Expression of both Th1 and Th2 cytokines correlates with the histological rejection of MHC-matched and MHC-mismatched foetal pancreas allografts in mice

Immunology and Cell Biology

Volumn 75, Issue 3, 1997, Pages 303-309

  Kovarik, Jiri ^a,c   Koulmanda, Maria ^a   Mandel, Thomas E ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

Allograft rejection; Complex antigens; Cytokine mRNA; Major histocompatibility; Minor histocompatibility

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; LYMPHOTOXIN; MAJOR HISTOCOMPATIBILITY ANTIGEN; MINOR HISTOCOMPATIBILITY ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; GRAFT REJECTION; HISTOINCOMPATIBILITY; IMMUNOPATHOGENESIS; IMMUNOREGULATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MINOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PANCREAS TRANSPLANTATION;

ANIMALIA;

EID: 0030743107     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1038/icb.1997.46     Document Type: Article

References (20)

1. Robertson RP. Pancreas transplantation in humans with diabetes mellitus. Diabetes 1991; 40: 1085-9.
2. Carlquist JF, Shelby J, Hammond EH, Greenwood JH, Anderson JL. Histoincompatibility-associated differences in the phenotypes of murine cardiac allograft infiltrating T cells. Immunology 1994; 82: 149-53.
3. Wang YC, Mayne A, Sell KW, Ahmed-Ansari A. The influence of MHC and non-MHC genes on the nature of murine cardiac allograft rejection. Transplantation 1990; 50: 313-24.
4. Hiller WFA, Steiniger B, Klempnauer J. The role of histocompatibility antigens in transplantation of isolated islets of Langerhans in the rat. Diabetes 1993; 42: 90-7.
5. Bishop DK, DeBruyne LA, Chan S, Xu S, Eichwald EJ. Dissociation of mouse cardiac transplant rejection and donor alloantigen-specific T cell responsiveness. Transpl. Immunol. 1995; 3: 222-8.
6. Nickerson P, Pacheco-Silva A, O'Connell PJ, Steurer W, Rubin Kelley V, Strom TB. Analysis of cytokine transcripts in pancreatic islet cell allografts during rejection and tolerance induction. Transplant. Proc. 1993; 25: 984-5.
7. Busker AE, Miller SD, Melvold RW. Induction of allograft tolerance to the H-Y antigen in adult C57BL/6 mice: differential effects on delayed-type hypersensitivity and cytolytic T-lymphocyte activity. Cell. Immunol. 1990; 125: 225-34.
8. + cytotoxic T cells directed to donor MHC class I peptides following mouse allotransplantation. Transplantation 1995; 60: 1621-4.
9. Georgiou HM, Mandel TE. Influence of tissue culture on the survival of major histocompatibility complex-compatible fetal pancreas allografts in the mouse. Transplant. Proc. 1987; 19: 942-3.
10. Mandel TE, Hoffman L, Collier S, Carter WM, Koulmanda M. Organ culture of fetal mouse and fetal human pancreatic islets for allografting. Diabetes 1982; 31: 39-47.
11. Simpson E, Tomonari K, Lovering E. Minor transplantation antigens: their role in shaping the T cell repertoire. Immunol. Lett. 1989; 21: 39-44.
12. Simpson E. Minor histocompatibility antigens. Immunol. Lett. 1991; 29: 9-14.
13. Warrens AN, Lombardi G, Lechler RI. MHC and alloreactivity: Presentation and recognition of major and minor histocompatibility antigens. Transpl. Immunol. 1994; 2: 103-7.
14. Simeonovic CJ, Lafferty KJ. Immunogenicity of mouse fetal pancreas and proislets: a comparison. Transplantation 1988; 45: 824-7.
15. Burdick JF, Clow LW. Rejection of murine cardiac allografts. Transplantation 1986; 42: 67-72.
16. Burkhardt K, Charlton B, Mandel TE. An increase in the survival of murine H-2-mismatched cultured fetal pancreas allografts using depleting or non-depleting anti-CD4 monoclonal antibodies, and a further increase with the addition of cyclosporine. Transplantation 1989; 47: 771-5.
17. Halloran PF, Broski AP, Batiuk TD, Madrenas J. The molecular immunology of acute rejection: an overview. Transpl. Immunol. 1993; 1: 3-27.
18. + T cells and B cells. Transplantation 1996; 61: 1678-84.
19. Cher DJ, Mosmann TR. Two types of murine helper T cell clone. 2: Delayed-type hypersensitivity is mediated by Th1 clones. J. Immunol. 1987; 138: 3688-94.
20. Kovarik J, Faulkner-Jones BE, Koulmanda M, Mandel TE. Expression of cytokines during rejection of fetal pig islet xenografts in non-obese diabetic mice. Transplant. Proc. 1996; 28: 831.