995; 82: 734-740.
70. Scott DB, Lee A, Fagan D, Bowler GMR, Bloomfield P, Lundh R. Acute toxicity of ropivacaine compared with that of bupivacaine. Anesthesia and Analgesia 1989; 69: 563-569.
71. Scott DB, McClure JH, Giasi RM, Seo J, Covino EG. Effects of concentration of local anaesthetic drugs in extradural blockade. British Journal of Anaesthesia 1980; 52: 1033-1037.
72. Steel GC, Dawkins CJM. Extradural lumbar block with bupivacaine (Marcain: LAC-43). Anaesthesia 1968; 23: 14-19.
73. Stienstra R, Jonker TA, Bourdrez P, Kuijpers JC, Van Kleef JW, Lundberg U. Ropivacaine 0.25 % versus bupivacaine 0.25% for continuous epidural analgesia in labor: A double-blind comparison. Anesthesia and Analgesia 1995; 80: 285-289.
74. Terasaki T, Pardridge WM, Denson DD. Differential effect of plasma protein binding on its in-vivo transfer into brain and salivary gland of rats. Journal of Pharmacology and Experimental Therapeutics 1986; 239: 724-729.
75. Tucker GT. Pharmacokinetics of local anaesthetics. British Journal of Anaesthesia 1986; 58: 717-731.
76. Van Kleef JW, Veering BT, Burm AGL. Spinal anesthesia with ropivacaine: A double-blind study on the efficacy and safety of 0.5% and 0.75% solutions in patients undergoing minor lower limb surgery. Anesthesia and Analgesia 1994; 78: 1125-1130.
77. Vanhoutte F, Vereecke J, Verbeke N, Carmeliet E. Stereo-selective effects of enantiomers of bupivacaine on the electrophysiological properties of the guinea-pig papillary muscle. British Journal of Pharmacology 1991; 103: 1275-1281.
78. Veering BT, Burm AGL, Van Kleef JW, Hennis PJ, Spierdijk J. Epidural anesthesia with bupivacaine: effects of age on neural blockade and pharmacokinetics. Anesthesia and Analgesia 1987; 66: 589-594.
79. Watt MJ, Ross DM, Atkinson RS. A double-blind trial of bupivacaine and lignocaine: Latency and duration in extradural blockade. Anaesthesia 1968; 23: 311-373.
80. Watt MJ, Ross DM, Atkinson RS. Clinical trial of bupivacaine. Anaesthesia 1968; 23: 2-13.
81. Whitehead E, Arrigoni B, Bannister J. An open study of ropivacaine in extradural anaesthesia. British Journal of Anaesthesia 1990; 64: 67-71.
82. Widman B. Clinical trial of a new local anaesthetic (LAC-43) with the aid of the pinprick and ninhydrin methods in finger blocks. Acta Anaesthesiologica Scandinavica 1964; 8: 219-226.
83. Wildsmith JAW, Brown DT, Paul D, Johnson S. Structure-activity relationships in differential nerve block at high and low frequency stimulation. British Journal of Anaesthesia 1989; 63: 444-452.
84. Wolff AP, Hasselstrom L, Kerkkamp HE, Gielen MJ. Extradural ropivacaine and bupivacaine in hip surgery. British Journal of Anaesthesia 1995; 74: 458-460.
85. Wood MB, Rubin AP. A comparison of epidural 1% ropivacaine and 0.75% bupivacaine for lower abdominal gynecologic surgery. Anesthesia and Analgesia 1993; 76: 1274-1278.
86. Zaric D, Axelsson K, Nydahl PA, Philipson L, Larsson P, Jansson JR. Sensory and motor blockade during epidural analgesia with 1%, 0.75%, and 0 5% ropivacaine - A double-blind study. Anesthesia and Analgesia 1991; 72: 509-515.
87. Zaric D, Axelsson K, Philipson L, Nydahl PA, Larsson P, Jansson JR, Leissner P. Blockade of the abdominal muscles measured by EMG during lumbar epidural analgesia with ropivacaine - A double-blind study. Acta Anaesthesiologica Scandinavica 1993; 37: 274-280.
88. Zaric D, Nydahl P, Philipson L, Samuelsson L, Heierson A, Axelsson K. The effect of continuous lumbar epidural infusion of ropivacaine (0 1%, 0.2% and 0.3%) and 0.25% bupivacaine on sensory and motor blockade in volunteers:-a double-blind study. Regional Anesthesia 1995; in press.